Studies
First KRAS G12D Protein Degrader Shows 36% Response Rate in Lung Cancer
For decades, KRAS mutations were considered undruggable — a frustrating reality given that KRAS G12D is the dominant…
PREPRINTLongevity
Regional Heart Wall Mapping Reveals Hidden CVD Risk in Women, 10.6% Score Jump
Cardiac MRI data from 1,789 adults across three European population cohorts (SHIP-TREND-0, SHIP-START-2, KORA-FF4)…
PREPRINTLongevity
Transdermal Clonidine Cuts Hyperkalemia Risk 52% vs. Spironolactone in Resistant Hypertension
In a retrospective analysis of 33,753 U.S. patients with resistant hypertension drawn from Merative MarketScan claims…
PREPRINTLongevity
Statins Show No Primary CVD Protection in 1,396 Lupus Patients Over 8,708 Person-Years
Among 1,396 patients with systemic lupus erythematosus (SLE) followed across 8,708 person-years, statin use failed to…
PREPRINTLongevity
Lp(a) Tracks Strongly From Age 7 Months—Girls Carry Higher Burden Through Adolescence
Analyzing 7,018 lipoprotein(a) measurements across 1,062 children at 10 age points — from 7 months to 15 years — the…
PREPRINTLongevity
Deep Learning ECG Model Links Prolonged QTc to 2.9x Higher Cardiovascular Event Risk
A deep learning framework trained on 11,330 expert-annotated ECG leads from 1,030 UK Biobank participants achieved…
Supplements
Curcumin & Resveratrol Dominate 33-Year Sports Phytotherapy Research Surge
A bibliometric sweep of 3,404 Web of Science records (1991–2024), narrowed to 368 qualifying publications, reveals…
Wellbeing
Wearable Sensors May Bridge UK Veterans' Mental Health Monitoring Gap
For the substantial population of veterans who disengage from conventional mental health services, continuous…
Supplements
Resveratrol Blocks AKT/mTOR/S6K Cascade to Reverse Neurogenic Bladder Fibrosis in Rats
In a rat model of neurogenic bladder (NB) created by bilateral L6-S1 spinal nerve transection, resveratrol…
Longevity
Gut Bacteria-Derived Phenylacetyl-Carnitine Associated with Aging and Cognitive Impairment in Alzheimer's Studies
A sweeping metabolomics atlas spanning 2,271 samples across multiple tissues from two AD transgenic mouse models (3xTg…
Longevity
Rhododendron Iridoids Extend C. elegans Lifespan 30.8%, Outperforming NMN
Two iridoid compounds isolated from Rhododendron pachypodum flowers — compound 5 (a newly characterized analogue) and…
Studies
CVD Kills 3 Million Annually in Europe With Stark Income-Based Mortality Gaps
Cardiovascular disease remains the single largest killer across Europe and neighboring nations, yet where you are…
PREPRINTLongevity
ML Analysis of 10,712 Patients Finds No Meaningful Benefit Heterogeneity in Intensive BP Control
Pooling data from two large-scale randomized controlled trials across 10,712 participants followed for up to three…
PREPRINTLongevity
Liver Fibrosis Score Predicts 2× Mortality Risk in 2,467 Primary Aldosteronism Patients
Among 2,467 patients with primary aldosteronism (PA) tracked in a multicenter retrospective cohort, those with a…
PREPRINTLongevity
Small-Artery Elasticity Predicts Heart Ejection Fraction in 991-Person Cohort
In a community-based Swedish cohort of 991 adults (mean age 51), non-invasive radial artery applanation tonometry…
PREPRINTLongevity
Early Finerenone After Acute MI Linked to 36% Lower Composite Mortality and Heart Failure Risk
In a propensity score-matched real-world analysis of 1,012 high-risk post-AMI patients (mean age 69, ~84% with type 2…
PREPRINTLongevity
15.7% of Repaired CHD Patients Had True Care Gaps; Serious Outcomes in 26.7% of Those Needing Post-Gap Intervention
Among 1,746 patients with surgically repaired congenital heart disease (CHD) treated at a tertiary center from…
Wellbeing
Snoring Vibrations Disrupt Muscle Mitochondria via Mechanosensing Pathways
Most people treat snoring as a nuisance rather than a biological stressor, but emerging mechanobiology research…
Studies
Tumor Cell Death Modes Reshape Immunity: ICD's Dual Role Explained
How a cancer cell dies turns out to matter enormously — not just for clearing the tumor, but for whether the immune…
Studies
Preterm Birth Leaves Lasting Marks on Teeth, Jaw, and Craniofacial Bone
For the millions of infants born preterm or underweight each year, surviving the neonatal unit is no longer the…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.