MERCS Dysfunction Proposed as Upstream Driver of Microglial Senescence in Alzheimer's
Mitochondria-endoplasmic reticulum contact sites (MERCS) coordinate calcium shuttling, mitochondrial fission-fusion dynamics, lipid trafficking, and the…
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Mitochondria-endoplasmic reticulum contact sites (MERCS) coordinate calcium shuttling, mitochondrial fission-fusion dynamics, lipid trafficking, and the…
A GLP-1 receptor agonist best known for diabetes and weight management demonstrates a compelling orthopedic application: locally administered Exendin-4…
Oral semaglutide, despite its commercial availability, achieves only 0.4–1% absolute bioavailability under strict fasting conditions — and essentially zero…
A pilot cross-sectional household survey of up to 600 adults aged 40 and older in Tecpan, Guatemala has established the foundational protocol for ELEGUA — the…
A temple-worn optical wearable device, outputting a proprietary dimensionless Brain Flow index, correlated strongly with transcranial Doppler (TCD)-measured…
One of oncology's most tantalizing puzzles — why localized radiation sometimes shrinks tumors far beyond the treatment field — is now closer to a working…
For the hundreds of millions living with diabetes worldwide, cardiac complications remain the leading cause of death — yet the precise molecular machinery…
Most longevity research focuses on the centenarians themselves, but the more actionable question may be what happens to their children. If the biology that…
For decades, Alzheimer's research has centered on amyloid plaques and tau tangles as the primary drivers of neurodegeneration. This Nature study challenges…
At just 0.15 mg/mL, egg-derived peptides (EPs) from American shad (Alosa sapidissima) extended Caenorhabditis elegans lifespan by 33.33% while improving…
The instinct to minimize all sun exposure may be incomplete. A growing body of evidence suggests that the dose-response relationship for ultraviolet radiation…
Osteoarthritis has long been framed as a mechanical wear-and-tear problem, but a growing body of evidence reframes it as a fundamentally inflammatory disease…
Two decades of American health data reveal a striking paradox: medicine has become remarkably effective at extending life from the diseases it has…
A single molecular target governing the pace of multi-organ aging would be transformative for longevity medicine. New findings published in Science suggest…
The assumption that aging's toll on organs is largely irreversible may need serious revision. A newly identified immune mechanism — not a genetic mutation or…
How the brain synchronizes activity across anatomically distant regions may matter more than how loudly those regions fire — and new methodology is beginning…
The class of drugs that reshaped obesity and metabolic medicine may be on the verge of a more profound repositioning — as genuine longevity agents. If GLP-1…
Short-course sodium valproate — an anticonvulsant repurposed as a cardioprotective agent — administered at 15 mg/kg/day for ≤14 days before cardiac surgery…
A data-driven screen of 16 extract combinations derived from broccoli, licorice, passionflower, and lemon balm identified an optimized three-component blend…
Understanding how infectious disease patterns shift under major societal disruptions reveals something important about transmission dynamics that routine…