Bacterial Pathway Engineering Produces Novel Lipidated Macrocyclic Peptides
Engineering bacterial metabolism to produce novel therapeutic compounds could revolutionize how we develop antibiotics and anticancer agents. Traditional drug…
Found 573 results for "cancer"
Engineering bacterial metabolism to produce novel therapeutic compounds could revolutionize how we develop antibiotics and anticancer agents. Traditional drug…
Adult tissue regeneration may depend on a previously unrecognized cellular recycling mechanism that allows mature cells to become stem-like again. This discove…
The discovery that our own immune system attacks a key brain protein could reshape how we understand and treat one of the most devastating neurodegenerative di…
The discovery that a common dandruff shampoo ingredient might help fight one of the deadliest cancers represents an unexpected convergence of dermatology and o…
Pancreatic adenocarcinoma remains one of oncology's most formidable challenges, with five-year survival rates below 12% and limited therapeutic breakthroughs o…
The safety of seafood consumption faces unprecedented challenges as ocean pollution reaches critical thresholds that directly impact human health through dieta…
Cancer treatment paradigms may shift dramatically if immunotherapy can replace chemotherapy for certain colon cancer patients, potentially eliminating the hars…
Health equity gaps often perpetuate disease burdens in marginalized populations, but targeted interventions can dramatically compress elimination timelines. Ab…
Personalized cancer recurrence prediction could transform how oncologists counsel patients and tailor treatment intensity for the most common form of breast ca…
The combination of withaferin A (0.2 µM) from Ashwagandha and sodium butyrate (2.5 mM), a gut microbiome metabolite, reduced viability in MCF-7, MDA-MB-231, an…
Cancer treatment advances increasingly depend on understanding which cell types populate tumors and how they interact, yet standard tissue analysis provides on…
Senescent cancer-associated fibroblasts orchestrate early lymph node metastasis in pancreatic ductal adenocarcinoma through a sophisticated lactate-driven meta…
The molecular mechanisms underlying exercise's protective effects against chronic disease have remained largely mysterious, despite decades of epidemiological…
The accumulation of damaged cholesterol molecules may represent a more significant health threat than previously recognized, potentially accelerating multiple…
Cancer cells may have found an unexpected Achilles' heel in their own evolutionary baggage. New research reveals that blocking a protein called menin not only…
The latest federal nutrition recommendations present a puzzling contradiction that could impact millions of Americans' cardiovascular health trajectories. Whil…
CRISPR/Cas9 screening identified MCL1 as a critical vulnerability in palbociclib-induced senescent colorectal cancer cells. The CDK4/6 inhibitor palbociclib cr…
Bile duct cancer patients who initially respond to targeted therapy face an inevitable challenge: their tumors develop sophisticated resistance mechanisms that…
Cancer drug resistance may have less to do with tumor genetics and more to do with basic cell biology. New evidence suggests that tiny cellular organelles call…
Cancer cells rely on sophisticated molecular machinery to migrate through tissues and establish metastases. This cellular choreography depends heavily on how g…