Longevity
PCPhenoAge Clock Links Biological Age Acceleration to Hippocampal Shrinkage in Two Cohorts
Among ten second-generation epigenetic clocks tested across two independent cohorts—AIBL and ADNI—the Principal…
Longevity
Short Telomeres Predict 30% Higher 10-Year Death Risk in Hospitalized Elderly
Among 872 hospitalized adults aged ≥65 in Italy's Report-AGE cohort, shorter-than-expected leukocyte telomere length…
Longevity
25-Year Bibliometric Maps Redox-Mitochondrial Mechanisms Behind Exercise-Telomere Protection
A bibliometric analysis of 858 telomere-exercise publications from 2000–2025 documents a field-wide mechanistic pivot…
Longevity
Review Maps 9 Shared Cellular Pathways Potentially Connecting Dementia, Mood Disorders, and Metabolic Issues Like Diabetes in Aging
After age 65, risk for both cognitive decline and mood disorders nearly doubles every five years — and a single…
Longevity
Rapamycin Attenuates Age-Related Changes in Marmoset Salivary Glands
In aging common marmosets (Callithrix jacchus), submandibular glands exhibit a striking degenerative profile: loss of…
Longevity
Piperlongumine Attenuates OA Progression by Clearing Senescent Joint Cells via ROS Pathway
Piperlongumine (PL), a natural alkaloid from long pepper, outperformed competing senolytics in selectively eliminating…
Longevity
Senolytic D+Q Mitigates Muscle Atrophy and Cartilage Degradation After ACL Injury in Preclinical Model
Anti-inflammatory macrophages emerge as the dominant senescent cell population in both skeletal muscle and knee joint…
Longevity
Five Molecular Hubs Drive Inflammaging — All Potentially Druggable
Chronic low-grade inflammation in aging — inflammaging — is mechanistically orchestrated through five convergent…
Longevity
Dual-Parameter qCAGEs Platform Classifies Senolytic vs. Anti-Aging Effects Using 6-Fold Biomarker Distinction
A new high-throughput screening framework called qCAGEs simultaneously measures α-L-fucosidase (4ME) enzymatic…
Studies
Genetic Testing Reclassifies 43% of Hypertension-Attributed Kidney Failure Cases
For the thousands of adults entering kidney transplant evaluation each year, the underlying cause of their kidney…
Studies
Precision Oncology Reshapes Treatment Landscape for Two Lethal GI Cancers
Two of oncology's most formidable diagnoses may be entering a new era — not through a single breakthrough, but through…
Studies
Blood Gene Signatures Distinguish Early Cervical Artery Dissection From Recovery Phase
Stroke in young adults remains one of medicine's more unsettling puzzles, partly because cervical artery dissection…
Studies
Lower Respiratory Infections Still Kill Millions Despite Three Decades of Progress
Lower respiratory infections remain one of the most persistent threats to human survival despite decades of vaccines…
Studies
Clemastine Alleviates Cognitive Dysfunction in Mouse SAH Model by Targeting Neuronal CNTN1 and ADA-Adenosine Pathway
Brain hemorrhage survivors face a largely invisible aftermath: even when the bleeding is controlled and the patient…
Studies
Chemistry-Guided PROTAC Delivery Systems Could Unlock Undruggable Disease Targets
For decades, roughly 80% of disease-causing proteins have been considered undruggable because conventional small…
Studies
PARP1 Enzyme Drives Heart Failure Fibrosis via FHL2 Protein Modification
For the millions living with ischaemic heart failure, cardiac fibrosis — the progressive stiffening of heart tissue…
Studies
Adenosine Receptor Pathways Emerge as Precision Targets for Vascular Disease Treatment
For the roughly one billion adults worldwide living with some form of cardiovascular or vascular disease, the…
Studies
DSC2 Gene Loss Drives Cardiac Fibrosis via TGF-β2 Pathway in Rare Cardiomyopathy
For the roughly 1-in-5,000 adults carrying mutations in desmosomal proteins, arrhythmogenic right ventricular…
Studies
Blocking BCL9 Proteins Boosts CD4+ T Cell Attack on Tumors Via STAT Pathway
Cancer immunotherapy's next frontier may lie not in checkpoint inhibitors, but in the molecular scaffolding that…
Studies
Endothelial Protein Loss Fuels Parasite-Driven Pulmonary Hypertension via Inflammatory Receptor
Pulmonary arterial hypertension linked to parasitic infection is the single largest cause of PAH globally, yet its…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.