Fitness
Exercise Modulates Gut Microbiota to Strengthen Bones Through Gut-Bone Axis
Exercise strengthens bones not just through mechanical loading but by fundamentally altering gut microbiota composition…
Fitness
Studies on physical activity, training, recovery, and movement.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
Dual Polyphenol Micelles Achieve 98% Encapsulation Efficiency for Enhanced Bioavailability
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency…
Longevity
GLP-1 Receptor Agonists Show Promise as 'Pharmacological Exercise' Against Neurodegeneration
GLP-1 receptor agonists like semaglutide and liraglutide demonstrate multiple neuroprotective mechanisms in preclinical…
Fitness
Resistance Training Reduces Brain Age by 2.3 Years in Adults
Resistance training reversed functional brain aging by 1.4 to 2.3 years in healthy adults, based on brain clock models…
Longevity
Resveratrol Stabilizes PER2 Clock Protein in Fetal Heart Cells
Resveratrol increases stability of the PER2 clock protein in both fetal cardiomyocytes and cardiac fibroblasts, shiftin…
Fitness
Ten-Hour Eating Window Plus Resistance Training Cuts 3.2kg Fat
A controlled trial of 54 overweight college students found that combining 10-hour daily eating windows with resistance…
Studies
Pseudo-Polyps Triple Colorectal Cancer Risk in Ulcerative Colitis Patients
Analysis of Japan's national disease registry identified pseudo-polyps as tripling colorectal cancer risk in ulcerative…
Wellbeing
Mindful Parenting Reduces Child Irritability Over Time, Study Finds
Analysis of 676 parent-child pairs reveals that mindful parenting practices predict lower child irritability scores ove…
Nutrition
Mediterranean Diet Reduces Death Risk 10% Per Quintile in Depression
Among 5,368 UK adults with depression followed for 12 years, adherence to Mediterranean diet, DASH, and HEFI-2019 patte…
Nutrition
Moderate Wine Within Mediterranean Diet Reduces Mortality by 33%
Analysis of 30,580 Spanish adults across two major cohorts reveals that moderate wine consumption within Mediterranean…
Longevity
Family Deaths Don't Shorten Telomeres Despite Increasing Mortality Risk
Tracking 4,837 older adults for 14 years, researchers found that experiencing multiple family deaths significantly incr…
Studies
AI Debriefing Tools Show Promise for Medical Simulation Training Enhancement
Medical simulation training received AI-powered enhancement through automated analysis of team communications during hi…
Longevity
Gut-Heart Axis Emerges as Key Regulator of Cardiac Hypertrophy Pathways
Multiple interconnected molecular pathways govern cardiac hypertrophy, including PI3K-Akt-mTOR, MAPK signaling, and AMP…
Nutrition
Hidden Sugar Sources Drive Childhood Cardiovascular Disease Risk
Childhood sugar exposure creates measurable cardiovascular risk markers that persist into adulthood, with non-obvious s…
Studies
Cardiovascular Disease Burden Rises 40% Globally Despite Prevention Efforts
Disability-adjusted life years from cardiovascular disease climbed from 320 million in 1990 to 437 million in 2023, rep…
Wellbeing
Adolescent Cannabis Exposure Doubles Young Adult Psychosis Risk
Cannabis exposure during adolescence increases the likelihood of developing psychotic disorders and bipolar disorder by…
Wellbeing
Neural Networks Toggle Between Continuous Processing and Event Boundaries
Cognitive neuroscience has identified distinct neural mechanisms that allow the brain to simultaneously maintain experi…
Studies
Heart Toxicity Mechanism in Cancer Immunotherapy Potentially Solved
Cardiac toxicity emerges as a critical limitation for immune checkpoint inhibitors like pembrolizumab and nivolumab, wi…
Studies
AI System Outperforms Doctors at Diagnosing Rare Genetic Conditions
A large language model combined with specialized diagnostic agents achieved superior accuracy in identifying rare genet…
Longevity
Liver enzyme GPLD1 restores memory by targeting brain blood vessels
The liver-produced enzyme GPLD1, released during exercise, can restore memory function in aged brains by modulating bra…
Studies
Sepsis Causes 21 Million Deaths Annually, One-Third of Global Mortality
Analysis of 149 million deaths across 195 countries reveals sepsis accounts for 31.5% of all global deaths, claiming 21…
Longevity
Cardiovascular Disease Burden Climbed 37% Globally Despite Age-Adjusted Rate Improvements
Cardiovascular disease now accounts for 437 million disability-adjusted life years worldwide, representing a 1.4-fold i…
Studies
AI Stethoscope Shows Promise But Faces Real-World Implementation Barriers
An AI-enhanced stethoscope demonstrated superior cardiovascular disease detection capabilities when properly utilized,…
Studies
Na+/H+ Exchanger 1 Blockers Demonstrate Coronary Vasodilation Against Angina Spasms
Targeting the Na+/H+ exchanger 1 (NHE1) protein produces significant coronary artery dilation, offering a novel therape…
Longevity
Cardiovascular Disease Burden Increased 37% Globally Despite Age-Adjusted Rate Improvements
Analysis of disability-adjusted life years across 204 countries reveals cardiovascular diseases generated 437 million D…
Studies
CETP Inhibitor Trial Tests Direct Coronary Plaque Reduction Effects
The REMBRANDT trial represents a methodological shift in cardiovascular drug evaluation, using coronary computed tomogr…
Studies
Thyroid Hormone Analog Resmetirom Reverses Multiple MASH Pathways
Transcriptomic analysis reveals that resmetirom, a selective thyroid hormone receptor-beta agonist, simultaneously targ…
Longevity
Liver-derived ApoE protein blocks bone healing in aged mice
Researchers identified apolipoprotein E (ApoE) as a key mechanism behind age-related bone healing impairment. In 24-mon…
Wellbeing
Combined Lifestyle Plus Supplement Interventions Show Mixed Dementia Prevention Results
A systematic analysis of twelve randomized controlled trials reveals the emerging evidence for combining multidomain li…
Studies
Beta-Blocker Guidelines Face Challenge in Post-Heart Attack Recovery
Clinical evidence suggests current beta-blocker protocols following heart attacks may need refinement, particularly reg…
Nutrition
Plant-Based Low-Carb Diets Reduce Diabetes Risk 16% Versus Animal-Based
Analysis of nearly 200,000 healthcare professionals tracked for three decades reveals that macronutrient source, not ju…
Studies
Watchful Waiting Matches Drug Therapy for Preterm Heart Defect
A randomized trial comparing immediate medication versus watchful waiting for patent ductus arteriosus in extremely pre…
Studies
Fixed-Dose Combination Pills Show Superior Hypertension Control Over Monotherapy
Fixed-dose combination medications demonstrate measurably better blood pressure control compared to single-agent therap…
Wellbeing
Chronic Stress Emerges as Key Pathway Linking Depression to Cardiovascular Events
Analysis of cardiovascular event data reveals chronic stress serves as a primary biological mediator connecting depress…
Studies
Elevated Lp(a) Biomarker Predicts Three-Decade Cardiovascular Risk in Women
Lipoprotein(a) emerges as a powerful long-term cardiovascular predictor in women, with elevated concentrations associat…
Studies
Watchful Waiting Matches Drug Treatment for Heart Defect in Premature Babies
A randomized trial involving 653 extremely preterm infants found that conservative monitoring of patent ductus arterios…
Studies
Physician Training Plus Patient Education Halves Unnecessary Antibiotic Prescriptions
A cluster randomized trial across rural Chinese clinics demonstrated that combining physician training with real-time d…
PREPRINTFitness
5,000-Protein Analysis Reveals HFpEF Rehabilitation Mechanisms Across Multiple Organs
Researchers analyzed over 5,000 circulating proteins from two randomized rehabilitation trials in heart failure with pr…
Studies
Contrast-Free MRI Protocol Equals Standard Scanning for Prostate Cancer
The PRIME clinical trial establishes that biparametric MRI (bpMRI) achieves equivalent diagnostic performance to multip…
PREPRINTSupplements
Vitamin D Supplementation Reduces LDL Cholesterol, Blood Pressure in Meta-Analysis
Analysis of 45 randomized controlled trials reveals vitamin D supplementation produces statistically significant but mo…
Fitness
Exercise Reduces Cancer Fatigue in Advanced Lung Cancer Patients
Pooled analysis of eight randomized trials involving 749 advanced lung cancer patients demonstrates that structured exe…
PREPRINTLongevity
Left Atrial Failure Point Identified at 107mL Preload Volume
Cardiac computed tomography analysis of 975 patients revealed that the left atrium's booster pump function follows an i…
Nutrition
3-Hour Pre-Sleep Fasting Window Improves Nighttime Blood Pressure Regulation
Extending overnight fasting by finishing meals at least three hours before bedtime significantly enhanced nighttime dia…
Studies
First Oral PCSK9 Inhibitor Enlicitide Achieves Significant Cholesterol Reduction
Enlicitide decanoate represents the first oral formulation to successfully target PCSK9, achieving meaningful LDL chole…
PREPRINTStudies
Heart MRI T1 Values Reveal Sex-Specific Cardiometabolic Risk Patterns
Researchers analyzed cardiac MRI data from 27,794 German adults aged 20-75, measuring myocardial T1 values—a marker of…
Wellbeing
Light Smokers Face Unique Cessation Barriers in Latin America
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from hea…
PREPRINTStudies
CNN Model with Temporal Attention Improves Coronary Artery Disease Detection
A convolutional neural network incorporating temporal attention mechanisms demonstrates enhanced accuracy in detecting…
PREPRINTWellbeing
Plastic Nanoparticles Drive Atherosclerosis Through Distinct Smooth Muscle Cell Programming
Polyethylene and polyvinyl chloride nanoparticles—the most common plastics found in human arterial plaques—accelerate a…
Wellbeing
Maternal Antibodies Reprogram Infant Intestinal Immune Development
Singapore researchers have identified how specific immunoglobulin A (IgA) antibodies in breast milk actively reshape th…
Studies
Prenatal mRNA Vaccination Shows No Autism Risk in 18,000-Child Study
A multicenter prospective study tracking 18,000 children found no association between maternal mRNA COVID-19 vaccinatio…
Fitness
Exercise Programs Could Transform Cancer Outcomes Across Sub-Saharan Africa
Cancer incidence is surging across Sub-Saharan Africa, with the region accounting for the majority of new cases in low-…
Fitness
AI Chatbots Help Students Practice Health Communication Skills
Medical and allied health students are using character-based generative AI chatbots to develop interviewing skills for…
Fitness
Structured Exercise Regimens Boost Cancer Patient Disease-Free Survival
An international randomized controlled trial demonstrated that structured exercise programs significantly improved both…
Studies
Para-Football Athletes Show 47% Cardiac Abnormality Rate During Screening
Comprehensive cardiac evaluation of 156 elite para-football players revealed electrical and structural heart abnormalit…
Studies
Male Female Heart Cells Show Distinct Structural Function Patterns at Birth
Cardiac tissue engineered from newborn rat heart cells reveals fundamental sex-based differences in how cellular archit…
Longevity
Brain Pattern Subtypes Show Differential Response to Multidomain Dementia Prevention
Machine learning analysis of 120 participants in the landmark FINGER trial revealed that individuals cluster into disti…
Longevity
Brain Structure Patterns Predict Lifestyle Intervention Success in Dementia Prevention
Analysis of 120 older adults from the landmark FINGER trial reveals that baseline brain architecture determines how ind…
Nutrition
Specific Foods Trigger IBD Inflammation Through Gut Barrier Disruption
Ultra-processed foods, high-fat diets, and red meat specifically trigger inflammatory bowel disease flares by disruptin…
Longevity
Hsp70 and Hsp90 Chaperones Display Protective and Pathological Functions in Aging Neurons
Molecular chaperones Hsp70 and Hsp90 demonstrate paradoxical effects in neurological aging, serving both protective and…
Studies
PD-1 Inhibitors Shrink Latent HIV Reservoirs in Cancer Patients
Cancer immunotherapy drugs targeting the PD-1 checkpoint protein significantly reduced latent HIV reservoirs in co-infe…
Studies
Mobile-Guided Community Workers Outperform Clinic Referrals for Blood Pressure Control
A cluster-randomized trial in rural Lesotho demonstrated that minimally trained community health workers equipped with…
Longevity
Blood Stem Cell Mutations Enhance Cancer Immunotherapy Effectiveness
Age-related mutations in blood stem cells, termed clonal hematopoiesis of indeterminate potential (CHIP), appear to amp…
Research
Publisher Correction: Strengthening vaccine capacity building on the African continent
The publisher has issued a correction to a previous article on strengthening vaccine capacity building in Africa. The o…
Wellbeing
Cognitive Impairment Worsens Non-Motor Parkinson's Symptoms Over Time
Analysis of 84 Parkinson's patients reveals that declining cognitive function specifically accelerates non-tremor motor…
Studies
UK Biobank Links 500,000 Participants to Primary Care Records
Primary care data from England's NHS has been integrated with genetic, imaging, and lifestyle information for half a mi…
Studies
GLP-1 Agonists Cut Mortality 40% in Psoriasis Patients
A matched cohort analysis of 6,096 psoriasis patients reveals that GLP-1 receptor agonists like semaglutide reduced all…
Fitness
Sports Medicine Must Integrate Complex Systems Beyond Traditional Injury Focus
A new framework emerges positioning sports medicine as a systems integrator rather than primarily an injury treatment s…
Studies
New MRI technique outperforms standard imaging for athletic bone injuries
A modified MRI protocol combining traditional soft tissue imaging with CT-like bone visualization demonstrates enhanced…
Wellbeing
Bedroom Heat Above 82°F Impairs Heart Recovery During Sleep
Continuous monitoring of 47 older adults across 14,179 nighttime hours revealed that bedroom temperatures exceeding 28°…
Longevity
German Nutrition Authority Declares Zero Safe Alcohol Threshold
The German Nutrition Society's position paper establishes that no risk-free threshold exists for alcohol consumption, m…
Research
The Future of Fitness: ACSM Announces Top Trends for 2026
The American College of Sports Medicine (ACSM) has released its predictions for the top fitness trends in 2026. The rep…
Research
Call for ACSM Certification Board Committee Members
The ACSM (American College of Sports Medicine) is seeking volunteers to serve on its Certification Board committees. Th…
Research
Medicare Greenlights Coverage for Physical Activity Assessments, Boosting Exercise Referral Efforts
The article discusses Medicare's decision to cover physical activity assessments, which may facilitate exercise referra…
Research
ACSM Members to Support Athletes at 2026 Olympic and Paralympic Games
The American College of Sports Medicine (ACSM) has announced that its members will provide support to athletes particip…
Nutrition
UCSF Researchers Question Role of Ultraprocessed Foods in Dietary Guidelines
UCSF researchers are examining whether ultraprocessed foods warrant explicit restrictions in federal dietary recommenda…
Research
Cardiology
Stanford Medicine News reports on various developments in the field of cardiology. The articles cover topics such as ne…
Nutrition
Saturated Fat and Cholesterol in Red Meat Linked to Cardiovascular Risk
Elevated cholesterol and saturated fat concentrations in red meat demonstrate measurable associations with cardiovascul…
Fitness
85,000-Person Study Links Daily Steps to Cancer Prevention Regardless of Intensity
Analysis of 85,000 older adults in the UK reveals that accumulated daily movement—including light activities like walki…
Nutrition
Curcumin-Whey Combination Protects Intestinal Barrier During High-Intensity Training
Exercise-induced intestinal permeability represents a significant challenge for athletes, with high-intensity training…
Supplements
Magnesium-L-Theanine Duo Shields Gut and Liver from Chronic Stress
A magnesium-L-theanine combination demonstrated protective effects against stress-induced organ damage in a controlled…