Found 66 results for "longevity"
Obesity triggers chronic systemic inflammation that compromises the blood-brain barrier and primes brain microglia toward pro-inflammatory states, while simult…
Scientists engineered micelles that simultaneously deliver resveratrol and rutin with over 98% encapsulation efficiency for both compounds. The system exploits…
Two-day weekly intermittent fasting produced dramatically different longevity and metabolic outcomes across 10 genetically distinct mouse strains, with effects…
ABT-263, a drug that eliminates senescent cells by blocking anti-apoptotic proteins Bcl-xL and activating Bax, showed dramatically different effects in two hea…
Virtual screening reveals 4,4'-diapophytofluene (4,4'-DPE), extracted from coconut leaves, demonstrates stronger binding affinity to five critical aging-regula…
Research demonstrates that menopausal estrogen withdrawal triggers accelerated accumulation of amyloid-beta plaques and tau tangles in female brains, while sim…
C. elegans research reveals a crucial distinction between living longer and aging well. While seven tested compounds universally extended male worm lifespan, o…
Researchers have constructed a comprehensive cellular atlas documenting approximately 10 million oligodendrocytes—specialized glial cells that produce myelin s…
Cardiovascular disease now accounts for 437 million disability-adjusted life years worldwide, representing a 1.4-fold increase since 1990 when the burden was 3…
Mendelian randomization analysis reveals that while interleukin-6 (IL-6) increases mortality risk, its soluble receptor (sIL-6R) demonstrates the opposite effe…
Analysis of disability-adjusted life years across 204 countries reveals cardiovascular diseases generated 437 million DALYs in 2023, up from 320 million in 199…
White adipose tissue accumulation around abdominal organs during midlife follows predictable patterns, but its metabolic consequences depend heavily on individ…
Mammary gland involution following weaning triggers widespread cellular senescence that orchestrates tissue remodeling but simultaneously creates microenvironm…
Analysis of 12,906 Chinese adults revealed that accumulating multiple age-related functional impairments creates a more powerful mortality predictor than any s…
The DELTA study introduces a comprehensive N=1 protocol combining time-restricted eating, Mediterranean diet, exercise regimens, and supplementation with conti…
A cross-sectional analysis of 57 patients who underwent surgical repair for coarctation of the aorta revealed that lower heart rates independently predicted gr…
Eliminating growth hormone receptors specifically in fat tissue dramatically protected aged mice from brain deterioration and cognitive decline. The interventi…
Nondaily and low-intensity smokers in Latin America present distinct cessation challenges that differ markedly from heavy daily users. These lighter smoking pa…
Larval zebrafish demonstrate sophisticated energy-optimization algorithms in their neural motor circuits, selectively modulating movement patterns to maximize…
Molecular chaperones Hsp70 and Hsp90 demonstrate paradoxical effects in neurological aging, serving both protective and detrimental functions depending on cell…