PREPRINTLongevity
New Intrinsic Capacity Score Predicts Disease Risk Across 500,000 People
A comprehensive health scoring system combining cognition, movement, sensory function, vitality, and psychological…
PREPRINTStudies
GPS Tracking Links Spatial Racism to Daily Sleep and Stress in Young Minorities
A novel GPS-based methodology tracked 32 young sexual and gender minorities of color across New York City…
PREPRINTLongevity
Shingrix Zoster Vaccine Associated With 26% Lower All-Cause Mortality Risk in Dementia Patients
A large-scale analysis of 68,960 US dementia patients found that those receiving the recombinant zoster vaccine…
PREPRINTStudies
1918 Swiss Flu Data Reveals Morbidity-Mortality Patterns Diverge
Analysis of Swiss data from the 1918-1920 influenza pandemic reveals that factors driving illness rates differ…
PREPRINTWellbeing
Early-Life Social Class Predicts Long-Term Memory Accuracy 50 Years Later
Analyzing 62-year-olds from Britain's 1958 birth cohort, researchers found that social class origins cast a shadow…
Studies
Arginine Cluster Engineering Boosts CAR-T Cell Tumor Killing Efficacy
A novel protein engineering approach could dramatically enhance one of medicine's most promising cancer treatments by…
Wellbeing
Semaglutide's 15% Weight Loss May Require Earlier Bone Monitoring
A 65-year-old woman achieved 15% weight loss on semaglutide over one year, improving her blood pressure, lipid…
Longevity
Geroscience Targets Four Aging Hallmarks to Delay Multiple Chronic Diseases
Scientists identify four core biological drivers that fuel multiple age-related diseases simultaneously: genomic…
Longevity
High-Salt Diet Triggers Vascular Aging Through IL-16 Immune Pathway
A 28-day high-salt diet (8% NaCl) induced endothelial dysfunction in mice through cellular senescence rather than…
Studies
Cellular Organelles Control Reflective Crystal Formation in Pigment Cells
The discovery of how cells manufacture reflective crystals could unlock new approaches to age-related vision loss and…
Studies
PD-1 Cancer Immunotherapy May Inadvertently Deplete Critical Liver T Cells
Cancer immunotherapy's most celebrated checkpoint inhibitor may be undermining its own effectiveness through an…
Longevity
Muscle FoxO Proteins Essential for Healthy Fat Processing During Fasting
Skeletal muscle may hold unexpected keys to preventing fatty liver disease during periods of caloric restriction or…
Wellbeing
Dopamine Receptors D1 and D2 Control Different Aspects of Decision-Making
Understanding how the brain makes complex decisions could unlock new approaches to treating cognitive disorders and…
Studies
AI Systems Reconstruct Human Metabolic Models with Enhanced Accuracy
The ability to map how the human body processes nutrients and energy represents one of the most complex challenges in…
Studies
Desert Microbes Time Pigment Production to Maximize Dawn Energy Capture
Desert survival hinges on split-second timing, and cyanobacteria have perfected one of nature's most precise…
Studies
CCR4 Receptor Structure Reveals Dual Drug Targeting Pathways
Cancer immunotherapy gains a powerful new roadmap as scientists decode how immune cells navigate to tumor sites. The…
Studies
Stabilizing Selection Creates Genetic Barriers Preventing Sex Chromosome Evolution
The evolutionary stability of sex determination systems varies dramatically across species, with some lineages…
Studies
Synthetic Membrane Proteins Successfully Designed Using Negative-Space Engineering Approach
Membrane protein engineering just cleared a major hurdle that has stymied biotechnology for decades. The ability to…
Wellbeing
Fetal Brain's Temporary Subplate Shows Regional Growth Patterns via MRI
Understanding how the fetal brain constructs its neural architecture could reshape approaches to preventing…
Studies
AI Designs Spatial Epitope Scaffolds to Advance Malaria Vaccine Development
Artificial intelligence could transform malaria vaccine development by precisely engineering how immune-activating…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.