Studies
Cryo-EM Reveals How Lipids Gate a Key Purine Transport Protein
Understanding how cells regulate the uptake of purines — the molecular precursors essential for DNA synthesis, cellular energy, and nucleotide signaling — has…
Search Results: "longevity"
Found 1276 results for "longevity"
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Studies
p53 Tumor Suppressor Sustains Mitochondrial Energy During METTL5 Loss
Cancer biology has long treated p53 as a straightforward tumor suppressor—a molecular brake that halts runaway cell growth. New evidence now complicates that…
Studies
Skin Blood Vessel Cells Coordinate Calcium Signals in Conserved 3D Networks
How the body regulates blood flow, inflammation, and vascular permeability at the microscopic level has enormous implications for wound healing, aging skin…
Studies
Lipid Nanoparticles Deliver Full Antibodies Inside Cells, Unlocking Intracellular Targets
One of the most stubborn barriers in precision medicine has been the inability to deploy antibody therapies against proteins that operate inside cells — where…
Studies
Fractional Flow Reserve Versus Imaging: Rethinking CAD Diagnostic Standards
For the tens of millions of adults living with coronary artery disease, the question of which lesions actually restrict blood flow — and which merely look…
Studies
Natural Genetic Self-Correction Resolves WHIM Syndrome in a Patient via Somatic Mutation
When the body repairs its own broken immune system without any medical intervention, it forces a fundamental rethink of how genetic diseases can resolve — and…
Longevity
IL-11 Cytokine Drives Ovarian Stiffening—Blocking It Reverses Aging Markers
For millions of women, ovarian aging arrives earlier and more aggressively than any other organ system's decline, cutting short fertility and accelerating…
Longevity
Network Medicine Maps Aging Hallmarks to Repurposable Drug Candidates
The prospect of extending healthy human lifespan without developing entirely new pharmaceuticals just became more tractable. By treating the biology of aging…
Longevity
IL-11 Inhibition Reverses Ovarian Fibrosis and Restores Fertility in Aged Mice
Ovarian aging quietly undermines both reproductive health and broader hormonal balance in women long before menopause becomes clinically apparent. A mechanism…
PREPRINTWellbeing
Dementia Patients Back AI Medication Reviews—With Key Conditions Attached
Among 12 people living with dementia (PLwD) and 14 carers recruited across two focus groups, qualitative interviews revealed broadly positive attitudes toward…
Supplements
Resveratrol Cuts Alveolar Bone Loss Up to 60% in Animal Periodontitis Models
Across 22 studies — 16 preclinical and 6 randomized clinical trials — resveratrol consistently reduced alveolar bone loss in animal models by a striking 7.09%…
Fitness
Exerkines BDNF and VEGF Link Exercise Directly to Brain Neuroprotection Mechanisms
Physical inactivity constitutes a measurable risk factor for neurodegeneration, with exercise triggering release of dozens of exerkines — bioactive proteins…
Studies
Two Small Molecules Disrupt Lipid Raft Order Via Protein-Dependent Mechanism
Cell membrane architecture may be far more druggable than previously assumed. Lipid rafts — highly ordered microdomains in the plasma membrane — govern how…
Longevity
Energy-Weighted Brain Maps Identify Metabolic Hotspots Associated with Neurodegeneration Vulnerability
Most brain imaging research treats all neural connections as roughly equal — but a neuron firing in your memory center consumes dramatically more energy than…
Studies
Hallucinogenic Compounds Evolved Independently Across Species Targeting Same Brain Receptors
Why would mescaline in a cactus, psilocybin in a mushroom, and DMT in a jungle vine all activate the same receptor in the human brain? The answer may lie not…
Studies
New Dynamic Model Predicts Myeloma Progression with 79% Accuracy Across 2,344 Patients
For the roughly 15,000 Americans diagnosed annually with smoldering multiple myeloma, the critical question is not whether they have cancer but when — or…
Longevity
ARDD 2025: Aging Field Pivots From Description to Engineered Longevity Interventions
For decades, aging research catalogued what goes wrong in aging bodies. The 2025 Aging Research and Drug Discovery conference signals a pivotal maturation…
Studies
Coercive Practices and Structural Discrimination Still Dominate Global Psychosis Care
For the hundreds of millions living with psychosis worldwide, the gap between international human rights standards and daily reality remains vast — and…
Longevity
Review Maps Senolytics Like Dasatinib+Quercetin Against Ovarian SASP Pathways in Preclinical Models
Ovarian aging accelerates through cellular senescence cascades: primordial follicle depletion, SASP-driven stromal inflammation, mitochondrial dysfunction…
Longevity
4 Skin Microbes Predict Age Group with 0.97 AUC Accuracy
A pilot study of 80 healthy Chinese participants across four age cohorts (centered at 10, 30, 50, and 70 years) mapped bacterial and fungal communities on…