Found 935 results for "longevity"
Cognitive resilience, autonomic regulation, sleep architecture, and behavioral capacity emerge as the primary determinants of functional longevity, with progre…
Researchers propose brainspan as a novel metric measuring the duration of life with sufficient neural network efficiency to maintain autonomy, adaptive capacit…
Chen and colleagues developed OMICmAge, which layers multiple molecular signatures onto DNA methylation patterns to create a more comprehensive biological age…
Two years of caloric restriction in healthy adults produced distinct metabolic signatures across 864 circulating compounds, with three major pathway changes em…
Muscle stem cells (MuSCs) undergo a fundamental trade-off with aging, prioritizing their own survival over regenerative capacity through increased expression o…
Cross-species research reveals that social isolation and loneliness operate through a destructive feedback cycle, where isolation impairs cognitive control and…
The DELTA study introduces a comprehensive N=1 protocol combining time-restricted eating, Mediterranean diet, exercise regimens, and supplementation with conti…
A cross-sectional analysis of 57 patients who underwent surgical repair for coarctation of the aorta revealed that lower heart rates independently predicted gr…
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency for both compounds. The system exploits…
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia toward pro-inflammatory states, while simult…
Larval zebrafish demonstrate sophisticated energy-optimization algorithms in their neural motor circuits, selectively modulating movement patterns to maximize…
Cross-species research demonstrates that taurine supplementation significantly extends both lifespan and healthspan across multiple organisms, from mice to mon…
Cellular powerhouses may hold critical answers to understanding why fertility declines with age. Mitochondrial dysfunction appears linked to oocyte quality det…
FOXO3 gene variants associated with exceptional longevity in centenarian populations demonstrate measurable protective effects against age-related cellular dam…
A Nature Aging economic analysis demonstrates that investments in aging research generate substantial financial returns through reduced healthcare costs and ex…
Two-day weekly intermittent fasting produced dramatically different longevity and metabolic outcomes across 10 genetically distinct mouse strains, with effects…
Elevated Akkermansia muciniphila levels in aged intestines directly suppress Wnt signaling through the Ascl2 pathway in intestinal stem cells, reducing their r…
Eliminating growth hormone receptors specifically in fat tissue dramatically protected aged mice from brain deterioration and cognitive decline. The interventi…
Contrary to longstanding assumptions linking early menopause with reduced longevity, emerging research challenges this narrative. While women experiencing meno…
Pankaj Kapahi at the Buck Institute raises a provocative question about the gap between understanding food's medicinal properties and implementing this knowled…