Supplements
Stevioside Activates YAP Pathway to Regenerate Liver Cells in Cholestasis
Liver diseases involving bile duct obstruction represent a serious and often underappreciated public health burden…
Supplements
Evidence reviews of supplements, vitamins, and nutraceutical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Studies
Omega-3 Plus Low-Dose Aspirin Matches Antibiotics for Severe Periodontitis
For the roughly half of adults over 30 living with significant periodontal disease, the standard clinical dilemma has…
Supplements
Melatonin's Prolactin Pathway May Link Long-Term Use to Heart Failure Risk
Melatonin is taken nightly by millions of adults who regard it as essentially harmless — a natural sleep aid with a…
Nutrition
DASH Diet Cuts Heart Failure Risk 11% Independent of Cardiometabolic Mediators
Among 124,777 UK Biobank participants followed for 12 years, highest versus lowest adherence to the DASH diet was…
Supplements
Vitamin C Modulates 7 Aging Hallmarks But Human Evidence Remains Thin
A comprehensive narrative review from the University of Szeged maps vitamin C's interactions across the canonical…
Wellbeing
Unconscious Behavioral Mimicry Found to Reinforce Smoking Addiction via Social Bonding
Social belonging is one of the most powerful forces shaping human behavior, and it may be quietly undermining millions…
Longevity
AI Digital Twins Could Personalize Nutrition Against Age-Related Muscle Loss
Sarcopenia's convergence with chronic multimorbidity represents a compounding mortality risk in aging populations, yet…
PREPRINTNutrition
UK Dietitians Survey: MUST Inadequate for Mental Health and Learning Disability Inpatients
Across 47 UK dietitians surveyed from inpatient mental health and learning disability settings, the dominant…
Studies
High-Dose Folate Raises Cell-Culture Alarm But Not Real-World DNA Damage
For the many patients prescribed high-dose folic acid for blood disorders — and for the general population routinely…
Nutrition
Mediterranean Diet Linked to Reduced IBD Inflammation Across 1,615 Patients
For the estimated 10 million people worldwide living with ulcerative colitis or Crohn's disease, dietary choices…
Nutrition
GLP-1 Trials Omit Diet Data: Ethical Blind Spot Undermines 4 Core Principles
Landmark GLP-1 receptor agonist trials — including those establishing semaglutide and tirzepatide as transformative…
Studies
Review Finds Semaglutide Linked to 7.6–11.5 kg Weight Loss and Menstrual Improvements in PCOS, but Evidence Remains Preliminary
Across 25 studies encompassing 356 screened records, semaglutide — a GLP-1 receptor agonist — produced mean weight…
Longevity
Rapamycin Cuts AF Risk via mTOR-Independent HIF-1α Suppression in Aging Hearts
In a D-galactose-accelerated aging mouse model, rapamycin administered via dietary supplementation significantly…
Supplements
Omega-3, D3, and K2 Share Overlapping Mechanisms Across Heart, Brain, and Bone
A structured narrative review synthesizing evidence from PubMed, Embase, Cochrane, and Web of Science proposes a…
Studies
Dual Macrophage Fates Identified as Opposing Controllers of Liver Scarring
Chronic liver disease affects hundreds of millions of people globally, and fibrosis — the progressive accumulation of…
Studies
Fragmented Urban Tree Canopy Linked to Higher Child Mortality in 420,000-Child Study
The spatial arrangement of urban greenery — not just how much exists, but how it is distributed — may carry…
Studies
Older Australians Score Below 30% on Osteoporosis Knowledge, Men Worst Affected
Osteoporosis quietly fractures lives before most people know they have it — and new survey data suggest that ignorance…
Nutrition
Emerging Review Highlights Gut-Eye Axis and Omega-3s in Dry Eye: Evidence Remains Preliminary
Dry eye disease affects an estimated 344 million people globally, yet clinical management has long focused narrowly on…
Studies
Piezo1 Mechanosensor Creates Self-Reinforcing Stiffness Loop Driving Squamous Cell Carcinoma
Understanding why certain cancers become increasingly aggressive despite standard treatment has long puzzled…
Longevity
Sarcopenia Diagnosis Hinges on Grip Strength, Not Mass Alone
Sarcopenia—progressive loss of muscle strength, mass, and physical performance—is increasingly prevalent in aging…
Studies
Viral Entry Triggers Nuclear DNA Expulsion, Activating Key Innate Immune Pathway
Understanding how cells first sense viral invasion has long been a central puzzle in immunology — and the answer has…
Nutrition
Dietary Arginine Controls Immune Tumor Recognition Via Codon-Dependent MHC-I Translation
The idea that what we eat could directly reshape whether our immune cells recognize tumors or clear viruses has long…
Nutrition
Colorless Tomato Compound Phytoene Fights Fatty Liver Via Enzyme-Dependent Pathway
Fatty liver disease now affects roughly one in four adults globally, yet dietary strategies beyond general caloric…
Studies
Buprenorphine Shows Promise Managing 7-Hydroxymitragynine Dependence in Small Clinic Series
As purified kratom alkaloid products proliferate in supplement markets, clinicians are encountering a novel dependence…
Studies
West Texas Measles Outbreak: 72% of Hospitalized Cases Developed Pneumonia
When measles resurfaces in under-vaccinated communities, the clinical consequences are swift and serious — and a 2025…
Studies
Lipid Management Shifts Beyond LDL: Lp(a), ApoB, and RNA Therapies Reshape ASCVD Prevention
For decades, LDL cholesterol was the near-exclusive target of cardiovascular prevention — but a growing body of…
Longevity
Gut Bacterium B. pseudocatenulatum and Metabolite 5-AVAB Extend Healthspan via Inflammaging Suppression
A microbiome aging clock (MicroAge) built from enterotype-specific gut microbial shifts across multiple Chinese…
Nutrition
First 1,000 Days of Low Sugar Linked to 31–69% Lower Adult Cancer Risk
The first thousand days of life may be among the most consequential nutritional windows a human ever passes through…
Studies
Host DNA Repair Machinery Drives Antiviral Drug Resistance in Cytomegalovirus
Drug resistance is one of the most stubborn obstacles in antiviral medicine, and the assumption has long been that…
Studies
Dual Nanoparticle Strategy Forces Liver Fibrosis Cells Into Permanent Dormancy
Liver fibrosis kills tens of thousands annually and has no approved cure — a deficit partly explained by how fibrotic…
Nutrition
Traditional Tajik Yaghnob Goat Cheese Reveals Yeast Genomic Signatures of Dairy Adaptation
The story of how microbes adapt to radically different food environments is central to understanding both fermentation…
Studies
Multi-Hospital African Trial Links Intrapartum Bundle to Lower Newborn Death Odds
Early newborn survival in sub-Saharan Africa remains one of global health's most persistent challenges, and rigorous…
Studies
Pan-European Survey Shows Fragmented GLP-1RA Adoption in OSA Care Despite SURMOUNT-OSA Trial Results
A pan-European survey across 24 sleep centres in 14 countries reveals that tirzepatide and other GLP-1 receptor…
Longevity
DAF-2 Receptor Deletion Extends Male C. elegans Lifespan 440% via Sex-Specific IGF-1 Mechanisms
Ubiquitous degradation of the DAF-2/IGF-1 receptor in male Caenorhabditis elegans extends median lifespan by over 440%…
Studies
Phase 3 Trial Compares 5-Fraction SBRT Against 20-Fraction IMRT for Prostate Cancer
For the roughly 100,000 men diagnosed annually with intermediate-risk prostate cancer in the United States alone, the…
Supplements
Berberrubine Targets HNRNPF Pathway to Shield Kidneys From Uremic Toxin Damage
Kidney tubular injury driven by accumulated uremic toxins represents one of the most underappreciated accelerants of…
Longevity
Gut Bacterium and Its Metabolite Shown to Counter Age-Driven Inflammation
Chronic low-grade inflammation — now widely termed inflammaging — is increasingly recognized as a central driver of…
Nutrition
Gut-Eye Axis: Omega-3s, SCFAs, and Microbiome Diversity Linked to Dry Eye Outcomes
The gut-eye axis emerges as a mechanistic bridge in dry eye disease (DED), with gut dysbiosis triggering systemic…
Studies
Plasma Histidine Levels Predict Immunotherapy Response Across Five Cancer Types
For the roughly 70–80% of advanced cancer patients who fail to respond to immune-checkpoint inhibitors (ICIs), the…
Nutrition
Rome V Criteria and Gut-Brain Axis Reshape IBS Clinical Management Framework
Irritable bowel syndrome affects roughly one in ten adults globally, yet its management remains inconsistent and often…
Studies
Macrophage Protease MMP14 Drives Obesity-Linked Inflammation and Insulin Resistance
Understanding why obesity so reliably triggers systemic metabolic dysfunction—insulin resistance, fatty liver…
PREPRINTNutrition
AI Meta-Analysis Links Lutein, Beta-Carotene to Lower Risk Across 3 Female Cancers
An automated evidence-synthesis platform called MetaFemina, integrating large language model (LLM)-assisted extraction…
PREPRINTNutrition
Food Support Linked to 68% Lower TB Mortality and Much Higher Medication Adherence in Benin-Togo Natural Experiment
A prospective cohort study across 13 sites in Benin and Togo (n=769) exploited a natural policy experiment: Benin…
PREPRINTNutrition
Low-Dose 27mg Iron Linked to Better Gut Diversity and Lower IL-6 in Small RCT of Female Soccer Players
A 3-month randomized controlled trial in 23 female soccer players (median age 21) found that 27 mg/day elemental iron…
Wellbeing
Multilingual Alzheimer's Patients Show Distinct Default Mode Network Connectivity Patterns
For decades, the idea that speaking multiple languages could buffer the brain against dementia has attracted both…
Supplements
Dietary Yeast Beta-Glucan Reprograms Bone Marrow to Restore Tumor Immunity in Obesity
Obesity doesn't just add weight — it fundamentally rewires the immune system in ways that linger even after weight…
PREPRINTLongevity
DBP at 80–90 mmHg Peaks Bone Density; ACE Inhibitor Target MMP9 Cuts BMD by 3.6%
In 366,443 UK Biobank participants of European ancestry, diastolic blood pressure (DBP) showed a striking inverted…
Studies
Bariatric Surgery Cuts CKD Risk but RYGB Raises Hyperoxaluria Danger
Obesity-related glomerulopathy — driven by glomerulomegaly, focal segmental glomerulosclerosis, and hyperfiltration…
Supplements
Single Patient Experiences Decade-Long Remission Following Selenite Then Chemotherapy: Case Report
Complete, durable remission in a patient with no remaining standard treatment options is among the rarest and most…
Supplements
Ketone Esters Preserve Muscle Mass Lost During Semaglutide Weight Treatment
One of the most underappreciated trade-offs of GLP-1 receptor agonist therapy is that a substantial portion of the…
Studies
Daily Zinc Cuts Infection Rate by One-Third in Young Sickle Cell Patients
For children with sickle cell anemia in sub-Saharan Africa, infections are not a complication — they are a leading…
Longevity
Dioscin Extends Lifespan in Worms and Reduces Senescence Markers in Aged Mice via UPRER Pathway
Dioscin, a steroidal saponin derived from medicinal herbs, extends lifespan in C. elegans and reduces senescence…
Studies
U-Shaped Hemoglobin Curve Reveals Narrow Safe Window in Pregnancy
For decades, clinical guidance on hemoglobin in pregnancy has focused almost exclusively on anemia — the lower bound…
Nutrition
Time-Restricted Eating Preserves Aging Muscle via Circadian and Mitochondrial Pathways
Sarcopenia silently erodes independence long before most people recognize it as a threat — and the timing of meals…
Studies
CYBA Gene Suppression Blocks Pancreatic Cancer Liver Spread via AKT/MLC2 Signaling
Pancreatic cancer's lethality is largely driven by its tendency to spread to the liver before diagnosis, and few…
Longevity
Meta-Analysis Tests 16 Epigenetic Clocks Against 51 Longevity Interventions
The promise of epigenetic clocks has always been tantalizing: a molecular readout of how fast you're actually aging…
Studies
FOBT Colorectal Screening Cuts CRC Mortality More Than Raw Data Suggest
Colorectal cancer screening statistics routinely understate the true benefit of fecal occult blood testing — a…
Supplements
GLP-1 Drugs Linked to 57% Lower Papilledema Risk in Intracranial Hypertension Patients
Across eight studies enrolling 13,243 patients, GLP-1 receptor agonists (GLP-1 RAs) produced striking reductions in…
Longevity
Evolved Gut Bacteria Extend Lifespan via Acetate in Drosophila Model
Applying directed evolution to the Drosophila gut microbiome outside the host generated a paraquat-resistant (PQR)…
Nutrition
Meal Skipping May Mediate Link Between Cannabis Use and Lower Diet Quality in University Students
For the millions of young adults who use cannabis regularly, the assumption has long been that the substance directly…
Studies
Review Maps Six Molecular Pathways Linking Nicotine to Cardiovascular Dysfunction
Most health discussions about tobacco focus on combustion byproducts like tar and carbon monoxide, but a comprehensive…
Nutrition
Cardiac Rehab Nutrition Evidence Remains Fragmented Despite 35-Study Review
For the millions of adults navigating life after a cardiac event, the quality of nutritional guidance they receive…
Studies
Parkinson's LRRK2 Mutation Boosts Immune Defense Against Bacteria via Oxidase Pathway
A mutation long associated with Parkinson's disease may have persisted in human populations partly because it confers…
Studies
Codon Optimization in mRNA Therapeutics Creates Unintended Off-Frame Protein Risk
A design assumption underlying virtually every mRNA vaccine and nucleic acid therapeutic may carry an underappreciated…
Studies
NEJM Editorial Examines Mucolytics Role in Acute Respiratory Failure Management
Mucus clearance has long been an underappreciated battleground in critical care, yet the pharmacological tools…
Longevity
Metformin's AMPK-mTOR Axis May Redefine Clinical Approaches to Biological Aging
A diabetes drug taken by hundreds of millions of people worldwide may be quietly doing something far more profound…
Fitness
Protein + Resistance Training Beats Synbiotics for T2DM Muscle Strength in Men Over 65
In a triple-blinded RCT, 51 men aged ≥65 with type 2 diabetes were randomized to resistance training plus either a…
Supplements
Kudzu Isoflavones and Lignin Fractions Restore 64 Liver Proteins in Toxic Injury Model
Liver disease affects hundreds of millions globally, yet the molecular mechanisms by which plant polyphenols exert…
Supplements
Urolithin A Repairs Mitochondria and Gut-Ceramide Axis in HFpEF Model
Heart failure with preserved ejection fraction — the form of heart failure where the heart pumps normally but fills…
Studies
Groundwater Fluoride Above 3.7 ppm Linked to Lower IQ in Indian Children
Fluoride's role as a neurotoxin at high concentrations is one of the more contested questions in environmental health…
Longevity
Hybrid Macrophage-Neuron Nanoparticles Break Tendinopathy's Inflammation-Senescence Loop
A multifunctional nanoplatform (MSM-DTM) fused from macrophage and sensory neuron membrane vesicles, combined with…
Longevity
Metabolic Network Maps 4-Billion-Year Archive of Enzyme Evolution
Understanding how life's molecular machinery originated touches one of the deepest questions in biology — and now…
Nutrition
Gut Microbe Metabolite Isovalerate Repairs Malnutrition-Induced Intestinal Barrier Sex Differences
Intestinal barrier failure is one of the deadliest and least-addressed consequences of severe malnutrition — bacteria…
Studies
RTK Fusion Oncoproteins Share EGFR Suppression and Drug Synergy Mechanism
Cancer treatment has long been hampered by the molecular diversity of oncogenic driver mutations — over a thousand…
Studies
PNAS Calls Out P-Value Misuse: Equivalence Testing Offers Rigorous Alternative
One of the most quietly damaging habits in health and medical research is the casual equation of 'statistically…
Studies
Engineered Probiotic Delivers Tumor-Selective IL-2 to Combat Pancreatic Cancer
Pancreatic cancer remains one of oncology's most formidable challenges, with five-year survival rates stubbornly below…
Studies
PROMETHEUS Trial Tests Gerotype-Personalized Supplements and Exercise for Healthspan
Personalized medicine is reaching geroscience in a meaningful way, and PROMETHEUS represents one of the more…
Studies
FDA Expands Gene Therapy Access for Sickle Cell Disease to Age Two
For families living with pediatric sickle cell disease, a regulatory milestone has arrived that meaningfully lowers…
Longevity
Gut Microbiome Shifts Linked to Inflammaging Through SCFAs, Bile Acids, and Tryptophan Metabolites
The composition of trillions of microbes lining the human gut turns out to be far more than a digestive footnote — it…
Studies
Dual-Cell Collagen Scaffold Transplant Shows Safety in Rare Corneal Blindness
For adults born without irises, progressive corneal clouding — aniridia-related keratopathy — has historically offered…