DNA Repair Defects Unlock Two Immune Signals That Amplify Checkpoint Therapy
For cancer patients whose tumors resist immunotherapy, understanding why some tumors respond and others don't has been one of oncology's most pressing…
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For cancer patients whose tumors resist immunotherapy, understanding why some tumors respond and others don't has been one of oncology's most pressing…
Cadmium is not a compound most people think about at the dinner table, yet it accumulates silently in the kidneys and liver over decades, and new…
Precision oncology is entering a phase where the same molecular probe that finds a tumor can also destroy it — a concept called theranostics that is rapidly…
For decades, therapeutic cancer vaccines were considered a promising but consistently underdelivering strategy — most candidates failed to move the survival…
For patients and clinicians weighing the trade-offs of adding immunotherapy to standard treatment in limited-stage small cell lung cancer, quality-of-life…
Endometrial cancer incidence is rising in lockstep with global obesity rates, and in early-stage disease, women are statistically more likely to die from…
Whole-genome sequencing data from the All of Us Research Program, covering 265 AML cases and 169,706 controls, identified four genes carrying statistically…
Dedifferentiated liposarcoma represents one of oncology's more frustrating treatment puzzles: a rare, aggressive fat-tissue cancer defined by amplification of…
Among 422 Black/African American women with systemic lupus erythematosus (SLE) followed for nearly two years, longer leukocyte telomere length (LTL)…
Clonal haematopoiesis — the silent accumulation of blood stem cells carrying somatic mutations — affects roughly half of adults over 70 and is one of the…
For the many patients prescribed high-dose folic acid for blood disorders — and for the general population routinely exceeding recommended folate intake…
Skin disease affects nearly five billion people annually, yet the global workforce trained to treat it remains dramatically unequal across income levels — a…
Preventing cancer deaths—not merely cases—is the ultimate benchmark for any vaccination program, and evidence reaching that threshold has been remarkably slow…
Personalized cancer treatment may be entering a genuinely new era. The convergence of two transformative biotechnologies — CRISPR genome editing and mRNA…
Pancreatic cancer remains one of oncology's most stubborn challenges, with five-year survival rates hovering below 12%. The discovery that a tumor's own…
Understanding precisely how ultra-processed foods (UPFs) damage the cardiovascular system has long been the missing mechanistic link in an otherwise…
Understanding why some breast cancer subtypes are more aggressive than others has long hinged on identifying the cells of origin and the molecular switches…
Understanding why certain cancers become increasingly aggressive despite standard treatment has long puzzled oncologists. This research identifies a plausible…
Pancreatic cancer remains one of oncology's most intractable challenges, with most patients experiencing rapid disease progression after standard…
Coronary artery calcium (CAC) scores extracted from routine staging 18F-FDG PET/CT scans in 276 women with newly diagnosed breast cancer (mean age 55.5 years…