Studies
Oral GLP-1 Agonist Plus Insulin Cuts HbA1c Beyond Insulin Alone
For the roughly one-third of people with type 2 diabetes who remain poorly controlled despite daily insulin injections, the therapeutic ceiling has long felt…
Search Results: "fasting"
Found 188 results for "fasting"
⚕️ Synthesized briefings — original sources linked for full context.
Studies
Oral GLP-1 Pill and Dual Agonist Show Promising Weight-Loss Efficacy in New Trials
The dominance of injectable GLP-1 medications may soon face a genuine challenge from oral and multi-receptor alternatives — a shift that could dramatically…
Studies
Global TB Deaths Continue to Decline, But MDR-TB and Other Factors Threaten Progress
Tuberculosis remains a stubborn paradox in global health: three decades of hard-won gains in reducing mortality are now threatened by drug resistance, funding…
Studies
Global TB Burden Mapped Across 204 Nations: Progress Stalls Before 2035 Targets
Tuberculosis remains one of the most consequential infectious disease challenges of the modern era, yet its burden is frequently overshadowed by newer…
Studies
Semaglutide May Trigger Sarcopenia-Driven Hyperglycemia via mTOR-GLUT4 Suppression
A case-driven hypothesis built around a single 53-year-old male with T2DM proposes that semaglutide-induced sarcopenia creates a self-reinforcing metabolic…
Studies
Pyruvate Directly Modifies Histones at 88 Sites, Linking Glycolysis to Gene Expression
Every time a cell ramps up glycolysis — burning more glucose for energy — it may be simultaneously rewriting its own gene expression program. A newly…
Studies
Global TB Burden Declines Since 1990 per GBD 2023, But MDR-TB Progress Lags
Three decades of progress against tuberculosis are now at serious risk of reversal. With global health funding contracting and drug-resistant strains proving…
Longevity
Narrative Review Maps IF Protocols to AMPK-mTOR-SIRT1 Pathways for Cardiometabolic Health
Four IF protocols — TRE (16/8), alternate-day fasting, 5:2, and OMAD — converge on a shared molecular architecture: AMPK activation suppresses mTOR while…
Nutrition
Pulse- vs Meat-Protein Diets Show Similar Cardiometabolic Benefits in Older Adults, With Possible Ferritin Edge for Pulses
For older adults navigating the intersection of cardiovascular risk and metabolic aging, protein source may matter as much as protein quantity — and this…
Supplements
Nitrate + Resveratrol Adds Liver-Specific Metabolic Gains Beyond Exercise Alone
In C57Bl/6N mice fed a high-fat diet for 6 weeks, aerobic exercise training (AET) alone reduced adipocyte size, attenuated adipose tissue inflammation, and…
Longevity
U-Shaped Mortality Risk: ≤8-Hour Eating Windows May Accelerate Biological Aging
Eating window duration follows a U-shaped mortality curve — a counterintuitive finding that challenges the blanket enthusiasm for aggressive time-restricted…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls
Tuberculosis remains one of the most consequential infectious disease challenges of our era, and this sweeping analysis arrives at a critical inflection…
Studies
Global TB Deaths Fell 37% Since 1990, But MDR-TB Gaps Remain Critical
Tuberculosis remains one of the most preventable mass killers on earth, and a granular 33-year accounting of its toll now arrives at a moment when global…
Studies
Gradual Semaglutide Tapering vs. Abrupt Stop: RCT Tests Weight Regain
A registered randomized controlled trial (NCT07294950) from Mount Sinai Hospital, Toronto, will compare gradual 16-week semaglutide dose tapering against…
Nutrition
Intermittent Fasting Trims Weight in Over-60s Without Muscle Loss
For older adults navigating the twin threats of excess adiposity and age-related muscle loss, a dietary intervention that reduces weight without eroding lean…
Nutrition
TRE-Conditioned Blood Reprograms Brain Vessel Cells Via ISR/ATF4 Axis
Vascular cognitive impairment and dementia represent one of the most underappreciated threats to healthy aging, and a central mechanism driving both is the…
Studies
Global TB Burden Mapped Across 204 Nations: MDR-TB Progress Stalls
Tuberculosis remains one of the most consequential unfinished battles in global infectious disease control — and this sweeping 33-year analysis arrives at a…
Studies
First OTC Continuous Glucose Monitor Cleared for Pediatric Use
Metabolic awareness tools have long been confined to adults with diagnosed diabetes, but a regulatory shift now brings real-time glucose tracking to the…
Studies
Childhood PM2.5 and NO2 Exposure at Home and School Linked to Metabolic Syndrome Risk
Metabolic syndrome in adulthood is a major driver of cardiovascular disease, type 2 diabetes, and premature mortality — and its roots may extend further back…
Studies
Global TB Deaths Declined Substantially Since 1990, But MDR-TB Threatens Hard-Won Gains
Tuberculosis remains one of the most consequential infectious diseases in human history, and for the first time in decades, the world has a granular 33-year…