Found 349 results for "longevity"
Cognitive resilience, autonomic regulation, sleep architecture, and behavioral capacity emerge as the primary determinants of functional longevity, with progre…
Cellular energy production may have a more flexible backup system than previously understood, offering new hope for treating metabolic disorders and age-relate…
The molecular architecture of life's most abundant macromolecules has remained frustratingly opaque to scientists despite glycans comprising more biological ma…
Chen and colleagues developed OMICmAge, which layers multiple molecular signatures onto DNA methylation patterns to create a more comprehensive biological age…
Understanding how cells absorb nutrients, medications, and other materials from their environment could transform approaches to drug delivery and cellular agin…
Muscle stem cells (MuSCs) undergo a fundamental trade-off with aging, prioritizing their own survival over regenerative capacity through increased expression o…
Two years of caloric restriction in healthy adults produced distinct metabolic signatures across 864 circulating compounds, with three major pathway changes em…
Cross-species research reveals that social isolation and loneliness operate through a destructive feedback cycle, where isolation impairs cognitive control and…
Understanding how cells translate physical forces into survival responses could reshape approaches to age-related tissue deterioration and cancer metastasis. A…
Understanding how blood reaches every neuron in the brain has profound implications for preventing cognitive decline and optimizing brain health throughout agi…
Understanding how natural selection shapes behavior requires direct observation of organisms in their native environments, yet traditional behavioral ecology h…
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency for both compounds. The system exploits…
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia toward pro-inflammatory states, while simult…
Two-day weekly intermittent fasting produced dramatically different longevity and metabolic outcomes across 10 genetically distinct mouse strains, with effects…
Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger binding affinity to five critical aging-regula…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two hea…
Research demonstrates that menopausal estrogen withdrawal triggers accelerated accumulation of amyloid-beta plaques and tau tangles in female brains, while sim…
C. elegans research reveals a crucial distinction between living longer and aging well. While seven tested compounds universally extended male worm lifespan, o…
Researchers have constructed a comprehensive cellular atlas documenting approximately 10 million oligodendrocytes—specialized glial cells that produce myelin s…
Cardiovascular disease now accounts for 437 million disability-adjusted life years worldwide, representing a 1.4-fold increase since 1990 when the burden was 3…