https://healthtolongevity.com Daily synthesized updates on health, longevity, nutrition, diet studies, and lifestyle research. https://healthtolongevity.com/article/30251/tai-chi-and-qigong-nudge-bone-density-up-in-women-modestly https://healthtolongevity.com/article/30251/tai-chi-and-qigong-nudge-bone-density-up-in-women-modestly Thu, 15 Oct 2026 15:00:04 +0000 Pooling 20 randomized trials, traditional Chinese mind-body training (tai chi, qigong and related practices) raised bone mineral density in middle-aged and older women, with a standardized mean difference of 0.55 (95% CI 0.24-0.87) and very high heterogeneity (I2 = 84.7%)… https://healthtolongevity.com/article/30250/calcium-supplements-modestly-cut-fractures-across-286584-adults-but-not-hip-brea https://healthtolongevity.com/article/30250/calcium-supplements-modestly-cut-fractures-across-286584-adults-but-not-hip-brea Thu, 15 Oct 2026 15:00:04 +0000 An umbrella review of 22 meta-analyses, covering 69 unique primary studies and 286,584 adults, found that calcium supplementation, with or without vitamin D, produced small but statistically significant gains in bone mineral density at the total body, hip, lumbar spine and… https://healthtolongevity.com/article/30248/sleeping-4-hours-or-less-raises-masld-odds-44-in-koreans https://healthtolongevity.com/article/30248/sleeping-4-hours-or-less-raises-masld-odds-44-in-koreans Thu, 15 Oct 2026 15:00:04 +0000 Across 26,909 Korean adults in the 2014-2021 national nutrition survey, 23.2% had metabolic dysfunction-associated steatotic liver disease (MASLD). Sleeping four hours or less was tied to 44% higher odds (OR 1.44, 95% CI 1.17-1.78), and sitting eight or more hours daily to 17%… https://healthtolongevity.com/article/30246/62-million-koreans-tracked-alcohol-raises-risk-across-dozens-of-diseases https://healthtolongevity.com/article/30246/62-million-koreans-tracked-alcohol-raises-risk-across-dozens-of-diseases Thu, 15 Oct 2026 15:00:04 +0000 Across 6,214,569 disease-free Korean adults followed from 2006-2009 through 2022, alcohol intake rose with risk for seven cancers in men and four in women, versus lifelong-abstainer-at-baseline reference groups. Men who drank faced a 9.96% lifetime incidence of alcohol-related… https://healthtolongevity.com/article/30226/beetroot-juice-nitrate-fails-to-speed-muscle-force-development-in-young-adults https://healthtolongevity.com/article/30226/beetroot-juice-nitrate-fails-to-speed-muscle-force-development-in-young-adults Thu, 15 Oct 2026 05:00:03 +0000 A single 200 μmol/kg nitrate dose from beetroot juice left rate of torque development unchanged versus a nitrate-free placebo in 14 men and 12 women. Voluntary rates (0–30, 0–50, 0–200 ms, maximal) and electrically evoked 100 Hz tetanic rates showed no effect across the triceps… https://healthtolongevity.com/article/30221/muscle-androgen-receptor-expression-falls-44-per-decade-across-364-men https://healthtolongevity.com/article/30221/muscle-androgen-receptor-expression-falls-44-per-decade-across-364-men Thu, 15 Oct 2026 05:00:03 +0000 Pooling 16 public RNA-seq datasets (364 healthy men aged 18-92), a new R pipeline called MetAR found androgen receptor (AR) expression in skeletal muscle declining by 0.006 log2 CPM per year, roughly 4.4% per decade (p < 0.001). Genes governing AR stability, transcriptional… https://healthtolongevity.com/article/30188/not-all-arb-blood-pressure-drugs-equal-dementia-hazard-varies-066093-versus-lisi https://healthtolongevity.com/article/30188/not-all-arb-blood-pressure-drugs-equal-dementia-hazard-varies-066093-versus-lisi Thu, 15 Oct 2026 05:00:03 +0000 Across 2,051,275 eligible adults aged 55–80 in the TriNetX network, starting an angiotensin receptor blocker (ARB) rather than lisinopril was linked to 14% lower incident dementia (HR 0.86, 95% CI 0.85–0.87) over a median 4.7–7.2 years. Individual agents diverged sharply, with… https://healthtolongevity.com/article/30185/diverse-diets-linked-to-lower-blood-pressure-stronger-grip-in-ghanaian-elders https://healthtolongevity.com/article/30185/diverse-diets-linked-to-lower-blood-pressure-stronger-grip-in-ghanaian-elders Thu, 15 Oct 2026 05:00:03 +0000 Among 200 Ghanaians aged 60 and over (mean 69.8 years), dietary inadequacy was widespread: more than half fell short on protein, fat, fiber, magnesium, potassium and vitamin E, and no one met the calcium reference intake. Each one-unit rise in minimum dietary diversity (MDD)… https://healthtolongevity.com/article/30183/57-of-asymptomatic-broward-adults-had-abnormal-heart-ct-scans https://healthtolongevity.com/article/30183/57-of-asymptomatic-broward-adults-had-abnormal-heart-ct-scans Thu, 15 Oct 2026 05:00:03 +0000 Among 7,135 insured, symptom-free Florida adults aged 45 to 70 with at least one cardiovascular risk factor, coronary CT angiography and calcium scoring flagged 56.8% as abnormal or very abnormal; 11.4% fell into the highest-risk category. Abnormal findings climbed from 39.3%… https://healthtolongevity.com/article/30176/cannabigerol-boosts-muscle-power-87-beyond-exercise-alone-in-mice https://healthtolongevity.com/article/30176/cannabigerol-boosts-muscle-power-87-beyond-exercise-alone-in-mice Thu, 15 Oct 2026 03:00:04 +0000 In mice given dexamethasone (20 mg/kg for 12 days) to induce muscle wasting, a 4-week ladder-climbing resistance program restored muscle morphology and fatigue resistance. Cannabigerol (CBG, 10 mg/kg i.p. on training days) did something different: it raised power output by… https://healthtolongevity.com/article/30158/healthy-adult-lifestyle-blunts-early-life-risks-for-heart-disease-and-diabetes https://healthtolongevity.com/article/30158/healthy-adult-lifestyle-blunts-early-life-risks-for-heart-disease-and-diabetes Wed, 14 Oct 2026 15:00:03 +0000 Among 174,718 UK Biobank adults followed a median 14.6 years, those with high early-life risk (low birth weight, maternal smoking around birth, no breastfeeding; score ≥2) and an unhealthy adult lifestyle score (0-49, built from Life's Essential 8 behaviors) fared worst. Their… https://healthtolongevity.com/article/30157/mediterranean-diet-alone-fails-to-reliably-cut-weight-after-menopause https://healthtolongevity.com/article/30157/mediterranean-diet-alone-fails-to-reliably-cut-weight-after-menopause Wed, 14 Oct 2026 15:00:03 +0000 A systematic review of PubMed, Embase, and Cochrane records through January 2026 found only three eligible studies (two randomized trials, one observational; 282 women in total) testing Mediterranean diet adherence against body weight in postmenopausal women. Results were… https://healthtolongevity.com/article/30073/better-lifes-essential-8-scores-track-lower-brain-small-vessel-damage-across-eth https://healthtolongevity.com/article/30073/better-lifes-essential-8-scores-track-lower-brain-small-vessel-damage-across-eth Wed, 14 Oct 2026 05:00:03 +0000 In a cross-sectional analysis of 44,982 adults (with a 1,426-person matched MRI subsample), each standard-deviation increase in Life's Essential 8 (LE8) cardiovascular health score corresponded to lower white matter hyperintensity volume (−0.13 SD) and lower combined… https://healthtolongevity.com/article/30070/high-blood-pressure-variability-plus-diabetes-raises-mortality-risk-28-fold-in-5 https://healthtolongevity.com/article/30070/high-blood-pressure-variability-plus-diabetes-raises-mortality-risk-28-fold-in-5 Wed, 14 Oct 2026 05:00:03 +0000 Among 57,611 UK Biobank participants followed a median 5.1 years, people with type 2 diabetes and high systolic blood pressure variability faced a 2.80-fold higher risk of all-cause mortality (95% CI 2.12-3.69) than those with normal glucose and low variability. Dementia risk… https://healthtolongevity.com/article/30069/low-carb-coaching-plus-tirzepatide-197-weight-loss-vs-156-in-4269-adults https://healthtolongevity.com/article/30069/low-carb-coaching-plus-tirzepatide-197-weight-loss-vs-156-in-4269-adults Wed, 14 Oct 2026 05:00:03 +0000 In a retrospective cohort of 4,269 adults in a telemedicine obesity program, those receiving individualized carbohydrate-reduced nutritional therapy alongside incretin-based medications lost more weight at 12 months than those on medication with coaching alone. Among… https://healthtolongevity.com/article/30061/statin-intolerance-affects-35-of-primary-care-users-comorbidities-raise-odds-6-f https://healthtolongevity.com/article/30061/statin-intolerance-affects-35-of-primary-care-users-comorbidities-raise-odds-6-f Wed, 14 Oct 2026 05:00:03 +0000 Among 4,016 Australian primary care patients starting statins for primary prevention, 3.5% met an electronic-record definition of intolerance (muscle symptoms plus creatine kinase testing) within two years. Female or other-gender patients had 1.5-fold higher adjusted odds (95%… https://healthtolongevity.com/article/30058/patients-with-type-2-diabetes-rank-a1c-and-heart-protection-above-weight-loss https://healthtolongevity.com/article/30058/patients-with-type-2-diabetes-rank-a1c-and-heart-protection-above-weight-loss Wed, 14 Oct 2026 03:00:04 +0000 Across 34 studies and 15,656 adults with type 2 diabetes, patients consistently ranked glycaemic efficacy, cardiovascular risk reduction and simple administration as their top priorities when weighing GLP-1 receptor agonists, SGLT-2 inhibitors, tirzepatide and finerenone. Oral… https://healthtolongevity.com/article/30053/exercise-plus-mental-social-activity-adds-7-years-free-of-cognitive-impairment https://healthtolongevity.com/article/30053/exercise-plus-mental-social-activity-adds-7-years-free-of-cognitive-impairment Wed, 14 Oct 2026 03:00:04 +0000 Across four harmonized aging cohorts spanning Asia, North America and Europe, adults at age 50 who did both structured exercise and cognitively or socially engaging activities could expect 24.7 years free of cognitive impairment, versus 17.5 years for those doing neither… https://healthtolongevity.com/article/30009/over-half-of-young-adults-with-primary-aldosteronism-miss-the-arr-20-cutoff https://healthtolongevity.com/article/30009/over-half-of-young-adults-with-primary-aldosteronism-miss-the-arr-20-cutoff Tue, 13 Oct 2026 15:00:04 +0000 Among 3,966 patients with confirmed primary aldosteronism (PA) in a 14,750-patient hypertensive cohort, the share testing below the conventional aldosterone-to-renin ratio (ARR) cutoff of 20 fell steadily with age: 57.5% under age 35, 50.6% at 35-44, 35.4% at 45-54, and 33.2%… https://healthtolongevity.com/article/30007/sglt2-inhibitors-cut-heart-failure-hospitalization-29-and-kidney-events-31-in-di https://healthtolongevity.com/article/30007/sglt2-inhibitors-cut-heart-failure-hospitalization-29-and-kidney-events-31-in-di Tue, 13 Oct 2026 15:00:04 +0000 Pooling 14 placebo-controlled trials (76,969 adults with type 2 diabetes), SGLT2 inhibitors lowered the composite of first heart failure hospitalization or cardiovascular death by 23% (HR 0.77, 95% CI 0.73-0.81; I2 = 0%). Heart failure hospitalization fell 29%, composite kidney… https://healthtolongevity.com/article/30004/midlife-exercise-linked-to-20-fewer-memory-complaints-three-decades-later https://healthtolongevity.com/article/30004/midlife-exercise-linked-to-20-fewer-memory-complaints-three-decades-later Tue, 13 Oct 2026 15:00:04 +0000 Among 4,397 women in the NYU Women's Health Study (mean age 46 at baseline, 79 at follow-up), those in the top tertile of midlife physical activity had 20% lower odds of reporting two or more subjective cognitive complaints nearly 30 years later (OR 0.80; 95% CI 0.68-0.95). The… https://healthtolongevity.com/article/29922/handgrip-strength-adds-nothing-beyond-body-fat-scans-for-cardiometabolic-risk https://healthtolongevity.com/article/29922/handgrip-strength-adds-nothing-beyond-body-fat-scans-for-cardiometabolic-risk Tue, 13 Oct 2026 05:00:03 +0000 Among 1,124 U.S. adults aged 40-59 from NHANES (508 for development, 616 for temporal validation), adding DXA body fat percentage and visceral fat to age, sex, BMI and waist circumference raised the logistic-regression AUC by about 0.021 in both cohorts. Adding absolute… https://healthtolongevity.com/article/29913/vitamin-d-tracks-with-faster-walking-in-taiwanese-men-not-women https://healthtolongevity.com/article/29913/vitamin-d-tracks-with-faster-walking-in-taiwanese-men-not-women Tue, 13 Oct 2026 03:00:04 +0000 Among 396 community-dwelling Taiwanese adults (mean age 65, mean serum 25(OH)D 28.3 ng/mL, mean gait speed 0.91 m/s), higher vitamin D was associated with faster walking in men (p = 0.047) but not in women. Age and BMI predicted slower gait in both sexes, while hypertension and… https://healthtolongevity.com/article/29909/chronic-stress-shortens-mouse-lifespan-nmn-and-bazi-bushen-herbal-formula-revers https://healthtolongevity.com/article/29909/chronic-stress-shortens-mouse-lifespan-nmn-and-bazi-bushen-herbal-formula-revers Mon, 12 Oct 2026 15:00:03 +0000 In a 12-month unpredictable chronic mild stress model in mice, chronic stress amplified systemic inflammation, damaged multiple tissues and shortened lifespan. Single-cell RNA sequencing across organs showed a shared signature: fewer lymphocytes and expanded myeloid cells, with… https://healthtolongevity.com/article/29902/exercise-blunts-mortality-penalty-of-high-resting-heart-rate-in-kidney-disease https://healthtolongevity.com/article/29902/exercise-blunts-mortality-penalty-of-high-resting-heart-rate-in-kidney-disease Mon, 12 Oct 2026 15:00:03 +0000 Across three cohorts totaling 12,042 patients with chronic kidney disease, higher resting heart rate (RHR) predicted greater all-cause and cardiovascular mortality, while higher physical activity (PA) was consistently protective. Joint analyses showed the worst outcomes in… https://healthtolongevity.com/article/29899/56754-adults-in-a-digital-diabetes-program-show-durable-glycemic-gains-over-five https://healthtolongevity.com/article/29899/56754-adults-in-a-digital-diabetes-program-show-durable-glycemic-gains-over-five Mon, 12 Oct 2026 05:00:04 +0000 Across 56,754 adults with type 2 diabetes in Teladoc's remote monitoring program (2021-2025), estimated A1c from cellular glucose meters fell 0.06 percentage points per year, and the odds of reaching eA1c below 7% rose 8% annually, with predicted control climbing from 75.2% to… https://healthtolongevity.com/article/29889/obesity-beyond-25-years-raises-heart-strain-markers-by-age-62 https://healthtolongevity.com/article/29889/obesity-beyond-25-years-raises-heart-strain-markers-by-age-62 Mon, 12 Oct 2026 05:00:04 +0000 In 4,901 members of the 1958 British birth cohort, 26.3% experienced obesity at some point between ages 7 and 62. Ever being obese did not predict NT-proBNP, but men with obesity history had 11% higher cardiac troponin I (hs-cTnI). Duration mattered most: hs-cTnI rose steadily… https://healthtolongevity.com/article/29887/60-90-minutes-of-weekly-vigorous-exercise-linked-to-35-lower-hip-fracture-risk https://healthtolongevity.com/article/29887/60-90-minutes-of-weekly-vigorous-exercise-linked-to-35-lower-hip-fracture-risk Mon, 12 Oct 2026 05:00:04 +0000 Across 16 years of follow-up in 324,284 UK Biobank adults aged 40-65, 2,674 hip fractures occurred. Middle quintiles of leisure-time activity carried the lowest risk: roughly one hour daily cut hip fracture hazard by 22% in women (HR 0.78) and 26% in men (HR 0.74). Vigorous… https://healthtolongevity.com/article/29886/wildfire-smoke-carbon-tied-to-9-higher-dementia-risk-in-397m-seniors https://healthtolongevity.com/article/29886/wildfire-smoke-carbon-tied-to-9-higher-dementia-risk-in-397m-seniors Mon, 12 Oct 2026 05:00:04 +0000 Across 39.7 million Medicare beneficiaries followed from 2005 to 2019, long-term exposure to wildfire-smoke PM2.5 was associated with incident Alzheimer's disease (HR 1.015 per 1 µg/m³) and related dementias (HR 1.029). The smoke carbonaceous fraction, meaning elemental and… https://healthtolongevity.com/article/29883/84-of-patients-with-high-hospital-blood-pressure-remain-hypertensive-four-weeks- https://healthtolongevity.com/article/29883/84-of-patients-with-high-hospital-blood-pressure-remain-hypertensive-four-weeks- Mon, 12 Oct 2026 05:00:04 +0000 Among 50 adults hospitalized for non-cardiac conditions who had asymptomatic blood pressure readings of 140/90 mmHg or higher on at least two occasions 24 hours apart, 84% (95% CI 70.9–92.8) met criteria for hypertension on 24-hour ambulatory monitoring four weeks after… https://healthtolongevity.com/article/29878/sglt2-inhibitors-cut-kidney-progression-37-but-evidence-quality-is-weak https://healthtolongevity.com/article/29878/sglt2-inhibitors-cut-kidney-progression-37-but-evidence-quality-is-weak Sun, 11 Oct 2026 15:00:03 +0000 Across 12 systematic reviews, SGLT2 inhibitors lowered the composite of cardiovascular death or first heart-failure hospitalisation (HR 0.77), major adverse cardiovascular events (HR 0.91) and kidney disease progression (RR 0.63). Liver fat fell by 2.05 percentage points on… https://healthtolongevity.com/article/29872/rare-sugar-d-psicose-eases-fatty-liver-in-diabetic-mice https://healthtolongevity.com/article/29872/rare-sugar-d-psicose-eases-fatty-liver-in-diabetic-mice Sun, 11 Oct 2026 15:00:03 +0000 In mice made diabetic with a high-fat diet plus streptozotocin, low- and high-dose D-psicose (a rare sugar) improved serum lipids, lowered ALT and AST, reduced circulating inflammatory cytokines and cut hepatic fat deposition. Treated animals also showed better intestinal… https://healthtolongevity.com/article/29864/alcohol-use-disorder-raises-womens-dementia-risk-nearly-fourfold-tenfold-before- https://healthtolongevity.com/article/29864/alcohol-use-disorder-raises-womens-dementia-risk-nearly-fourfold-tenfold-before- Sun, 11 Oct 2026 15:00:03 +0000 In the Million Women Study, 20,070 women with hospital-recorded alcohol use disorder (AUD) were matched to 100,339 controls and followed for over 20 years. AUD carried a hazard ratio of 3.73 for all-cause dementia, highest for mixed (5.03), unspecified (4.29) and vascular… https://healthtolongevity.com/article/29861/severe-obesity-doesnt-block-diabetes-remission-after-bariatric-surgery-duration- https://healthtolongevity.com/article/29861/severe-obesity-doesnt-block-diabetes-remission-after-bariatric-surgery-duration- Sun, 11 Oct 2026 15:00:03 +0000 In an Australian tertiary-hospital cohort of adults with obesity and type 2 diabetes who underwent metabolic bariatric surgery between 2018 and 2024, complete remission (HbA1c <6.0% at 12 months) occurred in 66.7% of those with baseline BMI ≥50 kg/m² versus 37.8% of those below… https://healthtolongevity.com/article/29724/fat-tissue-scarring-barely-tracks-with-fatty-liver-after-bariatric-surgery https://healthtolongevity.com/article/29724/fat-tissue-scarring-barely-tracks-with-fatty-liver-after-bariatric-surgery Sun, 11 Oct 2026 05:00:03 +0000 In patients with severe obesity undergoing two-stage bariatric surgery, picrosirius-red-measured pericellular fibrosis in abdominal fat showed no baseline association with MASLD features, steatohepatitis or liver fibrosis, and changes in liver histology were unrelated to… https://healthtolongevity.com/article/29722/selenium-restores-fat-tissue-insulin-receptors-via-gpx3-in-obese-mice https://healthtolongevity.com/article/29722/selenium-restores-fat-tissue-insulin-receptors-via-gpx3-in-obese-mice Sun, 11 Oct 2026 05:00:03 +0000 In diet-induced obese mice, prolonged therapeutic selenium supplementation lowered oxidative damage in epididymal fat, restored suppressed levels of the secreted selenoprotein GPX3 and the insulin receptor (InsR), boosted insulin-stimulated AKT phosphorylation, and improved… https://healthtolongevity.com/article/29709/genetics-show-higher-bmi-raises-hba1c-026-sd-in-african-adults https://healthtolongevity.com/article/29709/genetics-show-higher-bmi-raises-hba1c-026-sd-in-african-adults Sun, 11 Oct 2026 05:00:03 +0000 Mendelian randomization using 363 BMI-associated variants with consistent effects across ancestries indicates that higher body mass index causally raises blood sugar markers in both African and European adults. In UK Biobank, each 1 SD increase in BMI raised HbA1c by 0.26 SD in… https://healthtolongevity.com/article/29705/intensive-nak-feedback-program-cuts-salt-intake-by-053-gday-in-japanese-communit https://healthtolongevity.com/article/29705/intensive-nak-feedback-program-cuts-salt-intake-by-053-gday-in-japanese-communit Sat, 10 Oct 2026 15:00:03 +0000 A post hoc regional analysis of Japan's Population-based Sodium/Potassium Improvement Program compared two Hokkaido municipalities over one year: 218 participants receiving standard support versus 213 receiving intensive support — including on-site urinary sodium-to-potassium… https://healthtolongevity.com/article/29703/mediterranean-lifestyle-cuts-mortality-3046-across-all-income-groups https://healthtolongevity.com/article/29703/mediterranean-lifestyle-cuts-mortality-3046-across-all-income-groups Sat, 10 Oct 2026 15:00:03 +0000 In the prospective Lifelines cohort tracking 105,812 Dutch adults over a median 13.25 years, adherence to the MEDLIFE index — a 23-item composite scoring Mediterranean diet quality, physical activity, rest, and social habits — showed a clear dose-response relationship with… https://healthtolongevity.com/article/29702/10-m-zinc-supplementation-extends-healthspan-and-fights-protein-aggregation-in-w https://healthtolongevity.com/article/29702/10-m-zinc-supplementation-extends-healthspan-and-fights-protein-aggregation-in-w Sat, 10 Oct 2026 05:00:03 +0000 In aging C. elegans, whole-body zinc levels fall by roughly 90% between day 1 and day 13 of adulthood. Supplementing old animals with a low dose of zinc chloride (10 µM) restored zinc levels and improved healthspan, thermotolerance, and oxidative stress resistance — while… https://healthtolongevity.com/article/29644/cbt-for-insomnia-improves-subjective-cognition-but-not-brain-activity-over-1-yea https://healthtolongevity.com/article/29644/cbt-for-insomnia-improves-subjective-cognition-but-not-brain-activity-over-1-yea Sat, 10 Oct 2026 05:00:03 +0000 In a randomized controlled trial of 56 adults with insomnia disorder and 20 good sleepers, CBT for insomnia (CBTi) significantly improved self-reported cognitive functioning and sleep quality at both three months and one-year follow-up — but produced no measurable changes in… https://healthtolongevity.com/article/29641/early-post-bariatric-weight-loss-predicts-2-year-but-not-long-term-outcomes https://healthtolongevity.com/article/29641/early-post-bariatric-weight-loss-predicts-2-year-but-not-long-term-outcomes Sat, 10 Oct 2026 05:00:03 +0000 Among 216 adults undergoing sleeve gastrectomy or Roux-en-Y gastric bypass, percentage total weight loss (%TWL) at 3 months strongly predicted %TWL at 1 year (incremental R² = 38.23%) and modestly at 2 years (R² = 11.75%), but lost predictive value beyond that (R² = 2.25%, p =… https://healthtolongevity.com/article/29639/part-time-work-into-your-70s-cuts-dementia-risk-by-38 https://healthtolongevity.com/article/29639/part-time-work-into-your-70s-cuts-dementia-risk-by-38 Sat, 10 Oct 2026 05:00:03 +0000 Among 13,879 U.S. Health and Retirement Study participants, those who maintained sustained part-time employment between ages 51 and 75 had 38% lower odds of dementia after age 76 (OR: 0.62, 95% CI: 0.48–0.80) compared with people who retired from full-time work in their… https://healthtolongevity.com/article/29637/vitamin-d-below-10-ngml-doubles-10-year-mortality-risk-in-412000-adults https://healthtolongevity.com/article/29637/vitamin-d-below-10-ngml-doubles-10-year-mortality-risk-in-412000-adults Sat, 10 Oct 2026 05:00:03 +0000 In a UK Biobank analysis of 412,020 adults with 31,197 deaths, seasonally normalized 25-hydroxyvitamin D [25(OH)D] levels below 5 ng/mL were associated with a mortality hazard ratio of 2.03 (95% CI 1.90–2.18) versus levels ≥20 ng/mL. Even moderate deficiency (5–10 ng/mL)… https://healthtolongevity.com/article/29619/ketogenic-diet-and-aerobic-exercise-top-rankings-for-pcos-cardiometabolic-risk https://healthtolongevity.com/article/29619/ketogenic-diet-and-aerobic-exercise-top-rankings-for-pcos-cardiometabolic-risk Sat, 10 Oct 2026 03:00:04 +0000 A Bayesian network meta-analysis of 43 randomized controlled trials (2,433 participants) systematically compared lifestyle interventions for cardiometabolic health in women with polycystic ovary syndrome across 16 outcomes spanning body composition, glucose regulation, lipids… https://healthtolongevity.com/article/29612/16-week-vegan-diet-cuts-liver-fat-33-restores-beta-cell-function-in-t2d https://healthtolongevity.com/article/29612/16-week-vegan-diet-cuts-liver-fat-33-restores-beta-cell-function-in-t2d Fri, 09 Oct 2026 15:00:03 +0000 A 16-week ad libitum low-fat vegan dietary intervention in 25 adults with type 2 diabetes produced striking metabolic improvements across multiple organ systems. Body weight fell by 6.0 kg (6.6%), driven predominantly by fat loss (-4.2 kg), with visceral fat volume dropping 290… https://healthtolongevity.com/article/29610/higher-pre-diagnosis-vo2max-cuts-post-cancer-mortality-risk-by-2959 https://healthtolongevity.com/article/29610/higher-pre-diagnosis-vo2max-cuts-post-cancer-mortality-risk-by-2959 Fri, 09 Oct 2026 15:00:03 +0000 Among 10,462 UK Biobank participants who later developed cancer, higher cardiorespiratory fitness (CRF) at baseline was associated with dramatically lower all-cause mortality after diagnosis. Relative to a median VO2max of 27.9 ml·kg⁻¹·min⁻¹, those at 12.5 ml·kg⁻¹·min⁻¹ faced… https://healthtolongevity.com/article/29608/higher-plasma-omega-3-linked-to-20-lower-mortality-in-144900-adults https://healthtolongevity.com/article/29608/higher-plasma-omega-3-linked-to-20-lower-mortality-in-144900-adults Fri, 09 Oct 2026 15:00:03 +0000 In the Mexico City Prospective Study — 144,900 adults followed for up to 24 years — higher circulating omega-3 fatty acids were consistently linked to lower all-cause mortality. Per interquintile range, hazard ratios were 0.94 for DHA, 0.83 for non-DHA omega-3, and 0.88 for… https://healthtolongevity.com/article/29602/bone-hormone-osteocalcin-reverses-age-related-locomotor-decline-via-motoneuron-m https://healthtolongevity.com/article/29602/bone-hormone-osteocalcin-reverses-age-related-locomotor-decline-via-motoneuron-m Fri, 09 Oct 2026 05:00:04 +0000 The bone-derived hormone osteocalcin (OCN) acts on spinal motoneurons via the receptor GPR158 to regulate autophagy, mitophagy, and mitochondrial activity. Mice lacking GPR158 globally or specifically in spinal motoneurons, or lacking OCN itself, show impaired locomotion and… https://healthtolongevity.com/article/29561/year-long-brain-implant-study-maps-how-seasons-and-weather-reshape-sleep https://healthtolongevity.com/article/29561/year-long-brain-implant-study-maps-how-seasons-and-weather-reshape-sleep Fri, 09 Oct 2026 05:00:04 +0000 Continuous subcutaneous EEG recordings from 20 healthy adults across a full year reveal that sleep architecture is meaningfully shaped by environmental and social factors. Early summer brought shorter total sleep time and reduced REM duration. Bright sunshine shortened sleep…