Studies
78 Trials, 8,452 Adults: Which Exercise-Diet Combos Best Fix Metabolic Syndrome?
Across 78 randomized trials (8,452 adults with metabolic syndrome and overweight or obesity), every structured…
Fitness
Studies on physical activity, training, recovery, and movement.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
Angelica keiskei Chalcone Clears Fatty Liver in Mice via TFEB
In male C57BL/6N mice fed a fast-food diet for 15 weeks, then dosed daily for 9 more weeks with an Angelica keiskei…
PREPRINTFitness
Free Testosterone Reshapes Muscle Gene Activity, Not Mass or Strength, in 81 Men
In 81 healthy men aged 18 to 80, free testosterone fell with age, as did muscle mass and leg press strength. Yet…
PREPRINTFitness
Knee Osteoarthritis Muscle Holds 45% More Collagen and Blunts MMP2/9 Response to Lifting
Adults with moderate-to-severe knee osteoarthritis had weaker knee extensors, poorer muscle quality, and more…
Supplements
2 g/Day Plant Sterols Fail to Lower LDL in Obesity Trial
In a double-blind crossover trial of 23 adults with overweight or obesity (mean BMI 36.4) and mild…
Fitness
Treadmill Running Beats Enalapril at Calming Fatty-Liver Inflammation in Obese Mice
In obese mice, 8 weeks of treadmill running (300 min/week) and the ACE inhibitor enalapril (10 mg/kg/day) each cut…
PREPRINTFitness
Vivifrail Exercise Lifts SPPB 1.33 Points, Cuts Probable Sarcopenia From 17% to 5%
A 36-week community multicomponent exercise programme (the Vivifrail model, combining strength, balance, gait and…
PREPRINTStudies
Type 2 Diabetes Remission Rare and Brief: 4% in Treated Adults, Median 226 Days
Across 136,781 US adults with confirmed type 2 diabetes in linked health records, remission (two HbA1c readings below…
PREPRINTLongevity
Frailty Raises Risk of 458 Diseases and Doubles Multimorbidity Pace
Across 466,864 UK Biobank participants followed a median 13.8 years, Fried-phenotype frailty was linked to higher risk…
Studies
GLP-1 Drugs Linked to 6.5-Point Lower 3-Year Death Risk in Serious Mental Illness
In a propensity-matched TriNetX cohort of 218,043 adults with serious mental illness, type 2 diabetes, obesity, and…
Supplements
Curcumin Cuts Liver Fat in Rats by Suppressing a Gut Microbe
A meta-analysis of seven clinical studies found curcumin supplementation lowered serum aminotransferases in people…
Studies
Fatty Liver Raises Death Risk 28-70% Across Two Million Koreans
Among 2,049,641 Korean health-checkup participants, fatty liver (Fatty Liver Index ≥30) raised all-cause mortality in…
Nutrition
Extra Leucine or Protein Added No Benefit to 28-Day Fasting Diet
Sixty-one older men (BMI ≥ 23) completed 28 days of alternate-day fasting, randomized to calorie-matched supplements…
Nutrition
Japanese-Style Diets Cut All-Cause Death 12%, But Not Cancer Mortality
Pooling three independent Japanese cohorts (five analytic estimates per outcome), adherence to predefined…
Studies
Digital-Platform GLP-1 Prescribing Matches Trial-Level Weight Loss in 8,127 Women
Whether the weight loss seen in tightly controlled GLP-1 trials survives contact with everyday life is one of the most…
PREPRINTFitness
Starting Exercise After 65 Cuts Mobility Difficulty Risk 7 Points at Two Years
Among Health and Retirement Study participants aged 65 and older who had been persistently inactive and were free of…
PREPRINTStudies
ARBs like losartan linked to 30% lower Parkinson's risk in 270,000 hypertensives
Among 269,617 Medicare-age adults starting first-line hypertension treatment, those who began an angiotensin receptor…
Fitness
Tai Chi and Qigong Nudge Bone Density Up in Women, Modestly
Pooling 20 randomized trials, traditional Chinese mind-body training (tai chi, qigong and related practices) raised…
Supplements
Calcium Supplements Modestly Cut Fractures Across 286,584 Adults, But Not Hip Breaks
An umbrella review of 22 meta-analyses, covering 69 unique primary studies and 286,584 adults, found that calcium…
Studies
6.2 Million Koreans Tracked: Alcohol Raises Risk Across Dozens of Diseases
Across 6,214,569 disease-free Korean adults followed from 2006-2009 through 2022, alcohol intake rose with risk for…
PREPRINTStudies
Muscle androgen receptor expression falls 4.4% per decade across 364 men
Pooling 16 public RNA-seq datasets (364 healthy men aged 18-92), a new R pipeline called MetAR found androgen receptor…
PREPRINTNutrition
Diverse Diets Linked to Lower Blood Pressure, Stronger Grip in Ghanaian Elders
Among 200 Ghanaians aged 60 and over (mean 69.8 years), dietary inadequacy was widespread: more than half fell short…
PREPRINTStudies
57% of Asymptomatic Broward Adults Had Abnormal Heart CT Scans
Among 7,135 insured, symptom-free Florida adults aged 45 to 70 with at least one cardiovascular risk factor, coronary…
PREPRINTFitness
Beetroot Juice Nitrate Fails to Speed Muscle Force Development in Young Adults
A single 200 μmol/kg nitrate dose from beetroot juice left rate of torque development unchanged versus a nitrate-free…
Studies
Cannabigerol Boosts Muscle Power 87% Beyond Exercise Alone in Mice
In mice given dexamethasone (20 mg/kg for 12 days) to induce muscle wasting, a 4-week ladder-climbing resistance…
Studies
Healthy Adult Lifestyle Blunts Early-Life Risks for Heart Disease and Diabetes
Among 174,718 UK Biobank adults followed a median 14.6 years, those with high early-life risk (low birth weight…
Nutrition
Mediterranean Diet Alone Fails to Reliably Cut Weight After Menopause
A systematic review of PubMed, Embase, and Cochrane records through January 2026 found only three eligible studies…
PREPRINTNutrition
Low-Carb Coaching Plus Tirzepatide: 19.7% Weight Loss vs 15.6% in 4,269 Adults
In a retrospective cohort of 4,269 adults in a telemedicine obesity program, those receiving individualized…
PREPRINTStudies
Better Life's Essential 8 Scores Track Lower Brain Small-Vessel Damage Across Ethnic Groups
In a cross-sectional analysis of 44,982 adults (with a 1,426-person matched MRI subsample), each standard-deviation…
Longevity
Exercise plus mental-social activity adds 7 years free of cognitive impairment
Across four harmonized aging cohorts spanning Asia, North America and Europe, adults at age 50 who did both structured…
Studies
Patients With Type 2 Diabetes Rank A1c and Heart Protection Above Weight Loss
Across 34 studies and 15,656 adults with type 2 diabetes, patients consistently ranked glycaemic efficacy…
Fitness
Midlife Exercise Linked to 20% Fewer Memory Complaints Three Decades Later
Among 4,397 women in the NYU Women's Health Study (mean age 46 at baseline, 79 at follow-up), those in the top tertile…
Studies
SGLT2 Inhibitors Cut Heart Failure Hospitalization 29% and Kidney Events 31% in Diabetes
Pooling 14 placebo-controlled trials (76,969 adults with type 2 diabetes), SGLT2 inhibitors lowered the composite of…
PREPRINTFitness
Handgrip Strength Adds Nothing Beyond Body Fat Scans for Cardiometabolic Risk
Among 1,124 U.S. adults aged 40-59 from NHANES (508 for development, 616 for temporal validation), adding DXA body fat…
Studies
Vitamin D Tracks With Faster Walking in Taiwanese Men, Not Women
Among 396 community-dwelling Taiwanese adults (mean age 65, mean serum 25(OH)D 28.3 ng/mL, mean gait speed 0.91 m/s)…
Fitness
Exercise Blunts Mortality Penalty of High Resting Heart Rate in Kidney Disease
Across three cohorts totaling 12,042 patients with chronic kidney disease, higher resting heart rate (RHR) predicted…
Longevity
Chronic Stress Shortens Mouse Lifespan; NMN and Bazi Bushen Herbal Formula Reverse It
In a 12-month unpredictable chronic mild stress model in mice, chronic stress amplified systemic inflammation, damaged…
PREPRINTStudies
Obesity Beyond 25 Years Raises Heart Strain Markers by Age 62
In 4,901 members of the 1958 British birth cohort, 26.3% experienced obesity at some point between ages 7 and 62. Ever…
PREPRINTStudies
56,754 Adults in a Digital Diabetes Program Show Durable Glycemic Gains Over Five Years
Across 56,754 adults with type 2 diabetes in Teladoc's remote monitoring program (2021-2025), estimated A1c from…
PREPRINTFitness
60-90 Minutes of Weekly Vigorous Exercise Linked to 35% Lower Hip Fracture Risk
Across 16 years of follow-up in 324,284 UK Biobank adults aged 40-65, 2,674 hip fractures occurred. Middle quintiles…
Studies
Rare Sugar D-Psicose Eases Fatty Liver in Diabetic Mice
In mice made diabetic with a high-fat diet plus streptozotocin, low- and high-dose D-psicose (a rare sugar) improved…
Studies
SGLT2 Inhibitors Cut Kidney Progression 37%, but Evidence Quality Is Weak
Across 12 systematic reviews, SGLT2 inhibitors lowered the composite of cardiovascular death or first heart-failure…
PREPRINTStudies
Fat-Tissue Scarring Barely Tracks With Fatty Liver After Bariatric Surgery
In patients with severe obesity undergoing two-stage bariatric surgery, picrosirius-red-measured pericellular fibrosis…
Nutrition
Intensive Na/K Feedback Program Cuts Salt Intake by 0.53 g/day in Japanese Communities
A post hoc regional analysis of Japan's Population-based Sodium/Potassium Improvement Program compared two Hokkaido…
Nutrition
Mediterranean Lifestyle Cuts Mortality 30–46% Across All Income Groups
In the prospective Lifelines cohort tracking 105,812 Dutch adults over a median 13.25 years, adherence to the MEDLIFE…
PREPRINTSupplements
Vitamin D below 10 ng/mL doubles 10-year mortality risk in 412,000 adults
In a UK Biobank analysis of 412,020 adults with 31,197 deaths, seasonally normalized 25-hydroxyvitamin D [25(OH)D]…
PREPRINTStudies
Early post-bariatric weight loss predicts 2-year but not long-term outcomes
Among 216 adults undergoing sleeve gastrectomy or Roux-en-Y gastric bypass, percentage total weight loss (%TWL) at 3…
Studies
Ketogenic Diet and Aerobic Exercise Top Rankings for PCOS Cardiometabolic Risk
A Bayesian network meta-analysis of 43 randomized controlled trials (2,433 participants) systematically compared…
Nutrition
Higher Plasma Omega-3 Linked to 20% Lower Mortality in 144,900 Adults
In the Mexico City Prospective Study — 144,900 adults followed for up to 24 years — higher circulating omega-3 fatty…
Fitness
Higher Pre-Diagnosis VO2max Cuts Post-Cancer Mortality Risk by 29–59%
Among 10,462 UK Biobank participants who later developed cancer, higher cardiorespiratory fitness (CRF) at baseline…
PREPRINTLongevity
Bone hormone osteocalcin reverses age-related locomotor decline via motoneuron mitophagy
The bone-derived hormone osteocalcin (OCN) acts on spinal motoneurons via the receptor GPR158 to regulate autophagy…
PREPRINTLongevity
Restoring noradrenaline-like signalling in fly neurons extends lifespan and reverses motor decline
In aging Drosophila brains, octopamine (the invertebrate equivalent of noradrenaline) normally drives glucose uptake…
PREPRINTFitness
Sarcopenia Risk Linked to 44.6 mg/dL Higher Post-Meal Glucose Spike in Older Diabetics
In a cross-sectional study of 300 older Indian adults (mean age 67.6 years) with type 2 diabetes and controlled…
PREPRINTLongevity
Higher Ambient UV Linked to 36,000 Fewer CV Deaths and 50,000 Fewer Cancer Deaths Annually in US
Across 704,808 annual cardiovascular deaths and 565,287 annual cancer deaths in US Health Service Areas, higher…
Nutrition
Pro-inflammatory diet nearly doubles MASLD mortality; antioxidant diet halves it
Among 3,048 U.S. adults with steatotic liver disease (2,146 MASLD, 902 MetALD) followed across the 2005–2018 NHANES…
Longevity
Bariatric Surgery Cuts Dementia Risk 52%, Parkinson's 30% in Obese Adults
Among 32,552 propensity-score-matched pairs of adults with BMI ≥35 kg/m², bariatric surgery was associated with a 52%…
Fitness
Exercise Boosts Balance by 0.83 SMD in Osteoporosis: Dose Thresholds Identified
Pooling 13 randomized controlled trials, exercise interventions produced a statistically robust improvement in balance…
Studies
T2D Remission Cuts Vascular Risk 27–32% Across Lifestyle and Surgery Pathways
Across eight reports from seven independent longitudinal cohorts, achieving biochemical remission of type 2 diabetes…
PREPRINTSupplements
Rapamycin, Canagliflozin & Caloric Restriction Alter Canine Immune Markers at 90 Days
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
PREPRINTFitness
Voluntary Running Cuts Glucose Intolerance 35% in Obese Mice — Gut Microbiome Mediates Effect
In three genetically distinct BXD mouse strains fed a 60% fat diet for 32 weeks, voluntary wheel running (~5 km/day…
PREPRINTSupplements
Dual SGLT1/2 Inhibitor Sotagliflozin Cuts Atherosclerosis Via Hepatic Fat Reprogramming
In a mouse model of cardiovascular-kidney-metabolic (CKM) syndrome, sotagliflozin — the only SGLT inhibitor shown to…
Fitness
Each 1-MET Fitness Gain Cuts 10-Year Death Risk by 16% in 562,000 Adults
In the largest exercise-testing cohort to date — 562,234 adults followed for a mean 10.2 years — each additional MET…
Nutrition
Stearic Acid Lowers Cholesterol via FXR Pathway, Not Just Microbiome
In a crossover RCT of 17 mildly hypercholesterolemic postmenopausal women, five-week diets enriched in stearic acid…
Nutrition
Ketogenic Diet Yields 2–3× Greater Liver Insulin Benefit Than Mediterranean at Equal Weight Loss
In adults with metabolically unhealthy obesity (prediabetes plus hepatic steatosis), ~10% weight loss across three…
PREPRINTWellbeing
Late Bedtime Predicts Visceral Fat in Postmenopausal Women with Obesity
In 122 postmenopausal women (mean age 58.1 years, mean BMI 33.2 kg/m²), later sleep onset was significantly associated…
PREPRINTWellbeing
Lifestyle intervention boosts cognition regardless of Alzheimer's blood biomarker levels
In a secondary analysis of the landmark FINGER randomized controlled trial (N=1,260 at-risk older adults), six core…
Studies
Baxdrostat Cuts Systolic BP by 6.9 mmHg in Resistant Hypertension Meta-Analysis
Pooling five randomized, double-blind, placebo-controlled trials (N = 1,730) — BrigHTN, HALO, BaxHTN, FigHTN, and…
Supplements
Rapamycin, Canagliflozin & Caloric Restriction Shift Immune Markers in Dogs
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
Studies
Coronary Calcium Scoring Sharpens New PREVENT Cardiovascular Risk Equations
Knowing your cardiovascular risk is only as good as the tools used to measure it. The AHA's 2023 PREVENT equations…
Nutrition
Early-Life Sugar Restriction in First 1000 Days Cuts Lifetime Dementia Risk
The first thousand days of life — from conception through age two — have long been considered a critical developmental…
Studies
CKM Syndrome Linked to Early Arterial Damage in 80% of Young Adults
Cardiovascular disease rarely announces itself — it builds silently over decades, starting with metabolic dysfunction…
Studies
Cochrane Review: E-Cigarettes Outperform Patches and Gum for Smoking Cessation
Smoking remains the leading preventable cause of premature death globally, and the persistent gap between quit…
Nutrition
Omega-3 Depletion Predicts Plaque Rupture Risk Despite Low LDL in 263K Adults
A specific fatty acid phenotype defined by omega-3 depletion and elevated omega-6/omega-3 ratio predicted structurally…
Studies
Bariatric Surgery Remodels Abdominal—Not Gluteal—Fat Proteome Over 12 Months
A randomised, prospective 12-month study in women with obesity combined proteomics, metabolomics, advanced imaging…
Studies
438,000-Veteran Study: Moderate Alcohol Cuts Heart Risk, Raises Cancer Risk
In 438,442 U.S. veterans followed from 2011 to 2024 in the Million Veteran Program, moderate alcohol consumption…
Fitness
Bariatric surgery boosts VO2 max despite muscle loss in all groups
In a longitudinal cohort of 1,022 adults undergoing metabolic bariatric surgery (MBS), fat-free mass (FFM) loss varied…
Nutrition
Cutting Dietary Fructose Drops Novel Glycation Biomarker by 20% in Overweight Adults
Restricting dietary fructose significantly reduces serum glucoselysine (GL), a fructose-specific glycation product, in…
Nutrition
App-Based Coaching Matches Dietitian Care for Fatty Liver in 297-Person RCT
In a 12-month randomised controlled trial of 297 adults with metabolic dysfunction-associated steatotic liver disease…
PREPRINTStudies
GLP-1 Drugs Skew to Younger, Heavier Older Adults — Sicker Patients Left Out
Among 58,754 adults aged 65 or older with type 2 diabetes treated at a regional US healthcare system between 2018 and…
PREPRINTWellbeing
Mental Stress Triples Heart Attack Risk in Women Post-MI, Black Women Hit Hardest
Among 602 adults (mean age 51; 46% women) studied within eight months of a premature myocardial infarction, mental…