Found 1248 results for "cancer"
Age-related decline in natural killer cell function stems from disrupted glycolysis and mitochondrial metabolism, according to new mechanistic research. Scient…
Laboratory experiments reveal quercetin activates the UBC6 enzyme, which orchestrates a cascade that degrades AURKA protein and activates AMPK signaling in ova…
Parasitic wasps deploy a viral-derived protein tyrosine phosphatase that specifically targets Rad9A, a critical cell cycle checkpoint protein, effectively hija…
Researchers have successfully modified CD4+ T cells with chimeric antigen receptors (CARs) to specifically recognize and target amyloid-β plaques characteristi…
MAPKAPK2, a stress-responsive kinase in the p38 signaling pathway, determines whether MEK1/2 inhibitors succeed or fail against colorectal cancer cells under m…
A comprehensive WHO analysis examining 30 modifiable risk factors reveals that 40% of global cancer cases stem from preventable causes, representing the most e…
A comprehensive WHO analysis examining 30 modifiable risk factors reveals that 40% of global cancer cases stem from preventable causes, representing the most e…
A computational framework successfully distinguishes between benign and pathogenic single amino acid substitutions in proteins, addressing a critical gap in ca…
Researchers have developed methods to selectively eliminate specific populations of senescent cells while preserving those that contribute to tumor suppression…
Platinum chemotherapy triggers cellular senescence in ovarian and lung cancer cells, paradoxically promoting malignancy through TGFβ ligand secretion. González…
Metastatic cancer cells actively acquire mitochondria from surrounding immune cells through a previously uncharacterized transfer mechanism, essentially comman…
A novel radiopharmaceutical demonstrates efficacy against small-cell lung cancer and neuroendocrine prostate cancer, two notoriously aggressive malignancies th…
The ATR/CHK1 signaling cascade can initiate genome protection responses even when stripped of RPA protein complexes, traditionally considered essential for pat…
Marcel Deckert's team at INSERM Nice has identified USP9X as a critical vulnerability in melanoma progression, where this deubiquitinating enzyme stabilizes th…
Marcel Deckert's team at INSERM in Nice has identified USP9X as a critical vulnerability in melanoma's adaptive machinery. This deubiquitinating enzyme stabili…
The MET-PREVENT trial enrolled over 1,000 participants to test whether metformin could delay onset of cardiovascular disease, cancer, dementia, and other age-r…
Scientists have engineered circular RNA structures that form self-looping configurations, demonstrating enhanced stability and prolonged therapeutic activity c…
French researchers have mapped the mechanisms by which mitochondria migrate between adjacent cells, particularly within tumor environments. This intercellular…
An international expert panel has established the first formal clinical definitions and assessment frameworks for loneliness specifically in older cancer patie…
The TROFFi trial represents a groundbreaking application of senolytic therapy, testing whether fisetin at 20 mg/kg daily can reverse chemotherapy-induced physi…