Longevity
Obesity and Gut Dysbiosis Drive Alzheimer's Neuroinflammation via Blood-Brain Barrier
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia towa…
Supplements
Evidence reviews of supplements, vitamins, and nutraceutical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Longevity
Prevotella corporis Bacteria Activates Hsp70 Protection Against Protein Aggregation
Prevotella corporis, a specific gut bacterium, uniquely activates the host's heat shock response and induces Hsp70 mole…
Supplements
Dual Polyphenol Micelles Achieve 98% Encapsulation Efficiency for Enhanced Bioavailability
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency…
Longevity
Resveratrol Stabilizes PER2 Clock Protein in Fetal Heart Cells
Resveratrol increases stability of the PER2 clock protein in both fetal cardiomyocytes and cardiac fibroblasts, shiftin…
Studies
Cesarean Section Infections Strike 15% Despite Modern Prevention Protocols
Post-cesarean surgical site infections affect 3-15% of the 21% of global births delivered by C-section, creating a subs…
Longevity
B-Vitamins May Protect Aging Brain Through Gut Microbiome Modulation
Low B-vitamin status—particularly B6, B12, folate, and riboflavin—correlates with cognitive dysfunction and dementia in…
Studies
Blood Microbiome Traces Link Gut Dysbiosis to Gestational Diabetes Risk
Microbial DNA fragments are being detected in the bloodstream of pregnant women with gestational diabetes, suggesting t…
Longevity
Family Deaths Don't Shorten Telomeres Despite Increasing Mortality Risk
Tracking 4,837 older adults for 14 years, researchers found that experiencing multiple family deaths significantly incr…
Supplements
Coconut Compound 4,4'-Diapophytofluene Outperforms Quercetin in Anti-Aging Protein Binding
Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger bindin…
Supplements
Natural Compounds Target PI3K/Akt/mTOR Autophagy Pathway Against Cancer
Natural compounds including alkaloids, flavonoids, terpenoids, and polyphenols demonstrate ability to modulate the PI3K…
Studies
Iron Deficiency Reduces Maternal Antibody Transfer to Newborns Globally
Analysis of 557 mother-infant pairs across eight countries reveals that maternal iron deficiency significantly impairs…
Studies
Talazoparib Cancer Drug Triggers Harmful Cellular Aging Through PARP1 Pathway
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among te…
Studies
Multicomponent Models Show Variable Accuracy Predicting Post-Stroke Cognitive Decline
Meta-analysis of multicomponent risk prediction models reveals inconsistent performance in identifying stroke survivors…
Wellbeing
Overnight Heat Above 80°F Drives 30% Jump in Crisis Calls
Analysis of Louisiana crisis hotline data reveals that overnight temperatures exceeding 80°F trigger a 30% increase in…
Studies
90-Day PrEP Prescriptions Improve HIV Prevention Adherence Rates
Analysis of 11,072 HIV prevention prescriptions across seven years reveals that prescription duration significantly imp…
Studies
Thyroid Hormone Analog Resmetirom Reverses Multiple MASH Pathways
Transcriptomic analysis reveals that resmetirom, a selective thyroid hormone receptor-beta agonist, simultaneously targ…
Wellbeing
Combined Lifestyle Plus Supplement Interventions Show Mixed Dementia Prevention Results
A systematic analysis of twelve randomized controlled trials reveals the emerging evidence for combining multidomain li…
Studies
Cannabis Substitution Reduces Alcohol Consumption in Severe AUD Population
A novel Canadian harm reduction program allowed 35 individuals with severe alcohol use disorder to substitute pre-rolle…
PREPRINTSupplements
Vitamin D Supplementation Reduces LDL Cholesterol, Blood Pressure in Meta-Analysis
Analysis of 45 randomized controlled trials reveals vitamin D supplementation produces statistically significant but mo…
Wellbeing
Chronic Stress Emerges as Key Pathway Linking Depression to Cardiovascular Events
Analysis of cardiovascular event data reveals chronic stress serves as a primary biological mediator connecting depress…
Studies
Infectious Disease Experts Warn Against Weakening Newborn Hepatitis B Policy
Medical experts are raising concerns about potential policy changes that could weaken universal hepatitis B vaccination…
Supplements
JAMA Trial Shows Myo-Inositol Ineffective for PCOS Pregnancy Outcomes
A double-blind, placebo-controlled trial examining myo-inositol supplementation in pregnant women with polycystic ovary…
Studies
Systematic Review Finds Weak Evidence for Pediatric Melatonin Efficacy
A comprehensive systematic review examining melatonin's therapeutic value in neurotypical children reveals substantial…
Nutrition
Most EU Consumers Unaware of Mercury Guidelines Despite High Fish Consumption
A European Food Safety Authority survey reveals widespread gaps in public knowledge about mercury exposure from seafood…
Wellbeing
African Gut Microbiota Shows Distinct Neuroprotective Patterns Against Cognitive Decline
Population-level analysis reveals that African gut microbiomes harbor distinct bacterial profiles that appear to confer…
Studies
Macrophage Lactate Triggers Epigenetic Scar Formation via MCT1 Transport
Macrophage-secreted lactate directly activates fibroblast scarring through MCT1 transporters and histone lactylation, r…
Studies
PD-1 Inhibitors Shrink Latent HIV Reservoirs in Cancer Patients
Cancer immunotherapy drugs targeting the PD-1 checkpoint protein significantly reduced latent HIV reservoirs in co-infe…
Longevity
Sleep Quality Directly Impacts Cellular Aging and Lifespan Extension
Sleep emerges as a fundamental driver of longevity through its regulation of cellular repair mechanisms, metabolic home…
Longevity
Akkermansia Bacteria Impair Intestinal Stem Cell Regeneration in Aging
Elevated Akkermansia muciniphila levels in aged intestines directly suppress Wnt signaling through the Ascl2 pathway in…
Studies
New MRI technique outperforms standard imaging for athletic bone injuries
A modified MRI protocol combining traditional soft tissue imaging with CT-like bone visualization demonstrates enhanced…
Wellbeing
Brain Protein Munc13 Forms Trimers to Enable Precise Neurotransmitter Release
Cryo-electron microscopy reveals that Munc13-1, a critical protein orchestrating neurotransmitter release, assembles in…
Wellbeing
Iron Regulator Hepcidin Drops in Malnourished Children with Subclinical Malaria
Children experiencing both moderate acute malnutrition and asymptomatic malaria infections showed significantly reduced…
Supplements
Magnesium-L-Theanine Duo Shields Gut and Liver from Chronic Stress
A magnesium-L-theanine combination demonstrated protective effects against stress-induced organ damage in a controlled…
Nutrition
Cultural Context Critical for Accurate Dietary Assessment Across Populations
Dietary assessment tools systematically underestimate nutritional intake in minority populations due to cultural blind…
Studies
Somatostatin Receptor 3 Crystal Structure Reveals New Drug Target Pathways
Researchers have determined the three-dimensional crystal structure of somatostatin receptor 3 (SSTR3), revealing preci…
Wellbeing
Ketone Body β-Hydroxybutyrate Shows Protective Effects Against Brain Aging
Elevated circulating β-hydroxybutyrate (BHB) concentrations demonstrate significant association with reduced cognitive…
Wellbeing
Sleep Apnea Risk Amplifies Depression, Anxiety in Adults Over 45
Canadian researchers analyzing over 5,000 adults found that high obstructive sleep apnea risk correlates with significa…
Supplements
Quercetin Targets UBC6 Enzyme to Trigger Ovarian Cancer Cell Death
Laboratory experiments reveal quercetin activates the UBC6 enzyme, which orchestrates a cascade that degrades AURKA pro…
Nutrition
Bacterial Gut Enzymes Show Novel Carbohydrate Processing Mechanisms
Glycogen phosphorylases from intestinal bacteria demonstrate previously unknown allosteric regulatory pathways that dif…
Wellbeing
Social Cues Shape Pain Perception Through Self-Fulfilling Prophecy Mechanisms
Brain imaging reveals that social expectations about pain intensity directly alter both personal pain experience and em…
Studies
Beta Arrestin 1 Protein Controls Lung Blood Vessel Constriction
Beta arrestin 1 emerges as a critical modulator of pulmonary vascular tone, with implications for treating pulmonary ar…
Wellbeing
Digital Health Literacy Declines Significantly After Age 65, Study Reveals
Digital trace data from four weeks of online activity reveals that adults over 65 distribute low-quality health content…
Longevity
Multiple Cellular Pathways Drive Stem Cell Decline During Aging Process
Stem cells lose their regenerative potency through five interconnected molecular pathways that accelerate with age. Cel…
Studies
Metastatic Cancer Cells Steal Immune Cell Mitochondria for Energy
Metastatic cancer cells actively acquire mitochondria from surrounding immune cells through a previously uncharacterize…
Longevity
Selective Senescent Cell Elimination Could Enhance Cancer Treatment Outcomes
Researchers have developed methods to selectively eliminate specific populations of senescent cells while preserving th…
Nutrition
Bile Acid Pool Size Controls Intestinal Fat Absorption Efficiency
Mouse experiments reveal that bile acid pool size and composition directly regulate intestinal fat absorption through a…
Supplements
British Guidelines Identify Three Probiotic Strains That Relieve Constipation
The British Dietetic Association's new evidence review pinpoints specific probiotic strains alongside psyllium and magn…
Supplements
Salmonella Outbreak Linked to Moringa Leaf Powder Supplements Expands to 65 Cases
A multistate Salmonella outbreak connected to dietary supplements containing moringa leaf powder has grown to 65 confir…
Wellbeing
Leucovorin Shows Promise for Autism Linked to Brain Folate Transport Defects
Leucovorin supplementation demonstrates therapeutic potential for autism spectrum disorders when underlying cerebral fo…
Longevity
Thai Transgender Adults Excluded From National Healthy Aging Policies
Despite Thailand's international reputation for transgender acceptance and medical expertise, transgender adults face s…
Fitness
Core Weakness Model for Pain Treatment Lacks Scientific Support
Clinical practice commonly attributes musculoskeletal pain to specific muscle weaknesses—weak cores, quadriceps, or glu…
Studies
Rolling on
This appears to be an editorial or commentary piece from the British Journal of Sports Medicine that uses a bicycle rid…
Wellbeing
Soccer Heading Safety Protocols Urgently Needed for Youth Players
Deliberate ball heading in youth soccer creates measurable neurological stress that current protective guidelines fail…
Supplements
Live It Up Super Greens Supplement Powders Linked to Salmonella Outbreak
A Salmonella outbreak has sickened 45 people across 21 states, with cases linked to Live It Up Super Greens supplement…
Longevity
Intestinal Barrier Failure Drives Mortality Independent of Microbiota in Aging
Genetic manipulation in Drosophila reveals that intestinal barrier failure operates as an independent driver of mortali…
Studies
CXCL10 and IFN-γ Drive mRNA Vaccine Myocarditis Risk
Two inflammatory mediators—CXCL10 chemokine and interferon-gamma—emerge as key drivers of the rare myocarditis observed…
Wellbeing
Hormone Therapy Shows Neutral Effect on Dementia Risk Across Studies
Meta-analysis of existing studies found menopausal hormone therapy (MHT) neither increases nor decreases dementia risk…
Nutrition
Omega-6 Fatty Acids Show Direct Inflammatory Pathway in Colorectal Tumors
University of South Florida researchers identified elevated omega-6 fatty acid concentrations within colorectal tumor t…
Nutrition
Metformin's Diabetes Benefits Depend on Specific Gut Bacteria Interactions
Escalating doses of metformin in diabetic mice revealed that the drug's glucose-lowering effects correlate directly wit…
Studies
Prime Editing Corrects p47phox Gene Defects in CGD Patients
Prime editing successfully corrected p47phox gene mutations in patient cells from chronic granulomatous disease (CGD),…
Studies
Medicare Analysis Uncovers 5.3 Million Cases of Undetected Dementia
Analysis of Medicare claims data identified approximately 5.3 million beneficiaries with probable Alzheimer's disease o…
Wellbeing
Gut Microbiome Dysbiosis Accelerates Neurodegeneration Through Inflammatory Pathways
Microbial imbalances in the intestinal tract appear to trigger cascading inflammatory responses that contribute to the…
Longevity
Skin Analysis Could Predict Biological Age Through Digital Photography
The Furman laboratory at Buck Institute has developed methods to assess biological aging through skin analysis captured…
Longevity
Taurine Supplementation Shows Cross-Species Longevity Benefits in Major Study
Cross-species research demonstrates that taurine supplementation significantly extends both lifespan and healthspan acr…