Polysaccharides extracted from Eurycoma longifolia Jack (Malaysian ginseng) significantly extended both lifespan and healthspan in fruit flies and roundworms by activating the evolutionarily conserved IIS/DAF-16 signaling pathway. The compounds reduced cellular aging markers including lipofuscin accumulation and protein aggregation while enhancing antioxidant enzyme activity and restoring metabolic balance across amino acid, carbohydrate, and lipid networks. This represents a noteworthy addition to the growing catalog of plant polysaccharides with longevity benefits, joining compounds from sources like astragalus and goji berries that target similar pathways. The dual-species validation strengthens confidence in the findings, as mechanisms conserved between invertebrates and mammals often translate meaningfully to human biology. However, the leap from laboratory organisms with 2-week to 3-month lifespans to human applications spanning decades requires substantial caution. The study's strength lies in its comprehensive mechanistic analysis, moving beyond simple lifespan extension to demonstrate concrete cellular protection and metabolic restoration. While promising for nutraceutical development, the practical impact will depend entirely on whether these polysaccharides survive human digestion and reach target tissues at effective concentrations.