Found 573 results for "cancer"
The FDA has authorized pembrolizumab combined with paclitaxel, optionally with bevacizumab, for treating recurrent ovarian cancers expressing PD-L1 protein. Th…
Chronic stress triggers the formation of a previously unknown neutrophil subtype called cancer stress-primed (CSP) neutrophils, characterized by elevated expre…
Mendelian randomization analysis of 738,000 individuals confirms that elevated BMI causally increases kidney cancer risk by 68% per 5-unit BMI increase, with w…
The CDC has launched the National Firefighter Registry, which aims to become the largest registry of its kind in the United States. The registry invites all U.…
Researchers have pinpointed the MERTK receptor tyrosine kinase as a potential drug target for ZFTA-RELA fusion-positive ependymomas, aggressive pediatric brain…
Age-related decline in natural killer cell function stems from disrupted glycolysis and mitochondrial metabolism, according to new mechanistic research. Scient…
Laboratory experiments reveal quercetin activates the UBC6 enzyme, which orchestrates a cascade that degrades AURKA protein and activates AMPK signaling in ova…
Researchers have successfully modified CD4+ T cells with chimeric antigen receptors (CARs) to specifically recognize and target amyloid-β plaques characteristi…
MAPKAPK2, a stress-responsive kinase in the p38 signaling pathway, determines whether MEK1/2 inhibitors succeed or fail against colorectal cancer cells under m…
Parasitic wasps deploy a viral-derived protein tyrosine phosphatase that specifically targets Rad9A, a critical cell cycle checkpoint protein, effectively hija…
A comprehensive WHO analysis examining 30 modifiable risk factors reveals that 40% of global cancer cases stem from preventable causes, representing the most e…
A comprehensive WHO analysis examining 30 modifiable risk factors reveals that 40% of global cancer cases stem from preventable causes, representing the most e…
A computational framework successfully distinguishes between benign and pathogenic single amino acid substitutions in proteins, addressing a critical gap in ca…
Platinum chemotherapy triggers cellular senescence in ovarian and lung cancer cells, paradoxically promoting malignancy through TGFβ ligand secretion. González…
Researchers have developed methods to selectively eliminate specific populations of senescent cells while preserving those that contribute to tumor suppression…
Metastatic cancer cells actively acquire mitochondria from surrounding immune cells through a previously uncharacterized transfer mechanism, essentially comman…
The ATR/CHK1 signaling cascade can initiate genome protection responses even when stripped of RPA protein complexes, traditionally considered essential for pat…
A novel radiopharmaceutical demonstrates efficacy against small-cell lung cancer and neuroendocrine prostate cancer, two notoriously aggressive malignancies th…
Marcel Deckert's team at INSERM Nice has identified USP9X as a critical vulnerability in melanoma progression, where this deubiquitinating enzyme stabilizes th…
Marcel Deckert's team at INSERM in Nice has identified USP9X as a critical vulnerability in melanoma's adaptive machinery. This deubiquitinating enzyme stabili…