A novel GPS-based methodology tracked 32 young sexual and gender minorities of color across New York City neighborhoods, revealing that a compound gendered racism index predicted daily mood deterioration (b=-0.048) and increased stress (b=0.121) more accurately than single-factor measures. Daily experiences of intersectional discrimination significantly disrupted sleep patterns (b=1.308). The research introduces the Spatial Intersectionality Health Framework, identifying three mechanisms by which physical spaces perpetuate health inequities: layered oppression systems activating simultaneously, the same location producing different health impacts based on identity, and ostensibly safe spaces carrying hidden costs for specific groups. This represents a methodological breakthrough in health disparities research, moving beyond documenting that place affects health to specifying exactly how spatial configurations generate different outcomes for multiply marginalized individuals. The framework could revolutionize targeted interventions by pinpointing precise mechanisms of harm rather than relying on broad geographic generalizations. However, the small pilot sample limits generalizability, and this preprint awaits peer review, so findings require replication. The integration of real-time GPS tracking with psychological assessment offers unprecedented granularity for understanding environmental health determinants.