Studies
GLP-1 Agonists Show No Clear Advantage Over Other Agents for Insulin Discontinuation
For the millions of people with type 2 diabetes who take daily basal insulin injections, the prospect of eventually dis…
Fitness
Studies on physical activity, training, recovery, and movement.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Wellbeing
One-Third of US Women Uncertain About Perimenopause Stage, Survey Finds
Perimenopause remains one of the most clinically under-served transitions in women's health, and a major reason may be…
Longevity
Lp(a): Genetic Cardiovascular Risk Factor Affecting 20% Awaits Targeted Therapies
For roughly one in five adults, cardiovascular risk is quietly elevated by a factor that standard lipid panels often ig…
Nutrition
Mediterranean Diet Cuts HbA1c and Reshapes Gut Microbiome in Diabetes-Risk Adults
For the roughly one-in-three adults who live with prediabetes or elevated cardiovascular risk, diet remains the most ac…
Studies
Tanzania Phase 1/2 Trial Tests Intranasal COVID Vaccine for Equity Gaps
Vaccine access inequity remains one of the most persistent structural failures exposed by the COVID-19 pandemic, and ad…
Studies
AI Stress Echocardiography Aligns with Cardiologists 60% of the Time
Cardiac imaging sits at a crossroads: AI tools are fast, scalable, and increasingly accurate, yet how they perform alon…
Studies
Review Links AI Natural Language Tools to ~28% Lower COPD Readmissions, Improved Chronic Disease Outcomes
As healthcare systems struggle to extract actionable signals from the vast volumes of unstructured clinical text—patien…
Nutrition
Lower Capsaicin Intake Linked to Aortic Dissection in Small Human Study; Mouse Experiments Implicate TRPV1-Macrophage and Gut Microbiome Pathways
Aortic dissection kills rapidly and remains pharmacologically underserved — no drug reliably slows its progression once…
Studies
Copper-Targeting Drug Trientine Shows Structural Heart Benefits in Phase 2 HCM Trial
Hypertrophic cardiomyopathy — a leading cause of sudden cardiac death in young adults and a driver of progressive heart…
Longevity
Mito-Nuclear Genome Mismatch Accelerates Mitochondrial Aging in Fly Populations
The compatibility between an organism's mitochondrial and nuclear genomes may be a surprisingly powerful determinant of…
Studies
RNA Aptamer 1R6 Blocks Alpha-Synuclein Aggregation Across Multiple Model Systems
For the estimated one million Americans living with Parkinson's disease — and the broader population affected by Lewy b…
Studies
NEJM Clinical Review Reframes Fibromyalgia Mechanisms and Management Approaches
For the millions of adults living with widespread chronic pain that defies easy diagnosis, a comprehensive clinical rev…
Studies
Extended Dual Antiplatelet Therapy in CAD: Weighing Bleeding Against Clot Risk
For the millions of adults living with coronary artery disease who have undergone stenting, one of the most consequenti…
Studies
Post-Pandemic Respiratory Virus Risk Map: Genetics, Behavior, and Comorbidities Charted
Understanding who is most vulnerable to respiratory viruses — and why — has never been more urgent. Post-pandemic shift…
Studies
Narrative Review Examines GIP's Role in Cardiorenal Effects of Dual GIP/GLP-1 Agonists Like Tirzepatide
Understanding how a widely prescribed diabetes and obesity drug protects the heart and kidneys — and whether that prote…
Studies
Extended Blood-Thinning Dual Therapy Cuts Heart Events in Multivessel Disease
For the tens of millions of adults living with multivessel coronary artery disease, the duration of antiplatelet therap…
Studies
First Oral PCSK9 Inhibitor Shows LDL Reduction in Phase 1 Trial
For the millions of adults managing elevated LDL cholesterol, the requirement for injectable PCSK9 inhibitors — adminis…
Studies
AI-Driven Venomics Accelerates Toxin-to-Therapy Pipeline for Human Disease
For decades, animal venoms have tantalized pharmacologists with their exquisite molecular precision — compounds honed b…
PREPRINTLongevity
Nodular Carotid Plaque Calcification Predicts 2.9x Higher Cardiac Death Risk
Among 479 patients (154 women) undergoing carotid endarterectomy and followed for a decade, nodular calcification withi…
PREPRINTLongevity
ECG 'Eyeball' Geometry Detects Heart Attacks from 30-Second Wearable Recordings
A geometric signal-processing framework called the ECG time-frequency "eyeball" successfully differentiated acute myoca…
PREPRINTLongevity
Aficamten Eliminates Invasive Heart Surgery Need in 97% of HCM Patients
Among 104 obstructive hypertrophic cardiomyopathy (oHCM) patients meeting 2024 ACC/AHA criteria for invasive septal red…
Nutrition
Dietary Capsaicin Linked to Lower Aortic Dissection Risk via TRPV1-Macrophage and Microbiome Pathways in Preliminary Study
Aortic dissection—a sudden, life-threatening tear in the aortic wall—carries mortality rates that can exceed 50% within…
Studies
Blocking Elastin Breakdown Slows Osteoarthritis Across Three Species
Osteoarthritis quietly dismantles the cartilage of roughly 500 million people worldwide, yet the field has long fixated…
Studies
GLP-1 Receptor Agonists Show Promise Reducing Binge Eating Episodes in Systematic Review
Binge eating disorder affects millions of adults and carries serious cardiometabolic consequences, yet the pharmacologi…
Wellbeing
Persistent Adolescent Loneliness Doubles Psychotic Experience Risk by Age 16
Most discussions of adolescent mental health focus on depression and anxiety — but the link between chronic loneliness…
Fitness
SDT-Coached Digital Intervention Boosts Children's MVPA but Gains Fade
Getting children to move more at home — without a gym, a coach, or a school PE class — remains one of the hardest probl…
Studies
AI-Enhanced ECG Detects Hidden Heart Disease From Normal-Looking Tracings
Most adults undergo an ECG at some point in their lives, yet the standard interpretation extracts only a fraction of th…
Studies
Deep Learning Synthesizes Tau-PET Brain Scans From Blood Tests and MRI
Access to definitive Alzheimer's imaging has long been constrained by cost and geography — a gap that disproportionatel…
Studies
EBV Molecular Mimicry and Helminth Tolerance Reframe MS Immune Mechanisms
Multiple sclerosis has long resisted a single explanatory framework, frustrating both patients and clinicians. A growin…
Studies
Selective D1/D5 Agonist Tavapadon Extends Parkinson's On-Time in Phase 3 Trial
Motor fluctuations — the unpredictable cycling between good mobility and frozen immobility — represent one of the most…
Longevity
Green Space Linked to 13% Lower CVD Odds, But NO2 May Attenuate the Benefit
Where someone lives may matter as much as how they live. The simultaneous pull of urban greenery and urban air pollutio…
Wellbeing
EEG Reveals Two-Stage Neural Breakdown in Autistic Children's Audiovisual Speech
How the brain stitches together what eyes see and ears hear during speech is a capability most people take for granted…
Studies
Bispecific ADC Targets EGFR/HER3 in Treatment-Resistant Prostate Cancer with Defined Resistance Mechanism
Metastatic castration-resistant prostate cancer carries one of oncology's bleakest prognoses, and the antibody-drug con…
Studies
72% of Sri Lankan Children Carry Dengue Antibodies by Age 16
In regions where dengue is endemic, understanding exactly when children acquire immunity — and to which viral strains —…
Studies
Recurrent Heart Attacks Carry Higher Mortality and Complication Burden Than First Events
Surviving a heart attack no longer means the danger has passed — it increasingly means a patient enters a higher-risk c…
Longevity
GDF15 and Activin A Emerge as Cross-Domain Senescence Biomarkers Linking 4 Age-Related Disease Categories
A comprehensive NIH-authored compendium identifies circulating senescence-associated secretory phenotype (SASP) factors…
Fitness
Semaglutide + Exercise Cuts Fat 45%, Partially Saves Muscle via Mitochondrial Pathways
In diet-induced obese Ldlr-/-.Leiden mice over 14 weeks, semaglutide alone reduced fat mass by 31% but also trimmed lea…
Supplements
Piceatannol Cuts IGFBP4/5/7 Senescence Signals, Improves Memory in Aging Mice
Oral piceatannol (PCT), a stilbene and direct resveratrol metabolite with superior bioavailability, demonstrably reduce…
Longevity
Irisin Links Muscle Contraction to Alzheimer's Protection via Brain Signaling
With Alzheimer's disease cases in the U.S. projected to more than double to 14 million by 2060, the search for modifiab…
Studies
E3 Ubiquitin Ligase RNF10 Loss Triggers Cardiac Mitophagy Failure and Hypertrophy
Cardiac hypertrophy — the pathological thickening of heart muscle — remains one of the leading precursors to heart fail…
Studies
Brain Tumor Growth Hijacks Cell Competition to Overcome Tissue Resistance
Understanding how nascent tumors escape the physical constraints of healthy tissue is one of cancer biology's most cons…
Studies
GCN2 Kinase Deficiency Drives IL-6-Mediated Pulmonary Hypertension in Mice
Pulmonary hypertension remains one of the most underdiagnosed and poorly understood cardiovascular conditions, with cur…
Nutrition
Online Food Delivery Widens China's Obesity Gap Along Socioeconomic Lines
The rapid digitization of food access may be quietly restructuring who gets sick and who stays healthy — and new large-…
Studies
Histone Chaperone HIRA Links Epigenomic Control to Fat Tissue Metabolism
Understanding why fat tissue malfunctions in obesity has long focused on hormones and calories, but the molecular switc…
Studies
One-Third of US Women Uncertain About Perimenopause Stage, Survey Finds
Perimenopause is one of the most consequential yet least clinically defined transitions in a woman's reproductive life…
Longevity
Senescent Liver Cells Drive Age-Specific Injury via IL-1α Signaling Axis
For older adults undergoing liver surgery or transplantation, the risk of serious postoperative complications is dispro…
PREPRINTLongevity
CFD Biomarkers Predict Post-Thrombectomy Pulmonary Pressure Outcomes in 6 PE Patients
Computational fluid dynamics (CFD) simulations of patient-specific pulmonary vasculature revealed that intermediate-ris…
PREPRINTLongevity
Solid-State Magnetocardiography Shows Lower Site-of-Origin Error Than ECGi in Preclinical Swine Arrhythmia Study
A novel solid-state magnetocardiography (MCG) system outperformed electrocardiographic imaging (ECGi) in pinpointing ar…
PREPRINTLongevity
AI ECG Model Predicts Heart Failure 5 Years Out With 0.97 C-Index
A convolutional neural network trained on raw 12-lead ECGs from Zhongshan Hospital and validated in two independent coh…
Longevity
Spermine Chelates Fe²⁺ to Block Ferroptosis, Completing Polyamine Longevity Model
A new mechanistic framework resolves a long-standing paradox in polyamine biology: spermidine drives autophagy by inhib…
Supplements
Asp9Glu Mutation Yields Biased GLP-1/Glucagon Dual-Agonist with Enhanced Weight Loss
A single conservative amino acid substitution — replacing aspartate with glutamate at position 9 of glucagon and GLP-1…
Fitness
Daily Step Count and Light Activity Linked to Lower Pregnancy Complication Risk
Pregnancy complications such as gestational hypertension and preeclampsia remain among the most dangerous — and potenti…
Studies
Opportunistic Salpingectomy Associated With Reduced Risk of Tubo-Ovarian Cancer, Per ESGO Consensus
Ovarian cancer remains one of the most lethal gynecologic malignancies partly because it is rarely detected early — whi…
Nutrition
Exocrine Pancreatic Insufficiency: Clinical Diagnosis and Management Insights
Malabsorption disorders often evade early detection, and exocrine pancreatic insufficiency (EPI) is among the most comm…
Longevity
Five Decades of Alzheimer Prevention Research: Where the Science Now Stands
For the tens of millions of adults who carry genetic or lifestyle risk factors for Alzheimer's disease, the question of…
Fitness
AHA Statement: Exercise Preserves Muscle Mass Where GLP-1 Drugs Fall Short
The rapid adoption of GLP-1 receptor agonists has reshaped obesity treatment, but a critical question has emerged: if w…
Nutrition
Ultra-Processed Food Consumption Tied to Mortality and Cardiometabolic Disease Risk
For decades, nutritional science has debated whether the danger in modern diets lies in specific macronutrients — fat,…
Studies
CGM Linked to Lower HbA1c and Mortality Risk in Type 2 Diabetes, But Access Gaps Persist
Continuous glucose monitoring has long been associated with tight glycemic control in type 1 diabetes, but its role in…
Studies
PM2.5 and Traffic Noise Linked to Hypertension Via Oxidative Stress Pathways
Hypertension is widely understood as a product of genetics, diet, and lifestyle — yet a growing body of evidence demand…
Nutrition
Daily Wholegrain Intake Above 90g Linked to 22% Lower Breast Cancer Risk
For the millions of women navigating breast cancer prevention, dietary choices remain one of the few modifiable levers…
Wellbeing
Biological Stress Load Moderates Mental Health Risk After Childhood Maltreatment
Understanding why some maltreated children develop serious psychiatric conditions while others remain more resilient ha…
Wellbeing
Acute Stress Linked to Lower Synaptic Density Across Psychosis Spectrum
Synaptic loss has long been suspected in schizophrenia, but identifying modifiable upstream drivers — ones that could b…
Studies
Newborn Collapse Risk Peaks in First Four Hours: 20-Year Swedish Cohort
A rare but devastating event that strikes seemingly healthy newborns has been systematically underestimated — and a lar…
Studies
Adolescent TBI Linked to 5-Year Surge in Psychiatric and Addiction Risk
Brain injuries during adolescence may leave a psychiatric fingerprint that extends years beyond the physical recovery p…
Studies
Semaglutide Linked to Bilateral Optic Nerve Damage in Diabetic Patient
The expanding use of GLP-1 receptor agonists like semaglutide has introduced an ophthalmologic safety question that pra…
Wellbeing
Aerobic Exercise and Mindfulness Show Mixed Effects on Brain Network Connectivity
For anyone investing time in meditation or cardio to protect cognitive aging, the assumption that these practices measu…
Nutrition
Nine Dietary Compounds Mapped to Sleep Architecture and Circadian Biology
Sleep is increasingly recognized not as passive downtime but as an active biological maintenance window — and the compo…
Studies
AI Nursing Tools Cut Workload in Half of Studies, But Technostress Risk Persists
Healthcare systems worldwide are betting heavily on artificial intelligence to solve a nursing workforce crisis that sh…
Longevity
Senolytic Drugs Reverse Aged Microglia Buildup in Brain White Matter
In naturally aged mice, a previously uncharacterized microglial population accumulates specifically in hippocampal-adja…
Studies
Phase 3 Semaglutide Trials Find No Cognitive Benefit in Early Alzheimer's
The hypothesis that GLP-1 receptor agonists could slow Alzheimer's progression was among the most watched bets in neuro…
Longevity
Semaglutide Cuts Epigenetic Age by Up to 4.9 Years in Randomized Trial
The possibility that a widely prescribed metabolic drug might also slow biological aging has moved meaningfully closer…
Longevity
Semaglutide Cuts Biological Age by Up to 4.9 Years in Controlled Trial
For decades, the quest for a drug that measurably slows biological aging has remained elusive. Evidence from a rigorous…
Nutrition
Chronic Xanthan Gum Intake Triggers Colon Inflammation and Microbiota Shifts in Rats
Xanthan gum appears in ingredient lists across thousands of packaged foods, gluten-free products, and clinical thickene…
Nutrition
Sarcopenia and Type 2 Diabetes Share Bidirectional Molecular Pathways Accelerating Muscle Loss
For aging adults managing blood sugar, muscle loss is not merely a side effect — it may be an active accelerant of meta…
Studies
Transcription Factor Drug Targeting: Why Cancer's 'Undruggable' Proteins May Yield
For decades, the proteins that control which genes get switched on or off inside cancer cells were considered essential…
Studies
Gestational Hypertension Linked to 3.5-Fold Higher Long-Term Hypertension Risk in 15-Year Cohort Study
For women who have experienced complications during pregnancy, the cardiovascular consequences can extend far beyond de…
Studies
Tau Spread Pattern Reveals Two-Phase Alzheimer's Progression Across Four Cohorts
Understanding exactly when and where Alzheimer's pathology becomes detectable — and measurable — has enormous consequen…
PREPRINTLongevity
79% Vitamin D Deficiency Found Alongside 58% Obesity in Kazakhstan Care Home Elders
Among 62 adults aged 60+ (mean age 74) residing in a state social-care facility in Astana, Kazakhstan, a striking cardi…
PREPRINTLongevity
Sex-Specific Protein Signatures Split HFpEF Into 2 Distinct Risk Groups
Applying Similarity Network Fusion to 92 circulating inflammatory proteins and 49 clinical variables in 698 HFpEF patie…
PREPRINTLongevity
Statins Cut DNMT3A-Mutant Clonal Hematopoiesis Risk 22–34% via Non-LDL Mechanism
In a UK Biobank analysis of 416,118 adults, statin users showed 7% lower odds of DNMT3A-mutant clonal hematopoiesis (CH…