Analysis of 94 studies reveals that TEGDMA, a widely used resin monomer in dental fillings and crowns, induces cellular senescence in dental pulp stem cells through oxidative stress and DNA damage. The research identifies p16, p21, and p53 as consistent senescence markers, with hydrogen peroxide and inflammatory lipopolysaccharides serving as primary triggers alongside replicative exhaustion. This finding extends beyond dentistry to illuminate how everyday medical materials might accelerate aging processes throughout the body. Dental pulp offers a unique window into senescence biology because these stem cells are readily accessible and naturally regenerative. The discovery that common dental resins compromise cellular vitality has immediate clinical implications—practitioners could select materials based on senescence potential rather than just mechanical properties. More broadly, this work suggests that medical devices and implants across specialties may unknowingly accelerate local tissue aging through similar oxidative pathways. The identification of effective senolytic compounds and antioxidants in this context provides a roadmap for developing anti-aging therapeutics that could preserve tissue regenerative capacity during medical interventions. This represents a paradigm shift toward evaluating all biomaterials through an aging lens.