Nutrition
Mediterranean Diet at 70: Dementia Signal in Men Fades After Correction
In 1,298 Swedish 70-year-olds followed up to 20 years, a higher Mediterranean Diet Score (eight food groups, alcohol…
Nutrition
Evidence-based findings on diet, micronutrients, and dietary patterns.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Nutrition
Blueberries Lift Anterior Cingulate Blood Flow 7% but Leave Brain Glutathione Unchanged
In a double-blind, placebo-controlled trial, 60 adults aged 65-89 with low berry intake consumed freeze-dried…
PREPRINTStudies
Schooling's Link to Cognitive Decline Flips Sign Across India's States
Among 2,510 Indians aged 60 or older assessed twice (2017-2019 and 2022-2024) in the HCAP/LASI cohort, the link…
PREPRINTWellbeing
Later Bedtimes Track With Worse DASH and HEI Diet Scores
In 106 emerging adults (median age 22) wearing actigraphy monitors, later sleep midpoint and bedtime independently…
PREPRINTStudies
Obesity Raises Nighttime Glucose 6 mg/dL Even When Averages Match
Across 261 matched pairs from the AI-READI cohort, lean adults and adults with obesity shared nearly identical mean…
Studies
GLP-1 Drugs Cut Heart, Kidney Risk 27-47% But Raise Osteoarthritis 48%
Across five University of California medical centers, 70,982 propensity-matched adults with type 2 diabetes starting a…
Studies
Fatty Liver Alone Didn't Predict Poorer Cognition; Metabolic Risk Factor Count Did
In 1,387 NHANES participants aged 60 and older, MASLD (hepatic steatosis index ≥36 plus a cardiometabolic risk factor)…
Studies
Metabolic Syndrome, HOMA-IR, hs-CRP, ApoB Show No Breast Cancer Link in 99,648 Korean Women
Across 99,648 Korean women (91.3% premenopausal) followed a median 7.75 years, 1,094 developed breast cancer…
PREPRINTStudies
Advanced Cardiovascular-Kidney-Metabolic Syndrome Speeds Cognitive Decline; Social Isolation Drives 7% of Risk
Across 28,242 older adults from international aging cohorts followed for roughly 5 to 6.5 years, advanced…
PREPRINTStudies
Calorie-matched high-fat diet normalizes mouse weight but leaves visceral fat inflamed
In male C57BL/6 mice (n=8/group) fed a high-fat diet (HFD) for 12 weeks, limiting intake to match low-fat-fed animals…
Studies
mHealth Diet Apps for Kidney Disease: Weak Evidence, No Proven Benefit in Dialysis
A systematic review of 23 studies on mobile health nutrition interventions in adults with chronic kidney disease…
Nutrition
Top Ultra-Processed Food Quintile Carries 28% Higher Fatty Liver Odds in Koreans
Among 11,168 adults in the 2016-2019 Korea National Health and Nutrition Examination Survey, those in the highest…
Studies
Gluten-Free Diet in Celiac Disease: Fatty Liver Signal, But Not Proven
In 85 non-diabetic adults, 32.5% of long-term gluten-free-diet (GFD) patients with celiac disease had CAP-defined…
Studies
Gastric Bypass Cuts Diabetes Relapse Risk 33% Versus Sleeve Gastrectomy
Across nine studies and 24,228 patients with obesity and type 2 diabetes who first achieved remission, Roux-en-Y…
Nutrition
8-Week Ketogenic Diet Cuts Liver Fat and Stiffness in 55 Adults
Fifty-five adults with obesity and MASLD followed an 8-week very-low-calorie ketogenic diet (VLCKD) and were assessed…
Studies
43% Restart Diabetes Drugs After Bariatric Surgery; Baseline Severity Predicts Who
In a retrospective cohort of 2,056 adults with type 2 diabetes who reached at least 90 days medication-free after…
Studies
Semaglutide's Cardiometabolic Benefits Held Across Frailty Levels, Easing a Key Prescribing Worry
Frailty is often the quiet reason older or medically complex adults are passed over for newer cardiometabolic drugs…
Nutrition
Ultra-Processed Food Linked to 12% Higher Myeloid Cancer Risk
Across 204,494 UK Biobank participants followed a median 10.5 years, each 1-SD increase in the share of energy from…
Nutrition
Intact Whole Grains Cut HbA1c 2.2 mmol/mol More Than Milled
In a 12-week randomised trial of 160 adults with type 2 diabetes (mean HbA1c 56.4 mmol/mol), participants received…
Studies
More Sleep, Less Sitting Linked to 14% Lower Liver Stiffness in MASLD
In 1,080 US adults with steatotic liver disease (NHANES 2017-2018), compositional analysis of sleep, sedentary time…
PREPRINTNutrition
DHA Supplements Shut Down Your Body's Own DHA Production, Randomized Trial Shows
In a double-blind trial, 72 vegans and non-seafood-eating vegetarians took 0 to 1,000 mg/d of algal DHA for 8 weeks…
PREPRINTStudies
Body Fat Drives CRP Inflammation: 3,213-Trait Mendelian Study
A two-sample Mendelian randomisation analysis tested 3,213 molecular, physiological and disease traits for causal…
Fitness
Digital Commitment Devices Add 665 Daily Steps and 1.9 kg Weight Loss
Across 29 randomised trials (7,534 adults with cardiometabolic risk factors), digital commitment devices, tools that…
Studies
Muscle Mass Predicts Strict Diabetes Normalization After Bariatric Surgery, Not Standard Remission
In 70 Korean adults with type 2 diabetes and BMI ≥27.5 who underwent gastric bypass or sleeve gastrectomy, 80% met…
Fitness
12 Weeks of Lifting Boosts Breathing Strength and Klotho in Seniors
In a randomized trial of 60 community-dwelling adults aged 60-75, 12 weeks of supervised resistance training (three…
PREPRINTStudies
Oral Yeast-Delivered GLP-1/GIP Agonist Fails to Cut Weight in 12-Week Trial
Engineers modified Saccharomyces cerevisiae to produce pro-DALAP, a precursor of a dual GLP-1/GIP receptor agonist…
Studies
MASLD Subtype Predicts Who Responds to 48-Week Lifestyle Change
In 618 MASLD patients following 48 weeks of guideline-based lifestyle management, metabolic-cluster subtypes…
Supplements
Dendrobium Compound Gigantol Shields Mouse Kidneys From Diet-Induced Damage via TFEB
In mice fed a high-fat, high-fructose diet, gigantol, a bibenzyl compound from Dendrobium orchids, restored kidney…
PREPRINTStudies
Beta-Carotene Heart Benefit Vanishes After Bias Adjustment Across RCTs, MR, Observational Data
Pooling five randomized trials, one Mendelian randomization study and thirteen conventional multivariable regression…
PREPRINTNutrition
Refined Inulin Raised Mouse Colon Tumor Incidence to ~70% Versus 10-20%
In mice given eight azoxymethane injections over 28 weeks, a 7.5% refined inulin diet produced colon tumors in roughly…
Nutrition
Nuts and Kidney Health: Promising Signals, But Evidence Stays Observational
A systematic review of observational studies and cohort analyses finds that higher nut consumption, and especially…
Studies
Quitting Alcohol After Breast Cancer Didn't Cut Death Risk in 1,558 Women
Among 1,558 postmenopausal women with non-metastatic breast cancer (mean age 71) from the Cancer Prevention Study-II…
Longevity
LSD at Nanomolar Doses Extends Worm Lifespan 17.6% via Serotonin Receptors
Chronic exposure to nanomolar lysergic acid diethylamide extended lifespan in the roundworm Caenorhabditis elegans by…
Studies
Self-Management Program Fails to Shift Diet or Urinary Markers in 266 CKD Adults
In a secondary analysis of a randomized trial of 266 low-income adults with early-to-moderate chronic kidney disease…
Nutrition
248 Studies Back Protein, Vitamin D and Mediterranean Diets Against Muscle Loss
A pre-registered PRISMA/SWiM synthesis of 248 studies (100 RCTs, 62 cohorts) in adults 60 and older found the most…
PREPRINTStudies
Smoking Carries 3.4x Peripheral Artery Disease Odds; Kidney Signal Falters
Among 3,268 US adults aged 40 and older with ankle-brachial index testing (NHANES 1999-2004, 235 with peripheral…
PREPRINTStudies
Sleep Apnea Severity Maps to Cardiometabolic Disease Across 222,109 Adults
Across 222,109 adults who underwent diagnostic sleep testing in Kaiser Permanente Southern California, apnea-hypopnea…
PREPRINTStudies
Diet plus exercise in your 20s-40s: 21.7-fold odds of high midlife heart health
Among 2,806 CARDIA participants followed from roughly age 25 to 60, those who combined a high-quality DASH-style diet…
Nutrition
Pro-Inflammatory Diets Linked to 23% Higher Death Risk in Kidney Disease
Among 7,113 US adults with chronic kidney disease in NHANES (2005-2018), those in the highest quartile of the dietary…
PREPRINTStudies
CGM Data From 716 Women Links PMOS to Higher Glucose Exposure
Across 247,316 continuous glucose monitoring days from 716 Apple Women's Health Study participants, women with…
PREPRINTStudies
Pulsatile FXR Agonist Linafexor Doubles Semaglutide Weight Loss in 62 Adults
Adding linafexor, a pulsatile oral FXR agonist (4 mg daily), to low-dose semaglutide (0.5 mg weekly) produced 6.17%…
Studies
Bariatric Surgery Delivers 58% Diabetes Remission Over 11 Years; Duration Predicts Who Succeeds
In the 14-year ARMMS-T2D follow-up of 262 adults with type 2 diabetes (mean BMI 36.4, HbA1c 8.5%), 58% randomized to…
Nutrition
Dietitian Education Cuts Systolic Pressure 6 mmHg in Kidney Disease
Across eight randomised trials (1,204 participants with chronic kidney disease stages 3a-5), dietitian-delivered…
PREPRINTStudies
Women Show Higher LDL-C and Lower Statin Use Than Men
In the All of Us Research Program, women had higher median LDL-C than men across most age strata, with the gap widest…
Studies
Two Probiotic Strains Protect Rat Livers Through Complementary Cholesterol and Antioxidant Routes
In rats fed a high-fat, high-cholesterol diet, two Lactiplantibacillus plantarum strains, LP5 and BX62, given alone or…
Supplements
Heat-Killed L. plantarum MYO Lifts Grip and Leg Strength in 12 Weeks
In a placebo-controlled trial of older adults with reduced muscle strength, 12 weeks of heat-treated…
Studies
78 Trials, 8,452 Adults: Which Exercise-Diet Combos Best Fix Metabolic Syndrome?
Across 78 randomized trials (8,452 adults with metabolic syndrome and overweight or obesity), every structured…
Supplements
Angelica keiskei Chalcone Clears Fatty Liver in Mice via TFEB
In male C57BL/6N mice fed a fast-food diet for 15 weeks, then dosed daily for 9 more weeks with an Angelica keiskei…
PREPRINTFitness
Free Testosterone Reshapes Muscle Gene Activity, Not Mass or Strength, in 81 Men
In 81 healthy men aged 18 to 80, free testosterone fell with age, as did muscle mass and leg press strength. Yet…
PREPRINTFitness
Knee Osteoarthritis Muscle Holds 45% More Collagen and Blunts MMP2/9 Response to Lifting
Adults with moderate-to-severe knee osteoarthritis had weaker knee extensors, poorer muscle quality, and more…
Fitness
Treadmill Running Beats Enalapril at Calming Fatty-Liver Inflammation in Obese Mice
In obese mice, 8 weeks of treadmill running (300 min/week) and the ACE inhibitor enalapril (10 mg/kg/day) each cut…
Supplements
2 g/Day Plant Sterols Fail to Lower LDL in Obesity Trial
In a double-blind crossover trial of 23 adults with overweight or obesity (mean BMI 36.4) and mild…
PREPRINTLongevity
Frailty Raises Risk of 458 Diseases and Doubles Multimorbidity Pace
Across 466,864 UK Biobank participants followed a median 13.8 years, Fried-phenotype frailty was linked to higher risk…
PREPRINTStudies
Type 2 Diabetes Remission Rare and Brief: 4% in Treated Adults, Median 226 Days
Across 136,781 US adults with confirmed type 2 diabetes in linked health records, remission (two HbA1c readings below…
Nutrition
Jabuticaba Peel Extract Shields Mouse Kidneys From High-Fat, High-Fructose Damage
In 50 male C57BL/6 mice fed a high-fat, high-fructose diet for 12 weeks, early renal damage appeared: more vascular…
Supplements
Curcumin Cuts Liver Fat in Rats by Suppressing a Gut Microbe
A meta-analysis of seven clinical studies found curcumin supplementation lowered serum aminotransferases in people…
Studies
Fatty Liver Raises Death Risk 28-70% Across Two Million Koreans
Among 2,049,641 Korean health-checkup participants, fatty liver (Fatty Liver Index ≥30) raised all-cause mortality in…
Nutrition
Japanese-Style Diets Cut All-Cause Death 12%, But Not Cancer Mortality
Pooling three independent Japanese cohorts (five analytic estimates per outcome), adherence to predefined…
Nutrition
Extra Leucine or Protein Added No Benefit to 28-Day Fasting Diet
Sixty-one older men (BMI ≥ 23) completed 28 days of alternate-day fasting, randomized to calorie-matched supplements…
PREPRINTStudies
Intermittent Fasting Extends Lifespan in Brain-Injured Fruit Flies, Cutting Neural Inflammation
In fruit flies subjected to repetitive mild traumatic brain injury, two intermittent fasting regimens produced longer…
PREPRINTStudies
Glucose Swings Peak in Late Luteal Phase; Mean Glucose Stays Flat
Among 209 naturally cycling women without diabetes (mean age 43, BMI 24.3) wearing continuous glucose monitors for up…
Nutrition
Folate plus B12 and omega-3 lead 12-study scoping review on cognition
A scoping review screened 803 records and kept 12 studies (8 randomised trials, 3 cohorts, 1 open-label trial) testing…
Studies
6.2 Million Koreans Tracked: Alcohol Raises Risk Across Dozens of Diseases
Across 6,214,569 disease-free Korean adults followed from 2006-2009 through 2022, alcohol intake rose with risk for…
Studies
Sleeping 4 Hours or Less Raises MASLD Odds 44% in Koreans
Across 26,909 Korean adults in the 2014-2021 national nutrition survey, 23.2% had metabolic dysfunction-associated…
Supplements
Calcium Supplements Modestly Cut Fractures Across 286,584 Adults, But Not Hip Breaks
An umbrella review of 22 meta-analyses, covering 69 unique primary studies and 286,584 adults, found that calcium…
PREPRINTNutrition
Diverse Diets Linked to Lower Blood Pressure, Stronger Grip in Ghanaian Elders
Among 200 Ghanaians aged 60 and over (mean 69.8 years), dietary inadequacy was widespread: more than half fell short…
PREPRINTFitness
Beetroot Juice Nitrate Fails to Speed Muscle Force Development in Young Adults
A single 200 μmol/kg nitrate dose from beetroot juice left rate of torque development unchanged versus a nitrate-free…
PREPRINTStudies
Muscle androgen receptor expression falls 4.4% per decade across 364 men
Pooling 16 public RNA-seq datasets (364 healthy men aged 18-92), a new R pipeline called MetAR found androgen receptor…
Studies
Cannabigerol Boosts Muscle Power 87% Beyond Exercise Alone in Mice
In mice given dexamethasone (20 mg/kg for 12 days) to induce muscle wasting, a 4-week ladder-climbing resistance…
Nutrition
Mediterranean Diet Alone Fails to Reliably Cut Weight After Menopause
A systematic review of PubMed, Embase, and Cochrane records through January 2026 found only three eligible studies…
PREPRINTStudies
Better Life's Essential 8 Scores Track Lower Brain Small-Vessel Damage Across Ethnic Groups
In a cross-sectional analysis of 44,982 adults (with a 1,426-person matched MRI subsample), each standard-deviation…
PREPRINTStudies
High Blood Pressure Variability Plus Diabetes Raises Mortality Risk 2.8-Fold in 57,611 Adults
Among 57,611 UK Biobank participants followed a median 5.1 years, people with type 2 diabetes and high systolic blood…
PREPRINTNutrition
Low-Carb Coaching Plus Tirzepatide: 19.7% Weight Loss vs 15.6% in 4,269 Adults
In a retrospective cohort of 4,269 adults in a telemedicine obesity program, those receiving individualized…
Studies
Patients With Type 2 Diabetes Rank A1c and Heart Protection Above Weight Loss
Across 34 studies and 15,656 adults with type 2 diabetes, patients consistently ranked glycaemic efficacy…
Fitness
Midlife Exercise Linked to 20% Fewer Memory Complaints Three Decades Later
Among 4,397 women in the NYU Women's Health Study (mean age 46 at baseline, 79 at follow-up), those in the top tertile…
Studies
SGLT2 Inhibitors Cut Heart Failure Hospitalization 29% and Kidney Events 31% in Diabetes
Pooling 14 placebo-controlled trials (76,969 adults with type 2 diabetes), SGLT2 inhibitors lowered the composite of…
PREPRINTFitness
Handgrip Strength Adds Nothing Beyond Body Fat Scans for Cardiometabolic Risk
Among 1,124 U.S. adults aged 40-59 from NHANES (508 for development, 616 for temporal validation), adding DXA body fat…
PREPRINTFitness
60-90 Minutes of Weekly Vigorous Exercise Linked to 35% Lower Hip Fracture Risk
Across 16 years of follow-up in 324,284 UK Biobank adults aged 40-65, 2,674 hip fractures occurred. Middle quintiles…
PREPRINTStudies
Obesity Beyond 25 Years Raises Heart Strain Markers by Age 62
In 4,901 members of the 1958 British birth cohort, 26.3% experienced obesity at some point between ages 7 and 62. Ever…
PREPRINTStudies
56,754 Adults in a Digital Diabetes Program Show Durable Glycemic Gains Over Five Years
Across 56,754 adults with type 2 diabetes in Teladoc's remote monitoring program (2021-2025), estimated A1c from…