Nutrition
French Cadmium Exposure Runs 3–4x Above European Peers, Report Warns
Cadmium is not a compound most people think about at the dinner table, yet it accumulates silently in the kidneys and liver over decades, and new…
Search Results: "longevity"
Found 1201 results for "longevity"
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Longevity
Multi-Tissue Histology Framework Reveals Independent Yet Synchronized Organ Aging Clocks
Understanding why some organs age faster than others — and whether that acceleration predicts disease — is one of the central puzzles of longevity science. A…
Studies
Review of Melanoma Vaccine Trials Highlights mRNA Platform Potential in Combination with Checkpoint Inhibitors
For decades, therapeutic cancer vaccines were considered a promising but consistently underdelivering strategy — most candidates failed to move the survival…
Wellbeing
Pet Ownership Shapes Human Health Access in Measurable Clinical Ways
The relationship between humans and their companion animals has long been studied for its psychological and cardiovascular benefits, but a growing body of…
Studies
NEJM Editorial Discusses SINGLE-AF Trial on Anticoagulation for Atrial Fibrillation with a Single Stroke Risk Factor
Atrial fibrillation affects tens of millions of adults globally, and the decision of when to start blood thinners sits at the center of one of cardiology's…
Studies
Large RCT: Atorvastatin Cuts Cardiovascular Events in Older Adults Without Prior Disease
For decades, the calculus of prescribing statins to older adults has been muddied by uncertainty: do the cardiovascular benefits outweigh the risks of muscle…
Studies
Five-Year Brain Organoids Replicate Postnatal Epigenetic Aging With Fidelity
The fidelity with which lab-grown tissue can replicate actual human biology has long been the central limitation of organoid research — and a new finding from…
Longevity
Mitochondrial DNA Leakage Into Oocyte Cytosol Fuels Ovarian Aging Via STING Pathway
Ovarian aging sets the biological clock for female fertility and hormonal health, yet its molecular drivers have remained poorly understood. A mechanistic…
Longevity
Mitochondrial DNA Leakage in Aging Eggs Ignites Ovarian Inflammation via Gap Junctions
Ovarian aging is one of the most consequential biological clocks in human health, setting the pace for fertility decline, hormonal shifts, and accelerated…
PREPRINTLongevity
Four AML Risk Genes Emerge from 170,000-Person Whole-Genome Biobank Scan
Whole-genome sequencing data from the All of Us Research Program, covering 265 AML cases and 169,706 controls, identified four genes carrying statistically…
PREPRINTLongevity
AD Genetic Risk Maps to Liver, Gut, Heart—Not Just Brain Microglia
A large-scale genomic analysis partitioning Alzheimer's disease (AD) polygenic risk across 166 tissue annotations and 4.4 million single cells spanning 28…
Supplements
Vitamin C Modulates 7 Aging Hallmarks But Human Evidence Remains Thin
A comprehensive narrative review from the University of Szeged maps vitamin C's interactions across the canonical hallmarks of aging — including epigenetic…
Studies
Study Links Two or More Years of Pretransplant Dialysis to Higher Graft Loss Risk in Living-Donor Recipients
For the millions of patients worldwide managing end-stage kidney disease, the timing of transplantation relative to dialysis initiation may be far more…
Studies
AI Drug Discovery Shows Minimal Clinical Impact Despite Decade of Hype
The gap between artificial intelligence's promise and its actual contribution to bringing better medicines to patients is wider than the pharmaceutical…
Nutrition
Blood Metabolomics Reveals 43 Validated Biomarkers Linking Ultra-Processed Foods to CVD Risk
Understanding precisely how ultra-processed foods (UPFs) damage the cardiovascular system has long been the missing mechanistic link in an otherwise…
Studies
Random Amino Acid Repeats Can Access Stable Folded Protein Structures
Understanding how functional proteins first arose from a primordial soup of random chemistry is one of biology's deepest unsolved puzzles — and new findings…
Studies
New Imaging Platform Maps Osteoblast Nutrient Use During Bone Formation
Understanding precisely how bone-building cells fuel themselves during active bone formation has long been a blind spot in skeletal biology — one with direct…
Longevity
GLP-1 Drugs Cut Obesity-Linked Cancer Risk 7–30% — But Causality Unproven
Large observational cohorts consistently link GLP-1 receptor agonist (GLP-1RA) exposure — drugs like semaglutide and liraglutide — to 7–30% relative risk…
Studies
Conserved KAT2–PGK–ALDO Cascade Amplifies Glycolysis Under Cellular Energy Stress
When cells run low on energy, their survival depends on rapidly upshifting glucose metabolism — and how they orchestrate that response at the molecular level…
Longevity
Hsp70 Chaperone Partners Show Stress-Selective Binding That Shapes Cellular Protein Quality Control
Protein quality control is one of the most consequential yet underappreciated pillars of healthy aging. When cells lose the ability to manage misfolded…