Found 1137 results for "cancer"
PARP inhibitors olaparib and niraparib trigger cellular senescence in pancreatic cancer cells through the Chk2-p21 pathway, independent of p53 status and BRCA…
Senescent cells in lung tumors actively reshape immune responses through their senescence-associated secretory phenotype (SASP), creating a complex microenviro…
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting chemicals (EDCs) playing a particularly si…
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among tested PARP inhibitors in lung cancer cell…
Researchers modified natural killer cells with 2B4 and DAP12 co-stimulatory domains, creating CAR-NK cells that demonstrated enhanced cytotoxic programming aga…
Cardiac toxicity emerges as a critical limitation for immune checkpoint inhibitors like pembrolizumab and nivolumab, with researchers now identifying the molec…
Analysis of 149 million deaths across 195 countries reveals sepsis accounts for 31.5% of all global deaths, claiming 21.4 million lives in 2021 alone. The cond…
Cancer stem cells that initiate breast tumors appear to originate from different mammary cell populations depending on patient age, with older women's tumors a…
Mouse studies reveal that cystatin-C, a protein released by certain tumors, penetrates the blood-brain barrier and activates microglia cells to break down amyl…
Risvodetinib, a selective c-Abl kinase inhibitor, demonstrated acceptable safety and tolerability profiles in a 12-week phase 2a trial involving patients with…
A population-based screening trial involving over 270,000 Swedish adults demonstrated that both colonoscopy and fecal immunochemical testing (FIT) significantl…
An experimental blood test analyzing tumor-associated extracellular vesicles and particles achieved 82.9% sensitivity for detecting high-grade serous carcinoma…
HDAC3, a histone deacetylase enzyme, directly regulates the Hippo signaling pathway through acetylation modifications of the Hpo protein, revealing a novel epi…
A novel imaging technique combines TROP2 protein targeting with near-infrared fluorescence to provide real-time visualization of cancer boundaries and lymph no…
Researchers developed lipid nanoparticles that reprogram immune cells directly inside the body to create panCAR T-cells—engineered immune cells capable of reco…
Ten patients with severe, treatment-resistant autoimmune conditions—five with antisynthetase syndrome and five with systemic sclerosis—experienced significant…
Nordihydroguaiaretic acid (NDGA), a lignin compound from creosote bush, demonstrates significantly enhanced anti-cancer activity against prostate tumors when p…
Nivolumab, a PD-1 checkpoint inhibitor, demonstrates remarkable durability in advanced melanoma patients with survival benefits persisting nearly a decade post…
Clinical trial data reveals that combining enfortumab vedotin with pembrolizumab before and after bladder cancer surgery significantly improved pathological co…
A dual-agent regimen combining the antibody-drug conjugate enfortumab vedotin with the PD-1 inhibitor pembrolizumab demonstrates clinical activity when adminis…