PREPRINTLongevity
42% Speed Drop at Home: Shorter Steps Expose Hidden Mobility Gap in 3,424 Seniors
Wearable inertial sensors tracking 3,424 older adults reveal a dramatic 0.41 m/s difference between clinical corridor…
Longevity
Oral Semaglutide Failed Symptomatic Alzheimer's Trials Despite Biomarker Gains
The EVOKE and EVOKE+ trials delivered a sobering verdict: oral semaglutide failed to slow clinical progression in…
Supplements
Narrative Review: GLP-1 Receptor Agonists May Improve Testosterone and Erectile Function Beyond Weight Loss
GLP-1 receptor agonists (GLP-1RAs) — originally developed for type 2 diabetes and now dominant obesity pharmacotherapy…
Supplements
NR Fumarate Salt Raises Blood NAD+ at 3× Lower Dose Than NMN or NR Chloride
A proprietary crystalline salt form of nicotinamide riboside — NR fumarate, branded Restorin NR — achieved blood NAD+…
Longevity
Single-Subject DELTA Protocol Integrates TRE, Mediterranean Diet, and AI Biomarkers for Healthspan
The DELTA protocol—a prospective, open-label, N=1 interventional study on one healthy individual—combined…
Studies
FGF23 Mutation Mechanisms Reveal New Targets for Phosphate Disease Treatment
Phosphate metabolism rarely makes headlines, yet its dysregulation underlies some of the most debilitating bone and…
Supplements
Genomic Map of 287 Ginseng Accessions Unlocks Ginsenoside Biosynthesis Pathway
For anyone who takes ginseng supplements or follows adaptogen research, a fundamental question has lingered: why do…
Studies
Endosomal Channel TPC1 Found to Regulate Cellular Iron Absorption Mechanism
Iron metabolism disorders—ranging from hereditary hemochromatosis to chronic anemia—affect hundreds of millions of…
Studies
3D Epigenomic Map Reveals Critical Gaps in Lab-Grown Retinal Cell Therapy
For the millions living with age-related macular degeneration and other RPE-related blinding diseases, cell-based…
Studies
Small-Molecule AT1R Agonist Challenges Decades of Cardiovascular Drug Design
For decades, the pharmacological playbook for the angiotensin II type 1 receptor has been written in one direction…
Studies
AgRP Neurons Identified as Essential Brain Circuit for GLP-1 Drug Weight Loss
Understanding why semaglutide and similar drugs produce such dramatic, sustained weight loss has been one of the…
Longevity
Gut Cells Sense Food Quantity Via Cytoplasmic Fluidity to Control Cell Fate
How intestinal cells decide whether to renew, differentiate, or die has long been framed around molecular signals…
Nutrition
Early Sugar Restriction Cuts Adult Cancer Risk via Slowed Biological Aging
The conventional focus on adult dietary habits may be missing a far more consequential window: the first years of…
Nutrition
Broken Liver Clock Protein Explains Why Keto Backfires in Metabolic Disease
The ketogenic diet has become one of the most debated nutritional interventions in metabolic medicine — praised for…
Studies
Microfluidic Cell-Sorting Platform Isolates Metastatic Tumor Subpopulations by Physical Deformability
Understanding why some cancer cells metastasize while others stay put has long been one of oncology's hardest problems…
Studies
IPD Meta-Analysis Protocol Targets Optimal BP Lowering After Brain Hemorrhage
For the roughly one in four stroke survivors whose event was hemorrhagic rather than ischemic, secondary prevention…
Studies
Oviduct Fold Alignment Proves Dispensable for Egg Transport to Uterus
A long-standing assumption in reproductive biology — that the precisely oriented longitudinal folds lining the oviduct…
Studies
CRISPR Screen Identifies Four Gene Knockouts That Boost CAR-T Persistence in Solid Tumors
The stubborn failure of CAR-T cell therapies against solid tumors — in contrast to their success in blood cancers…
Studies
Most Brain Science Sex-Difference Claims Lack Valid Statistical Support
Precision medicine's promise of personalized treatment hinges on identifying who actually responds differently to…
Nutrition
Maternal Vitamin A Intake Explains Why STRA6 Eye Mutations Vary in Severity
For decades, clinicians have puzzled over why two patients carrying identical mutations in the same gene can present…
Browse Topics
Longevity & Anti-Aging Research Nutrition & Diet Science Exercise & Fitness Science Wellbeing & Integrative Health Medical Studies & Clinical Trials Supplements & Nutraceuticals✉️ Stay Updated
Get daily health research summaries delivered to your inbox.
Health & Longevity Topics
Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.