Found 573 results for "cancer"
The AMPLITUDE phase 3 trial demonstrated that adding niraparib to standard hormone therapy significantly extends time to cancer progression in men with metasta…
Advanced gas sensor arrays analyzing volatile organic compounds in plasma successfully distinguished between ovarian cancer, endometrial cancer, and healthy co…
Computer-assisted screening platforms using whole slide imaging and artificial intelligence are demonstrating viable performance characteristics for Pap test a…
Radiation therapy triggers senescence in thyroid cancer cells, but these supposedly dormant cells develop a cunning survival strategy. When radiation disrupts…
Understanding how cells translate physical forces into survival responses could reshape approaches to age-related tissue deterioration and cancer metastasis. A…
Researchers identified that amlodipine, a widely prescribed calcium channel blocker for hypertension, demonstrates significant anti-tumor activity against hepa…
Analysis of 798 testicular cancer survivors reveals that four cycles of etoposide-cisplatin (EPx4) produce 55% higher odds of kidney impairment compared to thr…
Researchers analyzed 215 studies examining artificial intelligence applications in diffuse large B-cell lymphoma (DLBCL) prognosis, revealing that machine lear…
Analysis of 17,141 survivors across seven cancer types reveals that moderate-to-vigorous physical activity after diagnosis reduces cancer-specific mortality by…
Mediterranean and low-carbohydrate diets combined with exercise significantly reduced cardiovascular and metabolic risk factors in prostate cancer patients rec…
Analysis of Japan's national disease registry identified pseudo-polyps as tripling colorectal cancer risk in ulcerative colitis patients (hazard ratio 2.92), w…
Thyroid nodules develop in 2-3% of pregnancies, with existing nodules often enlarging due to hormonal changes that naturally increase thyroid gland size. Fine…
Scientists developed a molecular adapter called eCD16A/anti-CD3-BFP that transforms existing cancer antibodies into T cell-recruiting weapons. The bifunctional…
PARP inhibitors olaparib and niraparib trigger cellular senescence in pancreatic cancer cells through the Chk2-p21 pathway, independent of p53 status and BRCA…
Senescent cells in lung tumors actively reshape immune responses through their senescence-associated secretory phenotype (SASP), creating a complex microenviro…
Natural compounds including alkaloids, flavonoids, terpenoids, and polyphenols demonstrate ability to modulate the PI3K/Akt/mTOR pathway, which controls autoph…
Senescent cells exhibit a paradoxical dual nature in cancer biology, initially protecting against tumor formation through p53/p21 and p16INK4a-RB pathways, but…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two hea…
Environmental exposures contribute to breast cancer development through multiple pathways, with endocrine-disrupting chemicals (EDCs) playing a particularly si…
Talazoparib, a PARP1 inhibitor used in cancer therapy, demonstrates the strongest senescence-inducing activity among tested PARP inhibitors in lung cancer cell…