CRISPR/Cas12a Platform Unlocks Combinatorial Gene Interaction Analysis at Scale
CRISPR/Cas12a technology now permits systematic investigation of how multiple genes interact simultaneously, addressing a critical gap in genetic research wher…
Found 66 results for "longevity"
CRISPR/Cas12a technology now permits systematic investigation of how multiple genes interact simultaneously, addressing a critical gap in genetic research wher…
Sleep emerges as a fundamental driver of longevity through its regulation of cellular repair mechanisms, metabolic homeostasis, and inflammatory pathways. Qual…
Elevated Akkermansia muciniphila levels in aged intestines directly suppress Wnt signaling through the Ascl2 pathway in intestinal stem cells, reducing their r…
Continuous monitoring of 47 older adults across 14,179 nighttime hours revealed that bedroom temperatures exceeding 28°C (82°F) significantly compromised heart…
Scientists achieved precise control over insect metamorphosis using optogenetic techniques, allowing them to trigger or delay the developmental transition with…
The German Nutrition Society's position paper establishes that no risk-free threshold exists for alcohol consumption, marking a definitive stance against moder…
A magnesium-L-theanine combination demonstrated protective effects against stress-induced organ damage in a controlled study, specifically preserving liver and…
France has implemented a nationwide healthy longevity program based on the World Health Organization's Integrated Care for Older People (ICOPE) model, creating…
France has implemented the WHO's Integrated Care for Older People (ICOPE) framework as a nationwide program, representing the first large-scale deployment of t…
Analysis of polygenic risk scores across 35 health conditions in large population datasets reveals that genetic predisposition to certain diseases correlates w…
The FDA has authorized oral semaglutide tablets at 1.5mg, 4mg, and 9mg dosing levels, marking a significant formulation advancement for the GLP-1 receptor agon…
Scientists at PNAS have developed a novel bioconjugation technique using activated allylic bromides to selectively modify methionine amino acid residues in pro…
C. elegans nematodes demonstrate sophisticated pathogen avoidance learning through specific neural circuits that transform initial attraction to harmful bacter…
Presbycusis affects two-fifths of adults past 65, yet many dismiss auditory deterioration as inevitable aging rather than seeking intervention. The sensory def…
Researchers developed an artificial intelligence system that predicts where lysine residues undergo post-translational modifications by combining protein langu…
Swiss researchers analyzed circulating proteins in individuals who reached 100+ years, identifying specific molecular markers that distinguish exceptional long…
Rapamycin treatment effectively counteracted liver damage in aging mice fed high-fat diets, suggesting the mTOR pathway inhibitor may protect metabolic organs…
Scientists have identified mitochondrial dysfunction as the critical weakness that allows senolytic drugs to selectively eliminate aged cells. The research rev…
New epigenetic clock research reveals that early-life adversity triggers faster cellular aging in women compared to men, with DNA methylation patterns showing…
Stem cells lose their regenerative potency through five interconnected molecular pathways that accelerate with age. Cellular stress accumulation disrupts DNA i…