Found 768 results for "longevity"
Age-related deterioration in sepsis outcomes may stem from fundamental changes in how our gut bacteria interact with intestinal defenses. This mechanistic disc…
Vitamin D supplementation walks a precarious line between therapeutic benefit and serious harm, as demonstrated by a new clinical case that exposes the narrow…
The expanding therapeutic landscape for GLP-1 receptor agonists represents a paradigm shift in treating metabolic dysfunction beyond traditional diabetes manag…
Scientists engineered casein-polyethylene glycol hydrogels using UV-induced crosslinking, achieving 96.31% resveratrol encapsulation efficiency with 86% retent…
Analysis of 25 rodent longevity models reveals that enhanced blood flow and angiogenesis drive healthful aging in only seven cases, with brown adipose tissue (…
A CRISPR screen revealed that the transcription factor TFAP2C rescues cells from death when the prion-limiting protein hnRNP K is depleted, while connecting bo…
Two previously unknown iridoid glycosides from Verbascum nigrum subspecies abietinum activated multiple stress-resistance pathways in C. elegans worms, upregul…
BCLXL-PROTAC, a precision-designed protein degrader, successfully triggered apoptosis in senescent lung cells from COPD patients while sparing healthy cells. T…
Evolutionary biologist Michael Ringel argues that aging isn't a biological accident but an optimized process shaped by natural selection under resource constra…
A systematic analysis of 113 studies reveals that while NAD⁺ precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) consistently incr…
Terbinafine, a widely-used antifungal medication, and miglustat, a rare disease treatment, both extended lifespan in C. elegans by activating mitochondrial str…
Researchers using 5×FAD Alzheimer's mice discovered that dying brain cells release spermidine, a metabolite that triggers autophagy—the cellular cleanup proces…
AI analysis of handheld ultrasound measurements successfully estimated cardiovascular biological age in 243 adults, correlating strongly with chronological age…
The vast majority of human genetic variants linked to disease risk lie outside protein-coding regions, creating a massive blind spot in precision medicine. Whi…
N-acetylneuraminic acid (Neu5Ac), a sialic acid found in bird's nest and human milk, demonstrated remarkable gut-protective effects in both aging and inflammat…
The quest to measure how fast we truly age has moved far beyond counting birthdays. While chronological age ticks uniformly forward, biological age varies dram…
Understanding how the human brain builds itself could unlock new approaches to treating neurological diseases and potentially extending cognitive healthspan. T…
The vast universe of potentially functional proteins remains largely unexplored due to evolutionary bottlenecks that may constrain therapeutic innovation. Whil…
The long-suspected connection between psychological stress and hair loss now has a clear molecular pathway. Understanding how stress translates into visible he…
Understanding how skin naturally sheds dead cells could revolutionize approaches to treating aging, acne, and barrier dysfunction disorders that affect million…