Higher Step Counts Associated With Offsetting Sedentary Disease Risks for Some Conditions

The modern struggle between desk jobs and health just got quantified in unprecedented detail, revealing how many extra…

Keratin 16 Protein Suppresses Immune Inflammation in Skin Barrier Defense

The body's largest organ may have a previously unrecognized immune regulator working quietly beneath the surface. New m…

Plasma Acetic Acid Links Gut Microbes to Brain Volume in Older Adults

Specific gut microbial communities produce acetic acid that circulates in plasma and directly influences multiple healt…

Glial Cell Dysfunction Actively Drives Brain Aging: Insights from Single-Cell Analysis on Heterogeneity and Regional Vulnerability

Advanced single-cell analysis reveals that glial cells—microglia, astrocytes, and oligodendrocytes—undergo dramatic cel…

CAR-T Cell Senolytic Therapy Fails to Improve Outcomes in ALS Mouse Model

NKG2D CAR-T cells successfully eliminated senescent astrocytes and reduced inflammatory secretions in the central nervo…

Cellular Senescence Links Preeclampsia to Accelerated Cardiovascular Aging

Preeclampsia triggers cellular senescence—a state where cells stop dividing but release inflammatory molecules—creating…

Seven Evidence-Based Strategies Could Cut Eating Disorder Treatment Dropout Rates

Treatment dropout represents one of the most significant barriers to eating disorder recovery, yet receives surprisingl…

Multiple Brain Systems Must Be Targeted Simultaneously for Alzheimer's Treatment

The traditional approach of targeting single pathways in Alzheimer's disease has largely failed, prompting a fundamenta…

Alzheimer's Disease Requires Multi-Target Treatment Approach, Not Single Pathway Focus

The decades-long search for a single Alzheimer's cure may be fundamentally misguided. Rather than one broken system cau…

Strong Workplace Relationships Linked to Better Health in Childcare Teachers

The demanding world of early childhood education takes a measurable toll on teachers' wellbeing, but new evidence sugge…

Expert Consensus on CT Phenotypes Advances Classification and Supports Sarcoidosis Diagnosis Without Biopsy in Typical Cases

Accurate diagnosis of sarcoidosis has long required invasive tissue biopsy, but advanced imaging is changing this clini…

Hyaluronic Acid Knee Injections Show Patient-Centered Benefits for Osteoarthritis

For aging adults seeking alternatives to knee replacement surgery, the evidence base for hyaluronic acid injections has…

Traditional Serrated Adenomas Increase Colorectal Cancer Risk Sevenfold

Adults who harbor traditional serrated adenomas face dramatically elevated cancer risk that persists long after polyp r…

SARS-CoV-2 Protease Hijacks Cellular Death Switch to Trigger Senescence

The discovery of how viruses manipulate cellular aging could reshape our understanding of both infection recovery and t…

Latino Survival Advantage Masks Growing Health Disparities in US Population

Despite comprising one-fifth of the US population, Latino health outcomes present a paradox that challenges conventiona…

Thyroid-Stimulating Hormone Receptor Conformational Dynamics Reveal Potential Therapeutic Targets

Understanding how thyroid-stimulating hormone receptors function at the molecular level could unlock more precise treat…

Candida Fungal Cells Use Mechanical Sensing for Pathogenic Navigation

Pathogenic fungi may possess a previously unknown navigation system that could explain their remarkable ability to inva…

SKIP

Humanized Mouse Model Accelerates Discovery of Schistosomiasis Treatments

The fight against schistosomiasis, a parasitic disease affecting over 200 million people globally, may have gained a cr…

Brain Interface Training Enables Voluntary Cortical State Control in Humans

The ability to consciously control brain states on demand represents a frontier breakthrough that could revolutionize c…