Found 935 results for "longevity"
Finding reliable biomarkers of aging remains one of the most challenging puzzles in longevity research, with most studies limited to single tissues or time poi…
The translation of promising anti-aging compounds from laboratory to clinic faces a critical bottleneck: the absence of validated biomarkers to measure cellula…
The FAXAge trial will randomize 240 healthy adults over 65 into four groups—exercise alone, time-restricted feeding alone, both interventions combined, or cont…
Blood stem cells carrying faulty p53 genes may exploit the body's inflammatory responses to gain an unfair survival advantage, potentially explaining why certa…
Two compounds increasingly popular among longevity enthusiasts may work through fundamentally different cellular pathways, suggesting strategic timing and comb…
The trajectory of human cardiovascular health reveals a sobering paradox: despite decades of medical advances and prevention campaigns, the global burden of he…
The silent epidemic of gout is reshaping global health patterns, with 57 million people now living with this painful joint condition that disproportionately st…
The relationship between metabolic rate and body size may be far more complex than previously understood, with profound implications for how we interpret energ…
The most metabolically resilient animals on Earth may hold keys to solving humanity's most stubborn health challenges. From bears that emerge from months-long…
Understanding how immune cells maintain tissue health could unlock new approaches to inflammatory diseases and age-related tissue dysfunction. Macrophages serv…
Daily resveratrol supplementation at 500mg for 18 weeks significantly improved balance, gait speed, and knee range of motion in 129 osteoarthritis patients, wh…
High glucose levels accelerate bone marrow mesenchymal stem cell senescence through a newly identified Mettl3/Foxo3/Sirt1 molecular axis. In diabetic mice, hyp…
Lin's research reveals a sophisticated glucose-sensing mechanism where the AXIN:LKB1 complex translocates to lysosomal surfaces when aldolase detects low gluco…
Aspartame at 100 μM concentrations activated autophagy genes (bec-1, unc-51, lgg-1, lgg-2, atg-5) in C. elegans worms, extending lifespan while enhancing resis…
Eleutheroside B, a compound from Siberian ginseng, dramatically reduced amyloid-beta and tau protein accumulation while improving cognition and lifespan in tra…
The explosive rise in ultra-processed food consumption across Europe represents a fundamental shift in cancer risk that most adults underestimate. These conven…
The mystery of why kidney disease accelerates heart failure may finally have a molecular explanation. While cardiovascular complications kill more than half of…
Pathogenic gut bacteria and their metabolites accelerate telomere shortening through oxidative stress pathways, while shortened telomeres compromise gut barrie…
Reduced forms of NAD+ precursors—NMNH and NRH—triggered dramatically broader metabolic and transcriptional changes in mouse liver cells compared to their oxidi…
One month of rapamycin treatment in reproductively aged 10-month-old female mice suppressed mTOR signaling and reduced cellular senescence, inflammation, fibro…