C. elegans research reveals a crucial distinction between living longer and aging well. While seven tested compounds universally extended male worm lifespan, only sulforaphane and metformin preserved reproductive capacity in later life. This finding challenges the assumption that longevity interventions automatically improve all aspects of healthspan. The disconnect between survival and fertility suggests different biological pathways govern various aging processes, even within the same organism. For human health optimization, this research reinforces emerging evidence that metformin's benefits extend beyond glucose control to broader healthspan preservation. Sulforaphane, abundant in cruciferous vegetables like broccoli sprouts, continues to demonstrate multi-system anti-aging effects. The sex-specific response patterns observed here align with human epidemiological data showing men and women age differently and may require tailored interventions. While worm studies don't directly translate to humans, this model's genetic similarity to mammals makes it a valuable screening platform. The research establishes that effective longevity compounds must be evaluated not just for lifespan extension but for preserving specific functions that define quality of life, suggesting future anti-aging strategies should target multiple aging mechanisms simultaneously.