Found 1467 results for "cancer"
Targeting both mTOR and calcineurin signaling pathways simultaneously blocks natural killer cell-driven transplant rejection that occurs through 'missing self'…
Researchers have pinpointed the MERTK receptor tyrosine kinase as a potential drug target for ZFTA-RELA fusion-positive ependymomas, aggressive pediatric brain…
Laboratory experiments reveal quercetin activates the UBC6 enzyme, which orchestrates a cascade that degrades AURKA protein and activates AMPK signaling in ova…
Chronic stress triggers the formation of a previously unknown neutrophil subtype called cancer stress-primed (CSP) neutrophils, characterized by elevated expre…
Pancreatic cancer cells establish direct synaptic-like connections with sensory neurons, utilizing glutamate receptors typically found in the brain to accelera…
Researchers modified natural killer cells with 2B4 and DAP12 co-stimulatory domains, creating CAR-NK cells that demonstrated enhanced cytotoxic programming aga…
An experimental blood test analyzing tumor-associated extracellular vesicles and particles achieved 82.9% sensitivity for detecting high-grade serous carcinoma…
Analysis of 149 million deaths across 195 countries reveals sepsis accounts for 31.5% of all global deaths, claiming 21.4 million lives in 2021 alone. The cond…
Pooled analysis of eight randomized trials involving 749 advanced lung cancer patients demonstrates that structured exercise interventions produce a standardiz…
A cytoplasmic enzyme called N4BP2 has been identified as a key driver of catastrophic chromosome shattering in cancer cells. This nuclease enters ruptured micr…
Chimeric antigen receptor natural killer (CAR-NK) cells demonstrate significantly reduced cytokine release syndrome and neurotoxicity compared to CAR-T therapi…
Senescent cells in lung tumors actively reshape immune responses through their senescence-associated secretory phenotype (SASP), creating a complex microenviro…
Natural compounds including alkaloids, flavonoids, terpenoids, and polyphenols demonstrate ability to modulate the PI3K/Akt/mTOR pathway, which controls autoph…
Senescent cells exhibit a paradoxical dual nature in cancer biology, initially protecting against tumor formation through p53/p21 and p16INK4a-RB pathways, but…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two hea…
PARP inhibitors olaparib and niraparib trigger cellular senescence in pancreatic cancer cells through the Chk2-p21 pathway, independent of p53 status and BRCA…
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting chemicals (EDCs) playing a particularly si…
MAPKAPK2, a stress-responsive kinase in the p38 signaling pathway, determines whether MEK1/2 inhibitors succeed or fail against colorectal cancer cells under m…
Researchers have successfully modified CD4+ T cells with chimeric antigen receptors (CARs) to specifically recognize and target amyloid-β plaques characteristi…
Parasitic wasps deploy a viral-derived protein tyrosine phosphatase that specifically targets Rad9A, a critical cell cycle checkpoint protein, effectively hija…