Longevity
GPR40 Receptor Activation Reverses Thymic Aging in Mouse Model
Immune deterioration with age has long been attributed partly to the shrinking thymus, but pinning down a druggable mol…
Longevity
Latest research on aging, lifespan extension, and healthspan optimization.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Longevity
SIRT3 Loss in Aging Stem Cells Drives Chronic Inflammation Via Myeloid Reprogramming
One of the most persistent puzzles in aging biology is explaining why the immune system shifts from a protective force…
Longevity
Lp(a): Genetic Cardiovascular Risk Factor Affecting 20% Awaits Targeted Therapies
For roughly one in five adults, cardiovascular risk is quietly elevated by a factor that standard lipid panels often ig…
Supplements
Melatonin Shows Modest Pain Relief in Chronic Musculoskeletal Conditions, Meta-Analysis Finds
For the millions of adults managing chronic joint, back, or soft-tissue pain, the appeal of a non-opioid, low-side-effe…
Wellbeing
MEG Reveals How Aging Rewires Brain Networks During Noisy Speech Comprehension
Understanding why older adults struggle in noisy environments has long been attributed primarily to peripheral hearing…
Studies
Mutant KRAS Peptide Vaccine Generates Durable T-Cell Immunity in Pancreatic Cancer Prevention Trial
Pancreatic cancer kills the vast majority of those diagnosed because it is almost never caught early — but what if the…
Studies
AI Stress Echocardiography Aligns with Cardiologists 60% of the Time
Cardiac imaging sits at a crossroads: AI tools are fast, scalable, and increasingly accurate, yet how they perform alon…
Studies
2024 McDonald Criteria Enable Earlier MS Diagnosis Via Biomarker Integration
For the millions living with undiagnosed or delayed-diagnosis multiple sclerosis, earlier and more precise identificati…
Wellbeing
Extended Sleep Beyond 8.5 Hours Linked to Higher Alzheimer's Tau Biomarker
The relationship between sleep and brain aging is rarely simple, and this large cohort study adds a critical nuance: it…
Longevity
Cell Viscosity Emerges as Untapped Biomarker for Tracking Senescence and Aging
Cellular senescence — the irreversible growth arrest that drives tissue aging and age-related disease — has long been c…
Nutrition
Review Links MCTs, DHA, and Carnosine to Selective Cognitive Benefits in Early Cognitive Impairment via Glucose Metabolism Support
Cerebral glucose hypometabolism — the brain's progressive inability to efficiently metabolize its primary fuel — preced…
Studies
Review Links AI Natural Language Tools to ~28% Lower COPD Readmissions, Improved Chronic Disease Outcomes
As healthcare systems struggle to extract actionable signals from the vast volumes of unstructured clinical text—patien…
Studies
Two-Year Lenalidomide Maintenance Matches Lifelong Therapy in Myeloma Survival
For the roughly 160,000 people diagnosed with multiple myeloma each year worldwide, the standard expectation has been i…
Longevity
Mito-Nuclear Genome Mismatch Accelerates Mitochondrial Aging in Fly Populations
The compatibility between an organism's mitochondrial and nuclear genomes may be a surprisingly powerful determinant of…
Studies
Extended Dual Antiplatelet Therapy in CAD: Weighing Bleeding Against Clot Risk
For the millions of adults living with coronary artery disease who have undergone stenting, one of the most consequenti…
Wellbeing
Beyond Dopamine: Emerging Neurochemical Targets May Redefine Psychiatric Treatment
The persistent gap between psychiatric diagnosis and effective biological treatment is one of medicine's most stubborn…
Longevity
Gut Microbiome Diversity Inversely Tracks Frailty Severity in 2,000+ Older Women
For the millions of older adults navigating the gradual onset of frailty, the gut microbiome may be doing more than aid…
Studies
First Oral PCSK9 Inhibitor Shows LDL Reduction in Phase 1 Trial
For the millions of adults managing elevated LDL cholesterol, the requirement for injectable PCSK9 inhibitors — adminis…
Studies
CD19 Co-Stimulatory Fusion Protein Shows Encouraging Activity with Bispecific Antibody in Phase 1 Trial for Refractory Lymphoma
For patients with aggressive B cell lymphomas that have stopped responding to standard therapies, treatment options nar…
PREPRINTLongevity
ECG 'Eyeball' Geometry Detects Heart Attacks from 30-Second Wearable Recordings
A geometric signal-processing framework called the ECG time-frequency "eyeball" successfully differentiated acute myoca…
PREPRINTLongevity
Nodular Carotid Plaque Calcification Predicts 2.9x Higher Cardiac Death Risk
Among 479 patients (154 women) undergoing carotid endarterectomy and followed for a decade, nodular calcification withi…
PREPRINTLongevity
Normal Saline Depletes H₂S Enzymes in Bypass Vein Grafts, Blood Preserves Them
Among 20 coronary artery bypass grafting (CABG) patients, saphenous vein segments stored in autologous heparinized arte…
PREPRINTLongevity
Aficamten Eliminates Invasive Heart Surgery Need in 97% of HCM Patients
Among 104 obstructive hypertrophic cardiomyopathy (oHCM) patients meeting 2024 ACC/AHA criteria for invasive septal red…
Longevity
19 Mitochondria Transferred Via Microfluidics Reverse Senescence in Stem Cells
A droplet microfluidic platform using inertial focusing achieved 56% mitochondrial transfer efficiency at over 4,000 dr…
Studies
IL-13 Signaling in Dendritic Cells Drives Anaphylaxis Pathway from Skin Allergy
For the millions of adults managing allergic conditions, the chain of biological events linking a skin sensitization to…
Studies
Cryo-EM Reveals How C3aR Activation Could Unlock New Immune Therapies
Understanding precisely how the innate immune system's early-warning machinery switches on at the molecular level has l…
Studies
PEGylated IDO Enzyme Tames Inflammation Across Diseases Without Broad Immunosuppression
For millions living with autoimmune and chronic inflammatory conditions, the central therapeutic dilemma has long been…
Studies
Blocking Elastin Breakdown Slows Osteoarthritis Across Three Species
Osteoarthritis quietly dismantles the cartilage of roughly 500 million people worldwide, yet the field has long fixated…
Studies
High-Resolution fMRI Maps Amblyopia's Hidden Cortical Reorganization in Visual Cortex
How the brain compensates — or fails to — when one eye is suppressed during childhood development has enormous implicat…
Wellbeing
Astrocytes Coordinate Long-Distance Hippocampal Plasticity Across Distinct Brain Regions
How memory actually forms at the cellular level remains one of neuroscience's most consequential open questions — and t…
Studies
Patient Navigation Programs Most Effective at Closing Black Women's Mammography Gap
Breast cancer outcomes are strongly tied to stage at detection, making screening disparities a life-or-death equity iss…
Studies
Short-Lived Anti-PD-L1 Antibody Shows Safety Signal in Early Alzheimer's Trial
The boundary between oncology immunotherapy and neurodegenerative disease treatment may be narrowing in a clinically me…
Studies
AI Auto-Segmentation Cuts Cervical Cancer Radiotherapy Planning Time Significantly
Precision in radiation therapy hinges on one painstaking step: manually drawing boundaries around tumors and healthy or…
Studies
Engineered Bacteria With Programmable Gene Circuits Target Tumors With Precision
The idea of using living organisms as precision cancer-fighting agents is no longer science fiction — it is becoming an…
Studies
AI-Enhanced ECG Detects Hidden Heart Disease From Normal-Looking Tracings
Most adults undergo an ECG at some point in their lives, yet the standard interpretation extracts only a fraction of th…
Longevity
Muscle-Secreted Mimecan Protein Extends Lifespan via Hypothalamus-Brown Fat Axis
The conventional view of skeletal muscle as a passive tissue involved mainly in movement and metabolism is increasingly…
Studies
Deep Learning Synthesizes Tau-PET Brain Scans From Blood Tests and MRI
Access to definitive Alzheimer's imaging has long been constrained by cost and geography — a gap that disproportionatel…
Wellbeing
Cross-Frequency Brain Oscillations Coordinate Memory Consolidation Through Sleep-Wake Replay
Understanding precisely how the sleeping brain converts fleeting experiences into durable memories has enormous implica…
Studies
Sickle Cell Cure Debate: Transplant vs. Gene Therapy Compared Head-to-Head
For the roughly 20% of Americans with sickle cell disease (SCD) whose condition qualifies as severe, the gap between su…
Studies
Medicare Breast Screening Costs Surge as Low-Value Imaging Dominates Older Women
Spending more does not always mean screening better — and for older women on Medicare, a decade of data reveals a troub…
Longevity
Green Space Linked to 13% Lower CVD Odds, But NO2 May Attenuate the Benefit
Where someone lives may matter as much as how they live. The simultaneous pull of urban greenery and urban air pollutio…
Supplements
Piceatannol Cuts IGFBP4/5/7 Senescence Signals, Improves Memory in Aging Mice
Oral piceatannol (PCT), a stilbene and direct resveratrol metabolite with superior bioavailability, demonstrably reduce…
Longevity
GDF15 and Activin A Emerge as Cross-Domain Senescence Biomarkers Linking 4 Age-Related Disease Categories
A comprehensive NIH-authored compendium identifies circulating senescence-associated secretory phenotype (SASP) factors…
Longevity
Lipid-Rich Microglia Correlate with Hippocampal Memory Decline in Middle-Aged Rats
In middle-aged rats, hippocampal microglia adopted a lipid-rich, pro-inflammatory phenotype that correlated directly wi…
Longevity
Irisin Links Muscle Contraction to Alzheimer's Protection via Brain Signaling
With Alzheimer's disease cases in the U.S. projected to more than double to 14 million by 2060, the search for modifiab…
Longevity
Accelerated Biological Aging Linked to Rising Early-Onset Cancer Risk Across Generations
Early-onset cancer — diagnosed before age 50 — has been climbing globally for decades, and the explanation has remained…
Studies
KRAS Molecular Glues Expand From Single Mutations to Pan-RAS Cancer Targeting
For decades, KRAS was considered undruggable — a death sentence for patients whose tumors carried mutations in this mas…
Studies
E3 Ubiquitin Ligase RNF10 Loss Triggers Cardiac Mitophagy Failure and Hypertrophy
Cardiac hypertrophy — the pathological thickening of heart muscle — remains one of the leading precursors to heart fail…
Wellbeing
Procrastination and Impulsivity Share Measurable Neurogenetic Architecture in Brain
For anyone who has ever wondered why they delay important tasks despite knowing better, a convergence of genetics and n…
Wellbeing
Long-Lived Synaptic Proteins Show Sex-Dependent Turnover Rates in Brain
How the brain maintains stable memories and functional synapses over decades is one of neuroscience's most compelling p…
Longevity
Brain Blood Flow Regulation Traced to Endothelial Arf6-PIP2-Kir2.1 Molecular Cascade
Maintaining sharp cognitive function across decades depends critically on the brain's ability to rapidly route blood to…
Studies
Vestibular Ganglion Neurons Mapped Into Distinct Spatial Cell Types
Balance disorders and unexplained dizziness affect tens of millions of adults, yet the cellular architecture underlying…
Studies
GCN2 Kinase Deficiency Drives IL-6-Mediated Pulmonary Hypertension in Mice
Pulmonary hypertension remains one of the most underdiagnosed and poorly understood cardiovascular conditions, with cur…
Studies
Stress Granules Actively Gate Cancer Cell Communication During Oxidative Stress
How cancer cells manage their molecular communications under duress has long been a blind spot in tumor biology — and c…
Studies
Flynn Effect Reversal Hits Lower Socioeconomic Groups Hardest, 600K Study Finds
Cognitive test scores across entire populations have been declining in several wealthy nations after decades of gains —…
Studies
Histone Chaperone HIRA Links Epigenomic Control to Fat Tissue Metabolism
Understanding why fat tissue malfunctions in obesity has long focused on hormones and calories, but the molecular switc…
Studies
Dual-Drug Therapy Targets Adult Fracture Risk in Brittle Bone Disease
For the roughly one in 10,000 to 20,000 adults living with osteogenesis imperfecta (OI), fracture risk is a lifelong bu…
Studies
Enteric Disease Mortality Down ~66% Since 1990, With Ongoing Burden in High-Risk Regions
Diarrhoeal and enteric infections remain a leading killer of young children globally, yet the pace of improvement has m…
Wellbeing
Heated Yoga Shows Linear Dose-Response Effect on Moderate-to-Severe Depression
For the millions of adults managing depression who seek alternatives or complements to pharmaceutical treatment, the qu…
Longevity
Senescent Cells Drive Four Major Neurodegenerative Diseases via SASP Mechanisms
The accumulating burden of senescent cells in the aging brain may represent one of the most actionable upstream targets…
Studies
Blood Protein Patterns Signal Alzheimer's Risk Years Before Symptoms Emerge
The possibility of identifying Alzheimer's disease risk from a simple blood draw — years before any cognitive symptom a…
Longevity
Senescent Liver Cells Drive Age-Specific Injury via IL-1α Signaling Axis
For older adults undergoing liver surgery or transplantation, the risk of serious postoperative complications is dispro…
PREPRINTLongevity
ML Model Hits 88% Accuracy Predicting Dementia Progression From MRI + Cognitive Slopes
A longitudinal machine-learning framework trained on 150 subjects and 373 repeated observations from the OASIS-2 datase…
PREPRINTStudies
Synthetic Cohort Models 76% Inappropriate Prescribing Rate in Simulated Ghanaian Elderly
A validated synthetic cohort of 2,307 older Ghanaian adults (≥60 years) with comorbid hypertension and type 2 diabetes…
PREPRINTLongevity
Solid-State Magnetocardiography Shows Lower Site-of-Origin Error Than ECGi in Preclinical Swine Arrhythmia Study
A novel solid-state magnetocardiography (MCG) system outperformed electrocardiographic imaging (ECGi) in pinpointing ar…
PREPRINTLongevity
CFD Biomarkers Predict Post-Thrombectomy Pulmonary Pressure Outcomes in 6 PE Patients
Computational fluid dynamics (CFD) simulations of patient-specific pulmonary vasculature revealed that intermediate-ris…
PREPRINTLongevity
AI ECG Model Predicts Heart Failure 5 Years Out With 0.97 C-Index
A convolutional neural network trained on raw 12-lead ECGs from Zhongshan Hospital and validated in two independent coh…
Longevity
Spermine Chelates Fe²⁺ to Block Ferroptosis, Completing Polyamine Longevity Model
A new mechanistic framework resolves a long-standing paradox in polyamine biology: spermidine drives autophagy by inhib…
Studies
cfDNA Multicancer Screening Trial Linked to Reduced Diagnostic Delay in England
Early cancer detection has long been constrained by a paradox: the cancers most likely to be cured are often the hardes…
Studies
Alcohol Use Disorder Accounts for ~90% of Deaths Among Individuals with Substance Use Disorders in Large Korean Cohort
A near-comprehensive national dataset revealing that substance use disorders carry a dramatically elevated mortality bu…
Studies
Female Clinical Resilience Despite Pathologic Risk in Alzheimer Disease
The long-standing assumption that women face worse Alzheimer's disease outcomes simply because they live longer may be…
Nutrition
Exocrine Pancreatic Insufficiency: Clinical Diagnosis and Management Insights
Malabsorption disorders often evade early detection, and exocrine pancreatic insufficiency (EPI) is among the most comm…
Studies
JAMA Review Reframes Nonspecific Low Back Pain as Multifactorial Condition
Low back pain remains the leading cause of disability worldwide, yet clinical practice has long struggled with a fundam…
Longevity
Five Decades of Alzheimer Prevention Research: Where the Science Now Stands
For the tens of millions of adults who carry genetic or lifestyle risk factors for Alzheimer's disease, the question of…
Longevity
Combining Blood Recalibration and Epigenetic Reset May Synergize Against Aging
The dominant assumption in longevity research has long been that aging is either something that happens to cells from w…
Studies
PM2.5 and Traffic Noise Linked to Hypertension Via Oxidative Stress Pathways
Hypertension is widely understood as a product of genetics, diet, and lifestyle — yet a growing body of evidence demand…
Longevity
Insulin Resistance and Mitochondrial Failure Converge in Alzheimer's Neurodegeneration
The idea that Alzheimer's disease is partly a metabolic disorder of the brain — sometimes called 'type 3 diabetes' — ha…
Wellbeing
Acute Stress Linked to Lower Synaptic Density Across Psychosis Spectrum
Synaptic loss has long been suspected in schizophrenia, but identifying modifiable upstream drivers — ones that could b…
Wellbeing
Autistic Adolescents Show Reversed Brain Reward Responses to Peer Voices
The social scaffolding of adolescence — that well-recognized pivot away from parental attachment toward peer relationsh…
Studies
PET Imaging Maps Left-Lateralized Synaptic Loss Across Schizophrenia Brain Networks
Understanding where and why the schizophrenic brain loses synaptic connections has long eluded researchers — and that g…