Studies
Silencing a Hidden Gene Switch Boosts KCNQ2 Potassium Channel Output
For families affected by neonatal epilepsy linked to KCNQ2 mutations, therapeutic options remain frustratingly…
Nutrition
Evidence-based findings on diet, micronutrients, and dietary patterns.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
Stevioside Activates YAP Pathway to Regenerate Liver Cells in Cholestasis
Liver diseases involving bile duct obstruction represent a serious and often underappreciated public health burden…
Nutrition
French Cadmium Exposure Runs 3–4x Above European Peers, Report Warns
Cadmium is not a compound most people think about at the dinner table, yet it accumulates silently in the kidneys and…
Longevity
Frail Elders With Psychiatric Comorbidities Gain Most From Lifestyle Mobility Interventions
Not all frail older adults respond equally to structured lifestyle programs — and knowing which subgroups benefit most…
Studies
Radiotheranostics Precision Cancer Targeting: Current Approvals and Pipeline Review
Precision oncology is entering a phase where the same molecular probe that finds a tumor can also destroy it — a…
Studies
Eplontersen Shows Benefit Only as Monotherapy in ATTR-CM Phase 3 Trial; No Added Benefit With Tafamidis
For the growing number of patients diagnosed with transthyretin amyloid cardiomyopathy (ATTR-CM) — a progressive and…
Studies
Vutrisiran Suppresses TTR Protein by 82–86% Across Diverse Amyloidosis Patients
For the estimated 50,000 people worldwide living with transthyretin amyloidosis — a progressive, often fatal disease…
Longevity
Gut Microbiota, IPA, and Plasma Tau Associated with Postoperative Delirium in Observational Study
Among 491 surgical patients aged ≥65 undergoing elective laminectomy or joint replacement, 10% developed postoperative…
Studies
Inclisiran Outperforms Statin Uptitration: 85% vs 31% LDL Goal Achievement
For the millions of high-risk cardiovascular patients who fail to reach guideline-recommended LDL cholesterol targets…
Studies
Pulmonary Nerve Ablation Shows Promise for Heart Failure Hypertension in Trial
For the millions of adults living with heart failure complicated by pulmonary hypertension, therapeutic options have…
PREPRINTLongevity
IHD Deaths Rising in West Africa Since 2007 as Global Rates Fall 38%
While global stroke and ischemic heart disease (IHD) mortality dropped 51.7% and 38.2% respectively between 1990 and…
PREPRINTLongevity
HDL-Remodeling Metabolite Pattern Linked to 17% Higher Dementia Risk in T2D Subtypes (medRxiv Preprint)
Among 7,671 UK Biobank participants with type 2 diabetes (mean age ~60), NMR-based metabolomic profiling across…
PREPRINTLongevity
80 MHz Benchtop NMR Quantifies Key Lipoproteins and Triglycerides in Serum, Reproducing Epidemiological Associations
A benchtop NMR spectrometer operating at 80 MHz — far less powerful than laboratory-grade 600 MHz instruments…
Studies
Peroxisome Loss Corrupts Insulin Integrity and Destabilizes Beta Cell Identity
Glucose dysregulation is typically blamed on insufficient insulin — but what if the insulin itself is structurally…
Studies
Ferritinophagy Dysregulation Drives Iron-Mediated Injury Across Four Major Organs
Iron is a paradox in human biology — essential for life yet lethal in excess. A newly published review in Autophagy…
Longevity
GLP-1 + Menopause HRT Combo for Weight Loss: Promising But Premature
An expert consensus from Spain's Menopause Society synthesized evidence on GLP-1 receptor agonists and dual incretin…
Studies
CRISPR Liver Edit Sustains ANGPTL3 Suppression in Cardiovascular Risk Trial
Permanently rewriting a single gene in the liver to lower cardiovascular risk has long been a theoretical aspiration…
Longevity
Mitochondrial DNA Leakage Into Oocyte Cytosol Fuels Ovarian Aging Via STING Pathway
Ovarian aging sets the biological clock for female fertility and hormonal health, yet its molecular drivers have…
Studies
Multi-Biomarker Wearables Could Reframe Cardiometabolic Disease Monitoring Beyond Glucose
Continuous glucose monitoring transformed diabetes management by turning a snapshot test into a living physiological…
PREPRINTLongevity
Combined TyG-Biological Age Score Triples Cardiometabolic Multimorbidity Risk in 8,767 Adults
Among 8,767 Chinese adults aged 45+ followed for a median of 108 months, combining the triglyceride-glucose (TyG)…
PREPRINTLongevity
Four AML Risk Genes Emerge from 170,000-Person Whole-Genome Biobank Scan
Whole-genome sequencing data from the All of Us Research Program, covering 265 AML cases and 169,706 controls…
Studies
Phase 3 Trial Tests RNA-Silencing Drug Against Fatal Heart Amyloid Disease
Transthyretin amyloid cardiomyopathy remains one of cardiology's most underdiagnosed and lethal conditions — a disease…
Nutrition
DASH Diet Cuts Heart Failure Risk 11% Independent of Cardiometabolic Mediators
Among 124,777 UK Biobank participants followed for 12 years, highest versus lowest adherence to the DASH diet was…
Studies
Thioredoxin-Deficient Rats Develop Progressive CKD via Mitochondrial Redox Failure
Chronic kidney disease silently erodes kidney function in roughly 10% of the global population, yet the causal chain…
Nutrition
Healthy Lifestyle by Age One Linked to 23–43% Lower IBD Risk
Inflammatory bowel disease is increasingly understood as a condition shaped not just by genetics but by the cumulative…
Studies
NHEJ Pathway Inhibition Unlocks p53-Driven Senescence in Chemo-Resistant Liposarcoma
Dedifferentiated liposarcoma represents one of oncology's more frustrating treatment puzzles: a rare, aggressive…
Studies
AI Language Model Predicts Antigen-Specific Antibodies Directly from Blood RNA Sequences
The ability to rapidly pinpoint which antibodies in a complex immune response will actually bind a target pathogen has…
Longevity
AI Digital Twins Could Personalize Nutrition Against Age-Related Muscle Loss
Sarcopenia's convergence with chronic multimorbidity represents a compounding mortality risk in aging populations, yet…
Studies
Enteric Disease Deaths Fell 60% Since 1990, But Child Mortality Targets Remain Elusive
Over a billion episodes of gut infection still occur every year, yet the story of the past three decades is one of…
Studies
Aficamten Wins Global Approval as Second Cardiac Myosin Inhibitor for HCM
For the roughly one in 500 adults living with hypertrophic cardiomyopathy, the treatment landscape has just gained a…
Nutrition
Plant-Based Diet Shifts May Raise Mycotoxin Exposure in Children
As plant-based eating continues its mainstream ascent, a largely overlooked hazard deserves closer attention: the…
PREPRINTStudies
Default MR Instrument Settings Produce Suboptimal Causal Estimates Across 3 Phenotypes
Using UK Biobank data across three phenotypically distinct exposures — circulating amino acids, BMI, and major…
PREPRINTStudies
Wealth Strongly Associated with 4x Higher Odds of Overweight/Obesity Among ~10,740 Congolese Women in 2023 DHS Analysis
Among 10,740 non-pregnant Congolese women aged 15–49 drawn from the nationally representative 2023 Demographic and…
PREPRINTNutrition
UK Dietitians Survey: MUST Inadequate for Mental Health and Learning Disability Inpatients
Across 47 UK dietitians surveyed from inpatient mental health and learning disability settings, the dominant…
Studies
AMPK's Heart Failure Role Proves Complex, Context-Dependent, Not Simply Protective
The assumption that boosting a cell's energy sensor automatically protects a failing heart is being seriously…
Studies
High-Dose Folate Raises Cell-Culture Alarm But Not Real-World DNA Damage
For the many patients prescribed high-dose folic acid for blood disorders — and for the general population routinely…
Studies
Golgi Zinc Transport Defect Links SPAST Mutation to Alzheimer-Like Neurodegeneration
A molecular mechanism connecting a common hereditary spastic paraplegia mutation to Alzheimer's-like brain changes has…
Nutrition
Mediterranean Diet Linked to Reduced IBD Inflammation Across 1,615 Patients
For the estimated 10 million people worldwide living with ulcerative colitis or Crohn's disease, dietary choices…
Studies
Gestational PFBS Exposure Linked to Placental PI3K-Akt Pathway Changes and Offspring Anxiety-Like Behavior in Rats
Emerging evidence that the placenta functions as a neurological gatekeeper — not merely a nutrient conduit — has…
Nutrition
GLP-1 Drugs Shrink Fat and Muscle: What 2025 Evidence Says
Both semaglutide and tirzepatide produce substantial lean body mass (LBM) reductions alongside fat loss, yet this…
Nutrition
GLP-1 Trials Omit Diet Data: Ethical Blind Spot Undermines 4 Core Principles
Landmark GLP-1 receptor agonist trials — including those establishing semaglutide and tirzepatide as transformative…
Longevity
Implanted Muscle Grafts Reverse Aging Markers in Mice Without Exercise
Subcutaneous transplantation of autologous, differentiated myocytes — termed myografts — produced continuously…
Supplements
Omega-3, D3, and K2 Share Overlapping Mechanisms Across Heart, Brain, and Bone
A structured narrative review synthesizing evidence from PubMed, Embase, Cochrane, and Web of Science proposes a…
Longevity
Rapamycin Cuts AF Risk via mTOR-Independent HIF-1α Suppression in Aging Hearts
In a D-galactose-accelerated aging mouse model, rapamycin administered via dietary supplementation significantly…
Nutrition
Blood Metabolomics Reveals 43 Validated Biomarkers Linking Ultra-Processed Foods to CVD Risk
Understanding precisely how ultra-processed foods (UPFs) damage the cardiovascular system has long been the missing…
Studies
Random Amino Acid Repeats Can Access Stable Folded Protein Structures
Understanding how functional proteins first arose from a primordial soup of random chemistry is one of biology's…
Studies
Tmem117 in Oligodendrocytes Links Myelin Homeostasis to Counterregulation and Metabolic Health in Mice
The assumption that metabolic disease originates exclusively in peripheral tissues like the liver, muscle, or adipose…
Studies
Hidden TB Enzyme Sustains Alternative Metabolic Pathway Critical for Survival
Understanding how Mycobacterium tuberculosis persists inside human immune cells despite decades of antibiotic…
Fitness
Sprint vs. Moderate Exercise Elicit Distinct Protein Signals Associated with Cardiometabolic Health
How hard you exercise may matter as much as how long — and the molecular reasons why are finally coming into focus…
Nutrition
Emerging Review Highlights Gut-Eye Axis and Omega-3s in Dry Eye: Evidence Remains Preliminary
Dry eye disease affects an estimated 344 million people globally, yet clinical management has long focused narrowly on…
Studies
CAR T Cell Therapy Shows Clinical Improvement and Remission in Some Patients with Refractory Rheumatoid Arthritis in Phase 1 Trial
Autoimmune disease treatment may be entering a fundamentally new era. For the millions of rheumatoid arthritis…
Studies
HAL Spectacle Lenses Cut Myopia Progression 71% in US Children Over 24 Months
With myopia rates climbing steeply in Western countries, the absence of proven non-pharmacological interventions for…
Studies
Vutrisiran Linked to Cardiac Amyloid Reduction Visible on MRI Over Three Years
Transthyretin amyloid cardiomyopathy has long been treated as a condition of damage control — slowing an inevitable…
PREPRINTLongevity
Graph Neural Networks Hit AUC 0.82 Predicting Post-MI Heart Failure from Proteomics
A graph neural network (GNN) framework integrating plasma proteomics, clinical variables, and molecular…
PREPRINTNutrition
Personalized Meal Timing Cuts 2.1 kg in 6 Weeks—No Diet Required
Adults randomized to personalized meal schedules—derived from two weeks of app-based dietary records—lost 2.10 kg more…
Longevity
Sarcopenia Diagnosis Hinges on Grip Strength, Not Mass Alone
Sarcopenia—progressive loss of muscle strength, mass, and physical performance—is increasingly prevalent in aging…
Longevity
Exercise Modality and Timing Post-Menopause May Influence Alzheimer's Risk via BDNF and Brain Structure Pathways
Women comprise nearly two-thirds of Alzheimer's diagnoses, and the menopausal transition emerges as a discrete…
Studies
Neutrophil Protein Vgll4 Blocks Tumor-Driven Immune Suppression via STAT Pathway
Understanding why the immune system fails to eliminate tumors is one of cancer biology's central puzzles — and a new…
Studies
JNK Inhibitors Show Promise Against Endometriosis Pain in Preclinical Models
Endometriosis affects roughly one in ten women of reproductive age globally, yet treatment options remain stubbornly…
Studies
USP14-FBXW7 Protein Rivalry Drives Drug Resistance in Head-Neck Cancer
Drug resistance remains the dominant reason curative intent fails in head and neck squamous cell carcinoma (HNSCC)…
Studies
Conserved KAT2–PGK–ALDO Cascade Amplifies Glycolysis Under Cellular Energy Stress
When cells run low on energy, their survival depends on rapidly upshifting glucose metabolism — and how they…
Longevity
Hsp70 Chaperone Partners Show Stress-Selective Binding That Shapes Cellular Protein Quality Control
Protein quality control is one of the most consequential yet underappreciated pillars of healthy aging. When cells…
Nutrition
Domestication Erased Key Flavor Genes From Modern Tomatoes, PNAS Study Reveals
For anyone who has noticed that supermarket tomatoes taste oddly flat compared to heirloom or garden-grown varieties…
Studies
Tumor Bacteria Enhance MR1 Expression and MAIT Cell Activation in Lung Cancer
The immune system's ability to recognize and destroy cancer cells depends heavily on the molecular signals that summon…
Studies
RNA Methylation Checkpoint PCIF1 Controls T Cell Tumor Immunity via STAT1
Understanding why some immune responses against tumors succeed while others stall has been a central challenge in…
Studies
Single-Cell HIV Reservoir Mapping Reveals Proviral Landscape During ART
One of the most stubborn obstacles to curing HIV is not the virus itself in active circulation, but the silent…
Nutrition
Men Perceive Weight Loss Culture as Female-Centric, Hindering Sustainable Change
The persistent gap in men's engagement with structured weight management programs has real consequences for population…
Nutrition
Dietary Arginine Controls Immune Tumor Recognition Via Codon-Dependent MHC-I Translation
The idea that what we eat could directly reshape whether our immune cells recognize tumors or clear viruses has long…
Nutrition
Colorless Tomato Compound Phytoene Fights Fatty Liver Via Enzyme-Dependent Pathway
Fatty liver disease now affects roughly one in four adults globally, yet dietary strategies beyond general caloric…
Studies
Seven-Protein Plasma Panel Outperforms Standard Markers in Vasculitis Remission Detection
For patients with a rare but life-threatening autoimmune disease, one of the most consequential clinical questions is…
Longevity
Centenarian Offspring Show Delayed Disease Onset and Lower Mortality Risk Across Three Cohorts
The inheritance of healthy aging may be more powerful — and more measurable — than previously appreciated. Most…
Studies
Low-Dose Lithium Shows Multi-Pathway Neuroprotection Across 25 Years of Evidence
For decades, dementia research has fixated on single-target therapies — clearing amyloid plaques or silencing tau…
Studies
Buprenorphine Shows Promise Managing 7-Hydroxymitragynine Dependence in Small Clinic Series
As purified kratom alkaloid products proliferate in supplement markets, clinicians are encountering a novel dependence…
Longevity
Gut-Derived Succinate Drives Alpha-Synuclein Aggregation Via mTORC1 Pathway
The idea that Parkinson's disease begins in the gut has gained substantial traction over the past decade, but…
Studies
Synthetic Peptide K16ApoE Ferries Large Proteins Across Blood-Brain Barrier
One of the most stubborn obstacles in neurology is not finding the right drug — it is getting any drug into the brain…
Studies
Mitochondrial Signatures, Not Lewy Body Structure, Distinguish Parkinson's from DLB in Postmortem Study
Understanding why two diseases built on the same misfolded protein — α-synuclein — produce such different clinical…
Studies
Lipid Management Shifts Beyond LDL: Lp(a), ApoB, and RNA Therapies Reshape ASCVD Prevention
For decades, LDL cholesterol was the near-exclusive target of cardiovascular prevention — but a growing body of…
Longevity
Evolutionary Mismatch Drives 30-Year Estrogen-Deficiency Window in Modern Women
Evolution shaped menopause for ancestral environments where post-reproductive survival lasted only a few years — not…
Longevity
Gut Bacterium B. pseudocatenulatum and Metabolite 5-AVAB Extend Healthspan via Inflammaging Suppression
A microbiome aging clock (MicroAge) built from enterotype-specific gut microbial shifts across multiple Chinese…
Studies
GLP-1 Agonists Cut 7.7 kg and ESR in Rheumatology Patients Over 12 Months
In 119 rheumatology outpatients with high cardiometabolic burden (mean BMI 34.9 kg/m², 96.6% diabetic), GLP-1 receptor…