Studies
1-Hour Troponin Protocol Matches 3-Hour Safety While Cutting ER Wait Times
For millions of people who arrive at emergency departments each year with chest pain, how quickly clinicians can…
Fitness
Studies on physical activity, training, recovery, and movement.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Studies
18F-Flurpiridaz PET Establishes TID Reference Thresholds for Coronary Disease Grading
Accurate detection of extensive coronary artery disease depends on reliable imaging benchmarks — and until now, a…
Studies
TAVI-First vs PCI-First Strategy: Noninferiority Trial in Patients with Severe Aortic Stenosis and CAD
For the millions of adults living with both significant coronary artery disease and severe aortic stenosis, deciding…
Studies
Ambulatory ECG Monitoring After Syncope May Improve Cardiac Diagnosis Rates
Fainting episodes — clinically termed syncope — affect roughly one in three people over a lifetime, yet determining…
Nutrition
French Cadmium Exposure Runs 3–4x Above European Peers, Report Warns
Cadmium is not a compound most people think about at the dinner table, yet it accumulates silently in the kidneys and…
Studies
Cross-Trial Analysis of 38,753 Patients Maps Heart Failure Drug Combination Safety Signals
Optimizing heart failure treatment has long been complicated by a practical paradox: the drug combinations proven to…
Longevity
Frail Elders With Psychiatric Comorbidities Gain Most From Lifestyle Mobility Interventions
Not all frail older adults respond equally to structured lifestyle programs — and knowing which subgroups benefit most…
PREPRINTStudies
130,000-Adolescent Study Links Higher BMI to Faster Heart Rate and Worse Vision
In a multicenter retrospective cohort of 130,832 Chinese adolescents aged 8–17 screened between 2022 and 2024, every 1…
PREPRINTLongevity
Race-Specific AI Models Hit 0.91 AUC for 5-Year Dementia Risk in 55,004 Adults
Analyzing 55,004 participants from the National Alzheimer's Coordinating Center (NACC), race-stratified Random…
PREPRINTLongevity
Adolescent Parenting Style Shows Minimal Link to Adult CVD Risk Over 21 Years
In a US longitudinal cohort of 4,050 participants tracked from adolescence (ages 12–19, 1994–1995) to adulthood (ages…
Studies
Eplontersen Shows Benefit Only as Monotherapy in ATTR-CM Phase 3 Trial; No Added Benefit With Tafamidis
For the growing number of patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) — a progressive and…
Studies
Walkable Neighborhoods Associated with Lower Post-GDM Diabetes Risk—But Only in Affluent Areas
For the roughly one in five women who develop type 2 diabetes within a decade of a gestational diabetes diagnosis…
Studies
Vutrisiran Suppresses TTR Protein by 82–86% Across Diverse Amyloidosis Patients
For the estimated 50,000 people worldwide living with transthyretin amyloidosis — a progressive, often fatal disease…
Studies
AHA/ACC Unifies Risk Scoring Across Heart, Kidney, and Metabolic Disease
For decades, cardiovascular risk was calculated in silos — blood pressure managed separately from cholesterol…
Studies
ESC and ACC 2025 Guidelines Converge on IL-1 Blockade for Recurrent Pericarditis
For the millions of adults who develop chest pain after viral illness — or after mRNA vaccination — the clinical…
Studies
Inclisiran Outperforms Statin Uptitration: 85% vs 31% LDL Goal Achievement
For the millions of high-risk cardiovascular patients who fail to reach guideline-recommended LDL cholesterol targets…
Wellbeing
Pet Ownership Shapes Human Health Access in Measurable Clinical Ways
The relationship between humans and their companion animals has long been studied for its psychological and…
Studies
Head-to-Head Trial Finds Prasugrel Edges Ticagrelor in ACS Outcomes
For the millions of people who survive a heart attack or unstable angina each year, the choice of antiplatelet…
Studies
CT Coronary Angiography Reshapes Acute Chest Pain Triage in Large Trial
Chest pain is the second most common reason adults present to emergency departments worldwide, yet determining who…
Studies
Factor XIa Inhibitor Milvexian Cuts Ischemic Events Without Major Bleeding Rise
The holy grail of antithrombotic therapy has long been separating clot prevention from bleeding risk — a trade-off…
Studies
Extended Dual Antiplatelet Therapy Reduces Ischemic Events in High-Risk Patients
For millions of adults living with cardiovascular disease, the question of how aggressively to suppress platelet…
Studies
Aspirin-Free STEMI Intervention: Large Trial Challenges Decades-Old Antiplatelet Protocol
For decades, aspirin has been considered an untouchable cornerstone of heart attack treatment — a drug so foundational…
Studies
Functional Angiography Guidance Reshapes Multi-Vessel STEMI Revascularization Strategy
For the millions of heart attack patients who arrive with blockages in multiple coronary arteries, the question of how…
Studies
Pulmonary Nerve Ablation Shows Promise for Heart Failure Hypertension in Trial
For the millions of adults living with heart failure complicated by pulmonary hypertension, therapeutic options have…
Studies
13 Blood Markers Predict HFrEF Subtype Before Echocardiography With 0.789 AUC
Distinguishing heart failure subtypes quickly has real consequences: patients with reduced ejection fraction respond…
PREPRINTLongevity
IHD Deaths Rising in West Africa Since 2007 as Global Rates Fall 38%
While global stroke and ischemic heart disease (IHD) mortality dropped 51.7% and 38.2% respectively between 1990 and…
PREPRINTLongevity
80 MHz Benchtop NMR Quantifies Key Lipoproteins and Triglycerides in Serum, Reproducing Epidemiological Associations
A benchtop NMR spectrometer operating at 80 MHz — far less powerful than laboratory-grade 600 MHz instruments…
PREPRINTStudies
Digital Ad Spend Yields Only 36 Black, 27 Latino Recruits per $100K in AF Trial
A national digital recruitment campaign for the Phase 3 LIBREXIA-AF atrial fibrillation trial spent $163,949 across…
PREPRINTLongevity
HDL-Remodeling Metabolite Pattern Linked to 17% Higher Dementia Risk in T2D Subtypes (medRxiv Preprint)
Among 7,671 UK Biobank participants with type 2 diabetes (mean age ~60), NMR-based metabolomic profiling across…
Studies
CMR GUIDE Trial: ICD Implantation Neutral on Primary Arrhythmia Endpoint but Reduces SCD and Benefits Younger Patients with Mid-Range EF and Scar
Millions of heart disease patients fall into a diagnostic no-man's land — their cardiac function is too preserved to…
Studies
Pediatric Pneumonia Exam Findings Show Inconsistent Reliability Across Two Clinicians
When clinical guidelines steer physicians away from imaging and toward physical examination alone to diagnose…
Studies
CT Coronary Angiography Identifies High-Risk Plaque Beyond Stenosis Severity
For patients arriving at emergency departments with chest pain, the difference between unnecessary hospitalization and…
Longevity
GLP-1 + Menopause HRT Combo for Weight Loss: Promising But Premature
An expert consensus from Spain's Menopause Society synthesized evidence on GLP-1 receptor agonists and dual incretin…
Fitness
Myonuclear Retention and DNA Methylation Encode Decades-Long Muscle Training Memory
Skeletal muscle encodes prior exercise history through at least six parallel molecular mechanisms: myonuclear…
Supplements
Melatonin's Prolactin Pathway May Link Long-Term Use to Heart Failure Risk
Melatonin is taken nightly by millions of adults who regard it as essentially harmless — a natural sleep aid with a…
Studies
NEJM Editorial Discusses SINGLE-AF Trial on Anticoagulation for Atrial Fibrillation with a Single Stroke Risk Factor
Atrial fibrillation affects tens of millions of adults globally, and the decision of when to start blood thinners sits…
Studies
CRISPR Liver Edit Sustains ANGPTL3 Suppression in Cardiovascular Risk Trial
Permanently rewriting a single gene in the liver to lower cardiovascular risk has long been a theoretical aspiration…
Studies
Silent Artery Disease Found Across All Adult Age Groups, Not Just Elderly
Atherosclerosis has long been framed as a disease of older age — something that accumulates quietly over decades and…
Studies
Large RCT: Atorvastatin Cuts Cardiovascular Events in Older Adults Without Prior Disease
For decades, the calculus of prescribing statins to older adults has been muddied by uncertainty: do the…
Studies
NEJM Trial Challenges Anticoagulation Decisions for Intermediate AF Stroke Risk
One of the most contested gray zones in cardiology — whether patients with atrial fibrillation at intermediate stroke…
Studies
Aficamten Improves Exercise Capacity in Nonobstructive HCM Phase III Trial
Hypertrophic cardiomyopathy without outflow obstruction has long been a therapeutic dead end — a condition where the…
Studies
Potent P2Y12 Plus DOAC Raises Bleeding Risk Without Ischemic Benefit in AF-ACS
Managing patients who have both atrial fibrillation and an acute coronary syndrome is one of cardiology's sharpest…
Longevity
Mitochondrial DNA Leakage in Aging Eggs Ignites Ovarian Inflammation via Gap Junctions
Ovarian aging is one of the most consequential biological clocks in human health, setting the pace for fertility…
Studies
Multi-Biomarker Wearables Could Reframe Cardiometabolic Disease Monitoring Beyond Glucose
Continuous glucose monitoring transformed diabetes management by turning a snapshot test into a living physiological…
Longevity
Silent Coronary Calcium in Young Adults Raises CHD Death Risk Fivefold
Coronary artery disease is typically framed as a condition that declares itself in middle age or later — but…
PREPRINTStudies
TWAS Maps 684+ T2D Gene Associations Across 6 Tissues, Revealing JAZF1-IDE Axis
Integrating tissue-specific transcriptome-wide association studies (TWAS) with ancestry-aware gene expression models…
PREPRINTLongevity
Combined TyG-Biological Age Score Triples Cardiometabolic Multimorbidity Risk in 8,767 Adults
Among 8,767 Chinese adults aged 45+ followed for a median of 108 months, combining the triglyceride-glucose (TyG)…
PREPRINTLongevity
GLP-1 Drugs Linked to 0.21-Month Alzheimer's Delay vs. Sulfonylureas in 6,328 Diabetics
Among 6,328 adults aged 55+ with type 2 diabetes and no prior dementia, initiating GLP-1 receptor agonists was…
Studies
Phase 3 Trial Tests RNA-Silencing Drug Against Fatal Heart Amyloid Disease
Transthyretin amyloid cardiomyopathy remains one of cardiology's most underdiagnosed and lethal conditions — a disease…
Longevity
Sattar Perspective: Incretin-Driven Weight Loss (14-20%) and Causal Adiposity Effects Across Multiple Disease Domains
Using a triangulation framework—combining Mendelian randomisation, observational cohorts, and randomised trials—Sattar…
Nutrition
DASH Diet Cuts Heart Failure Risk 11% Independent of Cardiometabolic Mediators
Among 124,777 UK Biobank participants followed for 12 years, highest versus lowest adherence to the DASH diet was…
Longevity
Senescent Vascular Cells and SASP Linked to Intracranial Aneurysm Wall Weakening
Intracranial aneurysms may represent a localized manifestation of premature vascular aging, with senescent endothelial…
Studies
DOACs Cut Composite Cardiovascular Risk 69% in Intermediate-Risk Atrial Fibrillation
For millions of atrial fibrillation patients occupying the gray zone of stroke risk — not clearly high-risk enough to…
Studies
Physiotherapist-Led ED Care Cuts Wait Times and Costs in RCT
Emergency department overcrowding is one of the most persistent threats to patient safety in modern healthcare…
Nutrition
Healthy Lifestyle by Age One Linked to 23–43% Lower IBD Risk
Inflammatory bowel disease is increasingly understood as a condition shaped not just by genetics but by the cumulative…
Studies
Aficamten Achieves Multi-Domain Cardiac Improvement in Nonobstructive HCM Trial
For the estimated 750,000 Americans living with hypertrophic cardiomyopathy, the nonobstructive form has long…
Studies
Study Links Two or More Years of Pretransplant Dialysis to Higher Graft Loss Risk in Living-Donor Recipients
For the millions of patients worldwide managing end-stage kidney disease, the timing of transplantation relative to…
Longevity
Senescent Microglia in Brain White Matter Partially Reversed by Senolytic Drugs
White matter integrity is increasingly recognized as a critical determinant of cognitive aging, yet the specific…
Studies
AI Language Model Predicts Antigen-Specific Antibodies Directly from Blood RNA Sequences
The ability to rapidly pinpoint which antibodies in a complex immune response will actually bind a target pathogen has…
Longevity
AI Digital Twins Could Personalize Nutrition Against Age-Related Muscle Loss
Sarcopenia's convergence with chronic multimorbidity represents a compounding mortality risk in aging populations, yet…
Fitness
Injury Reported as Barrier by 1 in 5 Inactive Women Enrolled in Social Sport Programs
For the millions of women who cycle in and out of physical inactivity, injury is rarely discussed as a structural…
Studies
Ebola IPC Gains Erode Within Six Months Without Sustained Reinforcement
Healthcare facilities in outbreak zones are only as safe as their weakest post-crisis moment — and new evidence from…
Studies
Enteric Disease Deaths Fell 60% Since 1990, But Child Mortality Targets Remain Elusive
Over a billion episodes of gut infection still occur every year, yet the story of the past three decades is one of…
Studies
Aficamten Wins Global Approval as Second Cardiac Myosin Inhibitor for HCM
For the roughly one in 500 adults living with hypertrophic cardiomyopathy, the treatment landscape has just gained a…
Nutrition
Plant-Based Diet Shifts May Raise Mycotoxin Exposure in Children
As plant-based eating continues its mainstream ascent, a largely overlooked hazard deserves closer attention: the…
PREPRINTLongevity
Post-Hoc Analysis Suggests Possible Aspirin Benefit for Disability-Free Survival in Black and Hispanic Elders from ASPREE Trial
A post-hoc analysis of the ASPREE randomized controlled trial examined 1,270 U.S. participants aged 65+ who…
PREPRINTWellbeing
Systemic Right Ventricle Adults Show 46% Anxiety Rate Linked to VO2 Decline
Among 137 adults with systemic right ventricle (sRV) physiology followed over 25 years at a tertiary congenital heart…
PREPRINTStudies
Default MR Instrument Settings Produce Suboptimal Causal Estimates Across 3 Phenotypes
Using UK Biobank data across three phenotypically distinct exposures — circulating amino acids, BMI, and major…
Longevity
Longer Telomeres Associated with 87% Lower Mortality Risk in Black Women with Lupus
Among 422 Black/African American women with systemic lupus erythematosus (SLE) followed for nearly two years, longer…
Wellbeing
Cortical Circuits Use Two-Phase Strategy to Master Parallel Task Processing
The brain's capacity to juggle multiple demands simultaneously sits at the heart of cognitive performance, yet the…
Studies
AMPK's Heart Failure Role Proves Complex, Context-Dependent, Not Simply Protective
The assumption that boosting a cell's energy sensor automatically protects a failing heart is being seriously…
Longevity
Senescent Bone Marrow Cells Fuel Pre-Leukemic Clones via TNF-α/IL-6 Loop
Clonal haematopoiesis — the silent accumulation of blood stem cells carrying somatic mutations — affects roughly half…
Nutrition
Mediterranean Diet Linked to Reduced IBD Inflammation Across 1,615 Patients
For the estimated 10 million people worldwide living with ulcerative colitis or Crohn's disease, dietary choices…
Studies
Dermatologist Density Gap Exposes Severe Global Skin Care Inequity
Skin disease affects nearly five billion people annually, yet the global workforce trained to treat it remains…
Studies
Recombinant Shingles Vaccine Linked to 9–12% Drop in Cardiac Event Burden
Most adults treat the shingles vaccine as a pain-prevention tool. Emerging evidence now suggests it may quietly be…
Studies
AI Drug Discovery Shows Minimal Clinical Impact Despite Decade of Hype
The gap between artificial intelligence's promise and its actual contribution to bringing better medicines to patients…
Studies
HPV Vaccination Associated with Major Reduction in Cervical Cancer Deaths Among Young Women in England
Preventing cancer deaths—not merely cases—is the ultimate benchmark for any vaccination program, and evidence reaching…
Studies
Dupilumab Reverses 41 Dysregulated Biological Pathways in Eosinophilic Esophagitis
For patients living with eosinophilic esophagitis, the disease is far more than excess white blood cells in the wrong…
Supplements
Omega-3, D3, and K2 Share Overlapping Mechanisms Across Heart, Brain, and Bone
A structured narrative review synthesizing evidence from PubMed, Embase, Cochrane, and Web of Science proposes a…
Nutrition
GLP-1 Drugs Shrink Fat and Muscle: What 2025 Evidence Says
Both semaglutide and tirzepatide produce substantial lean body mass (LBM) reductions alongside fat loss, yet this…