Fitness
Exercise Modulates Gut Microbiota to Strengthen Bones Through Gut-Bone Axis
Exercise strengthens bones not just through mechanical loading but by fundamentally altering gut microbiota composition…
Longevity
Latest research on aging, lifespan extension, and healthspan optimization.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Supplements
Dual Polyphenol Micelles Achieve 98% Encapsulation Efficiency for Enhanced Bioavailability
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency…
Fitness
Resistance Training Reduces Brain Age by 2.3 Years in Adults
Resistance training reversed functional brain aging by 1.4 to 2.3 years in healthy adults, based on brain clock models…
Longevity
Prevotella corporis Bacteria Activates Hsp70 Protection Against Protein Aggregation
Prevotella corporis, a specific gut bacterium, uniquely activates the host's heat shock response and induces Hsp70 mole…
Longevity
Obesity and Gut Dysbiosis Drive Alzheimer's Neuroinflammation via Blood-Brain Barrier
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia towa…
Longevity
Surgery-Induced Cognitive Decline Shares Alzheimer's Pathways in Elderly
Postoperative cognitive dysfunction affects elderly surgical patients through neuroinflammation, blood-brain barrier di…
Longevity
Resveratrol Stabilizes PER2 Clock Protein in Fetal Heart Cells
Resveratrol increases stability of the PER2 clock protein in both fetal cardiomyocytes and cardiac fibroblasts, shiftin…
Longevity
GLP-1 Receptor Agonists Show Promise as 'Pharmacological Exercise' Against Neurodegeneration
GLP-1 receptor agonists like semaglutide and liraglutide demonstrate multiple neuroprotective mechanisms in preclinical…
Longevity
Blast Exposures Accelerate Neurological Aging in Laboratory Model Study
C. elegans nematodes exposed to controlled shock waves mimicking explosive blasts developed immediate neurological defi…
Wellbeing
Frontal Brain Activity Patterns Reveal OCD Cognitive Control Deficits
Brain imaging reveals that obsessive-compulsive disorder involves disrupted activity patterns in the rostrolateral pref…
Studies
Salivary Oxidized Fats Signal Early Cognitive Decline in Aging Adults
Analysis of saliva, plasma, and fecal samples from older adults with mild cognitive impairment revealed distinct lipid…
Longevity
Genetics Determines Intermittent Fasting Benefits Across 10 Mouse Strains
Two-day weekly intermittent fasting produced dramatically different longevity and metabolic outcomes across 10 genetica…
Longevity
Family Deaths Don't Shorten Telomeres Despite Increasing Mortality Risk
Tracking 4,837 older adults for 14 years, researchers found that experiencing multiple family deaths significantly incr…
Longevity
B-Vitamins May Protect Aging Brain Through Gut Microbiome Modulation
Low B-vitamin status—particularly B6, B12, folate, and riboflavin—correlates with cognitive dysfunction and dementia in…
Longevity
Akkermansia muciniphila reduces Alzheimer's amyloid plaques via tryptophan pathway
Akkermansia muciniphila administration in transgenic Alzheimer's mice reduced amyloid-beta plaques and improved cogniti…
Longevity
Dual Nano-Switches Cut Osteoarthritis Inflammation 73% in Rat Models
Scientists engineered a dual nanomedicine platform targeting both senescent fibroblasts and inflammatory macrophages in…
Studies
PCR Detects 480% More Aeromonas Cases Than Traditional Culture Methods
Analysis of 90,291 stool samples from symptomatic patients revealed dramatic differences in pathogen detection between…
Studies
New Zealand TBI Claims Jump 49% While Population Grows Only 9%
Analysis of New Zealand's national injury database reveals traumatic brain injury claims surged from 745 to 1,028 per 1…
Studies
AI Debriefing Tools Show Promise for Medical Simulation Training Enhancement
Medical simulation training received AI-powered enhancement through automated analysis of team communications during hi…
Longevity
Gut-Heart Axis Emerges as Key Regulator of Cardiac Hypertrophy Pathways
Multiple interconnected molecular pathways govern cardiac hypertrophy, including PI3K-Akt-mTOR, MAPK signaling, and AMP…
Studies
PARP Inhibitors Induce Reversible Senescence via Chk2-p21 Pathway in Pancreatic Cancer
PARP inhibitors olaparib and niraparib trigger cellular senescence in pancreatic cancer cells through the Chk2-p21 path…
Studies
CXCR2 Receptor Controls Head and Neck Cancer Radiotherapy Resistance
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed d…
Longevity
Senescent Cells Show Cancer Plasticity Through SASP Molecular Switches
Senescent cells exhibit a paradoxical dual nature in cancer biology, initially protecting against tumor formation throu…
Longevity
Mathematical Model Predicts Senolytic and Stem Cell Therapy Efficacy
Researchers developed a comprehensive mathematical model integrating DNA damage repair, senescence, quiescence, apoptos…
Longevity
Engineered IMD-CBM Peptide Degrades CAV1 Protein, Reduces Atherosclerotic Plaques
Researchers engineered a synthetic IMD-CBM peptide that selectively triggers autophagy to degrade CAV1 (caveolin 1), a…
Supplements
Coconut Compound 4,4'-Diapophytofluene Outperforms Quercetin in Anti-Aging Protein Binding
Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger bindin…
Longevity
Senescent Cells Drive Lung Cancer Resistance Through SASP Immune Remodeling
Senescent cells in lung tumors actively reshape immune responses through their senescence-associated secretory phenotyp…
Longevity
Six Drug Strategies Target Neuroinflammation Pathways Driving Brain Aging
This comprehensive review identifies neuroinflammation as the central mechanism connecting normal brain aging to pathol…
Nutrition
Combined Supply-Demand Fish Intervention Quadruples Consumption in Malnourished Rural Communities
Fish-aggregating devices paired with behavioral messaging produced dramatic consumption increases in Timor-Leste villag…
Studies
Cardiovascular Disease Burden Rises 40% Globally Despite Prevention Efforts
Disability-adjusted life years from cardiovascular disease climbed from 320 million in 1990 to 437 million in 2023, rep…
Longevity
Estrogen Decline During Menopause Accelerates Alzheimer's Pathology in Women
Research demonstrates that menopausal estrogen withdrawal triggers accelerated accumulation of amyloid-beta plaques and…
Wellbeing
Dental X-Ray Guidelines Emphasize Risk-Benefit Assessment Over Routine Imaging
Updated dental radiography protocols now emphasize individualized risk assessment rather than standardized imaging inte…
Studies
Talazoparib Cancer Drug Triggers Harmful Cellular Aging Through PARP1 Pathway
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among te…
Longevity
Sulforaphane and Metformin Extend Male Worm Fertility While Other Compounds Only Boost Lifespan
C. elegans research reveals a crucial distinction between living longer and aging well. While seven tested compounds un…
Nutrition
Anthocyanins Restore Gut Microbiome Balance While Suppressing Inflammatory Cytokines
Anthocyanin compounds from berries demonstrate dual therapeutic potential by simultaneously rebalancing gut microbiota…
Longevity
Single Toxin Event Creates Disease Risk Across 20 Generations
Exposure to environmental toxins creates heritable epigenetic changes that persist for approximately 500 years through…
Studies
Microglia Gene Changes in Amygdala Link to Chronic Pain Development
Analysis of 304 postmortem brains revealed distinct gene expression patterns in chronic pain sufferers, with over 2,000…
Studies
Brain Atlas Maps 10 Million Oligodendrocytes Controlling Neural Processing Speed
Researchers have constructed a comprehensive cellular atlas documenting approximately 10 million oligodendrocytes—speci…
Studies
New Fluorescent Dye Trodusquemine Enables Detailed Myelin Imaging in Cleared Tissues
Researchers developed HELF (High Efficiency Labeling of Fibers), a protocol using the fluorescent aminosterol trodusque…
Wellbeing
Neural Networks Toggle Between Continuous Processing and Event Boundaries
Cognitive neuroscience has identified distinct neural mechanisms that allow the brain to simultaneously maintain experi…
Studies
Heart Toxicity Mechanism in Cancer Immunotherapy Potentially Solved
Cardiac toxicity emerges as a critical limitation for immune checkpoint inhibitors like pembrolizumab and nivolumab, wi…
Longevity
Liver enzyme GPLD1 restores memory by targeting brain blood vessels
The liver-produced enzyme GPLD1, released during exercise, can restore memory function in aged brains by modulating bra…
Longevity
Cardiovascular Disease Burden Climbed 37% Globally Despite Age-Adjusted Rate Improvements
Cardiovascular disease now accounts for 437 million disability-adjusted life years worldwide, representing a 1.4-fold i…
Studies
Embryonic Stem Cell Therapy Shows Motor Improvements in Parkinson's Trial
Twelve Parkinson's patients received transplants of dopamine-producing cells derived from human embryonic stem cells, w…
Studies
c-Abl Kinase Inhibitor Risvodetinib Shows Safety Profile in Early Parkinson's
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week…
Longevity
Periodontal Disease Accelerates Alzheimer's Through Immune System Disruption
Blood cells from Alzheimer's patients show paradoxical immune responses when exposed to bacteria from gum disease. Whil…
Longevity
Soluble IL-6 Receptor Shows Protective Effects Against All-Cause Mortality
Mendelian randomization analysis reveals that while interleukin-6 (IL-6) increases mortality risk, its soluble receptor…
Longevity
Cardiovascular Disease Burden Increased 37% Globally Despite Age-Adjusted Rate Improvements
Analysis of disability-adjusted life years across 204 countries reveals cardiovascular diseases generated 437 million D…
Studies
CETP Inhibitor Trial Tests Direct Coronary Plaque Reduction Effects
The REMBRANDT trial represents a methodological shift in cardiovascular drug evaluation, using coronary computed tomogr…
Studies
Bispecific T-Cell Engagers Reverse Severe Autoimmune Disease in Small Trial
Ten patients with severe, treatment-resistant autoimmune conditions—five with antisynthetase syndrome and five with sys…
Longevity
Midlife Visceral Fat Expansion Isn't Universally Harmful, Nature Review Reveals
White adipose tissue accumulation around abdominal organs during midlife follows predictable patterns, but its metaboli…
Longevity
Liver-derived ApoE protein blocks bone healing in aged mice
Researchers identified apolipoprotein E (ApoE) as a key mechanism behind age-related bone healing impairment. In 24-mon…
Studies
Modified Stem Cells Deliver Functional CTNS Gene in Cystinosis Trial
Researchers successfully used genetically modified hematopoietic stem cells to deliver functional CTNS genes in patient…
Studies
Targeted RNA Therapy Reduces Toxic Transcripts in Myotonic Dystrophy
An antibody-oligonucleotide conjugate demonstrated selective reduction of toxic RNA transcripts in myotonic dystrophy t…
Longevity
Breast Tissue Senescence After Weaning Enables Repair But Raises Cancer Risk
Mammary gland involution following weaning triggers widespread cellular senescence that orchestrates tissue remodeling…
Longevity
Multiple Functional Deficits Predict Mortality Better Than Individual Measures
Analysis of 12,906 Chinese adults revealed that accumulating multiple age-related functional impairments creates a more…
Studies
Novel Arctigenin Derivative ARC-18 Clears Brain Amyloid Through Autophagy Enhancement
ARC-18, a synthetic derivative of the plant compound arctigenin, demonstrated dual mechanisms against Alzheimer's patho…
Studies
Contrast-Free MRI Protocol Equals Standard Scanning for Prostate Cancer
The PRIME clinical trial establishes that biparametric MRI (bpMRI) achieves equivalent diagnostic performance to multip…
Studies
Lab-Grown Platelets Could Address Global Transfusion Shortage Crisis
Declining donor populations and platelets' 5-7 day shelf life have created critical transfusion shortages worldwide, pa…
Studies
Simplified Two-Parameter MRI Matches Standard Protocol for Prostate Cancer Detection
Recent trial data indicates that biparametric MRI (bpMRI), which uses only two imaging sequences instead of the standar…
Studies
Biparametric MRI Equals Multiparametric for Prostate Cancer Detection
The PRIME trial found that biparametric MRI (bpMRI) performs equivalently to the standard multiparametric MRI (mpMRI) f…
Longevity
Blocking Fat Tissue Growth Hormone Receptors Preserves Brain Function in Aging
Eliminating growth hormone receptors specifically in fat tissue dramatically protected aged mice from brain deteriorati…
Studies
Split-Course Radiation Matches Standard Treatment in Frail Cancer Patients
A randomized trial of 190 frail elderly patients with head and neck cancer found that hypofractionated split-course rad…
PREPRINTLongevity
Left Atrial Failure Point Identified at 107mL Preload Volume
Cardiac computed tomography analysis of 975 patients revealed that the left atrium's booster pump function follows an i…
PREPRINTStudies
Heart MRI T1 Values Reveal Sex-Specific Cardiometabolic Risk Patterns
Researchers analyzed cardiac MRI data from 27,794 German adults aged 20-75, measuring myocardial T1 values—a marker of…
Wellbeing
Light Smokers Face Unique Cessation Barriers in Latin America
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from hea…
PREPRINTStudies
CNN Model with Temporal Attention Improves Coronary Artery Disease Detection
A convolutional neural network incorporating temporal attention mechanisms demonstrates enhanced accuracy in detecting…
PREPRINTWellbeing
Plastic Nanoparticles Drive Atherosclerosis Through Distinct Smooth Muscle Cell Programming
Polyethylene and polyvinyl chloride nanoparticles—the most common plastics found in human arterial plaques—accelerate a…
Longevity
Memory Cell Reprogramming Reverses Cognitive Decline in Alzheimer's Models
Scientists achieved cognitive restoration in aged and Alzheimer's disease mice by applying OSK transcription factor the…
Studies
Lactylation Process Links Energy Metabolism to Parkinson's Disease Neurodegeneration
Chinese researchers have identified lactylation—a recently discovered epigenetic modification—as a key mechanism throug…
Studies
Plasma Biomarkers Achieve 90%+ Accuracy Distinguishing Alzheimer's from Frontotemporal Dementia
Plasma AT(N) biomarkers—measuring amyloid, tau, and neurodegeneration markers—demonstrated high diagnostic accuracy in…
Nutrition
Most EU Consumers Unaware of Mercury Guidelines Despite High Fish Consumption
A European Food Safety Authority survey reveals widespread gaps in public knowledge about mercury exposure from seafood…
Studies
Creatinine-Based Muscle Index Outperforms Standard Tests for CKD Mortality Prediction
A creatinine muscle index (CMI) demonstrated superior mortality prediction compared to conventional sarcopenia markers…
Fitness
AI Chatbots Help Students Practice Health Communication Skills
Medical and allied health students are using character-based generative AI chatbots to develop interviewing skills for…
Fitness
Exercise Programs Could Transform Cancer Outcomes Across Sub-Saharan Africa
Cancer incidence is surging across Sub-Saharan Africa, with the region accounting for the majority of new cases in low-…
Studies
Zebrafish Larvae Reveal Energy-Optimized Hunting Strategy in Neural Motor Circuits
Larval zebrafish demonstrate sophisticated energy-optimization algorithms in their neural motor circuits, selectively m…
Wellbeing
Myelin Demonstrates Previously Unknown Self-Repair Mechanisms in Neural Networks
Neural tissue's protective myelin coating exhibits sophisticated regenerative properties that challenge current underst…
Studies
New Genetic Tool Tracks Beta Cell Division Over Extended Periods
Researchers developed a genetic recording system that continuously monitors pancreatic beta cell division across extend…
Studies
PTEN Gene Mutations Trigger Brain Overgrowth Through ARP2/3 Protein Complex
PTEN gene mutations, which cause neurodevelopmental disorders including autism and epilepsy, drive abnormal brain enlar…
Studies
Male Female Heart Cells Show Distinct Structural Function Patterns at Birth
Cardiac tissue engineered from newborn rat heart cells reveals fundamental sex-based differences in how cellular archit…