mRNA-LNP Vaccines Prime CD8 T Cells Via Cross-Dressing, Bypassing Classical Pathway
Understanding precisely how mRNA vaccines mobilize killer T cells matters enormously for cancer immunotherapy and next-generation vaccine design. If the classi…
Found 1467 results for "cancer"
Understanding precisely how mRNA vaccines mobilize killer T cells matters enormously for cancer immunotherapy and next-generation vaccine design. If the classi…
Understanding precisely how immune-signaling enzymes anchor to cell membranes and switch on could reshape the design of therapies for B-cell cancers and autoim…
Understanding precisely how a receptor switches from dormant to active matters enormously when that receptor sits at the intersection of embryonic development…
Precision control over gene expression inside living cells has long been a holy grail for therapeutic biology — and a new molecular architecture from Singapore…
About 70% of all breast cancer diagnoses are estrogen receptor-positive, yet the field's workhorse preclinical system — the genetically engineered mouse — has…
Obesity doesn't just strain the heart and joints — it fundamentally corrupts the immune system's ability to detect and destroy cancer cells. Compounding the pr…
For decades, transcription factors have occupied a frustrating blind spot in oncology drug development: they drive cancers but resist conventional targeting be…
Geographic equity in cancer care is often framed as an access problem, but this large registry analysis reframes it as a quality-of-care problem — one where wh…
For the roughly 150,000 Americans diagnosed with colorectal cancer annually, catching the disease early — when curative resection is still possible — remains t…
For decades, acute myeloid leukemia has been categorized largely through its genetic mutations — a framework that has guided treatment but left significant gap…
Cancer immunotherapy has transformed oncology, yet a substantial proportion of patients fail to respond — and understanding why remains one of the field's most…
For the roughly 3–7% of non-small-cell lung cancer patients whose tumors carry an ALK gene rearrangement, surgery remains the primary curative strategy — but r…
The gap between where a woman lives and whether she survives breast cancer remains one of medicine's starkest inequities — and a sweeping new analysis now quan…
The gap between chronological age and biological age may be one of the most clinically actionable gaps in modern medicine — and a comprehensive new review in N…
Pancreatic ductal adenocarcinoma remains one of oncology's most intractable problems, with five-year survival rates stubbornly below 15%. A central reason is t…
Checkpoint immunotherapy has largely failed in prostate cancer, not because the immune system lacks the tools, but because the tumor microenvironment systemati…
Across 676 studies enrolling roughly 180 million participants, active cancer prevalence in cardiovascular disease patients ranges from 4.22% in type 2 diabetes…
Senescent keratinocytes, fibroblasts, and melanocytes that resist clearance accumulate in aged skin and secrete the senescence-associated secretory phenotype (…
Nasopharyngeal carcinoma linked to Epstein-Barr virus remains notoriously difficult to treat, with limited targeted options and significant toxicity from stand…
Understanding where cancer stands globally in 2024 reframes how individuals and health systems should think about lifetime risk — because the numbers now confi…