Carotid Doppler's VRI Predicts Chronological Age Within 6.9 Years
The velocity reflection index (VRI), derived from carotid Doppler waveforms, showed the strongest correlation with chronological age among eight hemodynamic…
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The velocity reflection index (VRI), derived from carotid Doppler waveforms, showed the strongest correlation with chronological age among eight hemodynamic…
Endurance treadmill training in Fischer 344 rats progressively alters incretin receptor expression across 17 tissues in sex- and tissue-specific patterns…
Tuberculosis remains one of medicine's most urgent unsolved problems — not because science lacks tools, but because implementation gaps, funding volatility…
A first-in-human mechanistic trial of vortex wave stimulation (VWS) in 14 healthy older adults demonstrated elevated integrated myofibrillar protein synthesis…
The cyclin-dependent kinase inhibitor p21 (CDKN1A) behaves in fundamentally opposing ways across exercise contexts in the aging brain. Sustained physiological…
Sarcopenia silently erodes independence long before most people recognize it as a threat — and the timing of meals, not just their content, may be a…
The promise of epigenetic clocks has always been tantalizing: a molecular readout of how fast you're actually aging, responsive enough to detect whether an…
Analyzing weekly all-cause mortality data from 31 European countries (2015 onward, COVID-19 period excluded from baseline), NeMMo — an evolution of the…
When public health surveillance operates at the wrong geographic scale, it can miss a crisis building in plain sight. That appears to be precisely what…
When two serious vascular conditions overlap, outcomes worsen dramatically — yet the therapeutic toolkit remains surprisingly thin. For the millions of adults…
With dementia cases projected to surge most dramatically in lower-income regions, the uncomfortable reality is that nearly all prevention research has been…
In a triple-blinded RCT, 51 men aged ≥65 with type 2 diabetes were randomized to resistance training plus either a control, protein supplementation (P), or…
For decades, metformin has attracted intense interest as a potential longevity-extending compound beyond its glucose-lowering role — a hypothesis now being…
The intense scientific interest in repurposing a decades-old diabetes drug as a broad anti-aging intervention has reached a critical inflection point. A…
For the millions of adults who spend eight or more hours seated daily, the cognitive cost of uninterrupted sitting has long been a concern. This meta-analysis…
Personalized medicine is reaching geroscience in a meaningful way, and PROMETHEUS represents one of the more structured attempts to operationalize that idea…
Among 311 postpartum women in the PETALS-2 prospective cohort, each one-unit increase in intrinsic motivation (IM) score was associated with 42% greater…
For decades, coronary heart disease has been framed almost entirely as a consequence of individual choices — diet, exercise, smoking. A growing body of…
The explosive adoption of GLP-1 receptor agonists has outpaced understanding of what happens when patients stop taking them — a gap that matters enormously…
A massive multi-ancestry genome-wide association study spanning 345,687 heart failure cases across 4.47 million individuals uncovered 383 genomic loci — 166…