PREPRINTFitness
Vivifrail Exercise Lifts SPPB 1.33 Points, Cuts Probable Sarcopenia From 17% to 5%
A 36-week community multicomponent exercise programme (the Vivifrail model, combining strength, balance, gait and…
Longevity
Latest research on aging, lifespan extension, and healthspan optimization.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
PREPRINTLongevity
Frailty Raises Risk of 458 Diseases and Doubles Multimorbidity Pace
Across 466,864 UK Biobank participants followed a median 13.8 years, Fried-phenotype frailty was linked to higher risk…
Studies
Statins Harden Coronary Plaque: Denser Calcium Over 3 Years, Soft Plaque Shrinks
In a post hoc analysis of the CAUGHT-CAD randomized trial, 338 asymptomatic, statin-naive, intermediate-risk adults…
Supplements
Curcumin Cuts Liver Fat in Rats by Suppressing a Gut Microbe
A meta-analysis of seven clinical studies found curcumin supplementation lowered serum aminotransferases in people…
Studies
Fatty Liver Raises Death Risk 28-70% Across Two Million Koreans
Among 2,049,641 Korean health-checkup participants, fatty liver (Fatty Liver Index ≥30) raised all-cause mortality in…
Studies
Digital-Platform GLP-1 Prescribing Matches Trial-Level Weight Loss in 8,127 Women
Whether the weight loss seen in tightly controlled GLP-1 trials survives contact with everyday life is one of the most…
PREPRINTStudies
Glucose Swings Peak in Late Luteal Phase; Mean Glucose Stays Flat
Among 209 naturally cycling women without diabetes (mean age 43, BMI 24.3) wearing continuous glucose monitors for up…
PREPRINTFitness
Starting Exercise After 65 Cuts Mobility Difficulty Risk 7 Points at Two Years
Among Health and Retirement Study participants aged 65 and older who had been persistently inactive and were free of…
PREPRINTStudies
ARBs like losartan linked to 30% lower Parkinson's risk in 270,000 hypertensives
Among 269,617 Medicare-age adults starting first-line hypertension treatment, those who began an angiotensin receptor…
PREPRINTStudies
Intermittent Fasting Extends Lifespan in Brain-Injured Fruit Flies, Cutting Neural Inflammation
In fruit flies subjected to repetitive mild traumatic brain injury, two intermittent fasting regimens produced longer…
PREPRINTStudies
57% of Asymptomatic Broward Adults Had Abnormal Heart CT Scans
Among 7,135 insured, symptom-free Florida adults aged 45 to 70 with at least one cardiovascular risk factor, coronary…
Studies
Healthy Adult Lifestyle Blunts Early-Life Risks for Heart Disease and Diabetes
Among 174,718 UK Biobank adults followed a median 14.6 years, those with high early-life risk (low birth weight…
Longevity
Exercise plus mental-social activity adds 7 years free of cognitive impairment
Across four harmonized aging cohorts spanning Asia, North America and Europe, adults at age 50 who did both structured…
Longevity
Chronic Stress Shortens Mouse Lifespan; NMN and Bazi Bushen Herbal Formula Reverse It
In a 12-month unpredictable chronic mild stress model in mice, chronic stress amplified systemic inflammation, damaged…
Studies
SGLT2 Inhibitors Cut Kidney Progression 37%, but Evidence Quality Is Weak
Across 12 systematic reviews, SGLT2 inhibitors lowered the composite of cardiovascular death or first heart-failure…
Nutrition
Mediterranean Lifestyle Cuts Mortality 30–46% Across All Income Groups
In the prospective Lifelines cohort tracking 105,812 Dutch adults over a median 13.25 years, adherence to the MEDLIFE…
PREPRINTWellbeing
CBT for Insomnia Improves Subjective Cognition but Not Brain Activity Over 1 Year
In a randomized controlled trial of 56 adults with insomnia disorder and 20 good sleepers, CBT for insomnia (CBTi)…
PREPRINTSupplements
10 µM Zinc Supplementation Extends Healthspan and Fights Protein Aggregation in Worms
In aging C. elegans, whole-body zinc levels fall by roughly 90% between day 1 and day 13 of adulthood. Supplementing…
Studies
Ketogenic Diet and Aerobic Exercise Top Rankings for PCOS Cardiometabolic Risk
A Bayesian network meta-analysis of 43 randomized controlled trials (2,433 participants) systematically compared…
Fitness
Higher Pre-Diagnosis VO2max Cuts Post-Cancer Mortality Risk by 29–59%
Among 10,462 UK Biobank participants who later developed cancer, higher cardiorespiratory fitness (CRF) at baseline…
Nutrition
Higher Plasma Omega-3 Linked to 20% Lower Mortality in 144,900 Adults
In the Mexico City Prospective Study — 144,900 adults followed for up to 24 years — higher circulating omega-3 fatty…
PREPRINTLongevity
Bone hormone osteocalcin reverses age-related locomotor decline via motoneuron mitophagy
The bone-derived hormone osteocalcin (OCN) acts on spinal motoneurons via the receptor GPR158 to regulate autophagy…
PREPRINTLongevity
Restoring noradrenaline-like signalling in fly neurons extends lifespan and reverses motor decline
In aging Drosophila brains, octopamine (the invertebrate equivalent of noradrenaline) normally drives glucose uptake…
PREPRINTFitness
Sarcopenia Risk Linked to 44.6 mg/dL Higher Post-Meal Glucose Spike in Older Diabetics
In a cross-sectional study of 300 older Indian adults (mean age 67.6 years) with type 2 diabetes and controlled…
PREPRINTLongevity
Higher Ambient UV Linked to 36,000 Fewer CV Deaths and 50,000 Fewer Cancer Deaths Annually in US
Across 704,808 annual cardiovascular deaths and 565,287 annual cancer deaths in US Health Service Areas, higher…
Longevity
Bariatric Surgery Cuts Dementia Risk 52%, Parkinson's 30% in Obese Adults
Among 32,552 propensity-score-matched pairs of adults with BMI ≥35 kg/m², bariatric surgery was associated with a 52%…
Longevity
SGLT2i Cuts CKD Composite Risk 24% vs RAS Inhibitors in 36,000-Patient Study
In a propensity-score-matched cohort of 36,150 adults with moderate-to-severe CKD (eGFR 15–60 mL/min/1.73 m²)…
PREPRINTSupplements
Boosting Glycolysis in Osteoblasts Reverses Age-Related Bone Loss in Mice
In aged mice, bone formation declines in tandem with a measurable impairment of glycolysis within bone tissue itself…
PREPRINTSupplements
Rapamycin, Canagliflozin & Caloric Restriction Alter Canine Immune Markers at 90 Days
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
PREPRINTWellbeing
Low Social Connection Ages the Brain 5.8 Years; Heavy Smoking Costs 5 Years
In a cross-sectional analysis of 13,866 adults from the All of Us Research Program, four modifiable lifestyle factors…
PREPRINTWellbeing
MHT Raises Breast Cancer Risk But Cuts Mortality by 28% in 78,000-Woman Trial
In a secondary analysis of 78,209 women from the PLCO Cancer Screening Trial, ever-use of menopausal hormone therapy…
Supplements
Rapamycin, Canagliflozin & Caloric Restriction Shift Immune Markers in Dogs
In a controlled cross-sectional cohort of 80 intact Beagles aged 1–11 years, immune aging proved heterogeneous and…
Supplements
Two Fisetin Derivatives Outperform Parent Compound as Senolytics in Aging Mice
Two synthetic derivatives of the natural flavonoid fisetin — SR29384 and SR31133 — demonstrated superior senolytic…
Studies
Coronary Calcium Scoring Sharpens New PREVENT Cardiovascular Risk Equations
Knowing your cardiovascular risk is only as good as the tools used to measure it. The AHA's 2023 PREVENT equations…
Nutrition
Early-Life Sugar Restriction in First 1000 Days Cuts Lifetime Dementia Risk
The first thousand days of life — from conception through age two — have long been considered a critical developmental…
Studies
CKM Syndrome Linked to Early Arterial Damage in 80% of Young Adults
Cardiovascular disease rarely announces itself — it builds silently over decades, starting with metabolic dysfunction…
Studies
438,000-Veteran Study: Moderate Alcohol Cuts Heart Risk, Raises Cancer Risk
In 438,442 U.S. veterans followed from 2011 to 2024 in the Million Veteran Program, moderate alcohol consumption…
Nutrition
Cutting Dietary Fructose Drops Novel Glycation Biomarker by 20% in Overweight Adults
Restricting dietary fructose significantly reduces serum glucoselysine (GL), a fructose-specific glycation product, in…
Studies
Bariatric Surgery Remodels Abdominal—Not Gluteal—Fat Proteome Over 12 Months
A randomised, prospective 12-month study in women with obesity combined proteomics, metabolomics, advanced imaging…
PREPRINTSupplements
Apigenin Extends Worm Lifespan and Shields Against Alzheimer's Proteins via Redox Signalling
Chronic apigenin exposure extended median lifespan in wild-type C. elegans and improved multiple healthspan markers…
PREPRINTWellbeing
Mental Stress Triples Heart Attack Risk in Women Post-MI, Black Women Hit Hardest
Among 602 adults (mean age 51; 46% women) studied within eight months of a premature myocardial infarction, mental…
Nutrition
Healthy Plant-Rich Diets Linked to 31% Better Smell Function in 6,690 Adults
Among 6,690 adults in the CHRIS cohort study, higher adherence to five established healthy dietary patterns…
Fitness
10,000 Steps, 48-Min MVPA, 7.8-Hr Sleep Linked to Lower Disease Risk
Analyzing 11.8 million person-hours of wrist accelerometer data from 70,473 UK Biobank participants followed for up to…
PREPRINTWellbeing
Pre-Existing Depression and Anxiety Double Post-COVID Risk; Brain Structure Irrelevant
In 8,464 SARS-CoV-2-infected participants from the German National Cohort (NAKO), pre-infection mental health…
PREPRINTFitness
Sedentary Time Blunts VO2max Gains from Moderate Exercise in Parkinson's Patients
In a secondary analysis of the SPARX Phase 2 randomized clinical trial (128 de novo Parkinson's disease patients)…
PREPRINTNutrition
DASH Diet From Midlife Onward Cuts Dementia-Linked Brain Damage by 12%
In 892 older Singaporean adults tracked across 32 years (1993–2025), higher adherence to the DASH diet during midlife…
PREPRINTFitness
Tailored SMS + Motivational Interviewing Sustains Exercise in Over-50s with HIV
Among 92 adults over age 50 living with HIV (PWH), those receiving automated tailored text messages matched to daily…
PREPRINTStudies
Diabetes Drugs Show No Clear Genetic Link to Vascular Dementia Prevention
Applying two-sample drug-target Mendelian randomisation (MR) across eight antidiabetic drug targets, this analysis…
PREPRINTSupplements
Multi-ingredient NAD+ supplement raises blood NAD+ by 74% in 28 days
A 28-day double-blind, placebo-controlled pilot trial found that Qualia NAD+, a multi-ingredient nutraceutical…
PREPRINTSupplements
NAD+ Supplement Raises Blood Levels 67% in 28-Day Placebo-Controlled Trial
A 28-day double-blind, placebo-controlled trial of Qualia NAD+, a multi-ingredient supplement combining nicotinamide…
Longevity
Direct AMPK Activator Compound 991 Extends Lifespan Across Three Species
Direct activation of AMP-activated protein kinase (AMPK) using compound 991 — a small molecule that binds AMPK…
Supplements
Dasatinib + Quercetin Clears Senescent Cells, Reverses Liver Fibrosis in 47% of Patients
A phase-2 double-blind RCT of 31 participants with fibrotic metabolic dysfunction-associated steatohepatitis (MASH)…
Nutrition
Food Pantry 'Food is Medicine' RCT Achieves 81% Retention, Improves Diet Quality
A three-arm pilot RCT of 210 low-income patients in a Dallas safety-net healthcare system found that a Food is…
Longevity
High Cardiovascular Health Score Adds 5-10 Years of Disease-Free Life
Across 130,837 adults in two large prospective cohorts — UK Biobank and NHANES — scoring in the top tier of the Life's…
Fitness
Lifelong Exercise Primes Lung Cancer Cells to Respond Better to Cisplatin
Exposing cultured human non-small cell lung cancer cells to post-exercise serum from master athletes — representing…
PREPRINTNutrition
DASH Diet Adherence Among Hypertensive US Adults Dropped 16% by 2018
Among 14,163 US adults with self-reported hypertension drawn from NHANES cycles 2003–2018, adherence to the DASH diet…
PREPRINTWellbeing
Temperature-Regulated Sleep Surface Adds 33 Minutes of Sleep in Most Sleep-Deprived Adults
Among 171 adults tracked with wearables over seven baseline nights and seven nights on a temperature-controlled sleep…
PREPRINTLongevity
Four Inflammatory Markers Explain 57% of Black-White Heart Failure Gap
In a 16-year prospective follow-up of 6,785 multi-ethnic adults (MESA cohort, 2000–2002), four baseline biomarkers…
Fitness
Resistance Training After Weight Loss Prevents T2D Risk Rebound at 1 Year
Among 221 sedentary women with overweight (mean BMI 28.3), an 800 kcal/day diet drove BMI to 23.9, slashing predicted…
Fitness
Higher Lifelong Activity Cuts Dementia Risk 25% Across Four Nations
Across four major aging cohorts — HRS (USA), ELSA (UK), SHARE (Europe), and MHAS (Mexico) — adults who maintained…
Longevity
In-hospital Statins Cut Mortality 49% in Adults Over 75
Among 545 patients aged 75 or older admitted to an acute geriatric ward, receiving statin therapy on day 2 of…
Longevity
Weak Grip + Underweight Quintuples Premature Death Risk in 200K Adults
In a prospective analysis of 200,405 UK Biobank participants aged 60 and older (median follow-up ~14.5 years)…
Longevity
Atorvastatin 40mg Cuts CV Events 30% in Over-70s But Misses Disability-Free Survival
In the STAREE trial — a double-blind, randomized, placebo-controlled study of 9,971 community-dwelling Australians…
Nutrition
Dietitian-Led Nutrition Beats Standard Advice for Cirrhosis Sarcopenia: RCT
In a 180-patient randomised controlled trial of decompensated cirrhosis with sarcopenia, six months of…
Longevity
18-Month Exercise-Nutrition Program Slows Cognitive Decline in Targeted Older Adults
An 18-month multimodal intervention combining exercise, nutrition, and metabolic management produced significant…
Nutrition
Dietetic Counseling Cuts Systolic BP 5–7 mmHg; Wearables Add Modest Pulse Pressure Benefit
In a 954-person, three-arm RCT of adults aged ≥55 with metabolic syndrome risk factors, all intervention groups…
Supplements
Higher Omega-3 Blood Levels Linked to Less Amyloid in APOE4 Carriers
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
PREPRINTLongevity
Meeting BP, LDL, and A1c Targets Still Leaves 2–4× CV Risk Gap by Social Context
Among adults in the All of Us cohort who already met standard cardiovascular prevention targets — systolic BP below…
PREPRINTLongevity
Frequent High-NO2 Days Accelerate 14-Year Cognitive Decline in Older Adults
Among 12,235 English adults aged 50 and older followed for up to 14 years in the English Longitudinal Study of Ageing…
PREPRINTLongevity
HDL Cholesterol Shows J- and U-Shaped Mortality Curves in 150,000 Adults
In 47,123 Mexican men and 97,589 women followed prospectively, HDL cholesterol showed non-linear associations with…
PREPRINTWellbeing
Repeated Partner-Inflicted Head Injuries Age Women's Brains by Up to 28 Years
Among 207 women with lifetime exposure to physical intimate partner violence, those reporting ten or more…
Nutrition
Personalized Dietary Plans Beat Usual Care for MASLD Weight Loss by 6.7 kg
Across 14 randomized controlled trials enrolling 1,805 adults with metabolic dysfunction-associated steatotic liver…
PREPRINTWellbeing
Insomnia at 50 Predicts Cognitive Decline; Same Symptom Reverses After 75
Across 16,884 adults from three longitudinal cohorts (ELSA, Whitehall II, and Rush MAP), difficulty falling asleep at…
PREPRINTWellbeing
Social Isolation Raises Death Risk 34%; Transport Mode Modifies the Harm
In a UK Biobank cohort of 490,114 adults aged 40–69, followed from 2006 to 2022, social isolation was associated with…
PREPRINTWellbeing
Marijuana Cuts HRV by 0.47ms and Fragments Sleep Across 17,000 Wearable Users
Across 16,965 wearable-device users contributing over 5.2 million person-days of data, nightly marijuana use was…
PREPRINTNutrition
Oat Milk Delivers Far Fewer Amino Acids Than Dairy, Even With Added Pea Protein
In a randomized crossover trial, 12 healthy men consumed 750 ml of semi-skimmed dairy milk, a standard oat-based drink…
PREPRINTLongevity
Night Shift Work Raises CVD Risk 7% Per 5 Years; Morning Types Hit Hardest
Among 69,458 female nurses followed from 2009 to 2021 in the Nurses' Health Study II, each additional 5 years of…
Nutrition
KCl Tablets Cut Systolic BP ~8 mmHg by Flushing Hidden Tissue Sodium
In a 40-participant prospective study of adults with essential hypertension or hyperaldosteronism, personalised oral…
Nutrition
High Fat and SFA Intake Linked to 8× Mortality Risk in Cirrhosis
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
PREPRINTNutrition
High Omega-3 Index Linked to 4.7-Year Younger Biological Age in 4,863 Adults
In 4,863 U.S. adults aged 20–79 from NHANES 2021–2023, erythrocyte EPA and DHA concentrations rose with age while n-6…