Polyphenol extracts from unripe Annurca apple peels demonstrated dual senomorphic and senolytic activity in oxidatively stressed human dermal fibroblasts, reducing senescence markers while restoring mitochondrial homeostasis. The unripe peel extracts outperformed ripe peel extracts, which showed predominantly senolytic effects with increased oxidative stress, while flesh extracts proved largely ineffective. This represents a significant advancement in senotherapeutics research, as most compounds show either senomorphic or senolytic properties, but rarely both. The finding addresses a critical gap in anti-aging interventions where purely senolytic approaches can cause inflammation through senescent cell clearance. The ripening-dependent efficacy suggests optimal harvest timing could maximize therapeutic potential, making agricultural waste streams valuable for pharmaceutical applications. However, this remains early-stage research requiring human clinical validation. The selective toxicity toward senescent versus healthy cells is promising for safety profiles, but the transition from cell culture to topical or systemic human applications faces substantial hurdles. While confirmatory rather than paradigm-shifting, this work expands the senotherapeutic toolkit and validates fruit-derived polyphenols as legitimate anti-aging candidates beyond traditional antioxidant roles.