Studies
AI-Imaging Model Links Liver Cancer Recurrence Risk to Pyruvate Metabolism Disruption
For the roughly 70–80% of hepatocellular carcinoma patients who experience tumor recurrence within five years of…
Studies
Pyruvate Directly Modifies Histones at 88 Sites, Linking Glycolysis to Gene Expression
Every time a cell ramps up glycolysis — burning more glucose for energy — it may be simultaneously rewriting its own…
Nutrition
Fermented Foods Shape Oral-Gut Axis Through Probiotics, Metabolites, and Microbial Signaling
Most microbiome research focuses on the gut in isolation, but the digestive tract begins at the mouth — and what…
Studies
Personalized mRNA Cancer Vaccines Show Meaningful Recurrence Reduction Across Tumor Types
For decades, the idea of teaching the immune system to recognize and destroy a patient's own tumor has been more…
Studies
Digital Heart Twins May Unlock Precision Ablation for Persistent Atrial Fibrillation
Persistent atrial fibrillation remains one of cardiology's most stubborn therapeutic puzzles, and the gap between…
Wellbeing
Sensitive Early Caregiving Buffers Prenatal Inflammation's Link to Childhood ADHD
The window between conception and early infancy may be one of the most consequential periods for a child's…
Studies
AI Framework Cuts Lung Cancer Recurrence Labeling Error by Half
The quality of cancer outcomes research depends almost entirely on the accuracy and completeness of clinical…
Studies
AI Thermal Imaging Detects Diabetic Foot Risk With 97.5% Accuracy
Diabetic foot complications remain one of the leading causes of non-traumatic lower-limb amputation worldwide, yet…
Studies
Global Mental Disorder Burden Rose Sharply From 1990 to 2023
Mental health conditions now represent one of the most consequential drains on human healthspan worldwide — not…
Studies
Nine-Month Fluoxetine Course Reduces PTSD Symptoms After Orthopedic Trauma
Psychological trauma following severe physical injury is a clinically underappreciated comorbidity — yet orthopedic…
Studies
Deubiquitinase OTUD7b Stabilizes TAK1 to Accelerate Diabetic Heart Damage
Diabetic cardiomyopathy remains one of the leading causes of death among people with diabetes, yet its molecular…
Studies
Global TB Burden Declines Since 1990 per GBD 2023, But MDR-TB Progress Lags
Three decades of progress against tuberculosis are now at serious risk of reversal. With global health funding…
Studies
AI Scribes in Residency Training Risk Undermining Clinical Reasoning Development
As artificial intelligence reshapes the mechanics of clinical practice, its earliest and least-examined casualty may…
PREPRINTLongevity
Childhood Smoking Associated with 0.65 Years Accelerated GrimAge Decades Later
In 3,562 participants from the U.S. Health and Retirement Study (mean age 69.6 years), childhood smoking was…
PREPRINTStudies
Solanezumab's Amyloid Endpoint Fails Mediation Test in A4 Trial Analysis
Applying causal mediation analysis to the A4 trial — which tested solanezumab in cognitively unimpaired adults with…
PREPRINTStudies
BRCA1/2 Breast Cancer Survivors Show Lower CVD Rates—But Competing Risks Explain Why
Among 32 matched cohort pairs of breast cancer survivors in the Stockholm-Gotland region (2008–2019), women carrying…
PREPRINTLongevity
3-Domain Capacity Score Predicts 10-Year Mortality in 1,705 Men Over 70
A composite measure of intrinsic capacity — spanning cognition, locomotor function, psychological well-being, and…
PREPRINTStudies
5-Feature AI Model Identifies Type A Aortic Dissection Entry Tear with 97.6% Sensitivity but Only 17% Specificity in External Validation (Preprint)
An automated machine-learning model trained on preoperative CT angiography data correctly identified the primary entry…
Studies
Apelin Analog Reverses Pulmonary Hypertension and Right Heart Failure in Rat Model
Pulmonary arterial hypertension remains one of medicine's most stubborn vascular killers — progressive, difficult to…
Longevity
Cross-Species RNA Atlas Reveals Universal Molecular Clocks of Aging and Death
Understanding why some people age faster than others — and what interventions actually slow biological deterioration…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.