Longevity
GPR40 Receptor Activation Reverses Thymic Aging in Mouse Model
Immune deterioration with age has long been attributed partly to the shrinking thymus, but pinning down a druggable mol…
Nutrition
Evidence-based findings on diet, micronutrients, and dietary patterns.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Studies
Dual HIF-1/2 Inhibitor Achieves 50%+ Complete Responses in Mouse Models of Five Cancer Types
One of the most stubborn challenges in oncology is that tumors engineer their own survival environment — starving thems…
Longevity
Lp(a): Genetic Cardiovascular Risk Factor Affecting 20% Awaits Targeted Therapies
For roughly one in five adults, cardiovascular risk is quietly elevated by a factor that standard lipid panels often ig…
Studies
GLP-1 Drugs May Both Help and Harm Patients With Eating Disorders
As GLP-1 receptor agonist prescriptions continue to surge globally, a critical blind spot is emerging: the millions of…
Studies
GLP-1 Weight Loss Patients Choose Different Body Contouring Than Bariatric Patients
As GLP-1 receptor agonists reshape how millions achieve significant weight loss, a clinically important question emerge…
Nutrition
Mediterranean Diet Cuts HbA1c and Reshapes Gut Microbiome in Diabetes-Risk Adults
For the roughly one-in-three adults who live with prediabetes or elevated cardiovascular risk, diet remains the most ac…
Wellbeing
Extended Sleep Beyond 8.5 Hours Linked to Higher Alzheimer's Tau Biomarker
The relationship between sleep and brain aging is rarely simple, and this large cohort study adds a critical nuance: it…
Studies
Rare Brain Enzyme Controls Nerve Signal Speed via Sugar Chain Modifications
For decades, neurological research has focused on proteins and lipids as the architects of myelin structure, but a grow…
Studies
Even Mild Blood Sugar Elevation Triggers Early β-Cell Metabolic Breakdown
The conventional wisdom that pancreatic beta-cell damage in type 2 diabetes is a late-stage consequence of severe hyper…
Studies
Methanogenic Archaea Depleted, Caudoviricetes Phages Surge in Obese Gut Microbiome
Across three independent human cohorts, lean individuals consistently harbored enriched populations of methanogenic arc…
Nutrition
Review Links MCTs, DHA, and Carnosine to Selective Cognitive Benefits in Early Cognitive Impairment via Glucose Metabolism Support
Cerebral glucose hypometabolism — the brain's progressive inability to efficiently metabolize its primary fuel — preced…
Supplements
Vutiglabridin Breaks Semaglutide's Weight-Loss Plateau, Restores Normal Body Composition in Mice
Diet-induced obese mice treated with semaglutide hit a weight-loss plateau within two weeks — a well-documented ceiling…
Nutrition
Sweetener-Antidepressant Combo Synergistically Disrupts Key Gut Bacteria in Vitro
Millions of people consume low-calorie sweeteners daily while also taking medications or drinking caffeine-containing b…
Nutrition
Lower Capsaicin Intake Linked to Aortic Dissection in Small Human Study; Mouse Experiments Implicate TRPV1-Macrophage and Gut Microbiome Pathways
Aortic dissection kills rapidly and remains pharmacologically underserved — no drug reliably slows its progression once…
Studies
Sodium Butyrate Curbs Post-Traumatic Epilepsy Pathways via HDAC Inhibition in Mice
Post-traumatic epilepsy affects roughly 10–20% of moderate-to-severe TBI survivors and remains one of neurology's most…
Studies
RNA Aptamer 1R6 Blocks Alpha-Synuclein Aggregation Across Multiple Model Systems
For the estimated one million Americans living with Parkinson's disease — and the broader population affected by Lewy b…
Studies
Post-Pandemic Respiratory Virus Risk Map: Genetics, Behavior, and Comorbidities Charted
Understanding who is most vulnerable to respiratory viruses — and why — has never been more urgent. Post-pandemic shift…
Studies
DNASE1L3 Enzyme Reduces NETs and Symptoms in One Patient with Lupus and DNASE1L3 Deficiency (NEJM Correspondence)
For the millions living with systemic lupus erythematosus, current treatments suppress the immune system broadly — a bl…
Studies
Narrative Review Examines GIP's Role in Cardiorenal Effects of Dual GIP/GLP-1 Agonists Like Tirzepatide
Understanding how a widely prescribed diabetes and obesity drug protects the heart and kidneys — and whether that prote…
Longevity
Gut Microbiome Diversity Inversely Tracks Frailty Severity in 2,000+ Older Women
For the millions of older adults navigating the gradual onset of frailty, the gut microbiome may be doing more than aid…
Studies
First Oral PCSK9 Inhibitor Shows LDL Reduction in Phase 1 Trial
For the millions of adults managing elevated LDL cholesterol, the requirement for injectable PCSK9 inhibitors — adminis…
Studies
CD19 Co-Stimulatory Fusion Protein Shows Encouraging Activity with Bispecific Antibody in Phase 1 Trial for Refractory Lymphoma
For patients with aggressive B cell lymphomas that have stopped responding to standard therapies, treatment options nar…
Nutrition
Dietary Capsaicin Linked to Lower Aortic Dissection Risk via TRPV1-Macrophage and Microbiome Pathways in Preliminary Study
Aortic dissection—a sudden, life-threatening tear in the aortic wall—carries mortality rates that can exceed 50% within…
Studies
Multi-STING Activator mRNA Nanoparticle Vaccine Boosts Dendritic Cell Antitumor Response
Cancer immunotherapy stands at an inflection point: while mRNA vaccine platforms have proven clinically viable, their r…
Studies
Drosophila Study: Sleep Deprivation Triggers Gut-to-Brain ROS Cascade via Dopamine-Mitochondrial Pathway in Immune Cells
Oxidative stress has long been recognized as a downstream consequence of poor sleep, but pinpointing exactly where and…
Studies
Cryo-EM Reveals How C3aR Activation Could Unlock New Immune Therapies
Understanding precisely how the innate immune system's early-warning machinery switches on at the molecular level has l…
Studies
Blocking Elastin Breakdown Slows Osteoarthritis Across Three Species
Osteoarthritis quietly dismantles the cartilage of roughly 500 million people worldwide, yet the field has long fixated…
Studies
Atomic-Level Aβ1-40 Fibril Map Opens New Alzheimer's Drug Target Window
Understanding exactly how amyloid proteins fold and stack into the plaques that characterize Alzheimer's disease has be…
Nutrition
UK Iodine Paradox: Population Deficiency Meets Social-Media-Driven Excess
Iodine rarely makes headlines, yet it quietly governs thyroid hormone synthesis and fetal neurodevelopment — and the Un…
Longevity
Muscle-Secreted Mimecan Protein Extends Lifespan via Hypothalamus-Brown Fat Axis
The conventional view of skeletal muscle as a passive tissue involved mainly in movement and metabolism is increasingly…
Studies
EBV Molecular Mimicry and Helminth Tolerance Reframe MS Immune Mechanisms
Multiple sclerosis has long resisted a single explanatory framework, frustrating both patients and clinicians. A growin…
Nutrition
FPIES Misdiagnosed as Sepsis: What Clinicians Miss in Non-IgE Food Allergy
When a previously healthy infant presents to an emergency department with profuse vomiting, lethargy, and signs of circ…
Studies
Two Blood Biomarkers Outperform Eosinophil Counts in Pediatric Allergy Diagnosis
Diagnosing allergic rhinitis in children relies heavily on clinical symptoms and skin-prick tests, but objective blood…
Studies
FL118 Degrades Two Cancer Proteins Simultaneously, Targeting Treatment-Resistant Tumors
For patients facing cancers that have exhausted standard treatment options — pancreatic adenocarcinoma, glioblastoma, c…
Fitness
Semaglutide + Exercise Cuts Fat 45%, Partially Saves Muscle via Mitochondrial Pathways
In diet-induced obese Ldlr-/-.Leiden mice over 14 weeks, semaglutide alone reduced fat mass by 31% but also trimmed lea…
Nutrition
Lutein & Zeaxanthin Lead Ocular Nutraceuticals; Curcumin, Resveratrol Lag Behind
Among all food-derived bioactive compounds examined for ocular disease, lutein and zeaxanthin stand out as the only nut…
Longevity
Lipid-Rich Microglia Correlate with Hippocampal Memory Decline in Middle-Aged Rats
In middle-aged rats, hippocampal microglia adopted a lipid-rich, pro-inflammatory phenotype that correlated directly wi…
Nutrition
200–300 MPa Pressure Boosts Resveratrol Bioactivity and Enzyme Inhibition in 2 Minutes
Applying high-pressure processing (HPP) at 200–300 MPa for just 2 minutes measurably increased resveratrol content and…
Supplements
Piceatannol Cuts IGFBP4/5/7 Senescence Signals, Improves Memory in Aging Mice
Oral piceatannol (PCT), a stilbene and direct resveratrol metabolite with superior bioavailability, demonstrably reduce…
Longevity
Irisin Links Muscle Contraction to Alzheimer's Protection via Brain Signaling
With Alzheimer's disease cases in the U.S. projected to more than double to 14 million by 2060, the search for modifiab…
Longevity
Accelerated Biological Aging Linked to Rising Early-Onset Cancer Risk Across Generations
Early-onset cancer — diagnosed before age 50 — has been climbing globally for decades, and the explanation has remained…
Studies
Cavity-Nesting Birds Harbor Richer Uropygial Microbiomes Than Open-Cup Species
The microbial communities defending animal skin are not static—they shift with age, environment, and lifestyle in ways…
Studies
Phase 3 Semaglutide Trials Fail to Slow Alzheimer's Progression in Large RCT
The promise of GLP-1 receptor agonists for brain protection has been one of the most closely watched hypotheses in deme…
Studies
KRAS Molecular Glues Expand From Single Mutations to Pan-RAS Cancer Targeting
For decades, KRAS was considered undruggable — a death sentence for patients whose tumors carried mutations in this mas…
Wellbeing
Long-Lived Synaptic Proteins Show Sex-Dependent Turnover Rates in Brain
How the brain maintains stable memories and functional synapses over decades is one of neuroscience's most compelling p…
Longevity
Brain Blood Flow Regulation Traced to Endothelial Arf6-PIP2-Kir2.1 Molecular Cascade
Maintaining sharp cognitive function across decades depends critically on the brain's ability to rapidly route blood to…
Studies
GCN2 Kinase Deficiency Drives IL-6-Mediated Pulmonary Hypertension in Mice
Pulmonary hypertension remains one of the most underdiagnosed and poorly understood cardiovascular conditions, with cur…
Studies
Flynn Effect Reversal Hits Lower Socioeconomic Groups Hardest, 600K Study Finds
Cognitive test scores across entire populations have been declining in several wealthy nations after decades of gains —…
Nutrition
Online Food Delivery Widens China's Obesity Gap Along Socioeconomic Lines
The rapid digitization of food access may be quietly restructuring who gets sick and who stays healthy — and new large-…
Studies
Phase 1 Trial Shows SOD1-Targeting siRNA Conjugate Safe in ALS Patients
Amyotrophic lateral sclerosis remains one of the most devastating neurodegenerative diseases, and the SOD1-mutant subty…
Nutrition
Global Diet Homogenization Threatens Irreplaceable Immunity and Microbiome Data
Every decade, dozens of traditional food cultures quietly disappear into the gravitational pull of industrialized eatin…
Studies
Monoclonal Antibody L9LS Shows Strong Malaria Protection in Infants Under Two
For the millions of infants in sub-Saharan Africa living under year-round malaria pressure, existing tools—bed nets, se…
Studies
Blood Protein Patterns Signal Alzheimer's Risk Years Before Symptoms Emerge
The possibility of identifying Alzheimer's disease risk from a simple blood draw — years before any cognitive symptom a…
Studies
Blood Biomarker Panels Sharply Boost Dementia Detection Beyond Cognitive Testing Alone
Dementia diagnosis has long depended on a slow, resource-intensive funnel — cognitive screening in primary care, follow…
Supplements
Asp9Glu Mutation Yields Biased GLP-1/Glucagon Dual-Agonist with Enhanced Weight Loss
A single conservative amino acid substitution — replacing aspartate with glutamate at position 9 of glucagon and GLP-1…
Longevity
Spermine Chelates Fe²⁺ to Block Ferroptosis, Completing Polyamine Longevity Model
A new mechanistic framework resolves a long-standing paradox in polyamine biology: spermidine drives autophagy by inhib…
Nutrition
Exocrine Pancreatic Insufficiency: Clinical Diagnosis and Management Insights
Malabsorption disorders often evade early detection, and exocrine pancreatic insufficiency (EPI) is among the most comm…
Longevity
Five Decades of Alzheimer Prevention Research: Where the Science Now Stands
For the tens of millions of adults who carry genetic or lifestyle risk factors for Alzheimer's disease, the question of…
Nutrition
Ultra-Processed Food Consumption Tied to Mortality and Cardiometabolic Disease Risk
For decades, nutritional science has debated whether the danger in modern diets lies in specific macronutrients — fat,…
Studies
CGM Linked to Lower HbA1c and Mortality Risk in Type 2 Diabetes, But Access Gaps Persist
Continuous glucose monitoring has long been associated with tight glycemic control in type 1 diabetes, but its role in…
Studies
PM2.5 and Traffic Noise Linked to Hypertension Via Oxidative Stress Pathways
Hypertension is widely understood as a product of genetics, diet, and lifestyle — yet a growing body of evidence demand…
Nutrition
Daily Wholegrain Intake Above 90g Linked to 22% Lower Breast Cancer Risk
For the millions of women navigating breast cancer prevention, dietary choices remain one of the few modifiable levers…
Studies
Landfill Proximity Within 5 km Linked to Higher Airborne Microplastic Inhalation
For the millions of people living near municipal waste facilities, the air itself may carry an underappreciated respira…
Wellbeing
Biological Stress Load Moderates Mental Health Risk After Childhood Maltreatment
Understanding why some maltreated children develop serious psychiatric conditions while others remain more resilient ha…
Wellbeing
Acute Stress Linked to Lower Synaptic Density Across Psychosis Spectrum
Synaptic loss has long been suspected in schizophrenia, but identifying modifiable upstream drivers — ones that could b…
Studies
PET Imaging Maps Left-Lateralized Synaptic Loss Across Schizophrenia Brain Networks
Understanding where and why the schizophrenic brain loses synaptic connections has long eluded researchers — and that g…
Nutrition
Participatory Nutrition Workshops Linked to Positive Shifts in Children's Food Attitudes in Qualitative Study
When it comes to changing what children eat, knowledge alone rarely moves the needle. Traditional lecture-based nutriti…
Nutrition
Nine Dietary Compounds Mapped to Sleep Architecture and Circadian Biology
Sleep is increasingly recognized not as passive downtime but as an active biological maintenance window — and the compo…
Nutrition
Gut Bacteria's Fatty Acid Metabolites Block Candida Colonization via Three Distinct Mechanisms
For immunocompromised patients — transplant recipients, cancer patients on chemotherapy, ICU patients on broad-spectrum…
Supplements
Ergothioneine Restores Aging Circadian Clocks via NAD+ Redox Rescue
Ergothioneine (EGT), a sulfur-containing amino acid found in mushrooms and certain bacteria, dose-dependently restored…
Longevity
100-Year Bibliometric Analysis Maps Caffeine, Polyphenols, and Gut Microbiota as Core Alzheimer's Research Themes
A structured bibliometric sweep of 2,873 Scopus-indexed articles spanning 1911–2025 maps how coffee and tea research in…
Longevity
uPAR-Targeted Nanoparticles Deliver Dasatinib+Quercetin to Clear Senescent Fat Cells
Co-encapsulating dasatinib and quercetin — the canonical D+Q senolytic combination — into uPAR-targeted hybrid nanopart…
Studies
AUTAC-Lysosome Strategy Synergizes With Proteasome Inhibitors to Overcome Cancer Drug Resistance
One of the most stubborn problems in oncology is cancer cells that learn to survive the very drugs designed to kill the…
Nutrition
Chronic Xanthan Gum Intake Triggers Colon Inflammation and Microbiota Shifts in Rats
Xanthan gum appears in ingredient lists across thousands of packaged foods, gluten-free products, and clinical thickene…
Nutrition
Sarcopenia and Type 2 Diabetes Share Bidirectional Molecular Pathways Accelerating Muscle Loss
For aging adults managing blood sugar, muscle loss is not merely a side effect — it may be an active accelerant of meta…
Studies
Transcription Factor Drug Targeting: Why Cancer's 'Undruggable' Proteins May Yield
For decades, the proteins that control which genes get switched on or off inside cancer cells were considered essential…
Studies
FASN Overexpression Predicts Early Recurrence in Rare Peritoneal Cancer After Surgery
For one of the most difficult-to-treat abdominal cancers, identifying who will relapse early after aggressive combined…
Studies
Hybrid Graph-Transformer Model Advances Computational Drug-Target Binding Prediction
Every drug candidate that fails late in development represents years of research and hundreds of millions in wasted inv…
PREPRINTLongevity
79% Vitamin D Deficiency Found Alongside 58% Obesity in Kazakhstan Care Home Elders
Among 62 adults aged 60+ (mean age 74) residing in a state social-care facility in Astana, Kazakhstan, a striking cardi…
PREPRINTLongevity
Sex-Specific Protein Signatures Split HFpEF Into 2 Distinct Risk Groups
Applying Similarity Network Fusion to 92 circulating inflammatory proteins and 49 clinical variables in 698 HFpEF patie…