Found 91 results for "cancer"
Analysis of Japan's national disease registry identified pseudo-polyps as tripling colorectal cancer risk in ulcerative colitis patients (hazard ratio 2.92), w…
Thyroid nodules develop in 2-3% of pregnancies, with existing nodules often enlarging due to hormonal changes that naturally increase thyroid gland size. Fine…
Scientists developed a molecular adapter called eCD16A/anti-CD3-BFP that transforms existing cancer antibodies into T cell-recruiting weapons. The bifunctional…
PARP inhibitors olaparib and niraparib trigger cellular senescence in pancreatic cancer cells through the Chk2-p21 pathway, independent of p53 status and BRCA…
Senescent cells exhibit a paradoxical dual nature in cancer biology, initially protecting against tumor formation through p53/p21 and p16INK4a-RB pathways, but…
Senescent cells in lung tumors actively reshape immune responses through their senescence-associated secretory phenotype (SASP), creating a complex microenviro…
Natural compounds including alkaloids, flavonoids, terpenoids, and polyphenols demonstrate ability to modulate the PI3K/Akt/mTOR pathway, which controls autoph…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two hea…
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting chemicals (EDCs) playing a particularly si…
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among tested PARP inhibitors in lung cancer cell…
Researchers modified natural killer cells with 2B4 and DAP12 co-stimulatory domains, creating CAR-NK cells that demonstrated enhanced cytotoxic programming aga…
Cardiac toxicity emerges as a critical limitation for immune checkpoint inhibitors like pembrolizumab and nivolumab, with researchers now identifying the molec…
Analysis of 149 million deaths across 195 countries reveals sepsis accounts for 31.5% of all global deaths, claiming 21.4 million lives in 2021 alone. The cond…
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week phase 2a trial involving patients with…
A population-based screening trial involving over 270,000 Swedish adults demonstrated that both colonoscopy and fecal immunochemical testing (FIT) significantl…
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and activates microglia cells to break down amyl…
An experimental blood test analyzing tumor-associated extracellular vesicles and particles achieved 82.9% sensitivity for detecting high-grade serous carcinoma…
Ten patients with severe, treatment-resistant autoimmune conditions—five with antisynthetase syndrome and five with systemic sclerosis—experienced significant…
Nordihydroguaiaretic acid (NDGA), a lignin compound from creosote bush, demonstrates significantly enhanced anti-cancer activity against prostate tumors when p…
Nivolumab, a PD-1 checkpoint inhibitor, demonstrates remarkable durability in advanced melanoma patients with survival benefits persisting nearly a decade post…