Longevity
Limbic Subregions Shrink at Different Ages, Correlating with Memory Performance After 65
Understanding which brain structures erode first — and when — could transform how clinicians assess memory risk in…
Longevity
Latest research on aging, lifespan extension, and healthspan optimization.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Studies
18F-Flurpiridaz PET Establishes TID Reference Thresholds for Coronary Disease Grading
Accurate detection of extensive coronary artery disease depends on reliable imaging benchmarks — and until now, a…
Studies
Ambulatory ECG Monitoring After Syncope May Improve Cardiac Diagnosis Rates
Fainting episodes — clinically termed syncope — affect roughly one in three people over a lifetime, yet determining…
Nutrition
French Cadmium Exposure Runs 3–4x Above European Peers, Report Warns
Cadmium is not a compound most people think about at the dinner table, yet it accumulates silently in the kidneys and…
Longevity
Multi-Tissue Histology Framework Reveals Independent Yet Synchronized Organ Aging Clocks
Understanding why some organs age faster than others — and whether that acceleration predicts disease — is one of the…
Longevity
Frail Elders With Psychiatric Comorbidities Gain Most From Lifestyle Mobility Interventions
Not all frail older adults respond equally to structured lifestyle programs — and knowing which subgroups benefit most…
Studies
Radiotheranostics Precision Cancer Targeting: Current Approvals and Pipeline Review
Precision oncology is entering a phase where the same molecular probe that finds a tumor can also destroy it — a…
Studies
Review of Melanoma Vaccine Trials Highlights mRNA Platform Potential in Combination with Checkpoint Inhibitors
For decades, therapeutic cancer vaccines were considered a promising but consistently underdelivering strategy — most…
Studies
Blood Tau-217 Biomarker Shows Promise for Detecting CTE Risk In Vivo
Chronic traumatic encephalopathy has long been a diagnosis confined to the autopsy table — invisible during life…
PREPRINTLongevity
Race-Specific AI Models Hit 0.91 AUC for 5-Year Dementia Risk in 55,004 Adults
Analyzing 55,004 participants from the National Alzheimer's Coordinating Center (NACC), race-stratified Random…
PREPRINTLongevity
Adolescent Parenting Style Shows Minimal Link to Adult CVD Risk Over 21 Years
In a US longitudinal cohort of 4,050 participants tracked from adolescence (ages 12–19, 1994–1995) to adulthood (ages…
Studies
AHA/ACC Unifies Risk Scoring Across Heart, Kidney, and Metabolic Disease
For decades, cardiovascular risk was calculated in silos — blood pressure managed separately from cholesterol…
Studies
CD19 CAR-T Therapy Achieves Drug-Free Remission in Treatment-Resistant Rheumatoid Arthritis
For the roughly 10–20% of rheumatoid arthritis patients who exhaust multiple biologic and targeted therapies without…
Longevity
Gut Microbiota, IPA, and Plasma Tau Associated with Postoperative Delirium in Observational Study
Among 491 surgical patients aged ≥65 undergoing elective laminectomy or joint replacement, 10% developed postoperative…
Studies
ESC and ACC 2025 Guidelines Converge on IL-1 Blockade for Recurrent Pericarditis
For the millions of adults who develop chest pain after viral illness — or after mRNA vaccination — the clinical…
Studies
Inclisiran Outperforms Statin Uptitration: 85% vs 31% LDL Goal Achievement
For the millions of high-risk cardiovascular patients who fail to reach guideline-recommended LDL cholesterol targets…
Wellbeing
Pet Ownership Shapes Human Health Access in Measurable Clinical Ways
The relationship between humans and their companion animals has long been studied for its psychological and…
Studies
CT Coronary Angiography Reshapes Acute Chest Pain Triage in Large Trial
Chest pain is the second most common reason adults present to emergency departments worldwide, yet determining who…
Studies
13 Blood Markers Predict HFrEF Subtype Before Echocardiography With 0.789 AUC
Distinguishing heart failure subtypes quickly has real consequences: patients with reduced ejection fraction respond…
PREPRINTLongevity
IHD Deaths Rising in West Africa Since 2007 as Global Rates Fall 38%
While global stroke and ischemic heart disease (IHD) mortality dropped 51.7% and 38.2% respectively between 1990 and…
PREPRINTLongevity
HDL-Remodeling Metabolite Pattern Linked to 17% Higher Dementia Risk in T2D Subtypes (medRxiv Preprint)
Among 7,671 UK Biobank participants with type 2 diabetes (mean age ~60), NMR-based metabolomic profiling across…
PREPRINTLongevity
12-Ward Australian Trial Tests Staff-Led Education to Cut Hospital Falls
A 65-week, 12-ward stepped-wedge cluster randomised controlled trial across five Australian hospitals will test…
PREPRINTLongevity
80 MHz Benchtop NMR Quantifies Key Lipoproteins and Triglycerides in Serum, Reproducing Epidemiological Associations
A benchtop NMR spectrometer operating at 80 MHz — far less powerful than laboratory-grade 600 MHz instruments…
Studies
CMR GUIDE Trial: ICD Implantation Neutral on Primary Arrhythmia Endpoint but Reduces SCD and Benefits Younger Patients with Mid-Range EF and Scar
Millions of heart disease patients fall into a diagnostic no-man's land — their cardiac function is too preserved to…
Studies
Pediatric Pneumonia Exam Findings Show Inconsistent Reliability Across Two Clinicians
When clinical guidelines steer physicians away from imaging and toward physical examination alone to diagnose…
Studies
Peroxisome Loss Corrupts Insulin Integrity and Destabilizes Beta Cell Identity
Glucose dysregulation is typically blamed on insufficient insulin — but what if the insulin itself is structurally…
Studies
CT Coronary Angiography Identifies High-Risk Plaque Beyond Stenosis Severity
For patients arriving at emergency departments with chest pain, the difference between unnecessary hospitalization and…
Fitness
Myonuclear Retention and DNA Methylation Encode Decades-Long Muscle Training Memory
Skeletal muscle encodes prior exercise history through at least six parallel molecular mechanisms: myonuclear…
Longevity
GLP-1 + Menopause HRT Combo for Weight Loss: Promising But Premature
An expert consensus from Spain's Menopause Society synthesized evidence on GLP-1 receptor agonists and dual incretin…
Studies
NEJM Editorial Discusses SINGLE-AF Trial on Anticoagulation for Atrial Fibrillation with a Single Stroke Risk Factor
Atrial fibrillation affects tens of millions of adults globally, and the decision of when to start blood thinners sits…
Studies
Silent Artery Disease Found Across All Adult Age Groups, Not Just Elderly
Atherosclerosis has long been framed as a disease of older age — something that accumulates quietly over decades and…
Studies
Large RCT: Atorvastatin Cuts Cardiovascular Events in Older Adults Without Prior Disease
For decades, the calculus of prescribing statins to older adults has been muddied by uncertainty: do the…
Studies
Five-Year Brain Organoids Replicate Postnatal Epigenetic Aging With Fidelity
The fidelity with which lab-grown tissue can replicate actual human biology has long been the central limitation of…
Studies
Potent P2Y12 Plus DOAC Raises Bleeding Risk Without Ischemic Benefit in AF-ACS
Managing patients who have both atrial fibrillation and an acute coronary syndrome is one of cardiology's sharpest…
Longevity
Mitochondrial DNA Leakage Into Oocyte Cytosol Fuels Ovarian Aging Via STING Pathway
Ovarian aging sets the biological clock for female fertility and hormonal health, yet its molecular drivers have…
Longevity
Mitochondrial DNA Leakage in Aging Eggs Ignites Ovarian Inflammation via Gap Junctions
Ovarian aging is one of the most consequential biological clocks in human health, setting the pace for fertility…
Studies
New Consortium Targets Sex-Based Biological Gaps in Alzheimer's Research
Alzheimer's disease does not affect men and women equally — women account for nearly two-thirds of all cases — yet…
Longevity
Silent Coronary Calcium in Young Adults Raises CHD Death Risk Fivefold
Coronary artery disease is typically framed as a condition that declares itself in middle age or later — but…
PREPRINTLongevity
AD Genetic Risk Maps to Liver, Gut, Heart—Not Just Brain Microglia
A large-scale genomic analysis partitioning Alzheimer's disease (AD) polygenic risk across 166 tissue annotations and…
PREPRINTLongevity
Combined TyG-Biological Age Score Triples Cardiometabolic Multimorbidity Risk in 8,767 Adults
Among 8,767 Chinese adults aged 45+ followed for a median of 108 months, combining the triglyceride-glucose (TyG)…
PREPRINTLongevity
GLP-1 Drugs Linked to 0.21-Month Alzheimer's Delay vs. Sulfonylureas in 6,328 Diabetics
Among 6,328 adults aged 55+ with type 2 diabetes and no prior dementia, initiating GLP-1 receptor agonists was…
PREPRINTLongevity
Four AML Risk Genes Emerge from 170,000-Person Whole-Genome Biobank Scan
Whole-genome sequencing data from the All of Us Research Program, covering 265 AML cases and 169,706 controls…
Supplements
Vitamin C Modulates 7 Aging Hallmarks But Human Evidence Remains Thin
A comprehensive narrative review from the University of Szeged maps vitamin C's interactions across the canonical…
Nutrition
DASH Diet Cuts Heart Failure Risk 11% Independent of Cardiometabolic Mediators
Among 124,777 UK Biobank participants followed for 12 years, highest versus lowest adherence to the DASH diet was…
Longevity
Senescent Vascular Cells and SASP Linked to Intracranial Aneurysm Wall Weakening
Intracranial aneurysms may represent a localized manifestation of premature vascular aging, with senescent endothelial…
Longevity
Sattar Perspective: Incretin-Driven Weight Loss (14-20%) and Causal Adiposity Effects Across Multiple Disease Domains
Using a triangulation framework—combining Mendelian randomisation, observational cohorts, and randomised trials—Sattar…
Studies
Study Links Two or More Years of Pretransplant Dialysis to Higher Graft Loss Risk in Living-Donor Recipients
For the millions of patients worldwide managing end-stage kidney disease, the timing of transplantation relative to…
Studies
NHEJ Pathway Inhibition Unlocks p53-Driven Senescence in Chemo-Resistant Liposarcoma
Dedifferentiated liposarcoma represents one of oncology's more frustrating treatment puzzles: a rare, aggressive…
Longevity
Senescent Microglia in Brain White Matter Partially Reversed by Senolytic Drugs
White matter integrity is increasingly recognized as a critical determinant of cognitive aging, yet the specific…
Longevity
AI Digital Twins Could Personalize Nutrition Against Age-Related Muscle Loss
Sarcopenia's convergence with chronic multimorbidity represents a compounding mortality risk in aging populations, yet…
Studies
Aficamten Wins Global Approval as Second Cardiac Myosin Inhibitor for HCM
For the roughly one in 500 adults living with hypertrophic cardiomyopathy, the treatment landscape has just gained a…
PREPRINTLongevity
Post-Hoc Analysis Suggests Possible Aspirin Benefit for Disability-Free Survival in Black and Hispanic Elders from ASPREE Trial
A post-hoc analysis of the ASPREE randomized controlled trial examined 1,270 U.S. participants aged 65+ who…
PREPRINTNutrition
UK Dietitians Survey: MUST Inadequate for Mental Health and Learning Disability Inpatients
Across 47 UK dietitians surveyed from inpatient mental health and learning disability settings, the dominant…
Longevity
Longer Telomeres Associated with 87% Lower Mortality Risk in Black Women with Lupus
Among 422 Black/African American women with systemic lupus erythematosus (SLE) followed for nearly two years, longer…
Studies
Non-Destructive RNA Sampling Platform Enables Repeated Longitudinal Cell Profiling
Understanding how individual cells change over time is one of the fundamental challenges in biology and medicine — and…
Wellbeing
Cortical Circuits Use Two-Phase Strategy to Master Parallel Task Processing
The brain's capacity to juggle multiple demands simultaneously sits at the heart of cognitive performance, yet the…
Longevity
Senescent Bone Marrow Cells Fuel Pre-Leukemic Clones via TNF-α/IL-6 Loop
Clonal haematopoiesis — the silent accumulation of blood stem cells carrying somatic mutations — affects roughly half…
Studies
41,000 Young Children Recreational Drug Exposures Tracked Over 24 Years: Cannabis Dominates
When a toddler finds a forgotten edible or an unsecured pipe, the consequences can be severe — and the data now show…
Studies
AI Drug Discovery Shows Minimal Clinical Impact Despite Decade of Hype
The gap between artificial intelligence's promise and its actual contribution to bringing better medicines to patients…
Nutrition
GLP-1 Trials Omit Diet Data: Ethical Blind Spot Undermines 4 Core Principles
Landmark GLP-1 receptor agonist trials — including those establishing semaglutide and tirzepatide as transformative…
Supplements
Omega-3, D3, and K2 Share Overlapping Mechanisms Across Heart, Brain, and Bone
A structured narrative review synthesizing evidence from PubMed, Embase, Cochrane, and Web of Science proposes a…
Longevity
Implanted Muscle Grafts Reverse Aging Markers in Mice Without Exercise
Subcutaneous transplantation of autologous, differentiated myocytes — termed myografts — produced continuously…
Longevity
Rapamycin Cuts AF Risk via mTOR-Independent HIF-1α Suppression in Aging Hearts
In a D-galactose-accelerated aging mouse model, rapamycin administered via dietary supplementation significantly…
Studies
Shorter Reproductive Lifespan Linked to 22% Higher Bronchiectasis Risk in Women
Bronchiectasis — a chronic, progressive lung condition marked by permanently dilated airways — has long puzzled…
Studies
Mammogram Calcifications Linked to 82% Higher Cardiovascular Event Risk in Women
Cardiovascular disease remains chronically underdiagnosed in women, partly because standard risk scores were built on…
Nutrition
Blood Metabolomics Reveals 43 Validated Biomarkers Linking Ultra-Processed Foods to CVD Risk
Understanding precisely how ultra-processed foods (UPFs) damage the cardiovascular system has long been the missing…
Studies
Random Amino Acid Repeats Can Access Stable Folded Protein Structures
Understanding how functional proteins first arose from a primordial soup of random chemistry is one of biology's…
Studies
Tmem117 in Oligodendrocytes Links Myelin Homeostasis to Counterregulation and Metabolic Health in Mice
The assumption that metabolic disease originates exclusively in peripheral tissues like the liver, muscle, or adipose…
Wellbeing
Slow Brain Wave Amplitude May Signal Alzheimer's Pathology Before Symptoms Emerge
Early detection of Alzheimer's has long been the field's most urgent unsolved problem — treatments work best before…
Studies
Older Australians Score Below 30% on Osteoporosis Knowledge, Men Worst Affected
Osteoporosis quietly fractures lives before most people know they have it — and new survey data suggest that ignorance…
Studies
New Imaging Platform Maps Osteoblast Nutrient Use During Bone Formation
Understanding precisely how bone-building cells fuel themselves during active bone formation has long been a blind…
Wellbeing
Tanmaxxing Trend Exploits Social Algorithms to Normalize UV Harm in Adolescents
When beauty trends migrate onto algorithm-driven platforms, their reach and speed of adoption amplify risks that…
Nutrition
Emerging Review Highlights Gut-Eye Axis and Omega-3s in Dry Eye: Evidence Remains Preliminary
Dry eye disease affects an estimated 344 million people globally, yet clinical management has long focused narrowly on…
Studies
Vutrisiran Linked to Cardiac Amyloid Reduction Visible on MRI Over Three Years
Transthyretin amyloid cardiomyopathy has long been treated as a condition of damage control — slowing an inevitable…
Fitness
Phase 3 Trial Tests Exercise as Neuroprotection Against Post-Stroke Dementia
More than half of stroke survivors develop measurable cognitive decline within six months — a statistic that reframes…
PREPRINTLongevity
Graph Neural Networks Hit AUC 0.82 Predicting Post-MI Heart Failure from Proteomics
A graph neural network (GNN) framework integrating plasma proteomics, clinical variables, and molecular…
PREPRINTLongevity
Hidden CAC Data in Breast Cancer PET Scans Could Reclassify Statin Need in 64% of Small Prevention-Eligible Subgroup
Coronary artery calcium (CAC) scores extracted from routine staging 18F-FDG PET/CT scans in 276 women with newly…
Longevity
Exercise Modality and Timing Post-Menopause May Influence Alzheimer's Risk via BDNF and Brain Structure Pathways
Women comprise nearly two-thirds of Alzheimer's diagnoses, and the menopausal transition emerges as a discrete…
Longevity
Sarcopenia Diagnosis Hinges on Grip Strength, Not Mass Alone
Sarcopenia—progressive loss of muscle strength, mass, and physical performance—is increasingly prevalent in aging…
Longevity
GLP-1 Drugs Cut Obesity-Linked Cancer Risk 7–30% — But Causality Unproven
Large observational cohorts consistently link GLP-1 receptor agonist (GLP-1RA) exposure — drugs like semaglutide and…