Found 349 results for "longevity"
The nonoxidative pentose phosphate pathway, orchestrated by enzymes transketolase and transaldolase, emerges as a critical regulator of CD8+ T cell function by…
Mendelian randomization analysis reveals that while interleukin-6 (IL-6) increases mortality risk, its soluble receptor (sIL-6R) demonstrates the opposite effe…
Analysis of disability-adjusted life years across 204 countries reveals cardiovascular diseases generated 437 million DALYs in 2023, up from 320 million in 199…
HDAC3, a histone deacetylase enzyme, directly regulates the Hippo signaling pathway through acetylation modifications of the Hpo protein, revealing a novel epi…
White adipose tissue accumulation around abdominal organs during midlife follows predictable patterns, but its metabolic consequences depend heavily on individ…
Moss species in thawing Arctic permafrost regions are emerging as unexpected nitrogen suppliers, compensating for nutrient limitations that typically constrain…
Analysis of social network data reveals that problematic individuals within close personal circles—termed 'hasslers'—trigger measurable acceleration in biologi…
Mammary gland involution following weaning triggers widespread cellular senescence that orchestrates tissue remodeling but simultaneously creates microenvironm…
Analysis of 12,906 Chinese adults revealed that accumulating multiple age-related functional impairments creates a more powerful mortality predictor than any s…
Bioengineers developed implantable pressure sensors using liquid metal that wirelessly transmit cardiovascular data without rigid components or external wiring…
The LRRC26 auxiliary subunit fundamentally alters how BK potassium channels respond to voltage changes, enabling activation at resting membrane potentials rath…
A cross-sectional analysis of 57 patients who underwent surgical repair for coarctation of the aorta revealed that lower heart rates independently predicted gr…
The DELTA study introduces a comprehensive N=1 protocol combining time-restricted eating, Mediterranean diet, exercise regimens, and supplementation with conti…
Eliminating growth hormone receptors specifically in fat tissue dramatically protected aged mice from brain deterioration and cognitive decline. The interventi…
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from heavy daily users. These lighter smoking pa…
Larval zebrafish demonstrate sophisticated energy-optimization algorithms in their neural motor circuits, selectively modulating movement patterns to maximize…
CRISPR/Cas12a technology now permits systematic investigation of how multiple genes interact simultaneously, addressing a critical gap in genetic research wher…
Molecular chaperones Hsp70 and Hsp90 demonstrate paradoxical effects in neurological aging, serving both protective and detrimental functions depending on cell…
Sleep emerges as a fundamental driver of longevity through its regulation of cellular repair mechanisms, metabolic homeostasis, and inflammatory pathways. Qual…
Elevated Akkermansia muciniphila levels in aged intestines directly suppress Wnt signaling through the Ascl2 pathway in intestinal stem cells, reducing their r…