Fitness
Exercise Modulates Gut Microbiota to Strengthen Bones Through Gut-Bone Axis
Exercise strengthens bones not just through mechanical loading but by fundamentally altering gut microbiota composition…
Nutrition
Evidence-based findings on diet, micronutrients, and dietary patterns.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Longevity
Obesity and Gut Dysbiosis Drive Alzheimer's Neuroinflammation via Blood-Brain Barrier
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia towa…
Longevity
Resveratrol Stabilizes PER2 Clock Protein in Fetal Heart Cells
Resveratrol increases stability of the PER2 clock protein in both fetal cardiomyocytes and cardiac fibroblasts, shiftin…
Nutrition
Gut Bacteria Transform Soy Compounds Into Bioactive Health-Promoting Molecules
Gut microbes actively transform soy-derived compounds into bioactive molecules that influence host physiology, while so…
Longevity
Prevotella corporis Bacteria Activates Hsp70 Protection Against Protein Aggregation
Prevotella corporis, a specific gut bacterium, uniquely activates the host's heat shock response and induces Hsp70 mole…
Longevity
GLP-1 Receptor Agonists Show Promise as 'Pharmacological Exercise' Against Neurodegeneration
GLP-1 receptor agonists like semaglutide and liraglutide demonstrate multiple neuroprotective mechanisms in preclinical…
Fitness
Ten-Hour Eating Window Plus Resistance Training Cuts 3.2kg Fat
A controlled trial of 54 overweight college students found that combining 10-hour daily eating windows with resistance…
Nutrition
Digital Health Interventions Fail to Boost WIC Food Benefit Usage
A randomized trial involving 351 pregnant WIC participants found that digital health interventions designed to promote…
Studies
Engineered Adapter Protein Converts Cancer Antibodies into T Cell Killers
Scientists developed a molecular adapter called eCD16A/anti-CD3-BFP that transforms existing cancer antibodies into T c…
Longevity
B-Vitamins May Protect Aging Brain Through Gut Microbiome Modulation
Low B-vitamin status—particularly B6, B12, folate, and riboflavin—correlates with cognitive dysfunction and dementia in…
Nutrition
Moderate Wine Within Mediterranean Diet Reduces Mortality by 33%
Analysis of 30,580 Spanish adults across two major cohorts reveals that moderate wine consumption within Mediterranean…
Longevity
Genetics Determines Intermittent Fasting Benefits Across 10 Mouse Strains
Two-day weekly intermittent fasting produced dramatically different longevity and metabolic outcomes across 10 genetica…
Nutrition
Mediterranean Diet Reduces Death Risk 10% Per Quintile in Depression
Among 5,368 UK adults with depression followed for 12 years, adherence to Mediterranean diet, DASH, and HEFI-2019 patte…
Studies
Salivary Oxidized Fats Signal Early Cognitive Decline in Aging Adults
Analysis of saliva, plasma, and fecal samples from older adults with mild cognitive impairment revealed distinct lipid…
Studies
Blood Microbiome Traces Link Gut Dysbiosis to Gestational Diabetes Risk
Microbial DNA fragments are being detected in the bloodstream of pregnant women with gestational diabetes, suggesting t…
Longevity
Akkermansia muciniphila reduces Alzheimer's amyloid plaques via tryptophan pathway
Akkermansia muciniphila administration in transgenic Alzheimer's mice reduced amyloid-beta plaques and improved cogniti…
Wellbeing
Intranasal Oxytocin Reverses Social Isolation Brain Damage in Mice
Adolescent mice subjected to three months of social isolation developed anxiety, depression, and severe social memory d…
Studies
Red Blood Cells Triple Glucose Uptake During Hypoxia, Improving Diabetes
Hypoxic conditions trigger a three-fold increase in glucose uptake by red blood cells, with newly formed erythrocytes e…
Studies
Anti-integrin αvβ6 antibodies predict ulcerative colitis years before symptoms
Örebro University researchers identified anti-integrin αvβ6 antibodies as predictive biomarkers for ulcerative colitis…
Longevity
Engineered IMD-CBM Peptide Degrades CAV1 Protein, Reduces Atherosclerotic Plaques
Researchers engineered a synthetic IMD-CBM peptide that selectively triggers autophagy to degrade CAV1 (caveolin 1), a…
Studies
CXCR2 Receptor Controls Head and Neck Cancer Radiotherapy Resistance
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed d…
Longevity
Six Drug Strategies Target Neuroinflammation Pathways Driving Brain Aging
This comprehensive review identifies neuroinflammation as the central mechanism connecting normal brain aging to pathol…
Supplements
Coconut Compound 4,4'-Diapophytofluene Outperforms Quercetin in Anti-Aging Protein Binding
Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger bindin…
Nutrition
Combined Supply-Demand Fish Intervention Quadruples Consumption in Malnourished Rural Communities
Fish-aggregating devices paired with behavioral messaging produced dramatic consumption increases in Timor-Leste villag…
Studies
Iron Deficiency Reduces Maternal Antibody Transfer to Newborns Globally
Analysis of 557 mother-infant pairs across eight countries reveals that maternal iron deficiency significantly impairs…
Studies
EBV Reprograms B Cells to Present MS-Triggering Myelin Peptides
Epstein-Barr virus infection fundamentally alters the antigen presentation machinery in B cells carrying the HLA-DR15 g…
Nutrition
Hidden Sugar Sources Drive Childhood Cardiovascular Disease Risk
Childhood sugar exposure creates measurable cardiovascular risk markers that persist into adulthood, with non-obvious s…
Longevity
Sulforaphane and Metformin Extend Male Worm Fertility While Other Compounds Only Boost Lifespan
C. elegans research reveals a crucial distinction between living longer and aging well. While seven tested compounds un…
Nutrition
Anthocyanins Restore Gut Microbiome Balance While Suppressing Inflammatory Cytokines
Anthocyanin compounds from berries demonstrate dual therapeutic potential by simultaneously rebalancing gut microbiota…
Studies
Brain Atlas Maps 10 Million Oligodendrocytes Controlling Neural Processing Speed
Researchers have constructed a comprehensive cellular atlas documenting approximately 10 million oligodendrocytes—speci…
Studies
New Fluorescent Dye Trodusquemine Enables Detailed Myelin Imaging in Cleared Tissues
Researchers developed HELF (High Efficiency Labeling of Fibers), a protocol using the fluorescent aminosterol trodusque…
Studies
Diabetes Drug Tirzepatide Shows Promise for Alcohol Use Disorder
Tirzepatide, a dual GLP-1 and GIP receptor agonist approved for diabetes and weight management, demonstrated potent ant…
Studies
Specific Gene Variants Linked to Hereditary Food Allergy Risk
Genetic analysis has identified specific DNA variants that explain the familial clustering of food allergies, moving be…
Studies
FDA-Approved Epilepsy Drug Blocks Alzheimer's Amyloid Production at Synapses
Levetiracetam, an established antiepileptic medication, demonstrates a novel mechanism for preventing amyloid-beta 42 f…
Studies
PAK1 Inhibitor Protects Brain Synapses From Alzheimer's Protein Damage
Blocking the p21-activated kinase 1 (PAK1) enzyme with compound NVS-PAK1-1 prevented synapse destruction in neurons exp…
Studies
Na+/H+ Exchanger 1 Blockers Demonstrate Coronary Vasodilation Against Angina Spasms
Targeting the Na+/H+ exchanger 1 (NHE1) protein produces significant coronary artery dilation, offering a novel therape…
Studies
c-Abl Kinase Inhibitor Risvodetinib Shows Safety Profile in Early Parkinson's
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week…
Studies
Tumor Protein Cystatin-C Clears Amyloid Plaques in Mouse Brains
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and acti…
Studies
AI Platform Maps Common Drug Targets Across 500+ Genetic Disorders
Computational analysis of molecular pathways across 547 genetic disorders revealed 89 previously unrecognized druggable…
Studies
Blood Test Detects Early Ovarian Cancer with 83% Accuracy Using Extracellular Vesicles
An experimental blood test analyzing tumor-associated extracellular vesicles and particles achieved 82.9% sensitivity f…
Longevity
Soluble IL-6 Receptor Shows Protective Effects Against All-Cause Mortality
Mendelian randomization analysis reveals that while interleukin-6 (IL-6) increases mortality risk, its soluble receptor…
Studies
CETP Inhibitor Trial Tests Direct Coronary Plaque Reduction Effects
The REMBRANDT trial represents a methodological shift in cardiovascular drug evaluation, using coronary computed tomogr…
Longevity
Midlife Visceral Fat Expansion Isn't Universally Harmful, Nature Review Reveals
White adipose tissue accumulation around abdominal organs during midlife follows predictable patterns, but its metaboli…
Longevity
Liver-derived ApoE protein blocks bone healing in aged mice
Researchers identified apolipoprotein E (ApoE) as a key mechanism behind age-related bone healing impairment. In 24-mon…
Wellbeing
Combined Lifestyle Plus Supplement Interventions Show Mixed Dementia Prevention Results
A systematic analysis of twelve randomized controlled trials reveals the emerging evidence for combining multidomain li…
Nutrition
Cochrane Review Finds Intermittent Fasting Shows Modest Weight Loss
A comprehensive Cochrane systematic review evaluated randomized controlled trials comparing intermittent fasting protoc…
Studies
Modified Stem Cells Deliver Functional CTNS Gene in Cystinosis Trial
Researchers successfully used genetically modified hematopoietic stem cells to deliver functional CTNS genes in patient…
Studies
ALK2 Inhibitor Engasertib Reduces Nosebleeds in Rare Vascular Disease
Engasertib, a selective ALK2 kinase inhibitor, demonstrated significant reduction in epistaxis frequency among patients…
Studies
CTNS Gene Therapy Shows Promise for Inherited Kidney Disease
A novel gene therapy approach targeting CTNS mutations demonstrates therapeutic potential for nephropathic cystinosis,…
Studies
Diabetes Patients Prioritize Quality of Life Over Glucose Control in Islet Therapy
Patient-reported priorities for stem cell-derived islet transplantation diverge significantly from traditional clinical…
Studies
Novel Arctigenin Derivative ARC-18 Clears Brain Amyloid Through Autophagy Enhancement
ARC-18, a synthetic derivative of the plant compound arctigenin, demonstrated dual mechanisms against Alzheimer's patho…
Nutrition
Plant-Based Low-Carb Diets Reduce Diabetes Risk 16% Versus Animal-Based
Analysis of nearly 200,000 healthcare professionals tracked for three decades reveals that macronutrient source, not ju…
Studies
Prenatal Acid-Blocking Medications Increase Child Neurodevelopmental Disorder Risk
Analysis of 2.5 million Korean mother-child pairs reveals that prenatal exposure to proton pump inhibitors and H2 recep…
Studies
Elevated Lp(a) Biomarker Predicts Three-Decade Cardiovascular Risk in Women
Lipoprotein(a) emerges as a powerful long-term cardiovascular predictor in women, with elevated concentrations associat…
Studies
JAMA Challenges Simple Calorie Model of Obesity Causation
JAMA presents evidence contradicting the conventional calories-in-calories-out explanation for weight gain, highlightin…
PREPRINTSupplements
Vitamin D Supplementation Reduces LDL Cholesterol, Blood Pressure in Meta-Analysis
Analysis of 45 randomized controlled trials reveals vitamin D supplementation produces statistically significant but mo…
Nutrition
Nitrate Preservatives Show 54% Higher Diabetes Risk in 100,000-Person Study
Nitrate and nitrite preservatives, ubiquitous in processed meats and packaged foods, demonstrate a dose-dependent relat…
PREPRINTFitness
5,000-Protein Analysis Reveals HFpEF Rehabilitation Mechanisms Across Multiple Organs
Researchers analyzed over 5,000 circulating proteins from two randomized rehabilitation trials in heart failure with pr…
Longevity
Blocking Fat Tissue Growth Hormone Receptors Preserves Brain Function in Aging
Eliminating growth hormone receptors specifically in fat tissue dramatically protected aged mice from brain deteriorati…
Nutrition
3-Hour Pre-Sleep Fasting Window Improves Nighttime Blood Pressure Regulation
Extending overnight fasting by finishing meals at least three hours before bedtime significantly enhanced nighttime dia…
PREPRINTWellbeing
Plastic Nanoparticles Drive Atherosclerosis Through Distinct Smooth Muscle Cell Programming
Polyethylene and polyvinyl chloride nanoparticles—the most common plastics found in human arterial plaques—accelerate a…
Studies
Astrocyte CCN1 Protein Orchestrates Microglial Debris Clearance in Spinal Injuries
Spinal cord injury triggers specialized astrocytes distant from the damage site to secrete CCN1, a matricellular protei…
Wellbeing
Maternal Antibodies Reprogram Infant Intestinal Immune Development
Singapore researchers have identified how specific immunoglobulin A (IgA) antibodies in breast milk actively reshape th…
Nutrition
Most EU Consumers Unaware of Mercury Guidelines Despite High Fish Consumption
A European Food Safety Authority survey reveals widespread gaps in public knowledge about mercury exposure from seafood…
Studies
CAR-T Cell Engineering Targets Alzheimer's Amyloid Plaques Directly
Scientists have developed genetically modified immune cells that specifically target amyloid-beta plaques in Alzheimer'…
Wellbeing
Protein Synaptogyrin-3 Controls Dopamine Release Linked to Addiction Vulnerability
Synaptogyrin-3 (Syngr3), a presynaptic protein, emerges as a key regulator controlling dopamine neurotransmitter releas…
Studies
PTEN Gene Mutations Trigger Brain Overgrowth Through ARP2/3 Protein Complex
PTEN gene mutations, which cause neurodevelopmental disorders including autism and epilepsy, drive abnormal brain enlar…
Studies
Atomic Force Microscopy Maps Fungal Protein Assembly Into Protective Fibers
Advanced microscopy techniques have decoded how hydrophobin RolA, a fungal surface protein, transforms from individual…
Wellbeing
Myelin Demonstrates Previously Unknown Self-Repair Mechanisms in Neural Networks
Neural tissue's protective myelin coating exhibits sophisticated regenerative properties that challenge current underst…
Studies
Lower Cell Viscosity Enables Cancer Cells to Migrate and Metastasize
Researchers at INSERM have identified cellular viscosity as a critical biophysical parameter controlling cancer metasta…
Studies
Cell Viscosity Changes Enable Cancer Spread to Distant Organs
Biophysical measurements reveal that metastatic cancer cells undergo measurable changes in internal viscosity that corr…
Longevity
p62 Protein Forms Condensates That Orchestrate Mitochondrial Quality Control
The p62 protein creates liquid-like condensates that actively cluster damaged mitochondria, functioning as a cellular q…
Longevity
Brain Pattern Subtypes Show Differential Response to Multidomain Dementia Prevention
Machine learning analysis of 120 participants in the landmark FINGER trial revealed that individuals cluster into disti…
Longevity
Brain Structure Patterns Predict Lifestyle Intervention Success in Dementia Prevention
Analysis of 120 older adults from the landmark FINGER trial reveals that baseline brain architecture determines how ind…
Nutrition
Specific Foods Trigger IBD Inflammation Through Gut Barrier Disruption
Ultra-processed foods, high-fat diets, and red meat specifically trigger inflammatory bowel disease flares by disruptin…
Longevity
Hsp70 and Hsp90 Chaperones Display Protective and Pathological Functions in Aging Neurons
Molecular chaperones Hsp70 and Hsp90 demonstrate paradoxical effects in neurological aging, serving both protective and…
Wellbeing
African Gut Microbiota Shows Distinct Neuroprotective Patterns Against Cognitive Decline
Population-level analysis reveals that African gut microbiomes harbor distinct bacterial profiles that appear to confer…
Studies
PD-1 Inhibitors Shrink Latent HIV Reservoirs in Cancer Patients
Cancer immunotherapy drugs targeting the PD-1 checkpoint protein significantly reduced latent HIV reservoirs in co-infe…
Studies
Macrophage Lactate Triggers Epigenetic Scar Formation via MCT1 Transport
Macrophage-secreted lactate directly activates fibroblast scarring through MCT1 transporters and histone lactylation, r…
Studies
Immune Checkpoint Inhibitor Shrinks Latent HIV Reservoir Through Interferon Activation
Blocking the PD-1 immune checkpoint protein triggers interferon-driven antiviral responses that measurably reduce laten…