Molecular Glue Forces BCL6 Oncogene to Trigger Lymphoma Cell Death
For decades, oncogenic transcription factors like BCL6 have been considered largely undruggable — their surfaces lack the convenient pockets that conventional…
Found 1856 results for "cancer"
For decades, oncogenic transcription factors like BCL6 have been considered largely undruggable — their surfaces lack the convenient pockets that conventional…
For the roughly one-third of adults with metabolic dysfunction-associated steatohepatitis who face elevated liver cancer risk, a newly identified immune…
For the roughly 1-in-20 adults living with schizophrenia, bipolar disorder, or severe major depression, a cancer diagnosis arrives with a set of compounding…
Infectious cancers — malignancies that spread between individuals as living tumor cells — remain one of biology's most unsettling phenomena, and until…
Understanding precisely how the body's RNA-silencing machinery switches on has profound implications for RNA therapeutics — one of the fastest-growing classes…
The assumption that inflammation and DNA repair operate as parallel, largely independent systems during cancer treatment is overdue for revision. A mechanism…
A design assumption underlying virtually every mRNA vaccine and nucleic acid therapeutic may carry an underappreciated safety wrinkle — one that affects…
For decades, the cancer vaccine field carried a reputation for overpromising and underdelivering — Sipuleucel-T's 2010 approval stood as both a milestone and…
The boundary between cancer biology and neurodegeneration research is proving far more porous than previously assumed — and this matters enormously for how…
Blood cancers driven by clonal stem cell mutations occupy a unique space in oncology — they evolve slowly, often over decades, yet carry serious risks of…
Among 83 prescription drugs tested in 1,034 colonoscopy-referred adults aged 55–77, 38 altered gut microbial diversity and bacterial species abundance. Twelve…
Every time a cell's DNA suffers a double-strand break — one of the most catastrophic forms of genetic damage — it must orchestrate a precise molecular repair…
Nearly every adult on Earth carries Epstein–Barr virus silently in their memory B cells — a latency that occasionally resurfaces as lymphoma, multiple…
Diffuse midline glioma remains one of the most devastating brain cancers in children, with median survival under 15 months and no effective systemic…
Most genomic research can tell us which genes move together — but not which ones actually drive the others. That distinction matters enormously for drug…
Nearly one in ten human cancers carries a mutation that disables ARID1A, a chromatin-remodeling protein critical for suppressing tumor growth. When ARID1A is…
Understanding how immune enzymes acquired their precise biochemical identities matters because those identities determine which metabolic pathways they…
Immune checkpoint blockade has transformed oncology, yet the majority of cancer patients derive little or no lasting benefit from these therapies…
As global populations age and multimorbidity becomes the norm rather than the exception, the question of how to effectively support both patients and their…
For the roughly 90,000 adolescents and young adults diagnosed with cancer each year in the United States, surviving the disease is increasingly achievable…