The promise of managing stress from home without medication or therapy sessions could transform how millions approach mental wellness. With nearly one billion people affected by anxiety and depression globally, accessible interventions that build resilience before problems escalate represent a critical frontier in preventive health. Thirty-one healthy middle-aged adults self-administered transcranial direct current stimulation targeting the left dorsolateral prefrontal cortex for ten sessions over two weeks. This brain region governs executive function and emotional regulation. Participants achieved 98% adherence with remote monitoring, experiencing only mild transient side effects in four cases and no serious adverse events. The intervention significantly reduced acute stress appraisal when participants faced controlled stress challenges, though anxiety scores and physiological markers like skin conductance remained unchanged. This selective improvement suggests the stimulation may enhance cognitive reframing of stressful situations rather than broadly dampening stress responses. The feasibility of home-based brain stimulation marks a notable shift from clinic-dependent neurostimulation protocols. However, several limitations temper enthusiasm. The absence of a control group makes it impossible to separate genuine effects from placebo responses or natural adaptation. The brief two-week protocol may have been insufficient to produce measurable physiological changes, which often require longer intervention periods. Additionally, testing only healthy adults limits generalizability to populations with elevated baseline stress or clinical anxiety. While promising for stress resilience enhancement, this technology requires controlled trials and extended protocols before clinical recommendations.