Found 1255 results for "cancer"
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting chemicals (EDCs) playing a particularly si…
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among tested PARP inhibitors in lung cancer cell…
Researchers modified natural killer cells with 2B4 and DAP12 co-stimulatory domains, creating CAR-NK cells that demonstrated enhanced cytotoxic programming aga…
Cardiac toxicity emerges as a critical limitation for immune checkpoint inhibitors like pembrolizumab and nivolumab, with researchers now identifying the molec…
Analysis of 149 million deaths across 195 countries reveals sepsis accounts for 31.5% of all global deaths, claiming 21.4 million lives in 2021 alone. The cond…
Cancer stem cells that initiate breast tumors appear to originate from different mammary cell populations depending on patient age, with older women's tumors a…
A population-based screening trial involving over 270,000 Swedish adults demonstrated that both colonoscopy and fecal immunochemical testing (FIT) significantl…
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and activates microglia cells to break down amyl…
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week phase 2a trial involving patients with…
An experimental blood test analyzing tumor-associated extracellular vesicles and particles achieved 82.9% sensitivity for detecting high-grade serous carcinoma…
Researchers developed lipid nanoparticles that reprogram immune cells directly inside the body to create panCAR T-cells—engineered immune cells capable of reco…
A novel imaging technique combines TROP2 protein targeting with near-infrared fluorescence to provide real-time visualization of cancer boundaries and lymph no…
HDAC3, a histone deacetylase enzyme, directly regulates the Hippo signaling pathway through acetylation modifications of the Hpo protein, revealing a novel epi…
Nordihydroguaiaretic acid (NDGA), a lignin compound from creosote bush, demonstrates significantly enhanced anti-cancer activity against prostate tumors when p…
Ten patients with severe, treatment-resistant autoimmune conditions—five with antisynthetase syndrome and five with systemic sclerosis—experienced significant…
Nivolumab, a PD-1 checkpoint inhibitor, demonstrates remarkable durability in advanced melanoma patients with survival benefits persisting nearly a decade post…
Clinical trial data reveals that combining enfortumab vedotin with pembrolizumab before and after bladder cancer surgery significantly improved pathological co…
A dual-agent regimen combining the antibody-drug conjugate enfortumab vedotin with the PD-1 inhibitor pembrolizumab demonstrates clinical activity when adminis…
Metastatic melanoma cells exhibit elevated levels of lamin B receptor (LBR), a nuclear envelope protein that paradoxically makes their nuclei more fragile when…
Circulating tumor DNA analysis in blood and urine samples successfully identifies which muscle-invasive bladder cancer patients can avoid radical cystectomy wh…