Researchers engineered nano-aggregates combining natural polyphenols (resveratrol and piceatannol) with porphyrin photosensitizers, achieving remarkable 51.1% photothermal conversion efficiency under 730 nm light. The piceatannol formulation (T4PIC NPs) demonstrated superior bacterial sterilization at low doses while the multi-hydroxyl polyphenol structures simultaneously scavenged reactive oxygen species and reduced inflammation. This dual-action approach represents a significant advancement in wound care technology. Traditional wound treatments typically focus on either bacterial elimination or inflammation control, but rarely both effectively. The nano-aggregate's J-aggregate architecture—where molecules align in ordered arrays—explains the exceptional light-to-heat conversion that surpasses most existing porphyrin-based systems. The integration of well-studied polyphenols like resveratrol adds biological compatibility and antioxidant benefits that pharmaceutical approaches often lack. While promising for advanced wound management, the technology requires clinical validation to confirm safety and efficacy in human tissue. The carrier-free design eliminates potential toxicity from synthetic delivery vehicles, though manufacturing scalability and cost remain practical considerations for widespread therapeutic application.