Supplements
Dendrobium Compound Gigantol Shields Mouse Kidneys From Diet-Induced Damage via TFEB
In mice fed a high-fat, high-fructose diet, gigantol, a bibenzyl compound from Dendrobium orchids, restored kidney…
Supplements
Evidence reviews of supplements, vitamins, and nutraceutical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
Taurine Restrains NLRP3 Inflammasome and Boosts Healthspan in Aged Mice
Circulating taurine rises with age in humans and mice, contradicting the popular idea that falling taurine drives…
PREPRINTStudies
Beta-Carotene Heart Benefit Vanishes After Bias Adjustment Across RCTs, MR, Observational Data
Pooling five randomized trials, one Mendelian randomization study and thirteen conventional multivariable regression…
PREPRINTNutrition
Refined Inulin Raised Mouse Colon Tumor Incidence to ~70% Versus 10-20%
In mice given eight azoxymethane injections over 28 weeks, a 7.5% refined inulin diet produced colon tumors in roughly…
Nutrition
248 Studies Back Protein, Vitamin D and Mediterranean Diets Against Muscle Loss
A pre-registered PRISMA/SWiM synthesis of 248 studies (100 RCTs, 62 cohorts) in adults 60 and older found the most…
Nutrition
Pro-Inflammatory Diets Linked to 23% Higher Death Risk in Kidney Disease
Among 7,113 US adults with chronic kidney disease in NHANES (2005-2018), those in the highest quartile of the dietary…
Studies
Two Probiotic Strains Protect Rat Livers Through Complementary Cholesterol and Antioxidant Routes
In rats fed a high-fat, high-cholesterol diet, two Lactiplantibacillus plantarum strains, LP5 and BX62, given alone or…
Supplements
Heat-Killed L. plantarum MYO Lifts Grip and Leg Strength in 12 Weeks
In a placebo-controlled trial of older adults with reduced muscle strength, 12 weeks of heat-treated…
Wellbeing
Alcohol's 1-in-100 Death Risk Starts at 3 to 9 Weekly Drinks
A multi-state life-table model of a cohort followed from age 12, parameterized with New Zealand data and using WHO and…
Supplements
Angelica keiskei Chalcone Clears Fatty Liver in Mice via TFEB
In male C57BL/6N mice fed a fast-food diet for 15 weeks, then dosed daily for 9 more weeks with an Angelica keiskei…
PREPRINTFitness
Knee Osteoarthritis Muscle Holds 45% More Collagen and Blunts MMP2/9 Response to Lifting
Adults with moderate-to-severe knee osteoarthritis had weaker knee extensors, poorer muscle quality, and more…
Supplements
2 g/Day Plant Sterols Fail to Lower LDL in Obesity Trial
In a double-blind crossover trial of 23 adults with overweight or obesity (mean BMI 36.4) and mild…
Supplements
Curcumin Cuts Liver Fat in Rats by Suppressing a Gut Microbe
A meta-analysis of seven clinical studies found curcumin supplementation lowered serum aminotransferases in people…
Nutrition
Extra Leucine or Protein Added No Benefit to 28-Day Fasting Diet
Sixty-one older men (BMI ≥ 23) completed 28 days of alternate-day fasting, randomized to calorie-matched supplements…
Nutrition
Folate plus B12 and omega-3 lead 12-study scoping review on cognition
A scoping review screened 803 records and kept 12 studies (8 randomised trials, 3 cohorts, 1 open-label trial) testing…
Fitness
Tai Chi and Qigong Nudge Bone Density Up in Women, Modestly
Pooling 20 randomized trials, traditional Chinese mind-body training (tai chi, qigong and related practices) raised…
Supplements
Calcium Supplements Modestly Cut Fractures Across 286,584 Adults, But Not Hip Breaks
An umbrella review of 22 meta-analyses, covering 69 unique primary studies and 286,584 adults, found that calcium…
PREPRINTNutrition
Diverse Diets Linked to Lower Blood Pressure, Stronger Grip in Ghanaian Elders
Among 200 Ghanaians aged 60 and over (mean 69.8 years), dietary inadequacy was widespread: more than half fell short…
PREPRINTStudies
Statin Intolerance Affects 3.5% of Primary Care Users; Comorbidities Raise Odds 6-Fold
Among 4,016 Australian primary care patients starting statins for primary prevention, 3.5% met an electronic-record…
Studies
Vitamin D Tracks With Faster Walking in Taiwanese Men, Not Women
Among 396 community-dwelling Taiwanese adults (mean age 65, mean serum 25(OH)D 28.3 ng/mL, mean gait speed 0.91 m/s)…
Longevity
Chronic Stress Shortens Mouse Lifespan; NMN and Bazi Bushen Herbal Formula Reverse It
In a 12-month unpredictable chronic mild stress model in mice, chronic stress amplified systemic inflammation, damaged…
Studies
Severe Obesity Doesn't Block Diabetes Remission After Bariatric Surgery: Duration Matters More
In an Australian tertiary-hospital cohort of adults with obesity and type 2 diabetes who underwent metabolic bariatric…
PREPRINTStudies
Selenium restores fat-tissue insulin receptors via GPX3 in obese mice
In diet-induced obese mice, prolonged therapeutic selenium supplementation lowered oxidative damage in epididymal fat…
PREPRINTSupplements
10 µM Zinc Supplementation Extends Healthspan and Fights Protein Aggregation in Worms
In aging C. elegans, whole-body zinc levels fall by roughly 90% between day 1 and day 13 of adulthood. Supplementing…
PREPRINTSupplements
Vitamin D below 10 ng/mL doubles 10-year mortality risk in 412,000 adults
In a UK Biobank analysis of 412,020 adults with 31,197 deaths, seasonally normalized 25-hydroxyvitamin D [25(OH)D]…
Nutrition
Higher Plasma Omega-3 Linked to 20% Lower Mortality in 144,900 Adults
In the Mexico City Prospective Study — 144,900 adults followed for up to 24 years — higher circulating omega-3 fatty…
Fitness
Higher Pre-Diagnosis VO2max Cuts Post-Cancer Mortality Risk by 29–59%
Among 10,462 UK Biobank participants who later developed cancer, higher cardiorespiratory fitness (CRF) at baseline…
PREPRINTLongevity
Bone hormone osteocalcin reverses age-related locomotor decline via motoneuron mitophagy
The bone-derived hormone osteocalcin (OCN) acts on spinal motoneurons via the receptor GPR158 to regulate autophagy…
PREPRINTLongevity
Higher Ambient UV Linked to 36,000 Fewer CV Deaths and 50,000 Fewer Cancer Deaths Annually in US
Across 704,808 annual cardiovascular deaths and 565,287 annual cancer deaths in US Health Service Areas, higher…
PREPRINTLongevity
Restoring noradrenaline-like signalling in fly neurons extends lifespan and reverses motor decline
In aging Drosophila brains, octopamine (the invertebrate equivalent of noradrenaline) normally drives glucose uptake…
PREPRINTFitness
Voluntary Running Cuts Glucose Intolerance 35% in Obese Mice — Gut Microbiome Mediates Effect
In three genetically distinct BXD mouse strains fed a 60% fat diet for 32 weeks, voluntary wheel running (~5 km/day…
PREPRINTSupplements
Boosting Glycolysis in Osteoblasts Reverses Age-Related Bone Loss in Mice
In aged mice, bone formation declines in tandem with a measurable impairment of glycolysis within bone tissue itself…
PREPRINTSupplements
Rapamycin, Canagliflozin & Caloric Restriction Alter Canine Immune Markers at 90 Days
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
PREPRINTSupplements
Dual SGLT1/2 Inhibitor Sotagliflozin Cuts Atherosclerosis Via Hepatic Fat Reprogramming
In a mouse model of cardiovascular-kidney-metabolic (CKM) syndrome, sotagliflozin — the only SGLT inhibitor shown to…
PREPRINTSupplements
Only 30–36% Stay on GLP-1 Drugs at 12 Months; Real-World Weight Loss Far Below Trials
Among 743,153 US adults with obesity (no diabetes) who started injectable semaglutide or tirzepatide in 2024, only…
Supplements
Two Fisetin Derivatives Outperform Parent Compound as Senolytics in Aging Mice
Two synthetic derivatives of the natural flavonoid fisetin — SR29384 and SR31133 — demonstrated superior senolytic…
Supplements
Rapamycin, Canagliflozin & Caloric Restriction Shift Immune Markers in Dogs
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
Nutrition
Omega-3 Depletion Predicts Plaque Rupture Risk Despite Low LDL in 263K Adults
A specific fatty acid phenotype defined by omega-3 depletion and elevated omega-6/omega-3 ratio predicted structurally…
Fitness
Bariatric surgery boosts VO2 max despite muscle loss in all groups
In a longitudinal cohort of 1,022 adults undergoing metabolic bariatric surgery (MBS), fat-free mass (FFM) loss varied…
PREPRINTSupplements
Apigenin Extends Worm Lifespan and Shields Against Alzheimer's Proteins via Redox Signalling
Chronic apigenin exposure extended median lifespan in wild-type C. elegans and improved multiple healthspan markers…
PREPRINTSupplements
Multi-ingredient NAD+ supplement raises blood NAD+ by 74% in 28 days
A 28-day double-blind, placebo-controlled pilot trial found that Qualia NAD+, a multi-ingredient nutraceutical…
PREPRINTSupplements
NAD+ Supplement Raises Blood Levels 67% in 28-Day Placebo-Controlled Trial
A 28-day double-blind, placebo-controlled trial of Qualia NAD+, a multi-ingredient supplement combining nicotinamide…
Supplements
Dasatinib + Quercetin Clears Senescent Cells, Reverses Liver Fibrosis in 47% of Patients
A phase-2 double-blind RCT of 31 participants with fibrotic metabolic dysfunction-associated steatohepatitis (MASH)…
Nutrition
Pasture-Raised Red Meat Maintains Omega-3 DPA vs. Plant-Based Alternatives in 10-Week RCT
A 10-week randomized intervention in 78 healthy adults compared a flexitarian diet including moderate pasture-raised…
Nutrition
High Omega-3 Levels Neutralize H-FABP's 2× Heart Attack Risk
In 42,392 UK Biobank participants free of coronary heart disease and heart failure at baseline, elevated plasma…
Supplements
Crocin (saffron pigment) reverses fatty liver markers in rats on high-fat diet
In 42 male Wistar rats fed a high-fat diet for eight weeks to induce NAFLD, intraperitoneal crocin administered over…
PREPRINTNutrition
Diet-as-Medicine App Cuts Blood Pressure 5.5 mmHg After Correcting Statistical Bias
A retrospective cohort study of 329 US adults with obesity enrolled in a commercial digital food-as-medicine program…
PREPRINTSupplements
Lab4 Probiotic Cuts GP Visits by 52% in Healthcare Workers—But Trial Too Small
In a 16-week double-blind RCT of 104 healthcare workers, daily Lab4 probiotic supplementation produced consistently…
Supplements
Oral Semaglutide Cuts Body Weight 10.5% in 28 Weeks, Shrinks Liver Fat
In a 28-week randomized controlled trial of 116 non-diabetic adults with obesity or overweight plus comorbidities…
Supplements
Vitamin D Supplements Show Little Bone Benefit in Non-White Adults Across 8,000-Person Review
A systematic review and meta-analysis of 12 randomised controlled trials encompassing 8,023 adults from Black African…
Studies
Bariatric Surgery Neurological Risk: 1.4–16% Incidence, Thiamine Deficiency Dominates
Across 12 studies encompassing more than 5,000 bariatric surgery patients, neurological complication rates ranged from…
Supplements
Higher Omega-3 Blood Levels Linked to Less Amyloid in APOE4 Carriers
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
Wellbeing
Healthy Sleep Cuts Stroke Risk 14% Via Lipid and Inflammation Pathways
In 200,729 UK Biobank participants followed for a median 12.6 years, each one-point improvement on a six-component…
Fitness
12-Week RT+HIIT Shows Minimal Transcriptomic Gains; Polyphenols Add Nothing
A 12-week supervised concurrent resistance training plus HIIT programme in 38 adults aged 55–70 years produced…
Nutrition
Ultra-Processed Foods Raise Stroke Death Risk 21% Per 10-Point Increase in MI Survivors
In 4,365 post-myocardial infarction patients followed for a median 14 years in the Dutch Alpha Omega Cohort, each…
PREPRINTWellbeing
Six Lifestyle Clusters Predict Dementia Risk: Worst Combo Raises Hazard 2.4×
Among 151,832 UK Biobank participants aged 60–69, six distinct clusters of co-occurring modifiable risk factors were…
Studies
OAGB Cuts Long-Term Weight Regain Risk 66% vs Sleeve Gastrectomy
Across 1,498 adults followed for a median of 53–66 months after bariatric surgery, all three procedures achieved…
Nutrition
High Fat and SFA Intake Linked to 8× Mortality Risk in Cirrhosis
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
Nutrition
KCl Tablets Cut Systolic BP ~8 mmHg by Flushing Hidden Tissue Sodium
In a 40-participant prospective study of adults with essential hypertension or hyperaldosteronism, personalised oral…
PREPRINTSupplements
Phosphatidylserine 300mg/day Misses Primary Memory Target but Hints at Working Memory Gains
A 12-week randomized, double-blind, placebo-controlled trial in 70 adults aged 35–65 with subjective memory complaints…
PREPRINTNutrition
High Omega-3 Index Linked to 4.7-Year Younger Biological Age in 4,863 Adults
In 4,863 U.S. adults aged 20–79 from NHANES 2021–2023, erythrocyte EPA and DHA concentrations rose with age while n-6…
PREPRINTSupplements
Tirzepatide Cuts New Heart Failure Risk 10%, Mortality 20% vs Semaglutide in Obesity
In a propensity-score-matched retrospective cohort of 848,538 adults with obesity drawn from the TriNetX platform…
Nutrition
Low Fish, Legumes, and Fruit Intake Linked to 4-6x Higher MASLD Odds
In a case-control study of 111 adults attending a diet clinic in Turkey, consuming less than one fish serving per week…
Studies
Fracture-Prevention Drugs in Men: Cochrane Review Finds Thin Evidence
A Cochrane systematic review pooled 17 randomised controlled trials enrolling 4,132 men aged 50–73 to evaluate…
Longevity
High Uric Acid Triples Mortality Risk in Older Women: Cohort Data
In a retrospective cohort of 910 adults aged 60 and older (mean age 71; 67% female) followed from 2020 to 2024, both…
Supplements
Probiotic Converts Citrus Compound to Activate Longevity Gene, Reversing Age-Related Metabolic Decline
A specific probiotic strain, Bifidobacterium pseudocatenulatum CL256B, converts the poorly absorbed citrus flavanone…
Fitness
Telerehabilitation Boosts VO₂ Peak by 2.58 mL/kg/min in Heart Disease Patients
Across 13 randomized controlled trials enrolling 958 adults with cardiovascular disease, exercise-focused…
Nutrition
Glycine and LDL Cholesterol Fraction Causally Linked to Two Lacunar Stroke Subtypes
Among 2,408 participants — 1,456 MRI-confirmed lacunar stroke cases and 952 hospital controls — Mendelian…
Supplements
Vitamin D3 and Omega-3 Fail to Reduce Dementia Biomarkers Over 4 Years
Four years of daily supplementation with vitamin D3 (2000 IU) and marine omega-3 fatty acids (1 g) produced no…
Supplements
3g Daily Fish Oil Cuts Ceramide-Based Heart Risk Score by 2.4 Points
In the 20-week MoKaRi randomized trial, adults with elevated LDL-C (≥3.0 mmol/L) not on lipid-lowering therapy who…
PREPRINTNutrition
Feijoa Powder Cuts HbA1c by 0.5% in Prediabetic Adults Over 12 Weeks
A 12-week randomized controlled trial in 39 overweight adults with prediabetes (HbA1c 5.7–6.4%, BMI 25–29.9 kg/m²)…
Studies
Bundled Nutrition and Stimulation Interventions Show Mixed Results for At-Risk Infants
For the roughly 250 million children in low- and middle-income countries who fail to reach key developmental…
Studies
Methodological Flaw Shadows Thrombectomy-Alteplase Trial's Recovery Claims
When a stroke trial changes its primary outcome midway through enrollment, the integrity of its central conclusion…
Studies
2025 Blood Pressure Guidelines Leave Millions Undertreated Despite Expanded Criteria
Hypertension remains one of the most modifiable risk factors for cardiovascular disease and stroke, yet a troubling…
Studies
Catestatin Peptide Cuts Tau Pathology via Adrenergic Stress Suppression in Mice
A hormonal peptide already present in the human body may hold an overlooked key to slowing the molecular cascade…
Supplements
Resveratrol Blocks Coal Dust Nanoparticle Fibrosis via Alveolar Cell Protection
Coal dust nanoparticles (CD-NPs) — the primary driver of pneumoconiosis — significantly reduced type II alveolar cell…
Studies
Engineered Probiotic Targets Colorectal Tumors by Blocking Wnt Signaling Pathway
Colorectal cancer kills roughly 900,000 people annually, and its treatment landscape has changed little in over a…
Wellbeing
Macromastia Linked to Higher Rates of Chronic Migraine and Sleep Apnea in Women
For women with breast hypertrophy, the burden of neurological symptoms may extend far beyond musculoskeletal…
Studies
Insulin Resistance Linked to Harder-to-Treat Depression in 30,000-Person Study
The metabolic-psychiatric interface is becoming one of the most clinically consequential frontiers in medicine, and…
Wellbeing
Severe Sleep Apnea Disrupts Brain's Nightly Restoration Mechanism, Study Finds
The brain's ability to reset itself overnight may be quietly eroding in millions of people with untreated sleep apnea…