Found 349 results for "longevity"
The mystery of why kidney disease accelerates heart failure may finally have a molecular explanation. While cardiovascular complications kill more than half of…
One month of rapamycin treatment in reproductively aged 10-month-old female mice suppressed mTOR signaling and reduced cellular senescence, inflammation, fibro…
Reduced forms of NAD+ precursors—NMNH and NRH—triggered dramatically broader metabolic and transcriptional changes in mouse liver cells compared to their oxidi…
Pathogenic gut bacteria and their metabolites accelerate telomere shortening through oxidative stress pathways, while shortened telomeres compromise gut barrie…
The pursuit of longevity through dietary intervention may have found a previously overlooked molecular pathway that operates independently of the well-studied…
Just 14 days of head-down tilt bedrest in adults aged 55-65 significantly decreased beneficial gut bacteria including Akkermansia and Lactobacillus while incre…
The world's most vulnerable populations remain trapped in cycles of malnutrition despite nearly a decade of coordinated global health initiatives. This compreh…
The timing of disease onset may hold crucial clues for extending healthy lifespan, but until now, researchers lacked effective tools to analyze how rare geneti…
Researchers identified MPOL_B_1, a novel geroprotector compound that extends C. elegans lifespan by up to 30% through virtual screening targeting the proton-co…
Scientists identified ribonuclease κ (RNASEK) as a critical enzyme that degrades circular RNAs (circRNAs), which accumulate toxically in aging cells. RNASEK le…
Scientists at A*STAR have developed a light-controlled hydrogel system that can adjust tissue stiffness in real-time, revealing how mechanical changes in aging…
Advanced mapping techniques reveal that sympathetic nerve density increases in aging ovaries across both human and mouse models, with nerve ablation experiment…
CRISPR-edited human cord blood stem cells carrying the GATA2-R398W mutation display severe mitotic dysfunction and accelerated aging signatures that compromise…
Clinical evidence reveals semaglutide's therapeutic effects extend far beyond its original diabetes indication, with documented benefits across cardiovascular…
Bioengineers have created artificial liver environments using decellularized extracellular matrix scaffolds that successfully induce dormancy in colorectal can…
Adult vaccination appears to fundamentally rewire aging immune systems beyond simple pathogen protection, triggering "trained immunity" that reprograms innate…
Chronic kidney disease represents a significant and underrecognized consequence of SARS-CoV-2 infection, with multiple studies demonstrating elevated CKD risk…
Biogerontology researchers argue that extending human healthspan represents a fundamental ethical obligation rather than merely a beneficial outcome. Their deo…
Analysis of 876,805 Danish women followed for a median 14.3 years revealed that those using menopausal hormone therapy had an 11% reduction in all-cause mortal…
Researchers propose brainspan as a novel metric measuring the duration of life with sufficient neural network efficiency to maintain autonomy, adaptive capacit…