Found 1856 results for "cancer"
Senescent cells in lung tumors actively reshape immune responses through their senescence-associated secretory phenotype (SASP), creating a complex…
PARP inhibitors olaparib and niraparib trigger cellular senescence in pancreatic cancer cells through the Chk2-p21 pathway, independent of p53 status and BRCA…
Natural compounds including alkaloids, flavonoids, terpenoids, and polyphenols demonstrate ability to modulate the PI3K/Akt/mTOR pathway, which controls…
Senescent cells exhibit a paradoxical dual nature in cancer biology, initially protecting against tumor formation through p53/p21 and p16INK4a-RB pathways…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two…
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting chemicals (EDCs) playing a particularly…
MAPKAPK2, a stress-responsive kinase in the p38 signaling pathway, determines whether MEK1/2 inhibitors succeed or fail against colorectal cancer cells under…
Researchers have successfully modified CD4+ T cells with chimeric antigen receptors (CARs) to specifically recognize and target amyloid-β plaques…
Parasitic wasps deploy a viral-derived protein tyrosine phosphatase that specifically targets Rad9A, a critical cell cycle checkpoint protein, effectively…
A dual-agent regimen combining the antibody-drug conjugate enfortumab vedotin with the PD-1 inhibitor pembrolizumab demonstrates clinical activity when…
Trastuzumab deruxtecan demonstrated superior invasive disease-free survival compared to standard trastuzumab in patients with HER2-positive early breast…
Clinical trial data reveals that combining enfortumab vedotin with pembrolizumab before and after bladder cancer surgery significantly improved pathological…
Medical experts are raising concerns about potential policy changes that could weaken universal hepatitis B vaccination for newborns, currently recommended by…
Dimethyl sulfoxide-frozen platelets demonstrated equivalent hemostatic efficacy to standard liquid-stored platelets in controlling bleeding during cardiac…
Declining donor populations and platelets' 5-7 day shelf life have created critical transfusion shortages worldwide, particularly affecting cancer patients…
An international expert panel has established the first formal clinical definitions and assessment frameworks for loneliness specifically in older cancer…
A randomized trial of 190 frail elderly patients with head and neck cancer found that hypofractionated split-course radiotherapy achieved equivalent 6-month…
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and activates microglia cells to break down…
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week phase 2a trial involving patients with…
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among tested PARP inhibitors in lung cancer…