Natural experiment data from 60,768 UK Biobank participants revealed that sugar restriction during early life produces dose-dependent reductions in disease risk across multiple organ systems. Children exposed to wartime sugar rationing (ending September 1953) showed 17-21% lower risks for infections, cancer, mental disorders, and digestive, nervous, musculoskeletal, genitourinary, and skin conditions, plus 21% reduced all-cause mortality. The protection operated through two pathways: molecular memory (3-9% of effect) and dominant physiological programming (4-13% of effect) that creates a metabolically efficient adult phenotype with higher fat-free mass and lower basal metabolic rate. This represents the first comprehensive demonstration that early nutritional programming can coordinate protection across multiple organ systems simultaneously, rather than affecting isolated diseases. The finding strengthens the case for restricting added sugars in infant foods, given that metabolic programming in the first 1,000 days appears to create lasting systemic resilience. However, this preprint awaits peer review, and the observational design cannot definitively establish causation despite the natural experiment framework. The results suggest early sugar restriction may be among the most impactful longevity interventions available.