Found 1467 results for "cancer"
A dual-agent regimen combining the antibody-drug conjugate enfortumab vedotin with the PD-1 inhibitor pembrolizumab demonstrates clinical activity when adminis…
Trastuzumab deruxtecan demonstrated superior invasive disease-free survival compared to standard trastuzumab in patients with HER2-positive early breast cancer…
Clinical trial data reveals that combining enfortumab vedotin with pembrolizumab before and after bladder cancer surgery significantly improved pathological co…
Medical experts are raising concerns about potential policy changes that could weaken universal hepatitis B vaccination for newborns, currently recommended by…
Dimethyl sulfoxide-frozen platelets demonstrated equivalent hemostatic efficacy to standard liquid-stored platelets in controlling bleeding during cardiac surg…
Declining donor populations and platelets' 5-7 day shelf life have created critical transfusion shortages worldwide, particularly affecting cancer patients and…
An international expert panel has established the first formal clinical definitions and assessment frameworks for loneliness specifically in older cancer patie…
A randomized trial of 190 frail elderly patients with head and neck cancer found that hypofractionated split-course radiotherapy achieved equivalent 6-month tu…
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and activates microglia cells to break down amyl…
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week phase 2a trial involving patients with…
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among tested PARP inhibitors in lung cancer cell…
Cardiac toxicity emerges as a critical limitation for immune checkpoint inhibitors like pembrolizumab and nivolumab, with researchers now identifying the molec…
Researchers have determined the three-dimensional crystal structure of somatostatin receptor 3 (SSTR3), revealing precise molecular binding sites and conformat…
Nordihydroguaiaretic acid (NDGA), a lignin compound from creosote bush, demonstrates significantly enhanced anti-cancer activity against prostate tumors when p…
A computational framework successfully distinguishes between benign and pathogenic single amino acid substitutions in proteins, addressing a critical gap in ca…
The ATR/CHK1 signaling cascade can initiate genome protection responses even when stripped of RPA protein complexes, traditionally considered essential for pat…
A novel radiopharmaceutical demonstrates efficacy against small-cell lung cancer and neuroendocrine prostate cancer, two notoriously aggressive malignancies th…
Clinical trial data reveals that time-limited chronic lymphocytic leukemia treatment produces equivalent survival outcomes compared to indefinite therapy regim…
French researchers have mapped the mechanisms by which mitochondria migrate between adjacent cells, particularly within tumor environments. This intercellular…
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from heavy daily users. These lighter smoking pa…