Wellbeing
Hippocampus Actively Separates Memories by Meaning, Not Just Context
Memory is far more organized than a simple filing cabinet — and a new finding from a top-tier journal suggests the brain's memory hub plays a more…
Search Results: "longevity"
Found 1276 results for "longevity"
⚕️ Synthesized briefings — original sources linked for full context.
Studies
Alcohol-Related Liver Disease: JAMA Review Maps Diagnosis-to-Treatment Landscape
Liver disease driven by chronic alcohol use remains one of the most prevalent yet underdiscussed contributors to premature mortality in high-income countries…
Studies
Global TB Deaths Continue to Decline, But MDR-TB and Other Factors Threaten Progress
Tuberculosis remains a stubborn paradox in global health: three decades of hard-won gains in reducing mortality are now threatened by drug resistance, funding…
Longevity
Valine Restriction Extends Male Mouse Lifespan 23% Via Mitochondrial Pathway
Among the most consequential questions in longevity research is whether specific dietary signals — rather than broad caloric reduction — can be targeted to…
Studies
Targeted Agents and Immunotherapy Reshape Treatment Landscape for Aggressive TNBC Subtype
Triple-negative breast cancer represents one of oncology's most stubborn challenges — a subtype defined by the absence of estrogen, progesterone, and HER2…
Studies
Recent Developments in Levodopa Delivery and Parkinson's Disease Treatment
For the estimated ten million people worldwide living with Parkinson's disease, the central frustration of treatment has long been the same: levodopa works…
Longevity
Senolytic, Epigenetic, and Metabolic Strategies Converge on Precision Longevity Medicine
The boundary between aging and treatable disease is collapsing — and how medicine responds to that shift will define the next era of chronic-disease…
Fitness
mTORC1 Signaling to Weekly Volume: Hypertrophy Blueprint Synthesized Across Molecular and Practical Evidence
Skeletal muscle mass is not merely an aesthetic concern — it is a critical biomarker of metabolic health, fall resistance, and all-cause mortality risk. A…
Longevity
Biological Age vs. Health: Why the Distinction May Reshape Longevity Medicine
A perspective piece in Rejuvenation Research challenges the field's foundational vocabulary, arguing that 'biological age' and 'health' are functionally…
Studies
Pyruvate Directly Modifies Histones at 88 Sites, Linking Glycolysis to Gene Expression
Every time a cell ramps up glycolysis — burning more glucose for energy — it may be simultaneously rewriting its own gene expression program. A newly…
Studies
Global Mental Disorder Burden Rose Sharply From 1990 to 2023
Mental health conditions now represent one of the most consequential drains on human healthspan worldwide — not primarily through early death, but through…
Longevity
Cross-Species RNA Atlas Reveals Universal Molecular Clocks of Aging and Death
Understanding why some people age faster than others — and what interventions actually slow biological deterioration — has been hampered by the absence of…
Longevity
Narrative Review Maps IF Protocols to AMPK-mTOR-SIRT1 Pathways for Cardiometabolic Health
Four IF protocols — TRE (16/8), alternate-day fasting, 5:2, and OMAD — converge on a shared molecular architecture: AMPK activation suppresses mTOR while…
Nutrition
Pulse- vs Meat-Protein Diets Show Similar Cardiometabolic Benefits in Older Adults, With Possible Ferritin Edge for Pulses
For older adults navigating the intersection of cardiovascular risk and metabolic aging, protein source may matter as much as protein quantity — and this…
Longevity
TRF2 Protein Controls Muscle Stem Cell Fate Beyond Telomere Protection
The capacity to rebuild damaged muscle tissue erodes with age and disease, making the molecular switches governing muscle stem cell behavior among the most…
PREPRINTFitness
Blue-Collar Workers Move More at Work, Less at Leisure: 2,809-Person Accelerometry Study
Accelerometry data from 2,809 adults in the Northern Finland Birth Cohort 1966 (46-year follow-up) reveals stark occupational divides in how physical…
Longevity
Study Links Adverse Weather to Reversible Telomere Shortening in Dairy Goats
In 20 pluriparous Alpine dairy goats monitored across three 15-day intervals, acute environmental stress produced measurable, reversible telomere shortening…
Longevity
Contracted 'Life Space' Associated with Cognitive Decline and Mortality Risk in Older Adults: Concept Analysis
How far an older adult ventures from home on a typical week turns out to be one of the most information-dense signals available about their overall health…
Fitness
β2-Microglobulin Mediates ~38% of the Association Between Physical Activity and Slower Epigenetic Aging
In a cross-sectional analysis of 936 U.S. adults paired with single-cell RNA sequencing in exercised mice, higher physical activity levels associated with…
Longevity
Alzheimer's Brains Harbor Novel Mitochondrial Plaque Structures Driven by Lysosomal Failure
For decades, amyloid plaques have dominated the narrative of Alzheimer's disease pathology — but mounting evidence suggests the full picture is far more…