Longevity
Limbic Subregions Shrink at Different Ages, Correlating with Memory Performance After 65
Understanding which brain structures erode first — and when — could transform how clinicians assess memory risk in…
Wellbeing
Research on brain health, sleep, stress, integrative therapies, and psychological wellbeing.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Studies
1-Hour Troponin Protocol Matches 3-Hour Safety While Cutting ER Wait Times
For millions of people who arrive at emergency departments each year with chest pain, how quickly clinicians can…
Studies
18F-Flurpiridaz PET Establishes TID Reference Thresholds for Coronary Disease Grading
Accurate detection of extensive coronary artery disease depends on reliable imaging benchmarks — and until now, a…
Studies
Cross-Trial Analysis of 38,753 Patients Maps Heart Failure Drug Combination Safety Signals
Optimizing heart failure treatment has long been complicated by a practical paradox: the drug combinations proven to…
Studies
Blood Tau-217 Biomarker Shows Promise for Detecting CTE Risk In Vivo
Chronic traumatic encephalopathy has long been a diagnosis confined to the autopsy table — invisible during life…
PREPRINTLongevity
Adolescent Parenting Style Shows Minimal Link to Adult CVD Risk Over 21 Years
In a US longitudinal cohort of 4,050 participants tracked from adolescence (ages 12–19, 1994–1995) to adulthood (ages…
Wellbeing
Childhood Adversity Linked to Up to 40% Higher Postpartum Depression Prevalence
Postpartum depression remains one of the most underdiagnosed conditions in maternal health, and identifying who is…
Longevity
Gut Microbiota, IPA, and Plasma Tau Associated with Postoperative Delirium in Observational Study
Among 491 surgical patients aged ≥65 undergoing elective laminectomy or joint replacement, 10% developed postoperative…
Wellbeing
Pet Ownership Shapes Human Health Access in Measurable Clinical Ways
The relationship between humans and their companion animals has long been studied for its psychological and…
PREPRINTLongevity
HDL-Remodeling Metabolite Pattern Linked to 17% Higher Dementia Risk in T2D Subtypes (medRxiv Preprint)
Among 7,671 UK Biobank participants with type 2 diabetes (mean age ~60), NMR-based metabolomic profiling across…
Studies
Peroxisome Loss Corrupts Insulin Integrity and Destabilizes Beta Cell Identity
Glucose dysregulation is typically blamed on insufficient insulin — but what if the insulin itself is structurally…
Studies
Ferritinophagy Dysregulation Drives Iron-Mediated Injury Across Four Major Organs
Iron is a paradox in human biology — essential for life yet lethal in excess. A newly published review in Autophagy…
Longevity
GLP-1 + Menopause HRT Combo for Weight Loss: Promising But Premature
An expert consensus from Spain's Menopause Society synthesized evidence on GLP-1 receptor agonists and dual incretin…
Supplements
Melatonin's Prolactin Pathway May Link Long-Term Use to Heart Failure Risk
Melatonin is taken nightly by millions of adults who regard it as essentially harmless — a natural sleep aid with a…
Studies
Large RCT: Atorvastatin Cuts Cardiovascular Events in Older Adults Without Prior Disease
For decades, the calculus of prescribing statins to older adults has been muddied by uncertainty: do the…
Studies
Five-Year Brain Organoids Replicate Postnatal Epigenetic Aging With Fidelity
The fidelity with which lab-grown tissue can replicate actual human biology has long been the central limitation of…
Longevity
Mitochondrial DNA Leakage Into Oocyte Cytosol Fuels Ovarian Aging Via STING Pathway
Ovarian aging sets the biological clock for female fertility and hormonal health, yet its molecular drivers have…
Studies
New Consortium Targets Sex-Based Biological Gaps in Alzheimer's Research
Alzheimer's disease does not affect men and women equally — women account for nearly two-thirds of all cases — yet…
Studies
Multi-Biomarker Wearables Could Reframe Cardiometabolic Disease Monitoring Beyond Glucose
Continuous glucose monitoring transformed diabetes management by turning a snapshot test into a living physiological…
PREPRINTLongevity
AD Genetic Risk Maps to Liver, Gut, Heart—Not Just Brain Microglia
A large-scale genomic analysis partitioning Alzheimer's disease (AD) polygenic risk across 166 tissue annotations and…
Longevity
Senescent Vascular Cells and SASP Linked to Intracranial Aneurysm Wall Weakening
Intracranial aneurysms may represent a localized manifestation of premature vascular aging, with senescent endothelial…
Longevity
Sattar Perspective: Incretin-Driven Weight Loss (14-20%) and Causal Adiposity Effects Across Multiple Disease Domains
Using a triangulation framework—combining Mendelian randomisation, observational cohorts, and randomised trials—Sattar…
Supplements
Vitamin C Modulates 7 Aging Hallmarks But Human Evidence Remains Thin
A comprehensive narrative review from the University of Szeged maps vitamin C's interactions across the canonical…
Studies
Thioredoxin-Deficient Rats Develop Progressive CKD via Mitochondrial Redox Failure
Chronic kidney disease silently erodes kidney function in roughly 10% of the global population, yet the causal chain…
Studies
DOACs Cut Composite Cardiovascular Risk 69% in Intermediate-Risk Atrial Fibrillation
For millions of atrial fibrillation patients occupying the gray zone of stroke risk — not clearly high-risk enough to…
Wellbeing
Unconscious Behavioral Mimicry Found to Reinforce Smoking Addiction via Social Bonding
Social belonging is one of the most powerful forces shaping human behavior, and it may be quietly undermining millions…
Studies
Focused Ultrasound Cuts Seizures 14% Monthly in Drug-Resistant Epilepsy Pilot
For the roughly one-third of epilepsy patients whose seizures refuse to respond to medication, surgical options carry…
Longevity
Senescent Microglia in Brain White Matter Partially Reversed by Senolytic Drugs
White matter integrity is increasingly recognized as a critical determinant of cognitive aging, yet the specific…
PREPRINTNutrition
UK Dietitians Survey: MUST Inadequate for Mental Health and Learning Disability Inpatients
Across 47 UK dietitians surveyed from inpatient mental health and learning disability settings, the dominant…
PREPRINTWellbeing
Systemic Right Ventricle Adults Show 46% Anxiety Rate Linked to VO2 Decline
Among 137 adults with systemic right ventricle (sRV) physiology followed over 25 years at a tertiary congenital heart…
Studies
Observational Data Suggest Semaglutide May Improve Liver Stiffness Similarly to Surgery Despite Less Weight Loss
Across 92 adults with obesity and MASLD followed for 72 weeks, sleeve gastrectomy produced the largest absolute…
Longevity
Longer Telomeres Associated with 87% Lower Mortality Risk in Black Women with Lupus
Among 422 Black/African American women with systemic lupus erythematosus (SLE) followed for nearly two years, longer…
Studies
Non-Destructive RNA Sampling Platform Enables Repeated Longitudinal Cell Profiling
Understanding how individual cells change over time is one of the fundamental challenges in biology and medicine — and…
Wellbeing
Cortical Circuits Use Two-Phase Strategy to Master Parallel Task Processing
The brain's capacity to juggle multiple demands simultaneously sits at the heart of cognitive performance, yet the…
Studies
AMPK's Heart Failure Role Proves Complex, Context-Dependent, Not Simply Protective
The assumption that boosting a cell's energy sensor automatically protects a failing heart is being seriously…
Studies
High-Dose Folate Raises Cell-Culture Alarm But Not Real-World DNA Damage
For the many patients prescribed high-dose folic acid for blood disorders — and for the general population routinely…
Studies
Golgi Zinc Transport Defect Links SPAST Mutation to Alzheimer-Like Neurodegeneration
A molecular mechanism connecting a common hereditary spastic paraplegia mutation to Alzheimer's-like brain changes has…
Studies
Gestational PFBS Exposure Linked to Placental PI3K-Akt Pathway Changes and Offspring Anxiety-Like Behavior in Rats
Emerging evidence that the placenta functions as a neurological gatekeeper — not merely a nutrient conduit — has…
Studies
Weight Loss and Metabolic Drugs May Target Different AF Recurrence Pathways Post-Ablation: Hypothesis-Generating Review
A structured physician-led weight reduction program cut 12-month AF recurrence by 47% (risk ratio 0.53) following…
Supplements
Omega-3, D3, and K2 Share Overlapping Mechanisms Across Heart, Brain, and Bone
A structured narrative review synthesizing evidence from PubMed, Embase, Cochrane, and Web of Science proposes a…
Nutrition
GLP-1 Drugs Shrink Fat and Muscle: What 2025 Evidence Says
Both semaglutide and tirzepatide produce substantial lean body mass (LBM) reductions alongside fat loss, yet this…
Studies
Sudan Virus Kills Nearly Half of Infected Adults, Immunity Persists 15 Years
When a hemorrhagic fever with a 49% historical fatality rate re-emerges, the clinical and immunological picture…
Studies
Brain's Enkephalin Circuit Mapped as Precise Pain-Inhibitory Pathway
Chronic pain affects hundreds of millions globally, yet the analgesic toolkit remains frustratingly blunt — opioids…
Studies
Maternal Spaceflight Stress Leaves Measurable Biological Marks Across Generations
The health consequences of space travel have long been studied in astronauts themselves, but an emerging and more…
Studies
Fragmented Urban Tree Canopy Linked to Higher Child Mortality in 420,000-Child Study
The spatial arrangement of urban greenery — not just how much exists, but how it is distributed — may carry…
Studies
Tmem117 in Oligodendrocytes Links Myelin Homeostasis to Counterregulation and Metabolic Health in Mice
The assumption that metabolic disease originates exclusively in peripheral tissues like the liver, muscle, or adipose…
Wellbeing
Slow Brain Wave Amplitude May Signal Alzheimer's Pathology Before Symptoms Emerge
Early detection of Alzheimer's has long been the field's most urgent unsolved problem — treatments work best before…
Studies
Hidden TB Enzyme Sustains Alternative Metabolic Pathway Critical for Survival
Understanding how Mycobacterium tuberculosis persists inside human immune cells despite decades of antibiotic…
Wellbeing
Tanmaxxing Trend Exploits Social Algorithms to Normalize UV Harm in Adolescents
When beauty trends migrate onto algorithm-driven platforms, their reach and speed of adoption amplify risks that…
Nutrition
Emerging Review Highlights Gut-Eye Axis and Omega-3s in Dry Eye: Evidence Remains Preliminary
Dry eye disease affects an estimated 344 million people globally, yet clinical management has long focused narrowly on…
Fitness
Phase 3 Trial Tests Exercise as Neuroprotection Against Post-Stroke Dementia
More than half of stroke survivors develop measurable cognitive decline within six months — a statistic that reframes…
PREPRINTNutrition
Personalized Meal Timing Cuts 2.1 kg in 6 Weeks—No Diet Required
Adults randomized to personalized meal schedules—derived from two weeks of app-based dietary records—lost 2.10 kg more…
Longevity
Exercise Modality and Timing Post-Menopause May Influence Alzheimer's Risk via BDNF and Brain Structure Pathways
Women comprise nearly two-thirds of Alzheimer's diagnoses, and the menopausal transition emerges as a discrete…
Studies
Newly Mapped Spinal Circuit Links Mechanical Pain Signals to Brain Stem
Chronic mechanical pain — the kind triggered by pressure, pinching, or tissue injury — remains one of the hardest…
Studies
JNK Inhibitors Show Promise Against Endometriosis Pain in Preclinical Models
Endometriosis affects roughly one in ten women of reproductive age globally, yet treatment options remain stubbornly…
Studies
Stem Cell Triculture Model Reveals Microglia Drive Retinal Neuron Loss
The mechanisms by which the brain's immune cells destroy retinal neurons have been nearly impossible to study in…
Studies
Conserved KAT2–PGK–ALDO Cascade Amplifies Glycolysis Under Cellular Energy Stress
When cells run low on energy, their survival depends on rapidly upshifting glucose metabolism — and how they…
Wellbeing
Nasal Breathing Frequency Causally Controls Anxiety via Dedicated Brain Circuit
Breathing exercises have long been prescribed for anxiety, yet the precise neural machinery converting nostril airflow…
Longevity
Hsp70 Chaperone Partners Show Stress-Selective Binding That Shapes Cellular Protein Quality Control
Protein quality control is one of the most consequential yet underappreciated pillars of healthy aging. When cells…
Studies
Rapid Cell Proliferation May Paradoxically Suppress Cancer Through Competition
Cancer prevention is rarely framed as a competition problem, yet emerging theoretical biology suggests that how…
Wellbeing
Childhood Adversity Linked to Greater Alcohol Use During Extreme Heat in Adults Over 50
As climate change pushes extreme heat events into more frequent and prolonged territory, a less-discussed downstream…
Nutrition
Dietary Arginine Controls Immune Tumor Recognition Via Codon-Dependent MHC-I Translation
The idea that what we eat could directly reshape whether our immune cells recognize tumors or clear viruses has long…
Studies
Endoscopic Sleeve Loses 12% Less Weight Than Surgical Alternative at One Year
For the estimated hundreds of millions of adults living with obesity, the choice between a surgical and an endoscopic…
Wellbeing
Psychiatric Diagnosis Reframed Through Biology's Species-Classification Framework
The way clinicians define and diagnose mental illness may rest on a fundamentally flawed premise — that psychiatric…
Studies
Low-Dose Lithium Shows Multi-Pathway Neuroprotection Across 25 Years of Evidence
For decades, dementia research has fixated on single-target therapies — clearing amyloid plaques or silencing tau…
Wellbeing
Systematic Review Links Excess Screen Time to Mental Health Risks in Under-12s
For parents and pediatric clinicians navigating an increasingly screen-saturated world, understanding the cumulative…
Studies
Adolescent Nicotine Vaping Exposure Heightens Adult Nicotine Vapor Seeking in Male Rats
As e-cigarette use among teenagers continues to climb, one of the most pressing unanswered questions in addiction…
Wellbeing
Auricular Vagus Stimulation Reduces Vascular Dementia Deficits via A2AR-Nrf2 Pathway
Vascular dementia remains one of the most treatment-resistant forms of cognitive decline, lacking the pharmacological…
Longevity
Gut-Derived Succinate Drives Alpha-Synuclein Aggregation Via mTORC1 Pathway
The idea that Parkinson's disease begins in the gut has gained substantial traction over the past decade, but…
Studies
Motor Neurons Actively Sequence Feeding Behavior via Disinhibition Cascade
A foundational assumption in neuroscience — that motor neurons are mere executors of commands issued by higher brain…
Studies
Wastewater IS481 DNA Signals Pertussis Outbreaks Months Before Clinical Reports
Conventional infectious disease surveillance has a fundamental blind spot: it only captures people who seek care, get…
Studies
Synthetic Peptide K16ApoE Ferries Large Proteins Across Blood-Brain Barrier
One of the most stubborn obstacles in neurology is not finding the right drug — it is getting any drug into the brain…
Studies
Mitochondrial Signatures, Not Lewy Body Structure, Distinguish Parkinson's from DLB in Postmortem Study
Understanding why two diseases built on the same misfolded protein — α-synuclein — produce such different clinical…
Studies
Multiphasic Biomimetic Scaffold Rebuilds Rotator Cuff's Complex Tissue Zones
Rotator cuff repair is one of the most performed orthopedic surgeries worldwide, yet retear rates remain stubbornly…
Wellbeing
Mukbang and Eating Challenge Videos Linked to Disordered Eating via Body Comparison
Social media's food content is rarely neutral — and a growing body of evidence suggests that certain formats may…
Longevity
Gut Bacterium B. pseudocatenulatum and Metabolite 5-AVAB Extend Healthspan via Inflammaging Suppression
A microbiome aging clock (MicroAge) built from enterotype-specific gut microbial shifts across multiple Chinese…
Studies
GLP-1 Drugs Show Multi-Organ Benefits Beyond Weight Loss Alone
The conventional framing of obesity drugs as weight-loss tools is being fundamentally dismantled. If accumulating…
Longevity
Retinal Photos Encode 12 Alzheimer's Risk Factors, Deep Learning Reveals
The eye may be the most accessible window into Alzheimer's disease vulnerability the medical community has yet to…
Studies
ER Retention Signal Locks Cardiac hERG Channel Subunit Ratio at 2:2
Precise subunit ratios in cardiac ion channels are not an accident of random assembly — they are actively enforced…
Wellbeing
Chronic Psychosocial Stress Mechanistically Triggers Sleep Apnea Onset in Two Species
Sleep apnea affects an estimated one billion people globally, yet its root causes have remained frustratingly opaque…