Among 638 adults eligible for HIV pre-exposure prophylaxis in coastal Kenya, nearly one in four (24.1%) reported lifetime intimate partner violence exposure, with women experiencing higher rates across all violence types. Having children doubled IPV risk for women (risk ratio 2.30), while sex work involvement increased risk 2.4-fold for men and 1.8-fold overall. The findings reveal a critical intersection between HIV vulnerability and domestic violence that undermines prevention efforts. This dual burden creates complex barriers to PrEP adherence, as violence can disrupt healthcare access, medication storage, and partner disclosure—all essential for successful HIV prevention. The study's strength lies in including men, who are often overlooked in IPV research despite comprising 37% of participants. However, the cross-sectional design cannot establish causality, and excluding participants with ongoing violence for safety reasons may underestimate true prevalence. As a preprint awaiting peer review, these results require confirmation through the review process. The research highlights an urgent need for integrated violence screening and support services within HIV prevention programs, particularly in high-burden settings where multiple vulnerabilities converge to compound health risks.