Cancer incidence is surging across Sub-Saharan Africa, with the region accounting for the majority of new cases in low-income countries globally. This analysis examines how structured physical activity interventions could serve as both preventive medicine and therapeutic support in resource-constrained healthcare systems. The timing is critical given Africa's rapid urbanization and lifestyle transitions that mirror patterns seen in developed nations decades earlier. Physical activity as medicine represents a particularly promising approach for Sub-Saharan Africa because it requires minimal infrastructure compared to pharmaceutical interventions or advanced medical technologies. The strategy could address multiple cancer risk factors simultaneously while building on existing community structures and cultural practices around movement and dance. However, successful implementation faces substantial barriers including limited healthcare workforce training, lack of standardized protocols, and competing health priorities in regions still managing infectious disease burdens. The approach also requires careful cultural adaptation to ensure programs align with local customs and economic realities. If properly executed with community engagement and government support, exercise-based interventions could provide a scalable, cost-effective tool for cancer prevention that leverages Africa's demographic advantages while addressing its growing non-communicable disease challenge.