Cancer Therapy Leaves Lasting Mutational Fingerprints Across Healthy Organs
For decades, the long-term genomic consequences of surviving cancer treatment have been poorly understood — particularly how chemotherapy, radiation, and immun…
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For decades, the long-term genomic consequences of surviving cancer treatment have been poorly understood — particularly how chemotherapy, radiation, and immun…
Antibiotics are the most commonly prescribed drug class globally, yet their long-term consequences beyond infection control have received comparatively little…
Chemotherapy-induced infertility and early menopause represent a largely unaddressed consequence of cancer treatment, affecting cardiovascular, cognitive, and…
For millions of women navigating menopause with histories of venous thromboembolism, certain gynecologic cancers, or coronary artery disease, standard estrogen…
Understanding why some people respond to anti-inflammatory drugs while others develop resistance or serious side effects may come down to a single molecular re…
Drug-target Mendelian randomization using genetic variants in the GLP1R gene region as instruments—analyzed across 21 cancer types via public GWAS consortia—fo…
For men whose prostate cancer returns after surgery, finding where it has spread is the decisive factor in whether treatment can remain curative. A new prospec…
As cannabis legalization spreads and cultural perceptions of its safety solidify, a critical assumption deserves scrutiny: that smoking cannabis is meaningfull…
For decades, one of the most stubborn barriers in transplant medicine has been the immune system's refusal to tolerate foreign tissue. People with type 1 diabe…
Among 2,069 lung cancer patients with cardiac biomarker data drawn from a 2018–2024 Renji Hospital cohort, 15.8% (326 patients) developed cardiotoxicity after…
Glioblastoma's near-universal fatality stems less from initial tumor biology than from its almost inevitable resistance to standard chemotherapy. When temozolo…
Cerebral ischemia drives dynamic accumulation of G-quadruplex (G4) DNA structures within microglia — the brain's resident immune cells — and this accumulation…
The idea that short-term fasting might protect the gut from radiation damage has circulated in oncology for years, but the mechanism has remained frustratingly…
Lung cancer remains stubbornly lethal partly because tumors commandeer the body's own cellular recycling machinery to sustain their growth — a biological irony…
Calcium homeostasis is one of the most consequential regulatory systems in biology — its disruption underlies conditions from cardiac arrhythmia to neurodegene…
Clear cell renal cell carcinoma remains one of the harder cancers to treat once it metastasizes, partly because the mutation driving most cases — loss of the V…
Glioblastoma remains one of medicine's most stubborn challenges — a brain cancer so immunologically inert that conventional immunotherapies largely fail. A new…
The immune system's capacity to sustain a cancer-fighting response hinges on preventing T cell exhaustion — a state where cytotoxic lymphocytes lose their kill…
Understanding precisely how mRNA vaccines mobilize killer T cells matters enormously for cancer immunotherapy and next-generation vaccine design. If the classi…
Understanding precisely how immune-signaling enzymes anchor to cell membranes and switch on could reshape the design of therapies for B-cell cancers and autoim…