Longevity
Lp(a): Genetic Cardiovascular Risk Factor Affecting 20% Awaits Targeted Therapies
For roughly one in five adults, cardiovascular risk is quietly elevated by a factor that standard lipid panels often ig…
Supplements
Evidence reviews of supplements, vitamins, and nutraceutical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
Melatonin Shows Modest Pain Relief in Chronic Musculoskeletal Conditions, Meta-Analysis Finds
For the millions of adults managing chronic joint, back, or soft-tissue pain, the appeal of a non-opioid, low-side-effe…
Supplements
Vutiglabridin Breaks Semaglutide's Weight-Loss Plateau, Restores Normal Body Composition in Mice
Diet-induced obese mice treated with semaglutide hit a weight-loss plateau within two weeks — a well-documented ceiling…
Nutrition
Review Links MCTs, DHA, and Carnosine to Selective Cognitive Benefits in Early Cognitive Impairment via Glucose Metabolism Support
Cerebral glucose hypometabolism — the brain's progressive inability to efficiently metabolize its primary fuel — preced…
Studies
Post-Pandemic Respiratory Virus Risk Map: Genetics, Behavior, and Comorbidities Charted
Understanding who is most vulnerable to respiratory viruses — and why — has never been more urgent. Post-pandemic shift…
Studies
Immunotherapy Era Challenges Routine Lymph Node Removal in Colorectal Cancer
A decades-old surgical assumption — that removing as many lymph nodes as possible improves colorectal cancer outcomes —…
PREPRINTLongevity
Normal Saline Depletes H₂S Enzymes in Bypass Vein Grafts, Blood Preserves Them
Among 20 coronary artery bypass grafting (CABG) patients, saphenous vein segments stored in autologous heparinized arte…
Longevity
19 Mitochondria Transferred Via Microfluidics Reverse Senescence in Stem Cells
A droplet microfluidic platform using inertial focusing achieved 56% mitochondrial transfer efficiency at over 4,000 dr…
Nutrition
Dietary Capsaicin Linked to Lower Aortic Dissection Risk via TRPV1-Macrophage and Microbiome Pathways in Preliminary Study
Aortic dissection—a sudden, life-threatening tear in the aortic wall—carries mortality rates that can exceed 50% within…
Studies
Multi-STING Activator mRNA Nanoparticle Vaccine Boosts Dendritic Cell Antitumor Response
Cancer immunotherapy stands at an inflection point: while mRNA vaccine platforms have proven clinically viable, their r…
Studies
Patient Navigation Programs Most Effective at Closing Black Women's Mammography Gap
Breast cancer outcomes are strongly tied to stage at detection, making screening disparities a life-or-death equity iss…
Nutrition
UK Iodine Paradox: Population Deficiency Meets Social-Media-Driven Excess
Iodine rarely makes headlines, yet it quietly governs thyroid hormone synthesis and fetal neurodevelopment — and the Un…
Supplements
GLP-1RA Dual Agonists May Elevate Fracture Risk; Urine DPD Biomarker Offers Early Warning
GLP-1 receptor agonist monotherapy appears largely bone-neutral, but dual agonists — such as tirzepatide targeting both…
Nutrition
Lutein & Zeaxanthin Lead Ocular Nutraceuticals; Curcumin, Resveratrol Lag Behind
Among all food-derived bioactive compounds examined for ocular disease, lutein and zeaxanthin stand out as the only nut…
Supplements
Piceatannol Cuts IGFBP4/5/7 Senescence Signals, Improves Memory in Aging Mice
Oral piceatannol (PCT), a stilbene and direct resveratrol metabolite with superior bioavailability, demonstrably reduce…
Studies
Mechanical Force Patterns Spatially Direct New Blood Vessel Growth in Tissue
Vascular biology has long assumed that chemical gradients—growth factors like VEGF diffusing through tissue—are the mas…
Studies
Sequential PTH Analogue Then Bisphosphonate Cuts Fracture Risk in Brittle Bone Disease
For adults living with osteogenesis imperfecta — a genetic disorder that leaves bones so fragile that ordinary movement…
Studies
Dual-Drug Therapy Targets Adult Fracture Risk in Brittle Bone Disease
For the roughly one in 10,000 to 20,000 adults living with osteogenesis imperfecta (OI), fracture risk is a lifelong bu…
Studies
One-Third of US Women Uncertain About Perimenopause Stage, Survey Finds
Perimenopause is one of the most consequential yet least clinically defined transitions in a woman's reproductive life…
Longevity
Spermine Chelates Fe²⁺ to Block Ferroptosis, Completing Polyamine Longevity Model
A new mechanistic framework resolves a long-standing paradox in polyamine biology: spermidine drives autophagy by inhib…
Supplements
Asp9Glu Mutation Yields Biased GLP-1/Glucagon Dual-Agonist with Enhanced Weight Loss
A single conservative amino acid substitution — replacing aspartate with glutamate at position 9 of glucagon and GLP-1…
Nutrition
Exocrine Pancreatic Insufficiency: Clinical Diagnosis and Management Insights
Malabsorption disorders often evade early detection, and exocrine pancreatic insufficiency (EPI) is among the most comm…
Nutrition
Nine Dietary Compounds Mapped to Sleep Architecture and Circadian Biology
Sleep is increasingly recognized not as passive downtime but as an active biological maintenance window — and the compo…
Nutrition
Gut Bacteria's Fatty Acid Metabolites Block Candida Colonization via Three Distinct Mechanisms
For immunocompromised patients — transplant recipients, cancer patients on chemotherapy, ICU patients on broad-spectrum…
Studies
Pancreatic Ductal Cells Acquire Immune-Presenting Function Under Inflammatory Cytokine Exposure
Understanding how type 1 diabetes progresses beyond beta-cell destruction could reshape therapeutic targeting — and a m…
Supplements
Ergothioneine Restores Aging Circadian Clocks via NAD+ Redox Rescue
Ergothioneine (EGT), a sulfur-containing amino acid found in mushrooms and certain bacteria, dose-dependently restored…
Studies
Vitamin K Refusal at Birth Linked to Higher Infant Bleeding Risk in 2M Cohort
A preventable cause of infant brain damage and death has quietly gained ground as parental refusal of a standard newbor…
Studies
New Functional Vision Tool Shows Strong Reliability for Pediatric CVI Trials
Cerebral visual impairment remains one of the most underdiagnosed and poorly measured conditions affecting children's d…
Studies
Once-Daily iTBS Brain Stimulation Outperforms Sham in Randomized Depression Trial
For the millions of adults with major depressive disorder who achieve inadequate relief from medication, non-invasive b…
Nutrition
Chronic Xanthan Gum Intake Triggers Colon Inflammation and Microbiota Shifts in Rats
Xanthan gum appears in ingredient lists across thousands of packaged foods, gluten-free products, and clinical thickene…
Studies
Tau Spread Pattern Reveals Two-Phase Alzheimer's Progression Across Four Cohorts
Understanding exactly when and where Alzheimer's pathology becomes detectable — and measurable — has enormous consequen…
PREPRINTLongevity
IL34 Stop-Gain Variant Associated with Event-Free Survival in French-Canadian FH Patients (Preprint)
Among 243 French-Canadian carriers of the LDLR p.Trp87Gly pathogenic variant, whole-exome sequencing identified a stop-…
PREPRINTLongevity
79% Vitamin D Deficiency Found Alongside 58% Obesity in Kazakhstan Care Home Elders
Among 62 adults aged 60+ (mean age 74) residing in a state social-care facility in Astana, Kazakhstan, a striking cardi…
Supplements
Silymarin Cuts Amyloid-Beta and SASP Markers in Senescent Mouse Brains
In a five-group mouse model combining doxycycline-accelerated cellular senescence (21 days) with lipopolysaccharide-ind…
Studies
Chronic Vaping Linked to Reduced Exercise Capacity and Ventilatory Inefficiency in Young Adults
Standard lung function tests clear millions of young vapers as healthy — but that reassurance may be masking real physi…
Studies
Combined ICU Cycling and IV Amino Acids Show No Functional Gain at Discharge
For the millions of ICU survivors who face months of debilitating weakness and lost muscle mass after critical illness,…
Studies
Sibling-Controlled Swedish Cohort Finds No Autism Link to Prenatal Acetaminophen
Two of the most anxiety-inducing questions circulating among parents and clinicians — whether a common pain reliever ta…
Studies
Beetroot Juice Meta-Analysis Reveals Design-Dependent Exercise Benefits in COPD
For the roughly 400 million people worldwide living with COPD, exercise intolerance is a defining and disabling feature…
Longevity
Omega-3s, Fiber, and Polyphenols Linked to Healthy Aging Biomarkers in Narrative Review
The gap between lifespan and healthspan — the years lived in genuinely good physiological condition — is one of the cen…
Longevity
Sirt3 Activation Reverses Disc Degeneration via Mitochondrial Calcium and ATP Pathways
Low back pain costs the global economy hundreds of billions of dollars annually and affects roughly 80% of adults at so…
Wellbeing
HIV Survivors Use Gendered Silence as Adaptive Moral Strategy, Not Failure
For the millions of people living with HIV on long-term antiretroviral therapy, the dominant clinical narrative has lon…
Studies
Post-Stroke Immune Window Concept May Reframe Neuroinflammation Treatment Timing
The window between brain damage and recovery after stroke may be far more dynamic than medicine has treated it. For mil…
Studies
Synthetic AMH-Mimicking Peptide Shields Ovarian Reserve From Chemotherapy Damage
Chemotherapy-induced infertility and early menopause represent a largely unaddressed consequence of cancer treatment, a…
Studies
Progestogen Monotherapy Offers Viable Menopause Relief When Estrogen Is Contraindicated
For millions of women navigating menopause with histories of venous thromboembolism, certain gynecologic cancers, or co…
PREPRINTStudies
Gut Metabolite TMAO Associated with Fewer Behavioral Problems in Children and Protection Against Heavy Metal Neurotoxicity in Preprint Study
Trimethylamine N-oxide (TMAO), a gut microbiota-host co-metabolite, associates with fewer internalizing behavioral prob…
PREPRINTNutrition
Fermentable Fiber Cuts Uremic Toxins IS and pCS in Kidney Disease Patients
A systematic review and meta-analysis pooling 13 randomized clinical trials (511 participants) and 15 controlled rodent…
Supplements
GLP-1 Agonists Boost Mitochondrial Bioenergetics, Cut ROS by 3.5 SMD in Human Cells
Pooling 17 in vitro studies using human-derived cell models, this meta-analysis found that GLP-1 receptor agonists — th…
Supplements
Resveratrol Restores Diaphragm Function in Epilepsy via SERCA2/Calcium Pathway
Chronic epilepsy—modeled via pentylenetetrazol (PTZ) in 32 male Wistar rats—produced measurable diaphragm contractile s…
Nutrition
Maternal Oxylipin Levels at Mid-Pregnancy Linked to Toddler Neurodevelopment Deficits
What happens in the womb during the second trimester may shape a child's brain trajectory far more than previously appr…
Supplements
Resveratrol Suppresses PCOS Inflammation via JAK2/STAT3-AIM2 Pathway Block
Chronic inflammation in polycystic ovary syndrome (PCOS) worsens hormonal dysregulation, yet its precise molecular driv…
Nutrition
AGEs, Oxysterols & NF-κB: Diet's Dual Role in Inflammaging Mapped
Chronic low-grade inflammation driven by dietary advanced glycation end products (AGEs), lipid peroxidation products, o…
Studies
Cruise Ship Ultrafine Particles Suppress Antiviral Immunity via Vanadium Signaling
Port communities and frequent maritime travelers may face an underappreciated respiratory hazard that goes beyond conve…
Studies
Adenosine Receptor Deletion Paradoxically Accelerates CD8 T Cell Burnout
The immune system's capacity to sustain a cancer-fighting response hinges on preventing T cell exhaustion — a state whe…
Longevity
Tau Protein's Dual Role: Mitochondrial Regulator in Health and Disease
Most discussions of tau protein center on its catastrophic role in Alzheimer's and other tauopathies — the tangles, the…
Wellbeing
Daytime Light Deficiency in Elderly Homes Linked to Poorer Sleep Quality
Most sleep-lighting research has been conducted in Western laboratory settings — a critical blind spot given that billi…
PREPRINTNutrition
Dual-Period BEP Supplementation Lifts Infant Language Scores by 2.1 Points in Nepal RCT
A randomized controlled trial in rural Sarlahi District, Nepal enrolled 400 mother-infant pairs across four interventio…
Studies
Prenatal COVID-19 Linked to Tenfold Rise in Infant Developmental Delay
The neurodevelopmental consequences of pandemic-era pregnancies are only beginning to surface, and this multinational c…
Studies
Cesarean Birth and Perinatal Antibiotics Associated with Differences in Infant Gut Microbiome Composition and Diversity
The composition of an infant's gut microbiome during the first year of life may carry consequences that extend well bey…
Supplements
Dietary Yeast Beta-Glucan Reprograms Bone Marrow to Restore Obesity-Impaired Anti-Tumor Immunity
Obesity doesn't just strain the heart and joints — it fundamentally corrupts the immune system's ability to detect and…
Studies
Apoptotic Body Uptake Drives ACE2-Independent COVID-19 Macrophage Infection
Understanding why severe COVID-19 triggers devastating cytokine storms has remained one of the pandemic's most clinical…
Longevity
SASP-Driven Macrophage Senescence and Pyroptosis Converge to Destabilize Atherosclerotic Plaques
Senescent macrophages accumulating within atherosclerotic plaques deploy a senescence-associated secretory phenotype (S…
Longevity
404 Gut Bacterial Species Linked to Frailty Severity in 2,081 Older Women
In 2,081 Swedish women aged 75–80 from the SUPERB cohort, metagenomic profiling revealed that 404 bacterial species wer…
Studies
AI Medical Chatbots Show Reduced Accuracy When Users Phrase Questions Confidently or Omit Key Data
The growing integration of AI into personal health decision-making rests on an underexamined assumption: that these too…
PREPRINTNutrition
DHA, Choline, and Iron Linked to White Matter Growth in Children 2–14
A longitudinal neuroimaging study tracking typically developing children aged 2 to 14 years found that six specific nut…
Longevity
Preterm Birth Reframed: Mitochondrial Dysfunction and Senescence Proposed as Unified Mechanism for Spontaneous Preterm Birth
Spontaneous preterm birth (sPTB), affecting ~15 million infants annually, may be better understood as accelerated gesta…
Studies
Body Contouring After Bariatric Surgery Yields Measurable Multidomain Quality-of-Life Gains
For the millions of adults who undergo bariatric surgery each year, dramatic weight loss is only part of the story. The…
Nutrition
Gut Microbes From Malnourished Children Transmit Stunting Across Generations in Mice
Malnutrition's grip on human development may be far more biologically entrenched than previously understood — transmitt…
Studies
Lentiviral Gene Therapy Achieves Durable Correction of Rare Metabolic Disorder in Mice
For the rare inherited metabolic disease methylmalonic acidemia, current treatment options remain severely limited — di…
Studies
PS-OCT Imaging Predicts Donor Liver Viability With 80% Pathology Correlation
Every year, thousands of patients die on liver transplant waiting lists while potentially usable donor organs are disca…
Studies
EV Adoption Plus Old Truck Retirement Could Prevent 3,600 Premature Deaths
Urban air quality rarely gets framed as a mortality intervention, yet the fine-grained particles escaping combustion en…
Supplements
Plant Compound Catalpol Reverses Chemo Brain in Preclinical Mouse Model
For the estimated millions of cancer survivors living with chemotherapy-related cognitive impairment — colloquially cal…
Longevity
Resveratrol Extends Female Drosophila Lifespan Across 2 Generations via H3K9ac Epigenetic Rewriting
At 50 μg/ml, resveratrol produced sharply divergent outcomes depending on timing: embryonic exposure accelerated pupati…
Studies
Weight-Loss RCTs Rarely Address Psychological Factors Linked to Eating Disorder Risk
Most adults pursuing structured weight loss assume the programs they enroll in have been designed with safety guardrail…
Nutrition
Daily Yogurt Intake Linked to Higher Essential Nutrient Density Across All Ages
As plant-based food guidance reshapes national dietary recommendations, a critical question emerges: are dairy alternat…
Studies
Cancer Drug Toxicity Tracking Lags Behind Survival Gains in Oncology
As cancer survival rates climb to historic highs, a growing population of long-term survivors is living with side effec…
PREPRINTStudies
Gut Microbiome Dysbiosis Precedes Cardiac Surgery in Children, Associated with PGE2 Elevation and Butyrate Depletion
In 62 pediatric patients (ages 0–5), children with congenital heart disease (CHD) undergoing cardiopulmonary bypass sur…
Studies
Gut-Pelvic Floor Axis: Three Bacterial Taxa Linked to Prolapse Severity Independent of Age
In 86 women undergoing hysterectomy, those with pelvic organ prolapse (POP) showed enrichment of three bacterial taxa —…
Studies
Pilot Study Finds Oral Calcium Carbonate with Oxytocin Feasible and Acceptable for Labor Induction
For the millions of women who undergo medically induced labor each year, the adequacy of uterine contractions remains a…
Wellbeing
Rural Tamil Nadu Women Face Compounded Heat and Eco-Anxiety Burden
As climate change intensifies extreme heat events globally, a critical but underexamined question is how gender-specifi…
Wellbeing
Wearable Ultrasound Patch Boosts REM Sleep 4.6% via Non-Invasive Deep Brain Targeting
For millions of adults struggling with inadequate restorative sleep, the prospect of a non-invasive wearable that can p…