Fitness
Exercise Modulates Gut Microbiota to Strengthen Bones Through Gut-Bone Axis
Exercise strengthens bones not just through mechanical loading but by fundamentally altering gut microbiota composition…
Wellbeing
Research on brain health, sleep, stress, integrative therapies, and psychological wellbeing.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
Longevity
GLP-1 Receptor Agonists Show Promise as 'Pharmacological Exercise' Against Neurodegeneration
GLP-1 receptor agonists like semaglutide and liraglutide demonstrate multiple neuroprotective mechanisms in preclinical…
Fitness
Resistance Training Reduces Brain Age by 2.3 Years in Adults
Resistance training reversed functional brain aging by 1.4 to 2.3 years in healthy adults, based on brain clock models…
Longevity
Obesity and Gut Dysbiosis Drive Alzheimer's Neuroinflammation via Blood-Brain Barrier
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia towa…
Longevity
Prevotella corporis Bacteria Activates Hsp70 Protection Against Protein Aggregation
Prevotella corporis, a specific gut bacterium, uniquely activates the host's heat shock response and induces Hsp70 mole…
Longevity
Surgery-Induced Cognitive Decline Shares Alzheimer's Pathways in Elderly
Postoperative cognitive dysfunction affects elderly surgical patients through neuroinflammation, blood-brain barrier di…
Wellbeing
Mindful Parenting Reduces Child Irritability Over Time, Study Finds
Analysis of 676 parent-child pairs reveals that mindful parenting practices predict lower child irritability scores ove…
Longevity
Blast Exposures Accelerate Neurological Aging in Laboratory Model Study
C. elegans nematodes exposed to controlled shock waves mimicking explosive blasts developed immediate neurological defi…
Studies
AI Sleep Model Predicts 130 Diseases From Single Night Recording
Scientists created SleepFM, an artificial intelligence system that analyzes polysomnography data from 585,000 hours of…
Wellbeing
Frontal Brain Activity Patterns Reveal OCD Cognitive Control Deficits
Brain imaging reveals that obsessive-compulsive disorder involves disrupted activity patterns in the rostrolateral pref…
Wellbeing
Pregnancy-Related Thyroid Nodules Rarely Progress to Cancer Despite Growth
Thyroid nodules develop in 2-3% of pregnancies, with existing nodules often enlarging due to hormonal changes that natu…
Longevity
Family Deaths Don't Shorten Telomeres Despite Increasing Mortality Risk
Tracking 4,837 older adults for 14 years, researchers found that experiencing multiple family deaths significantly incr…
Studies
Salivary Oxidized Fats Signal Early Cognitive Decline in Aging Adults
Analysis of saliva, plasma, and fecal samples from older adults with mild cognitive impairment revealed distinct lipid…
Longevity
Akkermansia muciniphila reduces Alzheimer's amyloid plaques via tryptophan pathway
Akkermansia muciniphila administration in transgenic Alzheimer's mice reduced amyloid-beta plaques and improved cogniti…
Longevity
B-Vitamins May Protect Aging Brain Through Gut Microbiome Modulation
Low B-vitamin status—particularly B6, B12, folate, and riboflavin—correlates with cognitive dysfunction and dementia in…
Wellbeing
Intranasal Oxytocin Reverses Social Isolation Brain Damage in Mice
Adolescent mice subjected to three months of social isolation developed anxiety, depression, and severe social memory d…
Studies
New Zealand TBI Claims Jump 49% While Population Grows Only 9%
Analysis of New Zealand's national injury database reveals traumatic brain injury claims surged from 745 to 1,028 per 1…
Studies
AI Debriefing Tools Show Promise for Medical Simulation Training Enhancement
Medical simulation training received AI-powered enhancement through automated analysis of team communications during hi…
Longevity
Six Drug Strategies Target Neuroinflammation Pathways Driving Brain Aging
This comprehensive review identifies neuroinflammation as the central mechanism connecting normal brain aging to pathol…
Studies
EBV Reprograms B Cells to Present MS-Triggering Myelin Peptides
Epstein-Barr virus infection fundamentally alters the antigen presentation machinery in B cells carrying the HLA-DR15 g…
Wellbeing
Environmental Toxins Link to Breast Cancer Through Hormonal Disruption
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting ch…
Longevity
Estrogen Decline During Menopause Accelerates Alzheimer's Pathology in Women
Research demonstrates that menopausal estrogen withdrawal triggers accelerated accumulation of amyloid-beta plaques and…
Wellbeing
Dental X-Ray Guidelines Emphasize Risk-Benefit Assessment Over Routine Imaging
Updated dental radiography protocols now emphasize individualized risk assessment rather than standardized imaging inte…
Studies
Microglia Gene Changes in Amygdala Link to Chronic Pain Development
Analysis of 304 postmortem brains revealed distinct gene expression patterns in chronic pain sufferers, with over 2,000…
Wellbeing
Hippocampal Circuit Dysfunction Links Genetic Risk to Schizophrenia Development
Analysis of 22q11.2 deletion syndrome reveals hippocampal dysfunction as a central mechanism in psychosis development.…
Studies
Brain Atlas Maps 10 Million Oligodendrocytes Controlling Neural Processing Speed
Researchers have constructed a comprehensive cellular atlas documenting approximately 10 million oligodendrocytes—speci…
Studies
New Fluorescent Dye Trodusquemine Enables Detailed Myelin Imaging in Cleared Tissues
Researchers developed HELF (High Efficiency Labeling of Fibers), a protocol using the fluorescent aminosterol trodusque…
Studies
Astrocytes Actively Generate Fear Memories Alongside Neurons in Amygdala
Amygdala astrocytes demonstrate direct memory encoding capabilities through calcium signaling and neurotransmitter rele…
Studies
Diabetes Drug Tirzepatide Shows Promise for Alcohol Use Disorder
Tirzepatide, a dual GLP-1 and GIP receptor agonist approved for diabetes and weight management, demonstrated potent ant…
Studies
Multicomponent Models Show Variable Accuracy Predicting Post-Stroke Cognitive Decline
Meta-analysis of multicomponent risk prediction models reveals inconsistent performance in identifying stroke survivors…
Wellbeing
Adolescent Cannabis Exposure Doubles Young Adult Psychosis Risk
Cannabis exposure during adolescence increases the likelihood of developing psychotic disorders and bipolar disorder by…
Wellbeing
Neural Networks Toggle Between Continuous Processing and Event Boundaries
Cognitive neuroscience has identified distinct neural mechanisms that allow the brain to simultaneously maintain experi…
Wellbeing
Star-Shaped Brain Cells Control Fear Memory Formation and Erasure
Calcium oscillations in amygdala astrocytes directly regulate both the encoding and extinction of fear memories, challe…
Wellbeing
Overnight Heat Above 80°F Drives 30% Jump in Crisis Calls
Analysis of Louisiana crisis hotline data reveals that overnight temperatures exceeding 80°F trigger a 30% increase in…
Longevity
Liver enzyme GPLD1 restores memory by targeting brain blood vessels
The liver-produced enzyme GPLD1, released during exercise, can restore memory function in aged brains by modulating bra…
Studies
FDA-Approved Epilepsy Drug Blocks Alzheimer's Amyloid Production at Synapses
Levetiracetam, an established antiepileptic medication, demonstrates a novel mechanism for preventing amyloid-beta 42 f…
Studies
PAK1 Inhibitor Protects Brain Synapses From Alzheimer's Protein Damage
Blocking the p21-activated kinase 1 (PAK1) enzyme with compound NVS-PAK1-1 prevented synapse destruction in neurons exp…
Studies
Embryonic Stem Cell Therapy Shows Motor Improvements in Parkinson's Trial
Twelve Parkinson's patients received transplants of dopamine-producing cells derived from human embryonic stem cells, w…
Studies
c-Abl Kinase Inhibitor Risvodetinib Shows Safety Profile in Early Parkinson's
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week…
Wellbeing
Superior Colliculus Circuit Mediates Visual Cue-Triggered Drug Seeking
Researchers identified a specific neural pathway in the superior colliculus that processes visual environmental cues an…
Studies
Tumor Protein Cystatin-C Clears Amyloid Plaques in Mouse Brains
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and acti…
Longevity
Periodontal Disease Accelerates Alzheimer's Through Immune System Disruption
Blood cells from Alzheimer's patients show paradoxical immune responses when exposed to bacteria from gum disease. Whil…
Studies
Plasma p-tau217 Clock Accurately Forecasts Alzheimer's Symptom Timeline
Researchers developed predictive algorithms using plasma p-tau217 levels to forecast when cognitively healthy individua…
Wellbeing
Combined Lifestyle Plus Supplement Interventions Show Mixed Dementia Prevention Results
A systematic analysis of twelve randomized controlled trials reveals the emerging evidence for combining multidomain li…
Studies
Targeted RNA Therapy Reduces Toxic Transcripts in Myotonic Dystrophy
An antibody-oligonucleotide conjugate demonstrated selective reduction of toxic RNA transcripts in myotonic dystrophy t…
Studies
Long-Acting HIV Injections Show Promise for Adherence-Challenged Patients
Monthly or bimonthly injections of cabotegravir combined with rilpivirine demonstrated sustained viral suppression in H…
Studies
Diabetes Patients Prioritize Quality of Life Over Glucose Control in Islet Therapy
Patient-reported priorities for stem cell-derived islet transplantation diverge significantly from traditional clinical…
Longevity
Multiple Functional Deficits Predict Mortality Better Than Individual Measures
Analysis of 12,906 Chinese adults revealed that accumulating multiple age-related functional impairments creates a more…
Studies
Novel Arctigenin Derivative ARC-18 Clears Brain Amyloid Through Autophagy Enhancement
ARC-18, a synthetic derivative of the plant compound arctigenin, demonstrated dual mechanisms against Alzheimer's patho…
Wellbeing
Alaska's Annual $1,500 Cash Payments Show No Rise in Injuries or Deaths
Analysis of Alaska's Permanent Fund Dividend examined whether sudden cash infusions trigger risky behaviors leading to…
PREPRINTFitness
5,000-Protein Analysis Reveals HFpEF Rehabilitation Mechanisms Across Multiple Organs
Researchers analyzed over 5,000 circulating proteins from two randomized rehabilitation trials in heart failure with pr…
Studies
Systematic Review Finds Weak Evidence for Pediatric Melatonin Efficacy
A comprehensive systematic review examining melatonin's therapeutic value in neurotypical children reveals substantial…
Studies
Five Cancer Types Drive 70% of Under-50 Deaths Despite Prevention Advances
Breast, colorectal, lung, brain, and lymphoid cancers account for approximately 70% of cancer deaths in Americans under…
Studies
Watchful Waiting Matches Drug Therapy for Preterm Heart Defect
A randomized trial comparing immediate medication versus watchful waiting for patent ductus arteriosus in extremely pre…
Studies
Prenatal Acid-Blocking Medications Increase Child Neurodevelopmental Disorder Risk
Analysis of 2.5 million Korean mother-child pairs reveals that prenatal exposure to proton pump inhibitors and H2 recep…
Wellbeing
Chronic Stress Emerges as Key Pathway Linking Depression to Cardiovascular Events
Analysis of cardiovascular event data reveals chronic stress serves as a primary biological mediator connecting depress…
Longevity
Blocking Fat Tissue Growth Hormone Receptors Preserves Brain Function in Aging
Eliminating growth hormone receptors specifically in fat tissue dramatically protected aged mice from brain deteriorati…
Studies
CD8 T Cells Deploy Caspase-8 Death Pathway Against Brain Parasites
Caspase-8 deficiency in CD8+ T cells dramatically impairs the immune system's ability to control Toxoplasma gondii brai…
PREPRINTWellbeing
High-Dose Brain Stimulation Shows 47% Response Rate in Early Alzheimer's
A 15-day high-dose accelerated intermittent theta-burst stimulation protocol delivered 7,200 magnetic pulses daily to s…
PREPRINTWellbeing
Clinician Subjective Cognitive Assessments Outperform Patient Self-Reports in 4,290 Adults
Analysis of 4,290 older adults across cognitive health spectrums reveals that clinician and informant reports of subjec…
Nutrition
3-Hour Pre-Sleep Fasting Window Improves Nighttime Blood Pressure Regulation
Extending overnight fasting by finishing meals at least three hours before bedtime significantly enhanced nighttime dia…
Studies
Pancreatic Cancer Cells Form Synaptic Connections With Sensory Neurons
Pancreatic cancer cells establish direct synaptic-like connections with sensory neurons, utilizing glutamate receptors…
Wellbeing
Black Carbon Pollution Triggers Depression Through Mitochondrial DNA Changes
Exposure to black carbon—fine soot particles from combustion sources—over just 28 days significantly increased depressi…
Wellbeing
Light Smokers Face Unique Cessation Barriers in Latin America
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from hea…
PREPRINTWellbeing
Plastic Nanoparticles Drive Atherosclerosis Through Distinct Smooth Muscle Cell Programming
Polyethylene and polyvinyl chloride nanoparticles—the most common plastics found in human arterial plaques—accelerate a…
Longevity
Memory Cell Reprogramming Reverses Cognitive Decline in Alzheimer's Models
Scientists achieved cognitive restoration in aged and Alzheimer's disease mice by applying OSK transcription factor the…
Wellbeing
Maternal Antibodies Reprogram Infant Intestinal Immune Development
Singapore researchers have identified how specific immunoglobulin A (IgA) antibodies in breast milk actively reshape th…
Studies
Lactylation Process Links Energy Metabolism to Parkinson's Disease Neurodegeneration
Chinese researchers have identified lactylation—a recently discovered epigenetic modification—as a key mechanism throug…
Wellbeing
12/15-Lipoxygenase Enzyme Amplifies Brain Inflammation Following Severe Seizures
The lipid-metabolizing enzyme 12/15-lipoxygenase becomes pathologically activated during status epilepticus, generating…
Studies
CAR-T Cell Engineering Targets Alzheimer's Amyloid Plaques Directly
Scientists have developed genetically modified immune cells that specifically target amyloid-beta plaques in Alzheimer'…
Research
Children relentlessly exposed to weight loss drug promotion online, commissioner warns
The Children's Commissioner of England has warned that a significant number of children and young people are being expo…
Wellbeing
Elite Athletes Face Heightened Suicide Risk After Career Transitions
Former England cricket star Graham Thorpe's death by suicide at 55 highlights a critical vulnerability among elite athl…
Wellbeing
Protein Synaptogyrin-3 Controls Dopamine Release Linked to Addiction Vulnerability
Synaptogyrin-3 (Syngr3), a presynaptic protein, emerges as a key regulator controlling dopamine neurotransmitter releas…
Studies
Zebrafish Larvae Reveal Energy-Optimized Hunting Strategy in Neural Motor Circuits
Larval zebrafish demonstrate sophisticated energy-optimization algorithms in their neural motor circuits, selectively m…
Wellbeing
Myelin Demonstrates Previously Unknown Self-Repair Mechanisms in Neural Networks
Neural tissue's protective myelin coating exhibits sophisticated regenerative properties that challenge current underst…
Studies
PTEN Gene Mutations Trigger Brain Overgrowth Through ARP2/3 Protein Complex
PTEN gene mutations, which cause neurodevelopmental disorders including autism and epilepsy, drive abnormal brain enlar…
Studies
New Genetic Tool Tracks Beta Cell Division Over Extended Periods
Researchers developed a genetic recording system that continuously monitors pancreatic beta cell division across extend…
Research
Imagining the rich lives of invertebrates
The article explores the cognitive and emotional capacities of invertebrates, suggesting they may possess richer inner…
Longevity
p62 Protein Forms Condensates That Orchestrate Mitochondrial Quality Control
The p62 protein creates liquid-like condensates that actively cluster damaged mitochondria, functioning as a cellular q…
Longevity
Brain Pattern Subtypes Show Differential Response to Multidomain Dementia Prevention
Machine learning analysis of 120 participants in the landmark FINGER trial revealed that individuals cluster into disti…