Studies
DNA Repair Defects Unlock Two Immune Signals That Amplify Checkpoint Therapy
For cancer patients whose tumors resist immunotherapy, understanding why some tumors respond and others don't has been…
Studies
Breaking results from peer-reviewed journals, clinical trials, and medical research.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Longevity
Limbic Subregions Shrink at Different Ages, Correlating with Memory Performance After 65
Understanding which brain structures erode first — and when — could transform how clinicians assess memory risk in…
Studies
Silencing a Hidden Gene Switch Boosts KCNQ2 Potassium Channel Output
For families affected by neonatal epilepsy linked to KCNQ2 mutations, therapeutic options remain frustratingly…
Studies
1-Hour Troponin Protocol Matches 3-Hour Safety While Cutting ER Wait Times
For millions of people who arrive at emergency departments each year with chest pain, how quickly clinicians can…
Studies
18F-Flurpiridaz PET Establishes TID Reference Thresholds for Coronary Disease Grading
Accurate detection of extensive coronary artery disease depends on reliable imaging benchmarks — and until now, a…
Supplements
Stevioside Activates YAP Pathway to Regenerate Liver Cells in Cholestasis
Liver diseases involving bile duct obstruction represent a serious and often underappreciated public health burden…
Studies
Tricuspid Valve Repair in Heart Failure Patients: NEJM Trial Findings
Tricuspid regurgitation has long been the neglected stepchild of structural heart disease — clinically significant…
Studies
TAVI-First vs PCI-First Strategy: Noninferiority Trial in Patients with Severe Aortic Stenosis and CAD
For the millions of adults living with both significant coronary artery disease and severe aortic stenosis, deciding…
Studies
Ambulatory ECG Monitoring After Syncope May Improve Cardiac Diagnosis Rates
Fainting episodes — clinically termed syncope — affect roughly one in three people over a lifetime, yet determining…
Nutrition
French Cadmium Exposure Runs 3–4x Above European Peers, Report Warns
Cadmium is not a compound most people think about at the dinner table, yet it accumulates silently in the kidneys and…
Studies
Cross-Trial Analysis of 38,753 Patients Maps Heart Failure Drug Combination Safety Signals
Optimizing heart failure treatment has long been complicated by a practical paradox: the drug combinations proven to…
Longevity
Frail Elders With Psychiatric Comorbidities Gain Most From Lifestyle Mobility Interventions
Not all frail older adults respond equally to structured lifestyle programs — and knowing which subgroups benefit most…
Studies
Lung Integrin Checkpoint Limits Cross-Reactive B Cell Memory After Influenza
For decades, systemic immunity has dominated vaccine design, yet respiratory viruses like influenza exploit the gap…
Studies
Radiotheranostics Precision Cancer Targeting: Current Approvals and Pipeline Review
Precision oncology is entering a phase where the same molecular probe that finds a tumor can also destroy it — a…
Studies
Review of Melanoma Vaccine Trials Highlights mRNA Platform Potential in Combination with Checkpoint Inhibitors
For decades, therapeutic cancer vaccines were considered a promising but consistently underdelivering strategy — most…
Studies
Blood Tau-217 Biomarker Shows Promise for Detecting CTE Risk In Vivo
Chronic traumatic encephalopathy has long been a diagnosis confined to the autopsy table — invisible during life…
PREPRINTStudies
Indoor Crowding and Behavior Drive US Flu Seasonality, with Southern Summer Reservoirs Seeding Epidemics
A modeling study integrating high-resolution influenza case data with human behavioral patterns across US counties…
PREPRINTLongevity
Adolescent Parenting Style Shows Minimal Link to Adult CVD Risk Over 21 Years
In a US longitudinal cohort of 4,050 participants tracked from adolescence (ages 12–19, 1994–1995) to adulthood (ages…
PREPRINTStudies
130,000-Adolescent Study Links Higher BMI to Faster Heart Rate and Worse Vision
In a multicenter retrospective cohort of 130,832 Chinese adolescents aged 8–17 screened between 2022 and 2024, every 1…
Studies
IPV Associated with Measurable Share of Female HIV Burden as Aid Cuts Threaten 2030 Progress
For the 39 million people living with HIV globally, the trajectory toward elimination has never been more fragile…
Studies
Eplontersen Shows Benefit Only as Monotherapy in ATTR-CM Phase 3 Trial; No Added Benefit With Tafamidis
For the growing number of patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) — a progressive and…
Wellbeing
Childhood Adversity Linked to Up to 40% Higher Postpartum Depression Prevalence
Postpartum depression remains one of the most underdiagnosed conditions in maternal health, and identifying who is…
Studies
Walkable Neighborhoods Associated with Lower Post-GDM Diabetes Risk—But Only in Affluent Areas
For the roughly one in five women who develop type 2 diabetes within a decade of a gestational diabetes diagnosis…
Studies
Chest-Tightness Asthma Variant in Children Linked to Airflow Obstruction and Atopic Risk Factors
Chest tightness as the sole presenting symptom of asthma is easy to dismiss — no wheeze, no cough, no classic alarm…
Studies
Vutrisiran Suppresses TTR Protein by 82–86% Across Diverse Amyloidosis Patients
For the estimated 50,000 people worldwide living with transthyretin amyloidosis — a progressive, often fatal disease…
Studies
AHA/ACC Unifies Risk Scoring Across Heart, Kidney, and Metabolic Disease
For decades, cardiovascular risk was calculated in silos — blood pressure managed separately from cholesterol…
Studies
CD19 CAR-T Therapy Achieves Drug-Free Remission in Treatment-Resistant Rheumatoid Arthritis
For the roughly 10–20% of rheumatoid arthritis patients who exhaust multiple biologic and targeted therapies without…
Studies
Omega-3 Plus Low-Dose Aspirin Matches Antibiotics for Severe Periodontitis
For the roughly half of adults over 30 living with significant periodontal disease, the standard clinical dilemma has…
Studies
Online-Sourced Retatrutide Complicates Impending Diabetic Ketoacidosis in T1DM Patient with Shigella Infection
A man in his mid-30s with longstanding type 1 diabetes self-administered an online-sourced product marketed as…
Longevity
Gut Microbiota, IPA, and Plasma Tau Associated with Postoperative Delirium in Observational Study
Among 491 surgical patients aged ≥65 undergoing elective laminectomy or joint replacement, 10% developed postoperative…
Studies
ESC and ACC 2025 Guidelines Converge on IL-1 Blockade for Recurrent Pericarditis
For the millions of adults who develop chest pain after viral illness — or after mRNA vaccination — the clinical…
Studies
Inclisiran Outperforms Statin Uptitration: 85% vs 31% LDL Goal Achievement
For the millions of high-risk cardiovascular patients who fail to reach guideline-recommended LDL cholesterol targets…
Studies
Head-to-Head Trial Finds Prasugrel Edges Ticagrelor in ACS Outcomes
For the millions of people who survive a heart attack or unstable angina each year, the choice of antiplatelet…
Studies
CT Coronary Angiography Reshapes Acute Chest Pain Triage in Large Trial
Chest pain is the second most common reason adults present to emergency departments worldwide, yet determining who…
Studies
Factor XIa Inhibitor Milvexian Cuts Ischemic Events Without Major Bleeding Rise
The holy grail of antithrombotic therapy has long been separating clot prevention from bleeding risk — a trade-off…
Studies
Extended Dual Antiplatelet Therapy Reduces Ischemic Events in High-Risk Patients
For millions of adults living with cardiovascular disease, the question of how aggressively to suppress platelet…
Studies
Aspirin-Free STEMI Intervention: Large Trial Challenges Decades-Old Antiplatelet Protocol
For decades, aspirin has been considered an untouchable cornerstone of heart attack treatment — a drug so foundational…
Studies
Functional Angiography Guidance Reshapes Multi-Vessel STEMI Revascularization Strategy
For the millions of heart attack patients who arrive with blockages in multiple coronary arteries, the question of how…
Studies
Pulmonary Nerve Ablation Shows Promise for Heart Failure Hypertension in Trial
For the millions of adults living with heart failure complicated by pulmonary hypertension, therapeutic options have…
Studies
13 Blood Markers Predict HFrEF Subtype Before Echocardiography With 0.789 AUC
Distinguishing heart failure subtypes quickly has real consequences: patients with reduced ejection fraction respond…
PREPRINTLongevity
HDL-Remodeling Metabolite Pattern Linked to 17% Higher Dementia Risk in T2D Subtypes (medRxiv Preprint)
Among 7,671 UK Biobank participants with type 2 diabetes (mean age ~60), NMR-based metabolomic profiling across…
PREPRINTLongevity
IHD Deaths Rising in West Africa Since 2007 as Global Rates Fall 38%
While global stroke and ischemic heart disease (IHD) mortality dropped 51.7% and 38.2% respectively between 1990 and…
PREPRINTStudies
Digital Ad Spend Yields Only 36 Black, 27 Latino Recruits per $100K in AF Trial
A national digital recruitment campaign for the Phase 3 LIBREXIA-AF atrial fibrillation trial spent $163,949 across…
PREPRINTLongevity
12-Ward Australian Trial Tests Staff-Led Education to Cut Hospital Falls
A 65-week, 12-ward stepped-wedge cluster randomised controlled trial across five Australian hospitals will test…
Studies
Immunotherapy Adds No Quality-of-Life Benefit in Limited-Stage Small Cell Lung Cancer
For patients and clinicians weighing the trade-offs of adding immunotherapy to standard treatment in limited-stage…
Studies
CMR GUIDE Trial: ICD Implantation Neutral on Primary Arrhythmia Endpoint but Reduces SCD and Benefits Younger Patients with Mid-Range EF and Scar
Millions of heart disease patients fall into a diagnostic no-man's land — their cardiac function is too preserved to…
Studies
Pediatric Pneumonia Exam Findings Show Inconsistent Reliability Across Two Clinicians
When clinical guidelines steer physicians away from imaging and toward physical examination alone to diagnose…
Studies
Peroxisome Loss Corrupts Insulin Integrity and Destabilizes Beta Cell Identity
Glucose dysregulation is typically blamed on insufficient insulin — but what if the insulin itself is structurally…
Studies
Ferritinophagy Dysregulation Drives Iron-Mediated Injury Across Four Major Organs
Iron is a paradox in human biology — essential for life yet lethal in excess. A newly published review in Autophagy…
Studies
CT Coronary Angiography Identifies High-Risk Plaque Beyond Stenosis Severity
For patients arriving at emergency departments with chest pain, the difference between unnecessary hospitalization and…
Studies
Shortened Antibiotic Courses Match Standard 6-Week Regimen in Endocarditis Trial
For decades, the six-week antibiotic course for infective endocarditis has been more tradition than evidence — a…
Fitness
Myonuclear Retention and DNA Methylation Encode Decades-Long Muscle Training Memory
Skeletal muscle encodes prior exercise history through at least six parallel molecular mechanisms: myonuclear…
Longevity
GLP-1 + Menopause HRT Combo for Weight Loss: Promising But Premature
An expert consensus from Spain's Menopause Society synthesized evidence on GLP-1 receptor agonists and dual incretin…
Studies
GLP-1 Agonists and Bariatric Surgery Show Promise in Endometrial Cancer Management
Endometrial cancer incidence is rising in lockstep with global obesity rates, and in early-stage disease, women are…
Supplements
Melatonin's Prolactin Pathway May Link Long-Term Use to Heart Failure Risk
Melatonin is taken nightly by millions of adults who regard it as essentially harmless — a natural sleep aid with a…
Studies
NEJM Editorial Discusses SINGLE-AF Trial on Anticoagulation for Atrial Fibrillation with a Single Stroke Risk Factor
Atrial fibrillation affects tens of millions of adults globally, and the decision of when to start blood thinners sits…
Studies
CRISPR Liver Edit Sustains ANGPTL3 Suppression in Cardiovascular Risk Trial
Permanently rewriting a single gene in the liver to lower cardiovascular risk has long been a theoretical aspiration…
Studies
Silent Artery Disease Found Across All Adult Age Groups, Not Just Elderly
Atherosclerosis has long been framed as a disease of older age — something that accumulates quietly over decades and…
Studies
Large RCT: Atorvastatin Cuts Cardiovascular Events in Older Adults Without Prior Disease
For decades, the calculus of prescribing statins to older adults has been muddied by uncertainty: do the…
Studies
NEJM Trial Challenges Anticoagulation Decisions for Intermediate AF Stroke Risk
One of the most contested gray zones in cardiology — whether patients with atrial fibrillation at intermediate stroke…
Studies
Personalized Antibiotic Duration Matches Standard Care for Endocarditis Outcomes
Infective endocarditis carries one of the highest mortality rates among bacterial infections, and the current standard…
Studies
Aficamten Improves Exercise Capacity in Nonobstructive HCM Phase III Trial
Hypertrophic cardiomyopathy without outflow obstruction has long been a therapeutic dead end — a condition where the…
Studies
London's Ultra-Low-Emission Zone Linked to Accelerated Lung Function Growth in Children
Lung function established during childhood is one of the strongest long-term predictors of adult respiratory health…
Studies
Five-Year Brain Organoids Replicate Postnatal Epigenetic Aging With Fidelity
The fidelity with which lab-grown tissue can replicate actual human biology has long been the central limitation of…
Studies
Potent P2Y12 Plus DOAC Raises Bleeding Risk Without Ischemic Benefit in AF-ACS
Managing patients who have both atrial fibrillation and an acute coronary syndrome is one of cardiology's sharpest…
Longevity
Mitochondrial DNA Leakage Into Oocyte Cytosol Fuels Ovarian Aging Via STING Pathway
Ovarian aging sets the biological clock for female fertility and hormonal health, yet its molecular drivers have…
Longevity
Mitochondrial DNA Leakage in Aging Eggs Ignites Ovarian Inflammation via Gap Junctions
Ovarian aging is one of the most consequential biological clocks in human health, setting the pace for fertility…
Studies
New Consortium Targets Sex-Based Biological Gaps in Alzheimer's Research
Alzheimer's disease does not affect men and women equally — women account for nearly two-thirds of all cases — yet…
Studies
Multi-Biomarker Wearables Could Reframe Cardiometabolic Disease Monitoring Beyond Glucose
Continuous glucose monitoring transformed diabetes management by turning a snapshot test into a living physiological…
Longevity
Silent Coronary Calcium in Young Adults Raises CHD Death Risk Fivefold
Coronary artery disease is typically framed as a condition that declares itself in middle age or later — but…
Studies
Enteric Disease Deaths Fell 60% in Children Since 1990, But Progress Stalls
Over a million deaths annually from gut infections — with children under five bearing a disproportionate share…
PREPRINTLongevity
Four AML Risk Genes Emerge from 170,000-Person Whole-Genome Biobank Scan
Whole-genome sequencing data from the All of Us Research Program, covering 265 AML cases and 169,706 controls…
PREPRINTStudies
TWAS Maps 684+ T2D Gene Associations Across 6 Tissues, Revealing JAZF1-IDE Axis
Integrating tissue-specific transcriptome-wide association studies (TWAS) with ancestry-aware gene expression models…
PREPRINTLongevity
GLP-1 Drugs Linked to 0.21-Month Alzheimer's Delay vs. Sulfonylureas in 6,328 Diabetics
Among 6,328 adults aged 55+ with type 2 diabetes and no prior dementia, initiating GLP-1 receptor agonists was…
PREPRINTLongevity
AD Genetic Risk Maps to Liver, Gut, Heart—Not Just Brain Microglia
A large-scale genomic analysis partitioning Alzheimer's disease (AD) polygenic risk across 166 tissue annotations and…
Studies
Phase 3 Trial Tests RNA-Silencing Drug Against Fatal Heart Amyloid Disease
Transthyretin amyloid cardiomyopathy remains one of cardiology's most underdiagnosed and lethal conditions — a disease…
Longevity
Senescent Vascular Cells and SASP Linked to Intracranial Aneurysm Wall Weakening
Intracranial aneurysms may represent a localized manifestation of premature vascular aging, with senescent endothelial…
Longevity
Sattar Perspective: Incretin-Driven Weight Loss (14-20%) and Causal Adiposity Effects Across Multiple Disease Domains
Using a triangulation framework—combining Mendelian randomisation, observational cohorts, and randomised trials—Sattar…
Nutrition
DASH Diet Cuts Heart Failure Risk 11% Independent of Cardiometabolic Mediators
Among 124,777 UK Biobank participants followed for 12 years, highest versus lowest adherence to the DASH diet was…
Supplements
Vitamin C Modulates 7 Aging Hallmarks But Human Evidence Remains Thin
A comprehensive narrative review from the University of Szeged maps vitamin C's interactions across the canonical…