PREPRINTStudies
Sleep Apnea Severity Tracks Brain-Clearance Impairment: DTI-ALPS Correlation of r=-0.53
Pooled data show that higher apnea-hypopnea index (AHI) tracks with lower DTI-ALPS values, an MRI proxy for glymphatic…
Wellbeing
Research on brain health, sleep, stress, integrative therapies, and psychological wellbeing.. Browse synthesized summaries from peer-reviewed journals and trusted health sources.
PREPRINTStudies
Sleep Apnea Severity Maps to Cardiometabolic Disease Across 222,109 Adults
Across 222,109 adults who underwent diagnostic sleep testing in Kaiser Permanente Southern California, apnea-hypopnea…
PREPRINTStudies
Sleeping 9+ Hours Linked to Lower Cognition; Insomnia Link Weaker
Pooling HCHS/SOL, MESA and ARIC (N=11,563), long sleep (9+ hours) tracked with lower baseline global cognitive…
Wellbeing
Social Ties Track Higher Brain and Mood Function, Not Slower Decline
Loneliness and social isolation are often framed as drivers of rapid aging, but this analysis suggests the story is…
Longevity
Untreated Hearing Loss Tracks With Higher Mortality; Hearing Aid Users Fare Better
Hearing loss affects a majority of adults over 70, yet it is often dismissed as a nuisance of aging rather than a…
Studies
Coronary Calcium Scores Drive Statin and Aspirin Decisions in 400 Patients
Among 400 primary prevention patients in a community cardiology practice, coronary artery calcium (CAC) score tracked…
Wellbeing
Alcohol's 1-in-100 Death Risk Starts at 3 to 9 Weekly Drinks
A multi-state life-table model of a cohort followed from age 12, parameterized with New Zealand data and using WHO and…
Fitness
Treadmill Running Beats Enalapril at Calming Fatty-Liver Inflammation in Obese Mice
In obese mice, 8 weeks of treadmill running (300 min/week) and the ACE inhibitor enalapril (10 mg/kg/day) each cut…
Nutrition
Jabuticaba Peel Extract Shields Mouse Kidneys From High-Fat, High-Fructose Damage
In 50 male C57BL/6 mice fed a high-fat, high-fructose diet for 12 weeks, early renal damage appeared: more vascular…
Wellbeing
Hazardous Drinking Linked to 2.5-Fold Suicide Risk in Women Only
In a nationally representative Korean cohort of 64,756 adults followed a median 9.7 years, hazardous drinking on the…
PREPRINTStudies
ARBs like losartan linked to 30% lower Parkinson's risk in 270,000 hypertensives
Among 269,617 Medicare-age adults starting first-line hypertension treatment, those who began an angiotensin receptor…
PREPRINTStudies
Quick Walking Speed Predicts Dementia Risk (HR 1.34) Where Usual Pace Doesn't
In the Framingham Offspring cohort (2,308 adults, mean age 61.5; 1,148 dementia-free adults aged 60+ followed 10…
PREPRINTStudies
Intermittent Fasting Extends Lifespan in Brain-Injured Fruit Flies, Cutting Neural Inflammation
In fruit flies subjected to repetitive mild traumatic brain injury, two intermittent fasting regimens produced longer…
Nutrition
Folate plus B12 and omega-3 lead 12-study scoping review on cognition
A scoping review screened 803 records and kept 12 studies (8 randomised trials, 3 cohorts, 1 open-label trial) testing…
Studies
Sleeping 4 Hours or Less Raises MASLD Odds 44% in Koreans
Across 26,909 Korean adults in the 2014-2021 national nutrition survey, 23.2% had metabolic dysfunction-associated…
PREPRINTStudies
Not all ARB blood-pressure drugs equal: dementia hazard varies 0.66–0.93 versus lisinopril
Across 2,051,275 eligible adults aged 55–80 in the TriNetX network, starting an angiotensin receptor blocker (ARB)…
PREPRINTFitness
Beetroot Juice Nitrate Fails to Speed Muscle Force Development in Young Adults
A single 200 μmol/kg nitrate dose from beetroot juice left rate of torque development unchanged versus a nitrate-free…
PREPRINTStudies
High Blood Pressure Variability Plus Diabetes Raises Mortality Risk 2.8-Fold in 57,611 Adults
Among 57,611 UK Biobank participants followed a median 5.1 years, people with type 2 diabetes and high systolic blood…
PREPRINTStudies
Better Life's Essential 8 Scores Track Lower Brain Small-Vessel Damage Across Ethnic Groups
In a cross-sectional analysis of 44,982 adults (with a 1,426-person matched MRI subsample), each standard-deviation…
Longevity
Exercise plus mental-social activity adds 7 years free of cognitive impairment
Across four harmonized aging cohorts spanning Asia, North America and Europe, adults at age 50 who did both structured…
Fitness
Midlife Exercise Linked to 20% Fewer Memory Complaints Three Decades Later
Among 4,397 women in the NYU Women's Health Study (mean age 46 at baseline, 79 at follow-up), those in the top tertile…
Longevity
Chronic Stress Shortens Mouse Lifespan; NMN and Bazi Bushen Herbal Formula Reverse It
In a 12-month unpredictable chronic mild stress model in mice, chronic stress amplified systemic inflammation, damaged…
PREPRINTStudies
84% of Patients With High Hospital Blood Pressure Remain Hypertensive Four Weeks Later
Among 50 adults hospitalized for non-cardiac conditions who had asymptomatic blood pressure readings of 140/90 mmHg or…
PREPRINTStudies
Obesity Beyond 25 Years Raises Heart Strain Markers by Age 62
In 4,901 members of the 1958 British birth cohort, 26.3% experienced obesity at some point between ages 7 and 62. Ever…
Studies
Alcohol Use Disorder Raises Women's Dementia Risk Nearly Fourfold, Tenfold Before Age 70
In the Million Women Study, 20,070 women with hospital-recorded alcohol use disorder (AUD) were matched to 100,339…
Studies
Rare Sugar D-Psicose Eases Fatty Liver in Diabetic Mice
In mice made diabetic with a high-fat diet plus streptozotocin, low- and high-dose D-psicose (a rare sugar) improved…
PREPRINTSupplements
10 µM Zinc Supplementation Extends Healthspan and Fights Protein Aggregation in Worms
In aging C. elegans, whole-body zinc levels fall by roughly 90% between day 1 and day 13 of adulthood. Supplementing…
PREPRINTWellbeing
Part-Time Work Into Your 70s Cuts Dementia Risk by 38%
Among 13,879 U.S. Health and Retirement Study participants, those who maintained sustained part-time employment…
PREPRINTWellbeing
CBT for Insomnia Improves Subjective Cognition but Not Brain Activity Over 1 Year
In a randomized controlled trial of 56 adults with insomnia disorder and 20 good sleepers, CBT for insomnia (CBTi)…
PREPRINTWellbeing
Year-Long Brain Implant Study Maps How Seasons and Weather Reshape Sleep
Continuous subcutaneous EEG recordings from 20 healthy adults across a full year reveal that sleep architecture is…
PREPRINTLongevity
Bone hormone osteocalcin reverses age-related locomotor decline via motoneuron mitophagy
The bone-derived hormone osteocalcin (OCN) acts on spinal motoneurons via the receptor GPR158 to regulate autophagy…
PREPRINTLongevity
Restoring noradrenaline-like signalling in fly neurons extends lifespan and reverses motor decline
In aging Drosophila brains, octopamine (the invertebrate equivalent of noradrenaline) normally drives glucose uptake…
Wellbeing
One Month Alcohol Abstinence Cuts Liver Enzymes by 60% in ALD Patients
In a prospective cohort of 72 adults with confirmed alcoholic liver disease (ALD) at a Kathmandu rehabilitation…
PREPRINTWellbeing
MHT Raises Breast Cancer Risk But Cuts Mortality by 28% in 78,000-Woman Trial
In a secondary analysis of 78,209 women from the PLCO Cancer Screening Trial, ever-use of menopausal hormone therapy…
PREPRINTWellbeing
Late Bedtime Predicts Visceral Fat in Postmenopausal Women with Obesity
In 122 postmenopausal women (mean age 58.1 years, mean BMI 33.2 kg/m²), later sleep onset was significantly associated…
PREPRINTWellbeing
Lifestyle intervention boosts cognition regardless of Alzheimer's blood biomarker levels
In a secondary analysis of the landmark FINGER randomized controlled trial (N=1,260 at-risk older adults), six core…
PREPRINTWellbeing
Low Social Connection Ages the Brain 5.8 Years; Heavy Smoking Costs 5 Years
In a cross-sectional analysis of 13,866 adults from the All of Us Research Program, four modifiable lifestyle factors…
Wellbeing
Sodium-Tracking App Cuts Blood Pressure in 88 Hypertensive Adults Over 2 Months
An 88-patient parallel RCT tested NamakBan, an Android app enabling self-reported salt intake logging, blood pressure…
Supplements
Two Fisetin Derivatives Outperform Parent Compound as Senolytics in Aging Mice
Two synthetic derivatives of the natural flavonoid fisetin — SR29384 and SR31133 — demonstrated superior senolytic…
Nutrition
Early-Life Sugar Restriction in First 1000 Days Cuts Lifetime Dementia Risk
The first thousand days of life — from conception through age two — have long been considered a critical developmental…
PREPRINTWellbeing
Mental Stress Triples Heart Attack Risk in Women Post-MI, Black Women Hit Hardest
Among 602 adults (mean age 51; 46% women) studied within eight months of a premature myocardial infarction, mental…
PREPRINTFitness
Swapping 30 Min of Sitting for Moderate Exercise Cuts AFib Risk 20%
Across 91,873 adults in the UK Biobank and US REGARDS cohorts tracked by accelerometry, replacing 30 minutes of daily…
PREPRINTSupplements
Apigenin Extends Worm Lifespan and Shields Against Alzheimer's Proteins via Redox Signalling
Chronic apigenin exposure extended median lifespan in wild-type C. elegans and improved multiple healthspan markers…
PREPRINTStudies
GLP-1 Drugs Skew to Younger, Heavier Older Adults — Sicker Patients Left Out
Among 58,754 adults aged 65 or older with type 2 diabetes treated at a regional US healthcare system between 2018 and…
Nutrition
Healthy Plant-Rich Diets Linked to 31% Better Smell Function in 6,690 Adults
Among 6,690 adults in the CHRIS cohort study, higher adherence to five established healthy dietary patterns…
Nutrition
5:2 Fasting Rebuilds Muscle and Liver in MASLD Mice via Gut-Bile Axis
In male C57BL/6J mice fed a 45% high-fat diet for 14 weeks to induce metabolic dysfunction-associated steatotic liver…
Fitness
10,000 Steps, 48-Min MVPA, 7.8-Hr Sleep Linked to Lower Disease Risk
Analyzing 11.8 million person-hours of wrist accelerometer data from 70,473 UK Biobank participants followed for up to…
PREPRINTNutrition
DASH Diet From Midlife Onward Cuts Dementia-Linked Brain Damage by 12%
In 892 older Singaporean adults tracked across 32 years (1993–2025), higher adherence to the DASH diet during midlife…
PREPRINTWellbeing
Pre-Existing Depression and Anxiety Double Post-COVID Risk; Brain Structure Irrelevant
In 8,464 SARS-CoV-2-infected participants from the German National Cohort (NAKO), pre-infection mental health…
PREPRINTWellbeing
Daily Negative Mood Predicts 60% Higher Heart Attack Recurrence Risk
Among 287 midlife adults (mean age 51, 43% women) monitored within 8 months of a myocardial infarction, each standard…
PREPRINTWellbeing
18-Month Meditation Trial Shows Minimal Sleep Benefits in Healthy Older Adults
An 18-month structured meditation intervention in 120 cognitively unimpaired adults aged 65 or older produced only one…
Nutrition
High Omega-3 Levels Neutralize H-FABP's 2× Heart Attack Risk
In 42,392 UK Biobank participants free of coronary heart disease and heart failure at baseline, elevated plasma…
Studies
Digital therapeutic + CGM cuts HbA1c 0.8% vs 0.3% in T2D RCT
In a 6-month, 24-site German RCT of 320 non-insulin-treated adults with type 2 diabetes (HbA1c 7–11%, BMI ≥25)…
Longevity
High Cardiovascular Health Score Adds 5-10 Years of Disease-Free Life
Across 130,837 adults in two large prospective cohorts — UK Biobank and NHANES — scoring in the top tier of the Life's…
Supplements
Crocin (saffron pigment) reverses fatty liver markers in rats on high-fat diet
In 42 male Wistar rats fed a high-fat diet for eight weeks to induce NAFLD, intraperitoneal crocin administered over…
PREPRINTWellbeing
Temperature-Regulated Sleep Surface Adds 33 Minutes of Sleep in Most Sleep-Deprived Adults
Among 171 adults tracked with wearables over seven baseline nights and seven nights on a temperature-controlled sleep…
PREPRINTSupplements
Lab4 Probiotic Cuts GP Visits by 52% in Healthcare Workers—But Trial Too Small
In a 16-week double-blind RCT of 104 healthcare workers, daily Lab4 probiotic supplementation produced consistently…
PREPRINTLongevity
Four Inflammatory Markers Explain 57% of Black-White Heart Failure Gap
In a 16-year prospective follow-up of 6,785 multi-ethnic adults (MESA cohort, 2000–2002), four baseline biomarkers…
Fitness
Higher Lifelong Activity Cuts Dementia Risk 25% Across Four Nations
Across four major aging cohorts — HRS (USA), ELSA (UK), SHARE (Europe), and MHAS (Mexico) — adults who maintained…
Fitness
Unstructured Daily Movement Cuts Depression and Blood Pressure in 8,551 Adults
Across 38 randomized controlled trials enrolling 8,551 adults, interventions that wove physical activity into daily…
Wellbeing
Healthy Sleep Cuts Stroke Risk 14% Via Lipid and Inflammation Pathways
In 200,729 UK Biobank participants followed for a median 12.6 years, each one-point improvement on a six-component…
Longevity
18-Month Exercise-Nutrition Program Slows Cognitive Decline in Targeted Older Adults
An 18-month multimodal intervention combining exercise, nutrition, and metabolic management produced significant…
Wellbeing
Social Isolation After Stroke Raises CVD Death Risk 57%, Loneliness Doubles Dementia
Among 7,267 stroke survivors in the UK Biobank followed for a median 10.2 years, social isolation independently raised…
Supplements
Higher Omega-3 Blood Levels Linked to Less Amyloid in APOE4 Carriers
Among 104 cognitively normal older adults enriched for preclinical Alzheimer's disease (69.2% preclinical AD, 44.2%…
Studies
Semaglutide Shows Measurable Kidney-Protective Mechanisms in Diabetic Patients
Chronic kidney disease is the leading cause of end-stage renal failure in adults with type 2 diabetes, and slowing its…
PREPRINTLongevity
Frequent High-NO2 Days Accelerate 14-Year Cognitive Decline in Older Adults
Among 12,235 English adults aged 50 and older followed for up to 14 years in the English Longitudinal Study of Ageing…
PREPRINTWellbeing
Repeated Partner-Inflicted Head Injuries Age Women's Brains by Up to 28 Years
Among 207 women with lifetime exposure to physical intimate partner violence, those reporting ten or more…
PREPRINTWellbeing
Sleep Hypoxic Burden Outperforms AHI for Heart Failure Prognosis Over 3.7 Years
Among 178 heart failure patients not receiving airway pressure therapy — followed for a median 3.7 years after acute…
Wellbeing
Smoking After Heart Attack Doubles Mortality Risk vs. Quitters
Among 65,990 Spanish adults tracked across three national health surveys (2011–2017) and linked to mortality data…
PREPRINTFitness
Daily Air Pollution Spikes Cut Next-Day Steps by 483 in Adults Over 50
In a micro-longitudinal study of 67 UK adults aged 50–85, days with higher-than-usual personal PM2.5 exposure — just…
PREPRINTWellbeing
Insomnia at 50 Predicts Cognitive Decline; Same Symptom Reverses After 75
Across 16,884 adults from three longitudinal cohorts (ELSA, Whitehall II, and Rush MAP), difficulty falling asleep at…
PREPRINTWellbeing
Six Lifestyle Clusters Predict Dementia Risk: Worst Combo Raises Hazard 2.4×
Among 151,832 UK Biobank participants aged 60–69, six distinct clusters of co-occurring modifiable risk factors were…
Nutrition
CBT-Enhanced Liver Program Cuts Cardiovascular Events 64% in Fatty Liver Disease
A randomized controlled trial of 286 adults with metabolic dysfunction-associated steatotic liver disease (MASLD)…
PREPRINTWellbeing
Social Isolation Raises Death Risk 34%; Transport Mode Modifies the Harm
In a UK Biobank cohort of 490,114 adults aged 40–69, followed from 2006 to 2022, social isolation was associated with…
PREPRINTWellbeing
Four Sleep Dimensions Tied to Cognitive Function in Adults 55+
In a Chicago-based observational study of 324 adults aged 55 and older (64% women, 37% Black, 14% Hispanic/Latino)…
PREPRINTWellbeing
Marijuana Cuts HRV by 0.47ms and Fragments Sleep Across 17,000 Wearable Users
Across 16,965 wearable-device users contributing over 5.2 million person-days of data, nightly marijuana use was…
Nutrition
High Fat and SFA Intake Linked to 8× Mortality Risk in Cirrhosis
In a 5-year prospective cohort of 121 ambulatory patients with newly diagnosed cirrhosis, higher dietary fat intake…
PREPRINTFitness
Five Proteins Predict Which Heart Failure Patients Gain Most from Exercise Rehab
In 243 older adults (≥60 years) hospitalized for heart failure and enrolled in the REHAB-HF trial, pre-intervention…
PREPRINTWellbeing
Home PEMF Therapy Cuts Blood Pressure by >1 Clinically Meaningful Unit in Small Meta-Analysis
A systematic review and meta-analysis of 10 randomised trials (353 participants) found that pulsed electromagnetic…
PREPRINTSupplements
Phosphatidylserine 300mg/day Misses Primary Memory Target but Hints at Working Memory Gains
A 12-week randomized, double-blind, placebo-controlled trial in 70 adults aged 35–65 with subjective memory complaints…