A 28-day double-blind, placebo-controlled trial of Qualia NAD+, a multi-ingredient supplement combining nicotinamide riboside (NR) with synergistic vitamins, minerals, and botanicals, produced a 67% increase in blood NAD+ levels versus 4% in the placebo group (p<0.001) among 63 healthy adults. Emotional well-being improved across multiple weekly timepoints (p<0.05), and female participants showed significant reductions in somatic and overall aging symptoms at day 28, while males showed no significant symptom improvement.
NAD+ decline is a well-established hallmark of cellular aging, and NR and NMN supplementation have attracted intense research interest as strategies to restore youthful NAD+ biology. Most prior single-ingredient NR trials have shown more modest blood NAD+ elevations at comparable doses, so the 67% rise here is noteworthy — though the formulation's complexity makes it impossible to isolate which ingredients drove the effect. Critically, this preprint has not yet been peer-reviewed, and results should be treated with caution. The sample is small (n=63), the trial lasted only four weeks, and outcomes rely heavily on self-reported quality-of-life surveys rather than hard physiological endpoints such as muscle function, metabolic markers, or cardiovascular outcomes. The sex-specific finding in females is intriguing but underpowered. Funding and potential conflicts of interest are not declared in the abstract, and the product is commercially branded — both flags for scrutiny. Overall, this is an incremental but directionally interesting contribution that warrants larger, longer, and independent replication.