Studies
Complement Immune Pathway Strengthens as Schizophrenia Research Target
Schizophrenia has long resisted disease-modifying therapies, with most existing treatments managing symptoms rather…
Longevity
7-Tesla MRI Reveals Glymphatic Stagnation in Pre-Parkinson's Sleep Disorder
Long before motor symptoms appear in Parkinson's disease and related synucleinopathies, the brain may already be…
Studies
Fever May Temporarily Block Malaria Transmission by Killing Infectious Gametocytes
A subtle but potentially consequential insight about malaria transmission emerges from molecular parasitology: the…
Studies
nNOS Inhibitor BA-101 Reverses Temozolomide Resistance in Glioblastoma Models
Glioblastoma's near-universal fatality stems less from initial tumor biology than from its almost inevitable…
Wellbeing
Wearable NIRS Device Maps Brain Glymphatic Water Shifts Across Sleep Stages
Understanding how the sleeping brain cleans itself has long been hampered by the inability to monitor the process in…
Studies
Million-Person Study Reveals How Gene Deletions and Duplications Shape Height and BMI
Understanding why individuals with identical rare genetic mutations end up with wildly different health outcomes has…
Nutrition
Maternal Oxylipin Levels at Mid-Pregnancy Linked to Toddler Neurodevelopment Deficits
What happens in the womb during the second trimester may shape a child's brain trajectory far more than previously…
Studies
Glicentin Activates GIP Receptor at 877nM: A Weak Cross-Receptor Agonist Discovered
Screening 42 candidate peptides against the glucose-dependent insulinotropic polypeptide receptor (GIPR), Cambridge…
Supplements
Resveratrol Suppresses PCOS Inflammation via JAK2/STAT3-AIM2 Pathway Block
Chronic inflammation in polycystic ovary syndrome (PCOS) worsens hormonal dysregulation, yet its precise molecular…
Longevity
PM2.5 Associated with Gut Microbiome Shifts Elevating 2-Oxoglutarate, Linked to Up to 56% Higher Odds of Cognitive Impairment
In 1,027 older adults, higher residential PM2.5 and ozone exposures were associated with reduced abundances of…
Longevity
DNA G-Quadruplex Buildup in Microglia Worsens Stroke via mTOR-Autophagy Suppression
Cerebral ischemia drives dynamic accumulation of G-quadruplex (G4) DNA structures within microglia — the brain's…
Longevity
Synthetic Cyclohexene UCM-17017 Clears Senescent Cells, Reverses Pulmonary Fibrosis in Mice
A tetrasubstituted cyclohexene compound, UCM-17017 (compound 25), identified through phenotypic screening of a human…
Nutrition
AGEs, Oxysterols & NF-κB: Diet's Dual Role in Inflammaging Mapped
Chronic low-grade inflammation driven by dietary advanced glycation end products (AGEs), lipid peroxidation products…
Studies
Tirzepatide Continuation Sustains 20% Weight Loss Over Two Years
For the millions of adults who achieve clinically meaningful weight loss on GLP-1/GIP receptor agonists, the real…
Studies
Bayesian Model Predicts Dual Alcohol-Cannabis Disorder Risk From Adolescent Data
Identifying which adolescents will develop substance use disorders before those disorders take hold could transform…
Nutrition
Fasting Activates Gut Microbe-Epigenetic Axis to Accelerate Intestinal Stem Cell Recovery
The idea that short-term fasting might protect the gut from radiation damage has circulated in oncology for years, but…
Studies
Autologous HIV Antibodies Quantify Which Latent Viruses Can Actually Rebound
One of the most vexing obstacles in HIV cure research is not eliminating the virus entirely — it is predicting which…
Studies
Lipid Pathways Important for Hepatitis E Virus Replication, with Potential Pregnancy Links
Hepatitis E virus remains one of the most underappreciated global health threats, killing tens of thousands annually…
Studies
TMED9 Protein Hijacks Autophagy Pathway to Fuel Lung Cancer Growth
Lung cancer remains stubbornly lethal partly because tumors commandeer the body's own cellular recycling machinery to…
Studies
Dual Electrostatic Gates Link Proton Sensing to Calcium Channel Leakage
Calcium homeostasis is one of the most consequential regulatory systems in biology — its disruption underlies…
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Browse our synthesized research summaries by topic. We cover the latest findings from journals like Nature Medicine, The Lancet, Cell Metabolism, and 100+ other peer-reviewed sources.